Category Archives: Cancer

Evolutionary history of a cancer-related gene

A study published today by scientists from the Spanish National Cancer Research Centre (CNIO) describes how a genetic duplication that took place in the vertebrate ancestor some 500 million years ago encouraged the evolution of the ASF1b gene; a gene essential for proper cell division and related to some types of cancer such as breast cancer. The results of the study are published in Molecular Biology and Evolution. The conclusions of the study are the result of collaboration between the team led by Alfonso Valencia, Vice-Director of Basic Research and Director of CNIO’s Structural Biology & Biocomputing Programme, and the team led by Genevieve Almouzni, a member of CNIO’s Scientific Advisory Committee, at the Institut Curie in Paris, France. Valencia says that: "When proteins have such a close similarity as the one that exists between the two human copies of the ASF1 gene — ASF1a and ASF1b — it is commonly assumed that they have similar functions in cells; in this case related to fundamental processes such as DNA remodelling and repair, cell division, cell proliferation and genetic transcription or activation." The Genomic Environment, Key to Success in Separating Functions Almouzni’s team discovered several years ago that, despite the similarity in structure, the two copies of ASF1 were not redundant, but rather had divided up their ancestral functions…

Woman gives birth to surprise baby after two-hour run

An aspiring half-marathon runner in Minnesota whose two-hour training session left her with a sore back was stunned to discover that the pain was not due to a pulled muscle or a slipped disc but that she was about to give birth. Trish Staine says she had no idea she was pregnant. The 33-year-old Duluth mother of three insists she gained no weight, felt no fetal movement - and that her husband has had a vasectomy. Staine says she noticed what she now realizes were labor pains after her run at noon on Sunday but she didn't go to the hospital until the following day. She gave birth to Mira - short for Miracle - at 3:25 p.m. Monday. Mira weighed 6 pounds, 6 ounces, and was 18.9 inches long.source : http://www.foxnews.com/health/2013/06/06/woman-gives-birth-to-surprise-baby-after-10-mile-run/

Medical breakthrough for multiple sclerosis sufferers

In a breakthrough discovery, researchers have discovered a treatment capable of reducing the debilitating autoimmune response that occurs in people suffering from multiple sclerosis (MS). When patients are diagnosed with multiple sclerosis, their bodies begin to attack the protein myelin, which insulates the body’s spinal cord, brain and optic nerves. As a result, MS patients experience symptoms such as numbness in their limbs, paralysis and sometimes blindness. However, during a phase one clinical trial of a new treatment for MS patients, researchers were able to curtail the body’s attacks on myelin by 50 to 75 percent, while sustaining the functionality of the rest of the immune system. Current treatments for MS seek to lessen the body’s autoimmune response to myelin, but this often results in decreased effectiveness of the entire immune system. “Most therapies for autoimmune diseases employ approaches broadly called immunosuppressors – they knock down immune response without specificity,” study co-author Stephen Miller, professor of microbiology-immunology at Northwestern University Feinberg School of Medicine, told FoxNews.com.  “People can become highly susceptible to everyday infections and develop higher rates of cancer.” Miller and his colleagues sought a more targeted ‘tolerance’ treatment that would leave the greater immune system intact while knocking out only the autoimmune response to myelin. “In MS, the idea is to target autoreactive T-cells directed against myelin…which would (reduce) disease progression, but wouldn’t make patient susceptible to higher rates of infection,” Miller said. In a study published in the journal Science Translational Medicine, a small group of MS patients were treated intravenously with an infusion of their own white blood cells, which had been engineered to carry billions of myelin antigens. Researchers hoped the cells would teach the body to stop attacking myelin. Miller and his team needed to determine if the treatment, which was based on 30 years of previous research, could be safely applied in humans – and they were pleased to discover it could be. “It was safe to infuse as many as 3 billion autologous cells that we collected and manipulated back into the same patient and didn’t trigger exacerbations,” Miller said. “Most patients didn’t show any increased signs of disease during the six-month follow up.” Furthermore, the treatment did not seem to impede the larger immune system. Researchers tested this by analyzing whether or not each patient continued to retain their immunity to tetanus, for which all of the patients had previously been vaccinated. “Among four patients receiving the highest doses (of autologous cells),  immune response to myelin antigens had diminished or gone away - but tetanus had not gone away,” Miller said. This indicated that the immune system’s ability to fight other diseases after the procedure remained intact. Though researchers caution that the study was too small to draw any significant conclusions, they are optimistic about the outcomes of larger studies and the ability of this treatment to help halt the progress of MS – particularly among recently-diagnosed patients. “The idea is that if we’re able to intervene early enough in disease process, we can stop the autoimmune destruction and (the patient) will have little or no clinical deficit as result of earlier attacks before being diagnosed,” Miller said. Researchers hope to receive funding to begin a phase two trial soon.source : http://www.foxnews.com/health/2013/06/06/medical-breakthrough-for-multiple-sclerosis-sufferers/

5 siblings may all need heart transplants

Two of Jason and Stacy Bingham's young children have required heart transplants and the other three are facing the same fate. The Oregon couple thought they had their fair share of bad luck when 6-year-old Sierra got a transplant due to her failing heart. Six years later they were devastated to find out that 8-year-old daughter Lindsey would also require a heart transplant. Lindsey had presented with stomach pains and difficulty breathing, and her face and stomach were swollen. The children suffer from rare genetic condition affects approximately six out of every 1 million kids under 18 each year. It is a disease called dilated cardiomyopathy, which makes the heart increasingly weaker - and larger, as it tries to compensate. “At the time when the older sister was first diagnosed, not much was known about the genetics that can cause these defects,” the family's cardiologist Dr Daniel Bernstein told TODAY.com. “Today there are genetic tests.” So the Binghams got their children tested. Their son Gage, 4, has already had a pacemaker installed and will likely need a heart transplant at some point. Their 10-year-old Megan has shown a minor heart abnormality while 6-year-old Hunter is yet to display any problems, but given the family history it is something that he too will possibly face at some point. Click for more from news.com.au. To help the Bingham, visit http://www.heartsforbinghams.org/ or follow their blog http://jasonandstacybingham.blogspot.com/.source : http://www.foxnews.com/health/2013/06/06/5-siblings-may-all-need-heart-transplants/

Disinfecting robot zaps superbugs

A new breakthrough in superbug fighting technology is changing the way patients view hospitals—and it goes by the name TRU-D. The Total Room Ultraviolet Disinfector uses a modified germicidal light to zap bacteria and viruses, and with just one use, it has 99.9 percent disinfection of bacteria and spores, such as influenza and norovirus. “It stops the bacterial organisms from reproducing, and any organism that can't reproduce can't colonize on a patients’ body,” said Michael Hossary, director of environmental services at Robert Wood Johnson University Hospital in New Brunswick, N.J. The TRU-D robot is used in patient isolation areas like the operating room and intensive care unit. After being placed in the room, all drawers are opened, all doors are closed and safety signs are put outside the room to ensure no one enters. The robot is then activated remotely. TRU-D’s Sensor360 technology automatically calculates the UV dose required to disinfect a room. It takes anywhere from 30 minutes to 2.5 hours and can destroy deadly superbugs like C. difficile and MRSA. According to the Centers for Disease Control, C. difficile is linked to 14,000 American deaths each year. TRU-D is only used after traditional hospital cleaning methods are used. “Traditional cleanup methods for isolation patients usually include use of germicidal chemicals on all high touch point surfaces, replacement of the curtains, washing of the walls to ensure patient safety and reduce infection rates,” Hossary said. Over 100 devices are now being used in hospitals across the U.S. and Canada, and Hossary said it’s just one more step to keep patients healthy – especially since most people who visit the hospital are already apprehensive. “It's not easy knowing that you have to go to the hospital,” Hossary said. “Whether it’s for elective surgery or some unexpected event that happens in your life where you have to end up in the ER. So the uncertainty is definitely there, and we want to give patients a piece of mind for that.”source : http://www.foxnews.com/health/2013/06/05/disinfecting-robot-zaps-superbugs/

US births remain steady in 2012

The number of babies born yearly in the United States appears to be leveling off, after declining for the last few years, a new report says. In 2012, there were 3,958,000 babies born in the United States, according to early estimates from the Centers for Disease Control and Prevention. That's about the same as the number of births in 2011, the report says. The number of U.S. births has been decline since 2007, when a record-breaking 4,316,233 babies were born —more births than at the height of the baby boom in the 1950s. But the downward trend slowed between 2010 and 2011, and “essentially flattened” between 2011 and 2012, the report says. The country's birth rate has followed a similar trend, peaking in 2007 at 69.3 births per 1,000 women, and declining until 2011, after which it stabilized. In 2012, there were 63.2 births per 1,000 women between ages 15 and 44, essentially the same as the rate in 2011, the report says. The report is published June 6 by the CDC's National Center for Health Statistics. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/06/us-births-remain-steady-in-2012/

Skipping shots at sick visits tied to vaccine delays

Kids who don't get vaccines when they see their pediatrician for a sick visit - despite being due for the shots - are more likely to fall behind on immunizations and routine check-ups, according to a new study. “It's pretty common that kids will come in (for a sick visit) at a time when they should be getting their shots,” said Steve Robison, the study's author and a researcher at the Oregon Immunization Program, part of the state's health department. Sometimes babies end up skipping those shots, perhaps because parents are concerned they could make a sick baby feel worse or doctors are worried that parents won't come back for a well-baby check-up if infants are already caught up on vaccines. “The challenge is, if they come in sick, are they going to come back and get shots and well-baby visits in a timely way?” Robison said. His findings suggest those babies end up worse off if doctors forgo shots until they're better. “It's very clear that vaccinating at sick visits improves the vaccination rate,” said Dr. Alexander Fiks, a pediatrician at The Children's Hospital of Philadelphia, who was not part of this study. “For parents, what I would say is, don't be afraid to get vaccines at sick visits because, for most kids with minor illnesses, it's really no problem. Medically, it's fine,” he added. The Centers for Disease Control and Prevention recommends that babies receive at least 16 vaccine doses during their first six months. Those are spread across well-child visits. In an earlier study, Robison and his colleagues found a growing number of parents in Oregon are not sticking to the recommended vaccine schedule - so kids end up getting their shots late or not at all. This time, Robison looked at the immunization records of 1,060 children who went to the doctor for an ear infection around the time when a well-baby check-up should occur. All of the children had state-funded health insurance. About 8 percent of the sick babies received a diphtheria, tetanus and pertussis (DTaP) vaccine at the sick visit itself, and another 57 percent had one within a few weeks. The others were late on their shots. Fiks said the findings support the results of other studies showing that when doctors skip shots at sick visits, kids are more likely to end up not following the immunization schedule. What's more, giving shots at sick visits did not seem to stop parents from bringing their baby back for well-child visits. Compared to babies who received their immunizations at routine check-ups, those who had their shots at sick visits had just as many well-baby visits by age two - about five, on average. And kids who skipped the shot at their sick visit, but had another visit within a few weeks, ended up receiving more routine check-ups compared to similar normally-vaccinated children, Robison reported in the medical journal Pediatrics. On the other hand, kids who didn't get a shot at the sick visit or within four weeks had slightly fewer routine visits over their first two years. Increasingly, children are becoming “under-vaccinated,” researchers said. A study earlier this year found that half of some 300,000 kids born between 2004 and 2008 had fallen behind on their immunizations at some point before age 2. The concern is that those children are vulnerable to the diseases that vaccines are designed to prevent. “The more kids within a given classroom who are unprotected, the more likely it is for there to be an outbreak,” said Fiks. The researchers agreed that a minor illness is not a reason to fall behind on routine shots. “If you want to keep the kids on schedule so that they're protected from disease, it's best to give the shot,” Robison said.source : http://www.foxnews.com/health/2013/06/06/skipping-shots-at-sick-visits-tied-to-vaccine-delays/

Public health crisis in Mexico as breastfeeding rates drop, experts claim

Despite the well-known advantages to breast milk and vigorous campaigns around the world championing breast as best, Mexican mothers say the bottle is better. In a dramatic decline over the past six years, today only one in seven mothers in Mexico breast-feeds exclusively in the first six months, the standard recommended by the World Health Organization. That leaves Mexico with nearly the lowest level of breast-feeding in Latin America. Experts call it a public health crisis for a country where millions still live in extreme poverty, dirty water threatens the health of many families and education is poor. Mother's milk is richer in nutrients and antibodies that protect newborns from infections. Mexico has the highest infant mortality rate among the world's 40 largest economies. Between 2005 and 2010, breast cancer deaths increased twice as fast as Mexico's female population, with some experts blaming declining rates of breast-feeding; studies show it cuts a woman's risk of cancer by 50 percent or more. Officials blame an invasion of baby food ads, little regulation of formula companies and the failure of doctors to promote breast-feeding for an overreliance on formula. “Mexico has become the example of what not to do. It's the strongest case of a setback in breast-feeding,” said Marcos Arana Cedeno, a child nutrition expert and health adviser for the state of Chiapas. Feeding newborns with breast milk can save lives in developing nations, where children have higher chances of dying from diarrhea and pneumonia. The WHO has recommended for the past decade that infants be given only breast milk for the first six months. The percentage of Mexican moms who nurse their babies that long fell from 22 percent in 2006 to 14 percent last year, according to a Health Department survey. Only the Dominican Republic has a lower rate of breast-feeding in the region, at 8 percent. Other nations have improved their numbers, led by Brazil and Colombia, which in the past two decades more than tripled the percentage of mothers breast-feeding - to 47 percent in Colombia and 39 percent in Brazil. For many mothers drawn into the urban workforce, nursing a baby while juggling a job is too difficult. “I had to go back to work and I wasn't going to be able to breast-feed him for long. That's why I chose formula,” said Ruth Gonzalez, a clothing company manager. Gonzalez nursed her baby boy, Luis, only at night, after work. He drank formula during the day, and went off breast milk completely after a month. “Formula was just easier,” she said. Yet, even in traditional rural areas, the trend is downward. Breast-feeding fell by half in poor, rural areas, where babies are exposed to more sanitation problems, according to the Health Department survey. Nutritionists complain that Mexico has not adopted laws to meet guidelines adopted by WHO in 1981, which asked countries to restrict companies from providing free samples of formula or approaching new mothers to push their product. “It really is a tragedy,” said Teresa Gonzalez de Cossio, a nutritionist who researches breast-feeding at the National Institute of Public Health. “There is no one making sure we are following international codes. The country is not setting any goals regarding breast-feeding.” Countries such as Brazil and the United States have long stressed the importance of breast-feeding. The U.S. has improved its rate of mothers who exclusively breast-feed for the first six months to 16 percent in 2012 from 11 percent in 2007, according to the U.S. Centers for Disease Control and Prevention. Most New York City hospitals no longer hand out promotional samples of formula and ask new mothers to participate in talks on why human milk is better. Portland, Maine, started a campaign asking businesses to make mothers feel welcome to breast-feed wherever they want. Brazil reversed a decline in breast-feeding in the 1980s by strictly limiting advertising by baby food companies and airing prime-time informational spots with national celebrities to dispel myths, such as that women with small breasts were incapable of nursing. Mexico lets companies self-regulate on following the WHO guidelines. It has rules that say hospitals and doctors should guide new mothers through breast-feeding, but it doesn't enforce them. Dr. Rufino Luna Gordillo, the Health Department's deputy director of maternal and newborn care, said Mexico is renewing periodic checks of breast-feeding practices at public and private hospitals, a policy born in the early 1990s that had fallen by the wayside. “It's clear that these efforts have not been enough to get to the ideal breast-feeding levels,” Luna said in a written statement. “We need to debunk many myths about breast-feeding, limit the abuse of infant formula makers ... and award companies that offer nursing rooms.” Some new mothers say they didn't receive any help on breast-feeding after giving birth and say nurses, without seeking permission, offered formula to newborns at the nursery. In addition, with half of the babies born in Mexico via cesarean-section, many mothers struggle to nurse in the first hours and days after surgery. With little government promotion of breast-feeding, myths proliferate: sagging breasts do not provide healthy milk, or that nursing babies will spoil them. Pediatricians also hear women say that they want to stop breast-feeding so they won't lose their perky breasts. “In Mexico, breast-feeding is not a normative behavior,” said Chessa Lutter, the Pan American Health Organization's regional adviser for food and nutrition. “You are going to see probably walking down the street in Mexico City a lot more bottle-feeding than you are breast-feeding.” Advocates for breast-feeding say big business is to blame. They claim doctors are plied with gifts by formula makers to get them to help introduce infant formula to newborns. Elia Rangel, mother of a 9-month-old girl, Samantha, said a family physician told her not to breast-feed after six months. “We don't have information that is up to date,” she complained. “I came across a doctor at a public hospital who asked me how old Samantha was. She was 7 months. He told me, `Breast milk is no good; it can even harm her.' I was like, `Wow, where did you get this information?'” The government says it discourages the unnecessary use of formula, but Mexico's own Social Security Institute, whose logo shows a mother breast-feeding, provides formula to women even without a medical need if they present a doctor's note. As long ago as 1993, a study warned that Mexico needed to review that policy because of the high cost in both financial and health terms. The government still pays about $35 million a year on cans of infant formula from the Swiss-based food company Nestle, which receives more than 96 percent of the public money spent on formula. Nestle and the U.S.-based Mead Johnson, the two main baby food companies in Mexico, responded in statements that they support the WHO's code for breast-milk substitutes and comply with the law. They say they don't advertise food for babies less than 1 year of age or discourage mothers from breast-feeding. Nestle said it “does not give free supplies of infant formula to hospitals” and cited a 1992 “self-regulatory agreement” that the industry signed with Health Department to end the provisions of formula samples to Mexico's hospitals and doctors. Chris Perille, spokesman for Mead Johnson, said the company tells health professionals about the benefits of their products but doesn't break the rules. “Our work with these experts is conducted in accordance with the highest standards of ethics and integrity, and in compliance with all applicable laws, professional requirements and industry guidelines,” Perille said in a statement.source : http://www.foxnews.com/health/2013/06/06/public-health-crisis-in-mexico-as-breastfeeding-rates-drop-experts-claim/

Early puberty may be caused by gene mutation

When a child enters puberty earlier than expected, doctors are often at a loss to explain why. But now, researchers have discovered a genetic mutation that they say causes some cases of early puberty. In the study, the researchers in Brazil screened the genomes of 32 people with early puberty from 15 families. (Some cases of early puberty run in families.) Mutations in a gene called MKRN3 were found in 15 people from five of the families. In all of these cases, the mutated MKRN3 gene was inherited from the father, the researchers said. Early puberty, also called precocious puberty, is puberty that occurs before age 8 in girls, or age 9 in boys. Some cases are caused by brain tumors or thyroid problems, but in many cases, a cause is not identified. The average age of puberty onset for those with mutations in the MKRN3 gene was about age 6 for girls, and age 8 for boys. It's not clear exactly how MKRN3 plays a role in puberty, but it may be involved in releasing the “brake” that normally prevents puberty from starting, Dr. Ieuan Hughes, of Cambridge University in the United Kingdom, wrote in an editorial accompanying the study. Puberty begins when the brain starts producing higher levels of a hormone called gonadotropin-releasing hormone. Mutations in the MKRN3 gene may trigger an increase in levels of this hormone at an earlier age, the researchers said. To further investigate the role of MKRN3 in puberty, the researchers studied the brains of mice. They found that levels of MKRN3 gene expression were highest when the mice were young, and reached a low point at the start of puberty, which provides more evidence to tie this gene to puberty. The study is published online June 5 in the New England Journal of Medicine. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/06/early-puberty-may-be-caused-by-gene-mutation/

Group therapy helps rape victims in poor countries

Group therapy works better than individual support for women in low-income countries who have been victims of sexual violence, according to the results of a new study done in the Democratic Republic of Congo (DRC). The method has already been shown to be effective in wealthier countries. Because measures of depression, anxiety, general functioning and post-traumatic stress disorder improved faster with group therapy, the technique may be useful in other countries were war and unrest often contribute to sexual violence, researchers reported in the New England Journal of Medicine. “We're giving them the skills to rethink the meaning they're giving to their thoughts and feelings” about their attack, lead author Judith Bass of the Johns Hopkins Bloomberg School of Public Health in Baltimore told Reuters Health. The study “offers promising evidence” that a form of group therapy can help women who have been exposed to sexual violence, Charlotte Watts and her colleagues at the London School of Hygiene and Tropical Medicine wrote in a linked editorial. In the DRC, 40 percent of women have been victims of some type of sexual violence. The researchers evaluated 157 women in seven villages who were offered one individual session and 11 group sessions of so-called cognitive processing therapy. “The women were being taught to identify what thoughts are not helpful to them,” Bass explained. “Thinking 'It's my fault' is not helpful to them. And it involves how to deal with that and get over some of these thoughts that are keeping them from healing.” Those women were compared with 248 women in eight villages who received individual support that included counseling and sympathetic listening. Women in both treatment groups improved even though each village had at least one major security incident during the trial, including attacks and armed robberies. But the improvement was most pronounced with group cognitive therapy. On a combined scale of depression and anxiety, where the worst score was 3 and the best was 0, women in the cognitive therapy group went from 2.0 at the outset to 0.8 at the end of treatment. Six months after treatment their average score was 0.7. The respective scores for women receiving individual support started at 2.2, dropped to 1.7 and eventually fell to 1.5. After six months, 9 percent of group therapy participants and 42 percent of women who received individual support still likely had a diagnosis of depression or anxiety, Bass and her colleagues found. The study did not include the most severe cases - seven of the 494 women screened for the study were found to be severely suicidal and were treated immediately. “Despite illiteracy and ongoing conflict, this evidence-based treatment can be appropriately implemented and effective,” the researchers concluded. “Given the high rates of sexual violence globally, and especially in conflict-affected countries such as the DRC, this finding is very important,” the Watts team wrote in its editorial. “Rape during war is not unique to the DRC; indeed, it affects many, if not most, countries that are at war, including several African states and, more recently, countries in the Middle East.” The study was funded by the World Bank and the U.S. Agency for International Development Victims of Torture Fund. “We do this because we see mental health as such a large cause of disability and dysfunction,” Bass said. “We want to improve people's health. But when you have such high rates of rape and violence, and such a high rate of mental health problems, it's an often-neglected piece in the bigger development picture.”source : http://www.foxnews.com/health/2013/06/06/group-therapy-helps-rape-victims-in-poor-countries/