Tag Archives: children

Classification of gene mutations in a children’s cancer may point to improved treatments

“Some mutations are more important than others,” said Ya�l P. Moss�, MD, a pediatric oncologist at The Children’s Hospital of Philadelphia, and a co-leader of the new study published online today in the journal Cancer Cell. “By integrating biochemistry into our clinical strategies, we can better match a patient’s specific ALK-mutation profile with an optimum treatment.” Moss� is also an assistant professor of Pediatrics in the Perelman School of Medicine, University of Pennsylvania. “Understanding the specific mutations that trigger signals in cell receptors to stimulate cell growth will help us identify biomarkers for specific subtypes of neuroblastoma,” said study co-leader Mark A…

Researchers engineer ‘smart bomb’ to attack childhood leukemia

In a November study in the new peer-reviewed, open-access journal EBioMedicine, they describe how this approach could eventually prove lifesaving for children who have relapsed after initial chemotherapy and face a less than 20 percent chance of long-term survival. “We knew that we could kill chemotherapy-resistant leukemia cells if we only knew what made them so resistant…

Cancer cell fingerprints in blood may speed up childhood cancer diagnosis

The researchers, from the University of Cambridge and Addenbrooke’s Hospital in Cambridge, found unique molecular fingerprints for 11 types of children’s tumours, which could be used to develop blood tests to diagnose these cancers. This may eventually lead to a quicker, more accurate way to diagnose tumours, and could also reduce the need for children to undergo surgery to get a diagnosis one day. The research was funded by Sparks, the children’s medical research charity, and Cancer Research UK. Each year almost 1,600 children are diagnosed with cancer in the UK…

Chest radiation to treat childhood cancer increases patients’ risk of breast cancer

Wilms tumor is a rare childhood kidney cancer that can spread to the lungs. When this spread occurs, patients receive a relatively low dose of 12-14 Gray of radiation therapy to the entire chest. To see if such exposure to radiation affects patients’ risk of developing breast cancer, Norman Breslow, PhD, of the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle, led a team that studied nearly 2500 young women who had been treated for Wilms tumor during childhood and who had survived until at least 15 years of age. …

Experimental breast cancer drug holds promise in combination therapy for Ewing sarcoma

The treatment paired two chemotherapy drugs currently used to treat Ewing sarcoma (EWS) with experimental drugs called poly-ADP ribose polymerase (PARP) inhibitors that interfere with DNA repair. PARP inhibitors are currently in clinical trials for the treatment of certain breast and ovarian cancers as well as other solid tumors. EWS is a cancer of the bone and soft tissue that strikes primarily adolescents and young adults. A clinical trial using the three-drug combination therapy detailed in this research is expected to open later this year for adolescents and young adults with EWS whose tumors have not disappeared with standard therapy or have returned after treatment…

Real-time tracking system developed to monitor dangerous bacteria inside body

“What we have produced is essentially a system that localizes the epicenter of infection and provides real-time tracking of bacterial activity, giving us rapid feedback on how the bacteria respond to antibiotics,” says principal investigator Sanjay Jain, M.D., an infectious disease specialist at the Johns Hopkins Children’s Center and director of the Center for Inflammation Imaging and Research at Johns Hopkins. Describing their work in the Oct. …

Personalized cellular therapy achieves complete remission in 90 percent of acute lymphoblastic leukemia patients studied

The new data, which builds on preliminary findings presented at the American Society of Hematology’s annual meeting in December 2013, include results from the first 25 children and young adults (ages 5 to 22) treated at the Children’s Hospital of Philadelphia and first five adults (ages 26 to 60) treated at the Hospital of the University of Pennsylvania. Twenty-seven of the 30 patients in the studies achieved a complete remission after receiving an infusion of these engineered “hunter” cells, and 78 percent of the patients were alive six months after treatment. “The patients who participated in these trials had relapsed as many as four times, including 60 percent whose cancers came back even after stem cell transplants. Their cancers were so aggressive they had no treatment options left,” said the study’s senior author, Stephan Grupp, MD, PhD, a professor of Pediatrics in Penn’s Perelman School of Medicine and director of Translational Research in the Center for Childhood Cancer Research at the Children’s Hospital of Philadelphia…