Category Archives: Cancer Treatment

Epigenomic changes play an important role during the progression of melanoma

Human DNA contains genetic information that makes our cells functional entities within a larger whole. The stream of information from DNA to function happens in the form of proteins that anchor themselves to various locations in the DNA and transcribe genetic information into functional cell parts. This process is strictly regulated and is thus very sensitive to change by external factors…

Review highlights potential of cancer immunotherapy plus targeted therapy

“To support this goal and accelerate these efforts, changes in directions of research support and funding may be required,” co-authors Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology, and Jim Allison, Ph.D., chair of Immunology, said in the review. The review, titled “Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential,” covers the strengths and weaknesses of the two forms of therapy and notes how their combination could be particularly potent. …

Dual therapy’s 1-2 punch knocks out drug-resistant lung cancer

In experiments that combined the drug the patient had taken with a second compound that blocks off this newly discovered resistance pathway, the researchers were able to durably wipe out cancer cells in mice implanted with cells from the drug-resistant tumor. “Even in cancers that are responding to targeted therapy by conventional criteria, resistance is… Read More »

Personalized melanoma vaccines marshal powerful immune response

The tailor-made vaccines, given to three patients with advanced melanoma, appeared to increase the number and diversity of cancer-fighting T cells responding to the tumors. The finding is a boost to cancer immunotherapy, a treatment strategy that unleashes the immune system to seek out and destroy cancer. The research is reported April 2 in Science… Read More »

Strong grasp of immune response dynamics will enhance checkpoint blockade

“Identifying in advance who will benefit from treatment and developing combination therapies to improve and expand on current results will require us to decipher the dynamics of human immune response to tumors and their surrounding microenvironment,” said co-author Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology at The University of Texas MD… Read More »

Natural extract shows promise for preventing breast cancer, study suggests

“Doctors, patients and researchers are looking for alternative treatments for triple negative breast cancer, and people are always looking for ways to prevent cancer,” said Patrick Martin, Ph.D., associate professor at North Carolina Agricultural and Technical State University and leader of the study. “How awesome would it be to be able to say: Here, take a daily vitamin tablet from the rose plant to possibly help prevent or treat cancer? It’s a natural product that we found to be effective, with no known side effects.” Triple negative breast cancer draws its name from the fact that the cancer cells in these tumors lack the three growth factor receptors that are normally targeted during breast cancer treatment. …

Immunotherapy delays recurrence for stage III and IV ovarian cancers

“This is cutting edge medicine for ovarian cancer,” said Jonathan Oh, MD, a gynecologic oncologist at Texas Oncology, P.A., in Dallas. Dr. Oh presented the results of a preliminary study on the vaccine at the Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer on March 28 in Chicago…

Stress management techniques improve long-term mood and quality of life for women with breast cancer

At the turn of the century, 240 women with a recent breast cancer diagnosis participated in a randomized trial that tested the effects of a stress management intervention developed by Michael Antoni, PhD, of the University of Miami. Dr. Antoni and his team found that, compared with patients who received a one-day seminar of education… Read More »

Sweeping prostate cancer review upends widely held view on radiation

“The common teaching has been, without clear evidence, that urinary incontinence and erectile function are worse when radiation is delivered earlier rather than later, but we didn’t see any protective effect of delayed radiation compared to earlier radiation,” said radiation oncologist Timothy N. Showalter, MD, of the UVA Cancer Center. “It contradicts the clinical principle… Read More »

Exercise linked to improved erectile, sexual function in men

While past studies have highlighted the relationship between better erectile function and exercise, African-American men have been underrepresented in this literature. “This study is the first to link the benefits of exercise in relation to improved erectile and sexual function in a racially diverse group of patients,” said Adriana Vidal, PhD, senior author of the… Read More »