Tag Archive investigation

Cancer’s ability to ‘hijack’ regulatory mechanism increases metastasis

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Scientists at The University of Texas MD Anderson Cancer Center and The University of North Carolina at Chapel Hill (UNC) have found that one component of this human scaffolding called collagen “cross-links” can determine a tumor’s ability to grow and spread. These cross-links of protein complexes enable connective tissue cells known as “stroma” to stiffen, stimulating tumor cell invasion and metastasis. Study results were published in today’s online edition of the Journal of Clinical Investigation…

Relationship between diet, inflammation and cancer: Key factor found

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A connection between inflammation and cancer has been recognized for over a hundred years. This connection is particularly evident in colon carcinogenesis, because patients with IBD have a higher incidence of colon cancer than the general population. …

Researchers discover mechanism controlling development of myelodysplastic syndromes

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MDS primarily affects older individuals, with approximately 12,000 new cases diagnosed each year. In MDS, a person’s blood is not able to make one or more types of healthy blood cells — red blood cells, white blood cells or platelets. …

Tipping the balance between senescence, proliferation

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In this issue of the Journal of Clinical Investigation, Abdul Mondal and colleagues at the National Cancer Institute evaluated the expression of these two p53 isoforms in T lymphocytes from healthy donors and donors with lung cancer. In healthy patients, the authors observed an age dependent accumulation of senescent cells and that these cells had an increase in p53β compared to Δ133p53. In lung tumor-associated cells, there was a higher level of the Δ133p53 isoform. …

New eye treatment effective in laboratory tests

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The studies involved controlling the actions of microRNAs, tiny pieces of RNA that were once considered to be "junk" but are now known to fine-tune gene activation and expression. The researchers showed that treating mice with short RNA strands that precisely target and inhibit microRNAs ("antimicroRNAs") can stop the aberrant growth of blood vessels ("neovascularization"). It is this abnormal proliferation of vessels that exacerbates vision loss in neovascular eye diseases like "wet" macular degeneration and diabetic retinopathy, two of the leading causes of blindness. Described in the cover story of the November issue of the Journal of Clinical Investigation, the microRNA treatments blocked aberrant vessel growth without damaging existing vasculature or neurons in three separate models of neovascular eye disease — a proof-of-principle that suggests future treatment based on the same approach may be effective in humans…

Chronic cannabis use may cause brain inflammation

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source : http://www.foxnews.com/health/2013/06/24/chronic-cannabis-use-may-cause-brain-inflammation/

Modulating the immune system to combat metastatic cancer

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In this issue of the Journal of Clinical Investigation, researchers led by Ronald Levy at Stanford University found that regulatory T cells that infiltrate tumors express proteins that can be targeted with therapeutic antibodies. Mice injected with antibodies targeting the proteins CTLA-4 and OX-40 had smaller tumors and improved survival. …