Category Archives: Cancer

FDA panel votes to relax Avandia restrictions

U.S. health advisers voted on Thursday to recommend relaxing market restrictions on GlaxoSmithKline's diabetes drug Avandia, the former blockbuster at the center of one of the biggest drug controversies in recent years. The vote, by a divided Food and Drug Administration advisory committee of outside health experts, could modestly enlarge the market for Avandia in the United States and lay the groundwork for further research into the drug's health risks. FDA will now take the vote into consideration for a final decision on how the pill also known by the generic name rosiglitazone can be used. The committee did not consider a specific change in protocol. But 13 experts on the 26-member panel who backed modification said current restrictions that require prescribing physicians and pharmacists to be certified should be relaxed or eliminated after a reexamination of Glaxo safety data settled longstanding concerns about the danger of death from cardiovascular disease. “In general, this drug doesn't look any different than any other diabetes drug,” said Dr. William Hiatt, a cardiologist from the University of Colorado, who was among seven experts who backed lifting restrictions altogether. Five committee members favored keeping the current sales restrictions, while one voted to withdraw Avandia from the market altogether. Glaxo, which no longer plans to promote Avandia, issued a statement saying the company would work with FDA as it considers its decision. “We continue to believe that Avandia is a safe and effective treatment option for type 2 diabetes when used for the appropriate patient and in accordance with labeling,” Dr. James Shannon, Glaxo's chief medical officer, said in a statement. The British drugmaker's stock closed nearly 1.5 percent lower in London trading before the committee voted. Avandia was once the world's best-selling treatment for type 2 diabetes, with annual sales of $3.2 billion. In 2010 its use in the United States was heavily restricted and it was withdrawn from the market in Europe because of the possibility of increased risk of heart attack and stroke. Only 3,000 people in the United States take it today, down from about 120,000 just before the restrictions were put in place. Much of the advisory committee's two-day meeting focused on a Duke University reexamination of a Glaxo safety study known as Record that confirmed initial findings of no significant increased heart risk from the drug. That reassured some experts that earlier concerns with the quality of the research had been unwarranted and encouraged support for the restrictive protocols, while retaining continued guidance on potential dangers for patients and care providers. A departing train But others said the original data was incomplete and compiled through a flawed study design, while other research pointed to the possibility of significant increased risk of cardiovascular death. “When you look at the overall totality of evidence, it is not sufficient enough to either implicate or exonerate rosiglitazone versus cardiovascular risk,” said advisory panel member Dr. Sanjay Kaul of the Cedars-Sinai Heart Institute. Several committee members endorsed suggestions for a major new clinical trial to determine precisely the drug's risks in the face of a growing worldwide diabetes threat. But other experts concluded that years of negative publicity made funding major research unfeasible except for new diabetes treatments now in the pharmaceutical pipeline. “The train has left the station,” said Gerald van Belle, director of the Clinical Trials Center at the University of Washington. Experts including the advisory committee's chairman, Dr. Kenneth Burman of the Washington Hospital Center, favored the creation of a registry to monitor the health of patients who currently take the drug if major studies into safety and efficacy were not an option. Some experts view Avandia as a potential alternative to other diabetes treatments, including insulin, that could become more important as the incidence of obesity and diabetes grows, bringing with it a host of costly chronic ailments ranging from heart and kidney disease to blindness and dementia. “When treating diabetes we really do need drugs that lower blood sugar without causing hypoglycemia, and there's not a lot that's available,” Dr. Ellen Seely of Harvard Medical School. “When you're dealing with individual patients, you come up often against dead ends on what you can do. And it's important to have options,” she said. But panel members agreed the market potential for Avandia may never again be large. Glaxo has settled lawsuits filed by tens of thousands of U.S. patients who had taken Avandia and claimed Glaxo failed to inform them about safety risks. Several thousand other cases remain pending. The drugmaker last July agreed to pay $3 billion to settle what U.S. officials called the largest case of healthcare fraud in U.S. history. The agreement resolved allegations that Glaxo failed through 2007 to provide the FDA safety data on Avandia and that the company improperly marketed other drugs.source : http://www.foxnews.com/health/2013/06/07/fda-panel-votes-to-relax-avandia-restrictions/

New vaccine drives Africa meningitis cases to lowest in decade

Case numbers in Africa's meningitis season this year were the lowest in 10 years thanks to a cheap new vaccine designed to treat a type of the disease common in the so-called meningitis belt, the World Health Organization said on Thursday. The vaccine, called MenAfriVac, was developed with funding from the Bill & Melinda Gates Foundation specifically for use against meningitis A, a type which causes regular epidemics in Africa. Detailing data for January 1 to May 12, the United Nations health agency said that just under 9,250 meningitis cases, including 857 deaths, were reported in 18 of the 19 African countries under enhanced surveillance for meningitis. Epidemics of meningitis A occur regularly in Africa's “meningitis belt”, a band of 26 countries stretching from Senegal to Ethiopia, and are particularly devastating to children and young adults. Bacterial meningitis, known as meningococcal meningitis, is a serious infection of the thin lining surrounding the brain and spinal cord. It can cause severe brain damage and is fatal in 50 percent of cases if untreated. According to the non-profit Meningitis Vaccine Project (MVP), which helped develop the MenAfriVac vaccine, the seasonal outbreak of meningitis across sub-Saharan Africa in 2009 infected at least 88,000 people and killed more than 5,000. The WHO said the falling numbers this year were due to the introduction of the newly developed vaccine. MenAfriVac costs just 50 U.S. cents a dose and has been progressively introduced in Africa since 2010, starting in Burkina Faso, Mali and Niger. “The introduction of this first meningococcal vaccine available for preventive purposes in Africa has enabled the immunization of over 100 million people from 10 countries in the meningitis belt in the past three years,” the WHO said. “The reduced case load and epidemic activity observed this year adds to the evidence on the impact...of this vaccine.”source : http://www.foxnews.com/health/2013/06/07/new-vaccine-drives-africa-meningitis-cases-to-lowest-in-decade/

15 ways to cancer-proof your life

We're all grown-ups here—nightmares aren't a big problem anymore. We're calm, we're cool, we're mostly collected...until it comes to the C-word. For adults, cancer is the thing that goes bump in the night; that bump gets louder when family or friends are diagnosed. Whether your risk is monumental or blessedly average, we know you want to protect yourself. So we've combed through research, interrogated experts, and found cutting-edge strategies to help keep you safe. Worship a wee bit of sun People who get the most vitamin D, which lies dormant in skin until ultraviolet rays activate it, may protect themselves from a variety of cancers, including non-Hodgkin's lymphoma, breast, and colon. Ironically, it even improves survival rates of melanoma, the most serious skin cancer. But 10 to 15 minutes a few days a week is all it takes to benefit. If you're out any longer than that, slather on the sunscreen (Are you applying enough? We’ve got the recommended amount for every body part, here.) If you go the supplement route, aim for 400 IU of vitamin D a day. Eat an orange every day It just may zap a strain of the H. pylori bacteria that causes peptic ulcers and can lead to stomach cancer. Researchers in San Francisco found that infected people with high levels of vitamin C in their blood were less likely to test positive for the cancer-causing strain. (Bonus: research shows a scent of citrus can reduce stress.) Listen to Katie Couric Though colonoscopies are about as popular as root canals, if you're 50 or older, get one. Colorectal cancer is the second leading cause of cancer death in the United States. Don't think you're off the hook because you got a digital fecal occult blood test at your last checkup: Research by the Veterans Affairs Cooperative Study found that the test missed 95 percent of the cases. Schedule your first colonoscopy before your 50th if you have a family history of colon cancer. Steam a little green Piles of studies have shown that piles of broccoli help stave off ovarian, stomach, lung, bladder, and colorectal cancers. And steaming it for three to four minutes enhances the power of the cancer-fighting compound sulforaphane, which has been shown to halt the growth of breast cancer cells. (Sorry, microwaving doesn't do the trick; it strips out most antioxidants.) Get more protection by sprinkling a handful of selenium-rich sunflower seeds, nuts, or mushrooms on your greens. Researchers are discovering that sulforaphane is about 13 times more potent when combined with the mineral selenium. Pick a doc with a past Experience—lots of it—is critical when it comes to accurately reading mammograms. A study from the University of California, San Francisco, found that doctors with at least 25 years' experience were more accurate at interpreting images and less likely to give false positives. Ask about your radiologist's track record. If she is freshly minted or doesn't check a high volume of mammograms, get a second read from someone with more mileage. Drink jolt-less java Drink jolt-less java. Downing two or more cups of decaf a day may lower the incidence of rectal cancer by 52 percent, finds a study from two large and long-term research projects—the Nurses' Health Study and the Health Professionals Follow-Up Study from Harvard University. One theory is that coffee increases bowel movements, which helps to reduce the risk. Why decaf reigns supreme, however, remains a mystery. Drop 10 pounds Being overweight or obese accounts for 20 percent of all cancer deaths among women and 14 percent among men, notes the American Cancer Society. (You're overweight if your body mass index is between 25 and 29.9; you're obese if it's 30 or more.) Plus, losing excess pounds reduces the body's production of female hormones, which may protect against breast, endometrial, and ovarian cancers. Even if you're not technically overweight, gaining just 10 pounds after the age of 30 increases your risk of developing breast, pancreatic, and cervical, among other cancers. Make like a monkey Or a bunny. Women who ate four to six antioxidant-laden bananas a week cut their risk of kidney cancer by 54 percent, compared with those who didn't eat them at all, found an analysis of 61,000 women at the Karolinska Institutet in Sweden. Gnawing on root vegetables such as carrots had the same benefit. Get naked with a friend You'll need help examining every inch of your body—including your back, scalp, and other hard-to-see places—for possible changes in the size or color of moles, blemishes, and freckles. These marks could spell skin cancer. Women, take special note of your legs: Melanoma mainly occurs there. For the guys, the trunk, head, and neck are the most diagnosed spots. While you're at it, check your fingernails and toenails, too. Gray-black discoloration or a distorted or elevated nail may indicate the disease. And whether you see changes or not, after age 40, everyone should see a dermatologist yearly. (Find out 7 more things your nails can say about your health.) See into the future Go to Your Disease Risk to assess your chance of developing 12 types of cancer, including ovarian, breast, and colon. After the interactive tool estimates your risk, you'll get personalized tips for prevention. Pay attention to pain If you're experiencing a bloated belly, pelvic pain, and an urgent need to urinate, see your doc. These symptoms may signal ovarian cancer, particularly if they're severe and frequent. Women and physicians often ignore these symptoms, and that's the very reason that this disease can be deadly. When caught early, before cancer has spread outside the ovary, the relative five-year survival rate for ovarian cancer is a jaw-dropping 90 to 95 percent. Get calcium daily Milk's main claim to fame may also help protect your colon. Those who took calcium faithfully for four years had a 36 percent reduction in the development of new pre-cancerous colon polyps five years after the study had ended, revealed Dartmouth Medical School researchers. (They tracked 822 people who took either 1,200 mg of calcium every day or a placebo.) Though the study was not on milk itself, you can get the same amount of calcium in three 8-ounce glasses of fat-free milk, along with an 8-ounce serving of yogurt or a 2- to 3-ounce serving of low-fat cheese daily. Sweat 30 minutes a day One of the best anticancer potions is a half hour of motion at least five days a week. Any kind of physical activity modulates levels of androgens and estrogen, two things that can protect women against estrogen-driven cancers such as ovarian and endometrial, as well as some types of breast cancer. The latest proof comes by way of a Canadian study that found that women who get regular, moderate exercise may lower their risk of ovarian cancer by as much as 30 percent. Bonus: All that moving might speed everything through your colon, which may help stave off colon cancer. (Trouble carving out 30 minutes a day? Be ready for a fitness opportunity at a moment’s notice by keeping a perfectly packed gym bag in your car at all times.) Stamp out smoking—all around you Lung cancer is well known as one of the main hazards of smoking. But everything the smoke passes on its way to the lungs can also turn cancerous: mouth, larynx, and esophagus. The fun doesn't stop there. Smokers are encouraging stomach, liver, prostate, colorectal, cervical, and breast cancers as well. The good news: If you give up the cigs today, within 15 years, your lung cancer risk will drop to almost pre-smoking lows. Share that news with the people who puff around you, because exposure to someone else's smoke can cause lung cancer, and it may boost your chances of cervical cancer by 40 percent. Step away from the white bread If you eat a lot of things with a high glycemic load—a measurement of how quickly food raises your blood sugar—you may run a higher risk of colorectal cancer than women who eat low-glycemic-load foods, finds a Harvard Medical School study involving 38,000 women. The problem eats are mostly white: white bread, pasta, potatoes, and sugary pastries. The low-glycemic-load stuff comes with fiber. Blew through our list already

Math technique de-clutters cancer-cell data, revealing tumor evolution, treatment leads

Using increasingly cheap and rapid methods to read the billions of "letters" that comprise human genomes — including the genomes of individual cells sampled from cancerous tumors — scientists are generating far more data than they can easily interpret. Today, two scientists from Cold Spring Harbor Laboratory (CSHL) publish a mathematical method of simplifying and interpreting genome data bearing evidence of mutations, such as those that characterize specific cancers. Not only is the technique highly accurate; it has immediate utility in efforts to parse tumor cells, in order to determine a patient’s prognosis and the best approach to treatment. …

Normal molecular pathway affected in poor-prognosis childhood leukemia identified

Leukemia often occurs due to chromosomal translocations, which are broken chromosomes that cause blood cells to grow uncontrollably. One gene that is involved in chromosomal translocations found at high frequency in childhood leukemia is the MLL1 (Mixed Lineage Leukemia 1) gene. Conventional chemotherapy is very ineffective at curing patients with this translocation, in contrast to other types of childhood leukemia, which are relatively curable. …

Gene variant may provide novel therapy for several cancer types

This landmark study is published in the June 6, 2013 issue of the journal Science. Ramon Parsons, MD, PhD, Professor and Chair of Oncological Sciences led the team that discovered a mutation in the tumor suppressor gene PTEN, which has subsequently been recognized as the second most common mutation in cancer, especially in breast, prostate, and brain cancers. PTEN encodes a 403 amino acid lipid phosphatase protein that is critical to cellular growth, proliferation, and survival…

Judge orders second child be put on adult waiting list for donated lungs

PHILADELPHIA – & A federal judge has ordered that a second child at a Philadelphia hospital -- a New York City boy -- be put on the adult waiting list for donated lungs. The ruling from U.S. District Judge Michael Baylson involves 11-year-old Javier Acosta of the Bronx, who has cystic fibrosis. His mother filed a lawsuit Thursday that says he will die soon unless he gets a lung transplant. The decision comes a day after a national organ transplant network complied with Baylson's unusual order to place a dying 10-year-old girl on the list. Children under 12 are currently matched with pediatric donors, which are rare, or wait at the end of the adult list. Medical ethicists question the judge's intervention. But lawyer Stephen Harvey, who represents both families, fears that Javier and Sarah will die while the issue is reviewed.source : http://www.foxnews.com/health/2013/06/06/judge-orders-second-child-be-put-on-adult-waiting-list-for-donated-lungs/

Tumors disable immune cells by using up sugar

The scientists found that when they kept sugar away from critical immune cells called T cells, the cells no longer produced interferon gamma, an inflammatory compound important for fighting tumors and some kinds of infection. "T cells can get into tumors, but unfortunately they are often ineffective at killing the cancer cells," said Erika Pearce, PhD, assistant professor of pathology and immunology. …

New liver cell for cellular therapy to aid in liver regeneration

"The discovery of the novel progenitor represents a fundamental advance in this field and potentially to the liver regeneration field using cell therapy," said the study’s senior author, Valerie Gouon-Evans, PharmD, PhD, Assistant Professor, in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount Sinai. "Until now, liver transplantation has been the most successful treatment for people with liver failure, but we have a drastic shortage of organs…

Study: Cannabis may prevent brain damage

Marijuana continues to be a paradox as it makes its way from illicit drug to wonder medicine being used to treat a number of symptoms and disorders more safely than traditional pharmaceuticals. In the latest news, cannabis, which has been associated with long-term cognitive deficits in chronic users, is now being tested as a treatment to preserve brain function after traumatic injury. Amidst the many “it-damages-your-brain” studies, some reports have shown that cannabis has neuroprotective effects. Studies have suggested that it has protective effects in neurodegenerative diseases like multiple sclerosis, Alzheimer’s, Huntington’s and Parkinson’s diseases. The author of the new study, Dr. Yosef Sarne of Tel Aviv University's Adelson Center for the Biology of Addictive Diseases, theorized that ultra-low doses of tetrahydrocannabinol (THC), the main psychoactive component of marijuana, induces minor damage to the brain, which may actually “precondition” the brain to protect it against more severe damage from injuries such as lack of oxygen, seizures or toxic drug exposure. In other words, it may act as a sort of vaccine against more traumatic harm. In Dr. Sarne's animal study, published in the journals Behavioural Brain Research and Experimental Brain Research, researchers injected mice with a single, very low dose of THC — around 1,000 to 10,000 times less than what is found in a conventional “joint” — either several days before or after exposing the mice to a brain trauma. They found that the treated mice had enhanced biochemical processes, which protected brain cells and preserved cognitive function over time, compared to control mice that were not treated with THC. Specifically, when the mice were examined three to seven weeks after the brain injury, those in the THC group performed better in learning and memory tests. They also showed increased amounts of neuroprotective chemicals compared to the control group. In past laboratory experiments, Sarne’s group found that ultra-low doses of THC affected cell signaling, preventing cell death and promoting certain growth factors.   The researchers concluded that the use of low doses of THC can prevent long-term cognitive damage that results from brain injury in mice, but the drug needs to be tested in human trials. “Since we deal, in this case, in a basic process (THC is protective against a variety of insults, not just a specific condition), I personally believe it will go beyond rodents,” Sarne wrote in an email. Aside from treating patients with traumatic injury to the brain, Sarne suggested several ways of using THC preventively, before an injury occurs. One use could be for patients on cardiopulmonary heart-lung machines used in open heart surgery. These come with a risk of interrupting the blood supply to the brain. Sarne said that THC could be injected beforehand as a preventive measure in case the brain is deprived of oxygen. It could also be tested for use in patients such as those with epilepsy, who are at constant risk of brain injury, or those with a high risk of heart attack. Sarne is currently testing the ability of low doses of THC to prevent heart damage during a heart attack, to prevent the death of heart muscle cells that are deprived of oxygen.Laurie Tarkan is an award-winning health journalist whose work appears in the New York Times, among other national magazines and websites. She has authored several health books, including “Perfect Hormone Balance for Fertility.” Follow her on Twitter and Facebook.source : http://www.foxnews.com/health/2013/06/06/study-cannabis-may-prevent-brain-damage/