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Stem cell disease model clarifies bone cancer trigger

The study results, published in the journal Cell, revolve around iPSCs, which since their 2006 discovery have enabled researchers to coax mature (fully differentiated) bodily cells (e.g. skin cells) to become like embryonic stem cells. Such cells are pluripotent, able to become many cell types as they multiply and differentiate to form tissues…

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Ovarian Cancer: Know your body, know your risk

“There is no effective surveillance technique for the detection of early stage ovarian cancer, so the only effective way to prevent it and save lives is to identify women at risk,” said David A. Fishman, MD, Director of the Mount Sinai Ovarian Cancer Risk Assessment Program and Professor and Fellowship Director in the Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Medicine at the Icahn School of Medicine at Mount Sinai. He recommends that women with a family history of ovarian and breast cancers get a formal genetic evaluation by a board-certified genetic counselor. For women who have tested positive for a BRCA mutation or are identified to be at a high risk for developing ovarian cancer, preventive surgery should be considered to remove the ovaries and fallopian tubes before ovarian cancer can develop…

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Value, limitations of patient assistance programs for women with breast cancer

Most breast cancer patients who had information about patient assistance programs used them to learn more about adjuvant therapy, obtain psychosocial support, and overcome practical/financial obstacles to getting treatment, reported researchers from the Icahn School of Medicine at Mount Sinai. Researchers found that, in most cases, patients who were referred to assistance programs did contact organizations running programs, such as Cancer Care Inc., SHARE, and the Mount Sinai Breast Health Resources Program. …

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New website keeps loved ones informed during surgery

Just mentioning the word surgery can send chills down a person's spine. Whether it’s a simple appendectomy or a more complicated procedure, going under the knife can be frightening for both patients and families alike. Now, a new website, MDconnectME.com, is helping to settle the nerves of friends, significant others and family members all across the globe. The website, which is free to use, was designed to allow family members to stay informed while their loved one undergoes an operation. Before surgery, patients make a list of people to notify during their procedure, which grants their doctor permission to send previously-typed notes like, “Ann is now heading into the operating room for surgery,” throughout the day. These messages can be sent through text or e-mail. MDconnectME.com is now being used throughout the country at centers such as Mount Sinai Hospital, Johns Hopkins, and UCLA. For more information, go to MDconnectME.comsource : http://www.foxnews.com/health/2013/06/12/new-website-keeps-loved-ones-informed-during-surgery/

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New liver cell for cellular therapy to aid in liver regeneration

"The discovery of the novel progenitor represents a fundamental advance in this field and potentially to the liver regeneration field using cell therapy," said the study’s senior author, Valerie Gouon-Evans, PharmD, PhD, Assistant Professor, in the Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, at the Icahn School of Medicine at Mount Sinai. "Until now, liver transplantation has been the most successful treatment for people with liver failure, but we have a drastic shortage of organs…

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Michael Douglas’ reveal: Can you get throat cancer from oral sex?

Michael Douglas made a shocking announcement on Sunday, maintaining that his throat cancer hadn’t been caused by drinking or smoking – but by having oral sex. “Without wanting to get too specific, this particular cancer is caused by HPV, which actually comes about from cunnilingus,” Douglas told The Guardian newspaper.  The 68-year-old actor also went on to speculate that the stress of his son Cameron’s incarceration might have helped trigger the cancer as well. While a connection between oral sex and cancer may seem bizarre, it is very possible that some oral cancers are the end result of intimate sexual contact. Rates of oral cancer – sometimes referred to as head and neck cancers – have been on the rise over the past decade.  While the main risk factors for oral cancers typically include drinking alcohol and smoking, around 25 percent of mouth and 35 percent of throat cancers are related to human papilloma virus (HPV) infection. “(HPV) is present within the fluids that are part of oral sexual behavior,” Dr. Marshall Posner, director of the head and neck oncology program at Mount Sinai Hospital in New York City, told FoxNews.com. “The vaginal fluids and semen will contain epithelial cells that have the virus on them and also free viral particles that can cause infection.” HPV cannot be transmitted through blood contact, but Posner said it may be possible to contract the virus from the direct contact of fluids through kissing. This can occur if an individual kisses someone who previously performed oral sex on someone else who had the virus. “If the virus is present in the oral pharynx and if it gets secreted in the saliva, then the saliva will contain potentially dangerous viral particles,” Posner said. There are more than 100 different types of HPV, and nearly everyone contracts some form of the virus in their youth.  Fortunately, the majority of HPV strains do not cause any symptoms, and in 90 percent of cases, the infection is naturally eradicated from the body within two years. However, some HPV types can cause genital warts, while others may lead to certain cancers in rare cases. HPV 16 and HPV 18 – which are sexually transmitted – are most closely associated with HPV-positive oropharyngeal cancer. According to Posner, 3 percent of adult males and 1 percent of adult females will have detectable HPV 16 in their saliva at any given moment in time.  However, just because HPV is detected in a sample of someone with oral cancer does not necessarily mean HPV caused the cancer.  According to the National Health Service in Britain, the virus becomes part of the pre-existing cancer cells’ genetic material, fostering the cells to grow. Oropharyngeal cancer symptoms include a lump in the back of the throat or mouth, pain in the ear or back of tongue, and difficulty swallowing. While the prognosis for HPV-negative oropharyngeal cancer is around 40 to 50 percent, the survival outcomes are generally better for HPV-positive cancers, ranging from 80 to 95 percent.  However, that prognosis is affected by drinking and smoking, which may have been a problem for Douglas. In the United States, HPV-related oropharyngeal cancer represents 60 percent of the total number of orapharyngeal cancer cases, which equal to about 15,000 per year.  Posner estimated that those cases will increase to 20,000 a year by the year 2015. While researchers cannot fully explain the rising rates of these cancers, one of the biggest risk factor for contracting HPV-positive oroharyngeal cancer includes having a high number of sexual partners, Posner said. “In smoking cigarettes and cancer, it doesn’t matter what brands you smoked, it matters how many you smoked,” Posner said.  “With HPV, it’s about the number of ‘brands’ you’ve been involved with. If you have numerous partners, you have a much higher risk of developing cancer. So (monogamous) people should go ahead and have the same intimate and personal relationship that they have with their partners and not be worried about it.” For those looking to protect themselves from contracting dangerous forms of HPV, practicing safe sex by using protection such as condoms and dental dams may help to diminish the spread of sexually transmitted diseases.  Posner also called for parents to get their children – including young boys –vaccinated against HPV. “I think people should make every effort to have children vaccinated, so I don’t have to treat this in the future,” Posner said.  I think it’s very important and to cure cancer we have to support research – it’s the best way we have to figure out how to cure this. Click to learn more about HPV from Mount Sinai Hospital.source : http://www.foxnews.com/health/2013/06/03/michael-douglass-reveal-can-get-throat-cancer-from-oral-sex/

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