"Cells normally monitor the availability of nutrients and will slow down or accelerate their growth and division accordingly. A key monitor of nutrients is a protein called the Target of Rapamycin (TOR), but we do not know the details of how this protein feeds signals downstream to control growth" says Dr. Stephen Michnick, senior author and a University of Montreal biochemistry professor…
Under conditions of oxygen starvation often encountered by tumors, the epidermal growth factor receptor (EGFR) gums up the cell’s miRNA-processing machinery, an international team led by scientists at The University of Texas MD Anderson Cancer Center discovered. "So when hypoxia stresses a cell, signaling by EGFR prevents immature miRNAs from growing up to fight cancer," said senior author Mien-Chie Hung, Ph.D., professor and chair of MD Anderson’s Department of Molecular and Cellular Oncology and holder of the Ruth Legett Jones Distinguished Chair…
"New treatment approaches are very much needed for children with high-risk childhood cancers; that is, those that are metastatic at diagnosis and likely to recur," says senior study author Kimberly Stegmaier of the Dana-Farber/Children’s Hospital Cancer Center and the Broad Institute of the Massachusetts Institute of Technology and Harvard University. "By focusing on an alternative strategy to treating neuroblastoma tumors, we identified a compound class that in early testing in neuroblastoma cells in the laboratory shows promise for treating children with this disease." Beyond the standard approach of using drugs that kill tumor cells, another promising strategy is to identify compounds that promote differentiation, which causes tumor cells to stop dividing and growing. But the benefits of differentiation therapy had not been fully explored. …
"This is the first study to examine DNA alterations using next generation sequencing in adjacent Gleason patterns in the same tumor allowing us to correlate genomics with changes in pathology," says John Cheville, M.D., Mayo Clinic pathologist and one of the authors on the paper. The standard method of evaluating prostate cancer biopsy samples is a numerical scoring system called Gleason grading. A pathologist examines the tumor sample under the microscope, giving it a Gleason score based on the pattern of its cells…
Officials investigating a cluster of mysterious illnesses in Alabama have so far found only cold and flu viruses. In tests on seven of the nine patients, the Centers for Disease Control and Prevention found no sign that the illnesses were caused by any single germ, CDC spokeswoman Sharon Hoskins said in an email. Meanwhile, Alabama officials said they had added two more cases to the cluster, which included two earlier deaths. Seven of the cases were reported last week, including the deaths. The two new illnesses were reported this week. Most of the nine were treated at Southeast Alabama Medical Center in Dothan, but one was seen at a hospital in Crenshaw County. Health officials have described the patients as ranging in age from 20 to more than 80. The nine people suffered a flu-like illness with symptoms like fever, cough and shortness of breath. Mysterious illnesses are always unnerving, but the cluster report came at a particularly sensitive time. Health officials have been monitoring two deadly new illnesses that recently surfaced in different parts of the world — one a deadly form of bird flu that has appeared in China, the other a SARS-like coronavirus that seems to have originated in the Middle East. The bird flu has caused 131 illnesses and 32 deaths since the beginning of the year, according to the World Health Organization. The SARS-like virus (called MERS) has been identified as the cause of 44 illnesses, including 22 deaths, the WHO said. Neither seems to be highly contagious so far, and neither illness has been reported in the United States. But in a world of daily international air travel, it's always possible that a concerning new germ will hitchhike on an infected globetrotter and enter this country. The CDC tested the Alabama patients for MERS, for different forms of flu and for more than a dozen other illnesses, the agency spokeswoman said.source : http://www.foxnews.com/health/2013/05/23/mystery-illness-in-alabama-mostly-colds-and-flu-tests-show/
Cells in the human body do not function in isolation. Living cells rely on communication with their environment — neighboring cells and the surrounding matrix — to activate a wide range of cellular functions, including reproduction of new cells, differentiation of stem cells into distinct cell types, cell adhesion, and migration of white blood cells to fight bodily infections. This cellular communication occurs on the molecular level and it is reciprocal: a cell receives cues from and also transmits function-activating cues to its neighbors…
Screening for lung cancer using low-dose computed tomography (CT scans) rather than chest X-rays may be a more effective way of detecting the disease, Medscape Today reported. Researchers hope that these results, collected as part of the National Lung Screening Trial, will provide more detailed information about the benefits of various types of lung cancer screening available to patients and physicians. During the study, 26,309 participants received low-dose CT scans, and 26,035 participants underwent chest radiography to detect for signs of lung cancer. Among those who received CT scans, a total of 7,191 participants (27.3 percent) had a positive screening result, compared to 2,387 (9.2 percent) in the chest X-ray group. Overall, lung cancer was diagnosed in 292 participants (1.1 percent) in the CT group compared with 190 (0.7 percent) in the radiography group. Previously, experts had been concerned that the high level of false-positive screenings that occur during CT scans would lead to undue stress, unnecessary testing and high medical bills for patients, Medscape Today reported. However, the new report reveals that the majority of patients who had a positive result after their CT scan only underwent one additional diagnostic test. “In many of the previous analyses people have assumed that there would be three or four or five additional diagnostic tests for every positive screen, and this has ramifications for the cost effectiveness of screening,” study author Dr. William C. Black, professor of radiology at the Dartmouth-Hitchcock Medical Center in Lebanon, N.H., told Medscape Today. Black is hopeful that these results will provide a good frame of reference for other lung cancer screening programs. “If patients and their clinicians are trying to decide whether or not to get screened, they can always refer to these results. They will let patients know what they can expect, what are the likely outcomes, not just in terms of dying of lung cancer, which is only going to happen to a small percentage of people who get screened, but also in terms of the false positives and what happens afterwards,” Dr. Black told Medscape Today. People eligible for lung cancer screening include men and women, ages 55 to 74, who have a 30-pack-per year history of smoking, those who have quit smoking in the last 15 years and those who are medically fit for surgery. Click for more from Medscape Today.source : http://www.foxnews.com/health/2013/05/23/lung-cancer-screening-ct-scans-more-effective-than-x-rays/
In 1996, Lynette Johnson, a professional photographer, was approached by her sister-in-law Sally Elliot with a difficult request.  Elliot’s daughter and Johnson’s niece, Lanie, had been stillborn and Elliot wanted Johnson to take a picture of her before her funeral. “It was the hardest thing I’ve ever done in my life,” Johnson, 59, based out of Seattle, Wash., told FoxNews.com.  “But I’m so glad I did it.” The memory of the experience stuck with Johnson, and a few years later, while shooting pictures for a wedding, the bride mentioned to Johnson that she worked for the palliative care unit at Seattle Children’s Hospital.  Johnson immediately thought back to her niece and offered to come by the hospital to take pictures for the patients’ families. “I just blurted out I would do this free of charge,” Johnson said. “It seemed like the least I could do to give back to the community.” What started as a small favor quickly blossomed into a thriving non-profit photography initiative called Soulumination.  Through the enterprise, Johnson and other volunteer photographers take professional photographs of children under the age of 18 who are facing life-threatening conditions, providing families with lasting keepsakes and “an enduring, positive record of the child’s life.” Initially, Johnson was the non-profit’s sole photographer, taking photographs of children in the greater Seattle area.  But since Soulumination’s inception, the organization has now grown to encompass more than 40 photographers and over 120 community volunteers, who help serve families across the country. “We don’t just take their photos; they get beautiful handmade albums too,” Johnson said. “But every person who is at the shoot gets their own personal one.  The mother even gets a bracelet with the child’s photo she can wear.” Johnson has now photographed hundreds of patients, including children with terminal cancer, heart disease, issues stemming from premature birth, Tay-Sachs disease and severe seizure disorders. When she first started Soulumination, Johnson said many of her friends and family would express amazement at how she was able to surround herself with such grief and pain.  But while it’s been emotionally difficult at times, she and the others continue the project without hesitation. “Once you do it, the sadness and grief in some ways feel almost unbearable, but almost every photographer says, ‘Yes, that was hard, but I’ll do it again,’” Johnson said.  “There’s just no doubt about it; it’s the right thing to do.” Johnson said that every family she has worked with has had a positive experience with the photo shoots, and not one parent has ever expressed regret over having pictures taken.  She noted that some families were hesitant to have the photographs done, as they felt it meant they were stepping into the dying process of their children.  However, Soulumination has photographed many children who do survive their illnesses. The photographs are more about honoring the individual than saying goodbye. “It means a great deal to us all,” said one Seattle mother whose daughter has been battling leukemia since 2003.  “Mainly to have the images and see [our daughter’s] expressions captured…It gives me a sense of peace to hang her and [her sister’s] pictures and make them a part of our world as it is now. So when it changes it will be there.” Soulumination operates purely on outside donations and the unpaid skills of the organization’s many photographers.  Johnson said that their work generates a fair amount of monetary contributions from people they come into contact with at the hospital or through photo shoots. She recalled a time when she took photos of a young teenage girl named Sidney, who suffered from a terminal brain tumor.  A few months after Sidney’s funeral, Johnson said she received a thick envelope in the mail. “It was a handmade card from Sidney’s mother, and she explains it’s from the last time she took an art class with Sidney,” Johnson recalled. “There was also a check in there for $1,200, and she said it was Sidney’s savings account and she knew she wanted me to have it so we could service other people. We have hundreds of heart felt ‘Thank You’s’ like that.” Johnson vows to keep Soulumination running as long as possible, and she said she has spoken with other photographers interested in starting similar initiatives in other states – and even other countries.  According to her, the project’s success must be credited to the many people who have graciously donated their money and talents to help preserve the legacies of so many children. “I’m proud of it, and I’m unbelievably thankful for the photographers,” Johnson said.  “We’re a little group that started and has now blossomed into something with national attention. The loss of my niece, which was so devastating, in her memory this thing started that will offer hope to people all over the world.”source : http://www.foxnews.com/health/2013/05/23/soulumination-non-profit-photographs-terminally-ill-children-for-families/
Heat-related deaths in New York City's borough of Manhattan may rise about 20 percent over the next decade, according to a new study. Researchers at Columbia University in New York analyzed the relationship between daily temperatures and temperature-related deaths across all seasons between 1982 and 1999 in Manhattan, which comprises the most densely populated county in the United States. The findings were published online May 19 in the journal Nature Climate Change. Using projections from 16 global climate models, the scientists found that the number of heat-related deaths in the city could increase by 20 percent by the 2020s, and in some worst-case scenarios, could rise by 90 percent or more by the 2080s, said study co-author Patrick Kinney, an environmental scientist at the Mailman School of Public Health at Columbia University. [Top 10 Surprising Results of Global Warming] To make their estimates, Kinney and his colleagues used the 1980s as a baseline, during which about 370 Manhattan residents died yearly from overheating. With this figure as a reference, a 20 percent increase could mean 74 additional yearly heat-related fatalities in Manhattan by the 2020s. “What we found was that there could be some benefits, in terms of reduced fatalities in the wintertime because of warmer temperatures, but our analysis suggests that those benefits are outweighed by extra fatalities that will occur in the hotter times of the year,” Kinney said. Mercury rising Daily readings in Manhattan's Central Park demonstrate that average monthly temperatures have increased 3.6 degrees Fahrenheit (2 degrees Celsius) between 1901 and 2000. Last year was the warmest year on record in Manhattan, and projections predict rising temperatures over the next six decades, the researchers said. In 2011, 206 people died due to extreme heat in the United States. “The warming that's anticipated from climate change is happening throughout the year, so the months that are already hot like June, July and August are going to get hotter, but months that are more moderate, like May and September, may become uncomfortably hot or fatally hot,” Kinney explained. In their study, Kinney and his colleagues applied climate models to two scenarios: one that assumed rapid global population growth with limited efforts to control emissions, and another that assumed slower population growth combined with technological advances to decrease emissions by the year 2040. The researchers found that both projections pointed to increases in temperature-related fatalities. “It was a little surprising that no matter which climate model we used, and which scenario of greenhouse gases we used, they all consistently showed this effect of increasing fatality risk in the future,” Kinney said. More of the same And Manhattan is not alone, Kinney added. The trend toward more fatalities is also expected for other cities, particularly in the northern United States. “Climate models of future temperatures do vary a bit from place to place, but generally the story is pretty much the same,” Kinney said. The effects are not limited to cities, but heat waves are typically more severely felt in densely populated areas. This is because cities tend to concentrate heat, with buildings and pavement surfaces soaking up heat during the day and releasing it at night, the researchers said. “This serves as a reminder that heat events are one of the greatest hazards faced by urban populations around the globe,” study co-author Radley Horton, a climate scientist at Columbia University, said in a statement. The way of the future The researchers acknowledge uncertainties in their projections, including that heat's effects could be made better or worse with changing demographics, and how fatalities may be prevented with better infrastructure or public policies. Still, the findings suggest that cities and governments need to do more to address the potential dangers posed by heat waves, said Richard Keller, an associate professor of medical history and bioethics at the University of Wisconsin-Madison, who was not involved with the study. “We have needed to rethink the dangers of heat for years,” Keller said. “The Chicago heat wave of 1995, and especially the European heat wave of 2003 both caused catastrophic excess mortality.” Major federal programs provide heating assistance in the winter, but there is no concomitant program for cooling assistance in the summer, Keller said. Kinney said that to combat the effects of deadly heat waves, cities can open community cooling centers, plant trees or construct “green” roofs. The new findings demonstrate the importance of developing strategies to adapt to future higher temperatures. “Heat is a major and often underestimated killer,” Keller said. “While we evacuate in the face of hurricanes and floods, we tend to ignore extreme heat, with deadly consequences. The 2003 heat wave killed nearly 15,000 people in France alone eight times the mortality associated with Hurricane Katrina.” Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/05/23/heat-related-deaths-in-nyc-may-increase-with-climate-change/
Researchers say they have made a major step towards the development of a universal flu vaccine, after a new immunotherapy approach has shown promise in animal studies, Medical News Today reported. The method involves creating a stronger immune reaction against the flu virus in the body, protecting against more viral strains than the current vaccines do. A new flu vaccine is developed each year in order to offer the most protection against the circulating viruses.  But for the developers, it is usually a race against the clock, as the data they use quickly becomes out of date once it reaches them. Also, there is always the possibility that new flu virus strains will emerge after the vaccine has been created. The development of a universal flu vaccine would eliminate the need for the development of annual flu shots. To test their new approach, researchers from the National Institute of Allergy and Infectious Diseases (NIAID) created a vaccine that utilized a fusion of the protein ferritin, which can assemble itself into tiny nanoparticles, and the protein hemagglutinin (HA), which is found on the surface of the influenza virus.   The protein combination ultimately produced nanoparticles with eight protruding viral spikes, which served as the basis for the vaccine’s antigen – what the immune system responds to when creating antibodies. Through a series of tests on mice and ferrets, the researchers found the vaccine was more effective at boosting immunity against a much wider range of virus strains than the current flu vaccine, including strains they were not testing for. According to the researchers, the vaccine is effective because it prompts the immune system to develop antibodies to the parts of the flu virus that stay the same from strain to strain.  They say the study’s findings, published in the journal Nature, could lead to a universal flu vaccine that protects against numerous strains of the influenza virus. Click for more from Medical News Today.source : http://www.foxnews.com/health/2013/05/23/researchers-move-closer-to-development-universal-flu-vaccine/