Category Archives: Cancer

Restless legs syndrome linked to higher risk of early death

Men who suffer from restless legs syndrome may not live as long as those without the condition, according to a new study. The study found that men with restless legs syndrome (RLS) were nearly 40 percent more likely to die over the eight-year study, compared to men without RLS. When the researchers excluded from their analysis men with major chronic conditions such as cancer, heart disease and high blood pressure, those with RLS were 92 percent more likely to die over the study period. “The results of this study indicate that men with RLS had a higher overall mortality,” the researchers wrote in their study. However, the study shows an association, not a cause-and-effect link between having RLSand an increased risk of dying, and the researchers said that it is not known how RLS might increase the mortality risk. In the study, deaths among men with RLS were frequently due to respiratory disease, endocrine disease, metabolic disease and immunologic disorders. Further research is needed to understand the relationship between these diseases and RLS, the researchers said. RLS is a bothersome chronic condition that affects 5 to 10 percent of adults. Patients have an irresistible urge to move the legs, and often experience burning and creeping sensations that are described as “an itch you can't scratch,” or “like insects crawling inside the legs.” In the study, researchers looked at 18,425 men, whose average age was 67, including 700 who were diagnosed with RLS. During an eight-year follow-up, 2,765 of the men died. Among the men with RLS, 25 percent died during the study, compared with 15 percent of those who did not have RLS. The researchers also found that men with RLS were more likely to use antidepressant drugs, had more insomnia complaints, and were more likely to have high blood pressure, cardiovascular disease and Parkinson's disease. However, controlling for these factors didn't change the results, they said. The link between RLS and higher risk of death was not related to other common risk factors such as smoking, older age, low physical activity and lack of sleep. Moreover, men who had conditions such as high blood pressure, cancer or insomnia, had a further increased risk of death if they had RLS too, according to the study. The study was published online June 12 in the journal Neurology. Some of the researchers who worked on the study have received money from pharmaceutical companies that make drugs used to treat restless legs syndrome. “Increasing awareness of RLS, especially training for health professions, should be encouraged if our findings are confirmed by future studies,” the researchers said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/restless-legs-syndrome-linked-to-higher-risk-early-death/

Infections linked to mood disorders

Infections and autoimmune disorders may increase the risk of developing a mood disorder such as depression later in life, a new study from Denmark suggests. In the study, which included more than 3 million people, those who were hospitalized for infections were 62 percent more likely to subsequently develop a mood disorder compared with people not hospitalized for infections. And those hospitalized for an autoimmune disease were 45 percent more likely to subsequently develop a mood disorder. Autoimmune diseases are those in which the immune system goes awry and attacks the body's own cells or tissues. The risk of mood disorders increased with the number of times a person was hospitalized. Those who were hospitalized three times with infections during the study had double the risk of a mood disorder, and those who were hospitalized seven times had triple the risk, compared to those not hospitalized with infections. The findings support the hypothesis that inflammation, from either an infection or autoimmune disease, may affect the brain in a way that raises the risk of mood disorders, the researchers say. If the link is confirmed in further studies, the researchers said, their estimates show that infections could be responsible for up to 12 percent of mood disorders. However, the study found an association, and cannot prove that infections or autoimmune diseases are the cause of mood disorders. It's possible that other factors, such as stress or the experience of hospitalization, may explain the link, said Ian Gotlib, a professor of psychology at Stanford University, who was not involved in the study. The study is published June 12 in the journal JAMA Psychiatry. Infections and mood disorders The study included people born in Denmark between 1945 and 1996 who were followed until the end of 2010. During the study, more than 91,000 people visited a hospital for a mood disorder, including bipolar disorder or depression. Of these, about 32 percent visited hospitals for an infection before their mood disorder, and 5 percent visited the hospital for an autoimmune disease before their mood disorder. The risk of a mood disorder was greatest in the first year following an infection or autoimmune disease. People who visited a hospital for both an infection and an autoimmune disease had a greater risk of developing a mood disorder than those who visited a hospital for either of the two conditions alone. This may indicate the two conditions interact to increase the risk of mood disorder, the researchers said. Because the study looked at information from only people hospitalized with infections, autoimmune disorders and mood disorders, its not clear whether the findings may apply to people with less severe infections, or mood disorders. What's the cause? Gotlib called the study “impressive” and said it raises important questions. Previous studies have shown that people with depression have lower numbers of T cells (a type of immune cell), and are at increased risk for autoimmune diseases, Gotlib said. But there are also many other risk factors for mood disorders that were not taken into account in this study, such as smoking and socioeconomic status, Gotlib said. Future studies should attempt to untangle whether infections are really the cause of mood disorders, or if the two just happen to occur together. In addition, studies should investigate how, on a biological level, infections and autoimmune diseases might affect the brain to cause mood disorders, Gotlib said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/infections-linked-to-mood-disorders/

Drugmakers to cooperate in safety review of diabetes drugs

Global drugmakers said on Wednesday they would cooperate with an independent review to address concerns of a potential link between widely used diabetes medicines and pancreatic cancer and other safety problems. The American Diabetes Association (ADA) this week called for a new evaluation of clinical data on drugs used to control blood sugar for patients with type 2 diabetes. They include Merck & Co's $4 billion a year Januvia franchise, Novo Nordisk's Victoza, and Byetta and Onglyza from Bristol-Myers Squibb Co and AstraZeneca Plc, among others. “People who are taking these medications, or who may consider taking them, should have the benefit of all that is currently known about their risks and advantages in order to make the best possible decisions about their treatment,” Dr. Robert Ratner, ADA's chief scientific and medical officer, said in a statement. The medicines are called incretin mimetics because they mimic hormones the body produces to stimulate release of insulin, and are from classes of drugs known as GLP-1 receptor agonists and DPP-4 inhibitors. GLP-1 drugs boost insulin production by the pancreas and slow absorption of food. DPP-4 inhibitors block an enzyme the breaks down the GLP-1 peptide in the gut, thereby increasing insulin production. The U.S. Food and Drug Administration in March said it was studying unconfirmed reports that the drugs cause inflammation of the pancreas and pre-cancerous changes to cells in the pancreas. European health regulators are also studying the issue. Around the same time, new concerns arose from a small study conducted by a leading diabetes expert, Dr. Peter Butler, from the University of California, Los Angeles. Butler examined human pancreases from patients who had died of causes unrelated to pancreatic disease and found more pancreas lesions and one cancerous tumor in those who had taken Januvia or Byetta compared with nondiabetics or diabetics who had not taken those medicines. More than 370 million people are living with diabetes worldwide, with type 2 accounting for 90 percent to 95 percent of the cases, according to the International Diabetes Federation. Without significant lifestyle changes to curb obesity and other causes of diabetes, that number could balloon to as many as 552 million by 2030, the organization projected. NO FIRM EVIDENCE OF RISK Bristol-Myers and AstraZeneca issued a joint statement expressing support for the ADA initiative. Merck said it is committed to participating in the ADA effort, and is separately conducting a 14,000-patient heart safety study of Januvia. Danish drugmaker Novo Nordisk, in an emailed comment, said its studies to assess safety signals of its $1.8 billion a year Victoza do not reveal any evidence of increased risk of pancreatitis or pancreatic cancer. “As far as the ADA proposal is concerned, this is something that I do support from a conceptual basis,” said Alan Moses, Novo's global chief medical officer, in a telephone interview. “In principle, Novo Nordisk absolutely supports working with the other companies, but the final details depend on what specifically is being proposed,” Moses said, adding “it all depends on the credibility of the data that's being evaluated.” The safety concerns are being discussed on Wednesday and Thursday at a workshop conducted by the National Institutes of Health (NIH) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). A document outlining the FDA's presentation at the workshop was handed out at the meeting. Attendees quoted it as saying the agency review of trial data on the drugs did not provide enough evidence to say whether there is a link to pancreatitis, and that long-term study would be required to determine any cancer risk. A FDA spokeswoman could not immediately confirm the contents of the document. “The FDA basically appears to just be saying 'look, there just isn't enough information here to make an informed decision',” said Mark Schoenebaum, a drug industry analyst with ISI Group who was attending to two-day NIH/NIDDK workshop. “There are no conclusions at this point in time from the meeting and I doubt very much there will be because the science quite frankly is immature about the whole area of pancreatic cancer,” said Novo's Moses, who will address the workshop on Thursday. “Everybody agrees that this is an incredibly complex area.” In an interview with Reuters earlier this week Peter Stein, Merck vice president of clinical research for diabetes, expressed full confidence in the safety of Januvia. During the workshop, Merck said it will present data on the safety profile of Januvia, known chemically as sitagliptin, including an updated analysis of data from more than 14,000 patients from 25 randomized clinical trials. Merck last month reported a surprising decline in first quarter sales of Januvia, which has been the drugmaker's fastest growing medicine since its 2006 approval. It was not clear if increased competition, safety concerns or other factors led to the 4 percent slip in quarterly sales to $884 million.source : http://www.foxnews.com/health/2013/06/13/drugmakers-to-cooperate-in-safety-review-diabetes-drugs/

AIDS drugs halve HIV risk for intravenous drug users in study

A daily dose of powerful anti-HIV medicine helped cut the risk of infection with the AIDS virus by 49 percent in intravenous drug users in a Bangkok study that showed for the first time such a preventive step can work in this high-risk population. “This is a significant step forward for HIV prevention,” said Dr. Jonathan Mermin, director of the U.S. Centers for Disease Control and Prevention, which helped conduct the clinical trial along with the Thailand Ministry of Health. The study, published on Wednesday in the journal Lancet, looked at the treatment approach known as pre-exposure prophylaxis, or PrEP, in which HIV treatments are given to uninfected people who are at high-risk for HIV infection. The drug used in the study was Gilead's older and relatively cheap generic HIV drug tenofovir. The study was launched in 2005. Prior studies of this approach showed it cut infection rates by 44 percent in men who have sex with men, by 62 percent in heterosexual men and women and by 75 percent in couples in which one partner is infected with HIV and the other is not. The new results showed that it also protects intravenous drug users. “We now know that PrEP can work for all populations at increased risk for HIV,” Mermin said in a statement. Based on the results, the CDC plans to recommend that U.S. doctors who wish to prescribe this treatment for their patients follow the same interim guidelines issued last year to prevent sexual transmission among other high-risk individuals. Intravenous use of drugs like heroin accounts for about 8 percent of all new HIV infections in the United States and about 10 percent of new HIV infections worldwide. In some regions, such as Eastern Europe and Central Asia, injection drug abuse accounts for about 80 percent of all new infections. The new findings involved more than 2,400 intravenous drug users in Bangkok who were not infected with the human immunodeficiency virus, which causes AIDS, and were being treated at the city's drug treatment clinics. Half took tenofovir and half took a placebo. All participants were given HIV prevention counseling, risk-reduction strategies such as condoms and methadone treatment, and monthly HIV testing. At the end of the study, there were 17 HIV infections among people taking the HIV medication, compared with 33 infections among those not taking the drugs, the researchers found. The researchers also looked to see what factors influenced infection rates among those taking the HIV medication. They found that people who took their medication at least 71 percent of the time had a 74 percent lower risk of becoming infected with HIV. Although it was not clear how the preventive drug treatment worked - by stopping infections caused by sharing dirty needles or by unprotected sex among drug users - the study produced a reduction in infection rates, said Dr. Salim Abdook Karim of the University of KwaZulu-Natal in Durban, South Africa and of Columbia University in New York. “The introduction of PrEP for HIV prevention in injecting drug users should be considered as an additional component to accompany other proven prevention strategies like needle exchange programs, methadone programs, promotion of safer sex and injecting practices, condoms, and HIV counseling and testing,” Karim, who was not involved in the study, wrote in a commentary accompanying the study in the Lancet. “PrEP as part of combination prevention in injecting drug users could make a useful contribution to the quest for an AIDS-free generation,” Karim added.source : http://www.foxnews.com/health/2013/06/13/aids-drugs-halve-hiv-risk-for-intravenous-drug-users-in-study/

5 white lies that stall weight loss

We all fib a little, but telling your co-worker her new haircut looks great (when what you're really thinking is “oh my!”) is pretty harmless. Lying to yourself about your own eating habits on the other hand, can wreak some real mental and physical havoc; and a new study shows it may be pretty common. In my private practice, I make it very clear to my clients that my role is not to scold, berate, or act like a food cop. In fact, it's just the opposite, because fostering an open, non-judgmental dialogue about your relationship with food is the only way to uncover some truths you may be pushing under the rug. And until they're exposed, they're pretty impossible to change. Here are five many of my clients reveal, and why coming clean with yourself can be the answer to finally losing weight—for good. 'I eat when I'm hungry, and stop when I'm full' When reviewing my clients' food diaries, I often see snacks, driven by hunger, just an hour or two after fairly substantial meals–generally a sign that something is out of sync. When I ask, “What did the hunger feel like?” it often turns out to be emotional or social, rather than physical in nature. In other words, there are no bodily symptoms that signaled a need for energy or nourishment, and in truth, many clients know this to be true. One once said, “I realize it's not really hunger, but I fool myself into thinking it is, because I don't know what else to do.” Alternative: The toughest part of recognizing that you want to eat, but not because your body is telling you to, is acknowledging that what you really need has nothing to do with food. But once you do just that, and find other healthy ways to cope with what's really going on (anxiety, relationship issues…), the weight may effortlessly fall off (day after day after day, just 200 surplus calories can keep you 20 pounds heavier). If you don't keep a food diary already, start one, and include not just what you eat and how much, but also your hunger level before and after meals, in addition to your emotions. The revelations may allow you to break the pattern. Health.com: 20 Snacks That Burn Fat 'I'm not a big drinker' I've heard this from many clients who, according to the Centers for Disease Control and Prevention criteria, are chronic binge drinkers (consuming four or more drinks in a two hour period for women, five for men). For some, the self-categorization is justified, because they don't drink during the week, have already cut back, or are comparing themselves to friends who drink a whole lot more. But after some reflection, I often hear sentiments like, “I know polishing off a bottle of wine by myself isn't good, even if it's only on the weekends.” Alternative: For most of my clients, drinking has a domino effect that travels in both directions. Knocking a few back drinks on Saturday night often leads to eating more at dinner, followed by going out to brunch on Sunday, skipping the gym Monday morning, and giving into the office candy dish Monday afternoon.  On the flip side, cutting back on booze often leads to feeling “cleaner,” more in control, and motivated to eat healthier and be more active—changes that can be transformative for both your waistline and health. If you're using alcohol as an emotional crutch, or it's integral to your social scene, reach out to someone you trust. I've had clients break out of this pattern simply by connecting with a close friend or family member who supported their decision to cut back, or stop drinking all together. Health.com: How to Drink Alcohol Without Gaining Weight 'I eat really healthfully most of the time' I often hear this statement right after a client tells me about a decadent vacation, dinner out, or holiday that involved overeating. And while some believe it to be true, many know that on a day-to-day basis, while they don't pig out, they're not exactly earning gold stars, especially when it comes to hitting the mark for veggies, or reaching for whole, rather than refined grains. After acknowledging that she was looking at her diet through rose-colored glasses, one client said, “I think I was giving myself an A when what I really earned was more like a B-.” Alternative: It's OK to admit that you're not perfect, even if you're not perfect most of the time! You can't set concrete goals that will improve your eating habits without coming to terms with how you really eat. For example, if you realize that you eat too much rice and not enough veggies at dinner, flip-flopping the portions (e.g. a half cup of brown rice and one cup of broccoli, instead of the reverse) shaves 20 grams of carbs from your meal. At one meal a day, that's a savings equivalent to walking on a treadmill at four miles per hour for 85 hours. Health.com: Best Superfoods for Weight Loss 'I eat 5 or 6 small meals a day' The operative word here is “small.” Many of my clients who say this are actually eating five full meals, which by today's portion distortion standards, may seem small, but are actually far more than their bodies need. Admitting to this, one client said, “I think I've just gotten used to eating every few hours, or I thought it was the best thing to do, but it's clearly not working for me.” Alternative: Long stretches without eating can lead to rebound overeating, so well timed meals are key. But whether you eat four, five, or six times a day, your body's needs remain the same, which means if you want to eat more often, you must eat less each time you chow. For example, if you need 1,600 calories a day, you can eat: four 400 calorie meals; five 320 calorie meals; or six 266 calorie meals. The latter is a real challenge, because the meals end up being so mini, they don't feel like meals, leading to extra nibbles, which wind up feeding your fat cells. I don't advocate calorie counting, but if you think that too-frequent eating may be an issue, take inventory for a day or two, to gain some perspective. Health.com: 25 Ways to Cut 500 Calories A Day 'I can eat more because I work out a lot' I work with pro athletes and performers, but most of my clients work full time, on top of juggling family and social responsibilities, which often leads to fitting in far fewer workouts than they'd like. When they do hit the gym, they hit it hard, but many get there three days a week, while continuing to eat as if they're starting every day with a workout. One client confessed, “I think of myself as such an active person, but the truth is, it's more wishful thinking than reality.” Alternative: Rather than following the same routine every day of the week, establish a “baseline” eating plan, for non-exercise days, and add to it on the days you workout. Mentally, it's much easier to add to your plate, rather than take foods away, and with a daily regime that doesn't factor in fitness, if you just can't make it happen, you won't stick yourself with a surplus. Cynthia Sass is a registered dietitian with master's degrees in both nutrition science and public health. Frequently seen on national TV, she's Health's contributing nutrition editor, and privately counsels clients in New York, Los Angeles, and long distance. Cynthia is currently the sports nutrition consultant to the New York Rangers NHL team and the Tampa Bay Rays MLB team, and is board certified as a specialist in sports dietetics. Her latest New York Times best seller is S.A.S.S! Yourself Slim: Conquer Cravings, Drop Pounds and Lose Inches. This article originally appeared on Health.com.source : http://www.foxnews.com/health/2013/06/13/5-white-lies-that-stall-weight-loss/

Experimental vaccine shows promise against TB meningitis

A report on the federally funded research is published online June 11 in the journal PLOS ONE. TB brain infections often cause serious brain damage and death even when recognized and treated promptly, researchers say. This is so because many drugs currently used to treat resistant TB strains cannot cross the so-called brain-blood barrier, which stops pathogens from entering the brain, but also keeps most medicines woefully out of the brain’s reach…

Chemotherapy: Greater potential benefit in overall survival for eribulin compared with capecitabine

The specific patient populations who appeared to benefit from eribulin, in comparison to capecitabine, are as follows: Patients with more than two organs involved with metastatic breast cancer Patients who had not received chemotherapy for six months or longer Patients who had received anthracycline and/or a taxane therapies in the metastatic setting Previous pre-specified exploratory analysis of overall survival and progression-free survival showed women with triple-negative, ER-negative, HER2-negative also had a greater relative benefit in overall survival with eribulin over capecitabine. …

The best foods for fertility

Many women dream of becoming mothers but few think about infertility until it affects them. According the Center for Disease Control, more than 7.4 million women have used fertility services. Diet is an often-overlooked component of fertility.  The right combination of treatments and following a proper fertility diet could increase a woman’s chances of achieving conception. Eliminate processed foods and choos natural, organic products whenever possible. To cut down on the number of toxins and hormones ingested, chose proteins from organic, grass-fed and pastured animals as often as you can. Certain vitamins and minerals might help a woman’s body prepare for conception. A good fertility diet is high in foods containing these five key components: Healthy fats Healthy fats, such as omega-3 fatty acids, may improve fertility by regulating hormones, increasing cervical fluid and promoting ovulation. A study published by the National Institute of Health found that women suffering from infertility had lower levels of omega-3s. There are 3 different types of omega 3 fats: ALA (alpha-linoleic acid), EPA (eicosapentaenioc) and DHA (docosahexaenioc acid). Good sources of plant-based ALA include hemp, flaxseeds or flax oil and walnuts. EPA and DHA are both animal-based and can be found in fatty fish such as salmon, herring, trout, tuna and cod as well as in egg yolks. Beef that has been pasture-raised is also a good source of omega-3 fatty acids. Vitamin D This fat-soluble vitamin helps support the production of estrogen and assists in regulating cell growth. Wild-caught fish, especially the fatty ones listed above, butter from grass-fed cows and pastured eggs are all good sources and are easy to incorporate into your diet. Other sometimes overlooked foods include organ meats (preferably from organic, pastured animals), oysters, fish roe and cod liver oil. Vitamin A This is an essential, fat-soluble vitamin that can help follicles develop and also improve cervical fluid. There are two groups of vitamin A: retinols and carotenoids. Retinols are found in animal products including beef liver, organic butter and cream, cod liver oil and eggs from pastured chickens. Beta-carotene is found in plant foods and more of it is required to obtain the same amount of usable vitamin A. The best sources of beta-carotene are carrots, pumpkin, sweet potato, spinach and collard greens. Vitamin E Vitamin E assists in the proper absorption of other fat-soluble vitamins and may further help fertility by normalizing hormone production. Butter from grass-fed cows, organ meats, sunflower seeds, almonds, dark leafy green vegetables, unrefined olive oil and pastured eggs are all a healthy part of a fertility diet. Iodine This mineral is required for healthy thyroid function which assists with the production of sex hormones. The best place to find iodine is in seafood as well as fruits and vegetables grown by the sea including seaweed, kelp and coconut products. Blackstrap molasses, spinach, eggs and whole milk dairy products are also beneficial. Besides focusing on the foods listed above, be sure to eat plenty of fresh fruits and vegetables. The key is to optimize nutrition and eliminate as many low-nutrient foods as possible. At the grocery store, shop the perimeter of the store where all the fresh foods are kept and limit the highly processed foods that are typically found in the aisles. Buying everything organic can be challenging so focus on purchasing organic proteins and organic vegetables that fall into the ‘dirty dozen,’ meaning they have been found to have the highest levels of pesticides (apples, celery, cherry tomatoes, cucumbers, grapes, hot peppers, imported nectarines, peaches, potatoes, spinach, strawberries and sweet bell peppers).Jacqueline Banks is a certified holistic health counselor and busy mother. & Her focus is on helping other busy moms in all stages of motherhood keep themselves and their little ones healthy and happy. & She uses natural and organic solutions to solve individual health problems and promote clean living. Check out her website at www.jbholistic.com.& & source : http://www.foxnews.com/health/2013/06/12/best-foods-for-fertility/

Stem cells may be secret to regenerating fingers and toes

Mammals can regenerate the very tips of their fingers and toes after amputation, and now new research shows how stem cells in the nail play a role in that process. A study in mice, detailed online June 12 in the journal Nature, reveals the chemical signal that triggers stem cells to develop into new nail tissue, and also attracts nerves that promote nail and bone regeneration. The findings suggest nail stem cells could be used to develop new treatments for amputees, the researchers said. [Inside Life Science: Once Upon a Stem Cell] More from LiveScience In mice and people, regenerating an amputated finger or toe involves regrowing the nail. But whether the amputated portion of the digit can regrow depends on exactly where the amputation occurs: If the stem cells beneath the nail are amputated along with the digit, no regrowth occurs, but if the stem cells remain, regrowth is possible. To understand why these stem cells are crucial to regeneration, researchers turned to mice. The scientists conducted toe amputations in two groups of mice: one group of normal mice, and one group that was treated with a drug that made them unable to make the signals for new nail cells to develop. They found that the signals that guided the stem cells' development into nail cells were vital to regenerating amputated digits. By five weeks after amputation, the normal mice had regenerated their toe and toenail. But the mice that lacked the nail signal failed to regrow either their nails or the toe bone itself, because the stem cells lacked the signals that promote nail-cell development. When the researchers replenished these signals, the toes regenerated successfully. In another experiment, the researchers surgically removed nerves from the mice toes before amputating them. This significantly impaired nail-cell regeneration, similar to what happened to the mice that lacked the signals to produce new nails. Moreover, the nerve removal decreased the levels of certain proteins that promote tissue growth. Together, the results show that nail stem cells are critical for regrowing a lost digit in mice. If the same turns out to be true in humans, the findings could lead to better treatments for amputees. Other animals, including amphibians, can also regenerate lost limbs. For example, aquatic salamanders can regrow complete limbs or even parts of their heart — a process that involves cells in their immune system. By studying these phenomena in other animals, it may be possible to enhance regenerative potential in people, the researchers said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/stem-cells-may-be-secret-to-regenerating-fingers-and-toes/

How safe is Splenda? Group urges caution for artificial sweetener

The artificial sweetener sucralose (sold under the brand name Splenda) could potentially pose health risks, so it needs to be better understood before the sweetener should be assumed to be safe, one advocacy organization says. The Center for Science in the Public Interest, a nonprofit watchdog group, said today that it was downgrading its safety rating of sucralose from “safe” to “caution,” meaning that the additive “may pose a risk and needs to be better tested.” The change was spurred by a recent study from researchers in Italy that found that sucralose caused leukemia in mice, according to the CSPI. This study has not been published, and needs to be reviewed by other scientists to determine whether the findings are credible. While sucralose may turn out to be safer than other artificial sweeteners, “the forthcoming Italian study warrants careful scrutiny before we can be confident that the sweetener is safe for use in food, said CSPI executive director Michael F. Jacobson. The CSPI recommends people avoid the artificial sweeteners saccharin (Sweet N Low), aspartame (NutraSweet and Equal), and acesulfame potassium (Sunett and Sweet One). The issue of whether artificial sweeteners pose health risks is controversial. Many of the studies showing risks, including the new Italian study, have been done in animals, and it's not known whether the same effects would be seen in humans. In addition, rodents, like humans, may develop cancer as a result of old age, and not exposure to chemical additives. This issue has caused some to question the results of studies showing that aspartame-fed rats are at increased risk for cancer over their lifetimes. Even the CSPI says that it considers drinking diet soda, which often contains artificial sweeteners, to be safer than drinking regular soda. Regular soda “poses the greater and demonstrable risks of obesity, diabetes, heart disease, gout, tooth decay, and other health problems,” the CSPI said in a statement. To avoid both the risks of sugar and artificial sweeteners, the CSPI recommends drinking water, seltzer water, flavored unsweetened waters, seltzer mixed with some fruit juice or unsweetened iced tea. It's worth noting that the CSPI also gives caffeine a safety rating of “caution.” Caffeine “keeps many people from sleeping, causes jitteriness, and affects calcium metabolism,” the CSPI says. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/how-safe-is-splenda-group-urges-caution-for-artificial-sweetener/