Murray Korc, M.D., the Myles Brand Professor of Cancer Research at the Indiana University School of Medicine and a researcher at the Indiana University Melvin and Bren Simon Cancer Center, and colleagues have shown that the retinoblastoma protein, a tumor suppressor, often malfunctions in pancreatic cancer. That dysfunction enables an inhibitory protein to promote pancreatic cancer growth. The research was published online today in the Journal of Clinical Investigation. As a result of the dysfunctional retinoblastoma protein, pancreatic cancer cells lose their ability to be inhibited by transforming growth factor-beta, or TGF-β, which is a key negative regulator of cell proliferation, according to Dr…
Nearly 15 million U.S. adults suffer from clinical depression. Treating them is currently a process of trial and error. “It's always been a combination of physician preference, patient preference andâ€¦ who you actually choose to see for your depression,” Dr. Helen Mayberg, a neurologist at Emory University School of Medicine, said. “If you choose to go see a psychologist, psychologists do therapy. If you go to your family doctorâ€¦ the likelihood is that you'll be prescribed a medication.” With fewer than 40 percent of patients achieving success with their initial treatment for depression, the majority have to wait to see if additional therapies are effective. “It's a serious illness,” Mayberg said. “There are consequences to going another six weeks, another eight weeks, another 12 weeks on a treatment that is unlikely to work.” Now, Mayberg and a team of researchers may have discovered a way to reduce the guesswork involved with treating clinical depression. Their study, published online in JAMA Psychiatry, suggests the solution is locked in a portion of the brain called the anterior insula. PET scans revealed that patients who benefitted from escitalopram (an antidepressant also known by the brand name Lexapro) had different activity levels in the anterior insula than patients who responded well to “talk therapy.” “The patients who did the best on escitalopram have high insula activity (compared to other parts of the brain),” Callie McGrath, an Emory graduate student and lead author of the study, said. “And the patients who do the best on cognitive behavioral therapy have low insula activity.” The researchers believe they've found the first reliable indicator to guide doctors in their selection of initial treatments for clinical depression. This has the potential to spare many patients from the prolonged suffering and uncertainty associated with current trial and error methods. “It's a very discouraging process,” said Edi Guyton, who leads local support programs with the National Alliance on Mental Illness (NAMI). “It's long. You begin to feel hopeless.” Guyton said she struggled with treatment-resistant depression for most of her life until she was able to bring it under control through deep brain stimulation (DBS), an experimental therapy developed by Dr. Mayberg. Guyton said she hopes Mayberg's separate study on the relationship between brain activity and treatment outcomes will lead to more research that takes the hit and miss factor out of helping people with depression. “That would be wonderful, just knowing what medicine,” Guyton said. “If you were pretty sure, even 80 percent sure, that this is gonna work for me, I think it would make all the difference in the world.”source : http://www.foxnews.com/health/2013/06/13/depression-treatments-brain-scans-may-suggest-best-course/
The artificial sweetener sucralose (sold under the brand name Splenda) could potentially pose health risks, so it needs to be better understood before the sweetener should be assumed to be safe, one advocacy organization says. The Center for Science in the Public Interest, a nonprofit watchdog group, said today that it was downgrading its safety rating of sucralose from “safe” to “caution,” meaning that the additive “may pose a risk and needs to be better tested.” The change was spurred by a recent study from researchers in Italy that found that sucralose caused leukemia in mice, according to the CSPI. This study has not been published, and needs to be reviewed by other scientists to determine whether the findings are credible. While sucralose may turn out to be safer than other artificial sweeteners, “the forthcoming Italian study warrants careful scrutiny before we can be confident that the sweetener is safe for use in food, said CSPI executive director Michael F. Jacobson. The CSPI recommends people avoid the artificial sweeteners saccharin (Sweet N Low), aspartame (NutraSweet and Equal), and acesulfame potassium (Sunett and Sweet One). The issue of whether artificial sweeteners pose health risks is controversial. Many of the studies showing risks, including the new Italian study, have been done in animals, and it's not known whether the same effects would be seen in humans. In addition, rodents, like humans, may develop cancer as a result of old age, and not exposure to chemical additives. This issue has caused some to question the results of studies showing that aspartame-fed rats are at increased risk for cancer over their lifetimes. Even the CSPI says that it considers drinking diet soda, which often contains artificial sweeteners, to be safer than drinking regular soda. Regular soda “poses the greater and demonstrable risks of obesity, diabetes, heart disease, gout, tooth decay, and other health problems,” the CSPI said in a statement. To avoid both the risks of sugar and artificial sweeteners, the CSPI recommends drinking water, seltzer water, flavored unsweetened waters, seltzer mixed with some fruit juice or unsweetened iced tea. It's worth noting that the CSPI also gives caffeine a safety rating of “caution.” Caffeine “keeps many people from sleeping, causes jitteriness, and affects calcium metabolism,” the CSPI says. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/how-safe-is-splenda-group-urges-caution-for-artificial-sweetener/
The Food and Drug Administration is cracking down on sex supplements again, warning the public on Monday about six products that were found to contain hidden drugs. The names of the tainted products are: Reload, Get It Up, Super Cheetah, Cave Diver, Nights to Remember and X Zen Platinum. All of the products are marketed for sexual enhancement, and sold on various websites and in some retail stores, the FDA said. All of the products were found to contain the drug sildenafil (sold under the brand name Viagra), and one was found to contain tadalafil (brand name Cialis). Sildenafil and tadalafil are prescription drugs used to treat erectile dysfunction. Sex supplements are not allowed to contain prescription drugs, and the drugs are not included on the products' labels. Undeclared drugs in supplements are dangerous because consumers ingest these drugs without being told about their risks. Sildenafil and tadalafil can cause adverse reactions, including dangerously low blood pressure, if taken along with other prescription drugs that contain nitrates, the FDA says. (Some drugs prescribed to treat chest pain and heart disease contain nitrates.) Consumers who take the products listed in today's warnings should stop using them immediately, and throw them away, the FDA says. Last month, the FDA recalled two sex supplements, called Vicerex and Black Ant, because the products contained sildenafil and tadalafil. Earlier this year, the FDA warned consumers that several other sexual enhancement supplements contained undeclared drugs. Because the FDA is unable to test and identify all tainted sexual enhancement products, consumers should exercise caution before buying any products in this category, the agency said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/10/6-sex-supplements-contain-hidden-drugs-fda-warns/
You may know that so-called low-fat and fat-free diet foods are often packed with sugar, salt, and chemical-laden additives. But did you realize that your body digests these “healthy” alternatives in record time, leaving you hungry for more?&#160; That's only part of the problem, according to New York City dietitian Keri Glassman, the author of The New You and Improved Diet. Packaging, no matter how well-intentioned and honest, is another culprit: When people see low-fat on a label, they think they can eat more than they really should and end up chowing down on 28 percent more calories, according to research from the Cornell University Food and Brand Lab. Below, we've rounded up five common low-fat foods that aren't scoring you a six-pack anytime soon. Chips Low-fat chips taste a whole lot better than they used to, thanks to the addition of more salt, carbs, and other additives. When fat is removed from chips, manufacturers make up for lost taste and texture with the salty stuff. Many bags of low-fat chips contain about 20 percent more sodium and 15 percent more carbohydrates than their full-fat versions—not to mention about twice the number of ingredients. Peanut Butter You already know peanuts are little fat repositories, but this is mostly good fat: Polyunsaturated fatty acids increase protein concentration and the size of muscular cells, adding to your lean muscle mass without a single workout, according to research published in Clinical Science. What's more, old fat stored in the body's peripheral tissues can't get worked off efficiently without new fat to activate fat-burning pathways in the liver, according to research from the Washington University School of Medicine in St. Louis.&#160; What many food companies don't tell you is that they've replaced that healthy fat with maltodextrin, a carbohydrate used as a filler in many processed foods. This means you're trading the healthy fat from peanuts for empty carbs and double the sugar for a savings of a meager 10 calories. So next time you're making a peanut butter and jelly sandwich, ditch the empty calories in the low-fat alternative and opt for the full-fat original—just be sure to spread it on in moderation. ___________________________________________________ More From Details: 7 Trends You'll Be Wearing Next Fall Foods That Will Make You Look Younger 14 Healthiest Snack Foods You Can Buy 12 Must-See Sneakers ___________________________________________________ Cheese You'll be hard-pressed to find low-fat or fat-free cheese at the deli counter. Why?