A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) shows that a molecule called nuclear factor kappa B (NF-kB) helps cancer cells by suppressing the immune system’s ability to detect and destroy them. …
source : http://www.sciencedaily.com/releases/2014/03/140318111319.htm
source : http://www.sciencedaily.com/releases/2014/03/140311184702.htm
A CWRU research team led by Analisa DiFeo, an assistant professor of General Medical Science-Oncology at the Case Comprehensive Cancer Center, found that the biomarker miR-181a is a molecular driver of epithelial ovarian cancer (EOC). The research team also found that elevated levels of miR-181a in ovarian tumors are associated with chemotherapy resistance and disease progression. "By looking at the expression of this microRNA in tumor samples, we get an idea which women may respond to standard chemotherapy and which are at a high risk for recurrence," DiFeo said. "This helps guide treatment decisions and improve survival rates." In the past, researchers have been unable to predict how EOC patients will respond to treatment…
Murray Korc, M.D., the Myles Brand Professor of Cancer Research at the Indiana University School of Medicine and a researcher at the Indiana University Melvin and Bren Simon Cancer Center, and colleagues have shown that the retinoblastoma protein, a tumor suppressor, often malfunctions in pancreatic cancer. That dysfunction enables an inhibitory protein to promote pancreatic cancer growth. The research was published online today in the Journal of Clinical Investigation. As a result of the dysfunctional retinoblastoma protein, pancreatic cancer cells lose their ability to be inhibited by transforming growth factor-beta, or TGF-β, which is a key negative regulator of cell proliferation, according to Dr…
A study published online October 27 by Nature Cell Biology by Bragado et al. reveals that bone marrow contains high levels of TGFβ2, which activates the tumor suppressor gene p38 in tumor cells and triggers a cascade of events that renders tumor cells dormant and keeps HNSCC growth in check. In the lungs, where TGFβ2 is in short supply, these cells rapidly form tumors…
Previous research shows that km23-1 is involved in the movement of cancer cells and in the control of specific proteins at the leading edge of moving cells. Kathleen Mulder, professor of biochemistry and molecular biology, who discovered the protein, now says km23-1 is used in the cancer cell’s ability to move out of a tumor in the early stages ofinvasion. "km23-1 may be able to help in this process due to its role in the assembly of large groups of proteins favorable to cancer invasion," Mulder said. Colorectal cancer is the third most common cancer in the United States. …