Tag Archive safety

Human neural stem cells restore cognitive functions impaired by chemotherapy

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In preclinical studies using rodents, they found that stem cells transplanted one week after the completion of a series of chemotherapy sessions restored a range of cognitive functions, as measured one month later using a comprehensive platform of behavioral testing. In contrast, rats not treated with stem cells showed significant learning and memory impairment. The frequent use of chemotherapy to combat multiple cancers can produce severe cognitive dysfunction, often referred to as “chemobrain,” which can persist and manifest in many ways long after the end of treatments in as many as 75 percent of survivors — a problem of particular concern with pediatric patients. “Our findings provide the first solid evidence that transplantation of human neural stem cells can be used to reverse chemotherapeutic-induced damage of healthy tissue in the brain,” said Charles Limoli, a UCI professor of radiation oncology…

Half of smokers using Liverpool Stop Smoking Services used e-cigs

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The data — presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool — also highlights that smokers are more likely to try e-cigarettes if they feel more confident that the products are safer than tobacco smoking. Researchers from the University of Liverpool quizzed more than 320 smokers from the Roy Castle FagEnds study to understand the number of people who used e-cigarettes and what smokers thought about the products. Smokers appear undecided towards e-cigarettes, possibly due to the widely documented uncertainties about safety and effectiveness in helping smokers to successfully break their addiction. Some also viewed using e-cigarettes as an extension of smoking and perceived them as an inferior tool for helping to quit smoking…

Cancer patients should not hesitate to speak with their doctors about dietary supplements

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This gap in communication can happen when patients believe that their doctors are indifferent or negative toward their use of these supplements. As a result, patients may find information about dietary supplements from unreliable sources, exposing themselves to unneeded risks. Since information on these dietary supplements is limited, researchers from the University of Texas Medical Branch describe a practical patient-centered approach to managing dietary supplement use in cancer care in a review article. Improving the communication between patient and doctor in this area is critical. …

Pertuzumab adds 16 months survival benefit to trastuzumab and chemotherapy treatment for HER2-positive metastatic breast cancer

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CLEOPATRA was a pivotal phase III study where researchers evaluated the safety and efficacy of pertuzumab, trastuzumb and chemotherapy in 808 patients with previously untreated HER2-positive metastatic breast cancer. …

Pertuzumab adds 16 months survival benefit to trastuzumab and chemotherapy treatment for HER2-positive metastatic breast cancer — ScienceDaily

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CLEOPATRA was a pivotal phase III study where researchers evaluated the safety and efficacy of pertuzumab, trastuzumb and chemotherapy in 808 patients with previously untreated HER2-positive metastatic breast cancer. HER2-positive metastatic breast cancer has historically been one of the most aggressive forms of the disease. “In CLEOPATRA we evaluated whether dual HER2 blockade by combining the antibody pertuzumab with trastuzumab and chemotherapy would help people live longer (overall survival, OS) or live longer without their disease worsening (progression-free survival, PFS),” explains lead author Dr Sandra Swain from Washington Hospital Center, Washington, USA…

One-two punch for brain tumors? New clinical trial opens

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The experimental approach, based on U-M research, delivers two different genes directly into the brains of patients following the operation to remove the bulk of their tumors. The idea: trigger immune activity within the brain itself to kill remaining tumor cells — the ones neurosurgeons can’t take out, which make this type of tumor so dangerous. …

Lung cancer diagnosis tool shown to be safe and effective for older patients

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Half of all lung cancer patients are over 70 years old when first diagnosed, but studies have shown that these older patients are less likely to receive an accurate diagnosis. A correct assessment of the stage of a patient’s disease — how much their tumor has grown and spread — is key to ensuring they receive the right treatment. Non-invasive methods of checking whether a patient’s cancer has spread to their lymph nodes have limited sensitivity and until recently the only way to obtain a tissue sample was under general anaesthetic — limiting its use in elderly patients who often present with other conditions that may restrict the use of general anaesthesia. …

Colon has safety mechanism that restricts tumor formation

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The scientists have observed that the formation of an adenoma in the colon is accompanied by an increase in the production of a molecule called BMP (bone morphogenetic protein). …

Experimental antibody shows early promise for treatment of childhood tumor — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/05/140508121316.htm

Focused ultrasound reduces cancer pain — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/05/140505155145.htm