Tag Archives: virus

Pork industry hunts for deadly pig virus

The sudden and widespread appearance of a swine virus deadly to young pigs - one never before seen in North America - is raising questions about the bio-security shield designed to protect the U.S. food supply. The swine-only virus, the Porcine Epidemic Diarrhea Virus (PEDV), poses no danger to humans or other animals, and the meat from infected pigs is safe for people to eat. Though previously seen in parts of Asia and Europe, the virus now has spread into five leading hog-raising U.S. states. How it arrived in the United States remains a mystery. While the U.S. imports millions of pigs each year from Canada, it imports pigs from virtually no other country, and no Canadian cases of PEDV have been confirmed. Veterinarians and epidemiologists say pigs are infected through oral means, and that the virus is not airborne and does it not occur spontaneously in nature. In recent years, with the emergence of dangerous pathogens such as H1N1, also known as swine flu, and bovine spongiform encephalopathy (BSE) or mad cow disease, the United States and other countries have sought to secure defenses both on the farm and at the national borders to protect against barnyard epidemics. “We're just trying to get a handle on what's happening,” said Tom Burkgren, executive director of the American Association of Swine Veterinarians. “It's like drinking water out of a fire hose. We're getting hits from all over the place.” Overall numbers of confirmed cases and mortality rates are not yet available, though anecdotal evidence suggests there are devastating losses for farms that are hit. “If you've got it, it's bad,” said Mark Greenwood, vice president of agri-business capital at AgStar Financial Services, who said none of his clients have been affected. “I spoke to a farmer in the Midwest who had it show up in a 2,000-head barn of pigs, and had a 40 percent death loss.” A spokeswoman for U.S. Department of Agriculture's Animal and Plant Health Inspection Service told Reuters the agency is working with state agencies and pork industry officials to discover where the virus originated. THE VIRUS SPREADS Confirmed cases have been reported in five hog-raising states including Iowa, the largest U.S. hog producer with 20 million hogs, according to the USDA. While only seven farms have had confirmed cases since May 17, more cases are expected as labs sift through samples, say sources investigating the outbreak. Colorado, Indiana, Illinois and Minnesota reportedly have positive tests for PEDV, according to state veterinarians and agriculture department officials, and the National Veterinary Services Laboratory in Ames, Iowa. PEDV, most often fatal to very young pigs, causes diarrhea, vomiting and dehydration. It also sickens older hogs, though their survival rate tends to be high. Known as a “coronavirus” because of the crown-like spikes on its surface, the virus afflicted China in recent years and killed more than 1 million piglets. PEDV is spread most commonly by pigs ingesting contaminated feces. Investigators are focused on physical transmission, perhaps a PEDV infected pig, equipment marred with feces, or even a person wearing dirty boots or with dirty nails. The mystery about how the virus entered the United States is raising concern about potential holes in the bio-security shield designed to protect the U.S. food and farming sectors. “Like everything else, we screw up from time to time,” said Ronald L. Plain, professor of agricultural economics at University of Missouri in Columbia, Missouri. “We know so little about the transmittal of this virus. We can't be sure if it's happening because of something we're supposed to do right and didn't - or by some mechanism we don't know that we're supposed to do differently.” Initial reporting about the virus may have been delayed, say sources, because its symptoms can be confused with a more common malady, transmissible gastroenteritis (TGE). Also, states are not required to report cases of PEDV to the federal government, and farmers are not required to report to state veterinarians. As part of its assessment of the situation, USDA will email epidemiological surveys to swine veterinarians who are dealing cases of PEDV. Meanwhile, the veterinarians are sending samples to diagnostic labs, where technicians are scrambling gathering the tools needed to check the samples for PEDV - supplies many labs did not have prior to the outbreak. While most farmers are taking a wait-and-see approach, some told Reuters they are turning away unnecessary visitors and double checking to ensure their safety protocols are being followed. LOOKING NORTH The search for leads also has turned to the nation's borders and ports of entry - specifically, Canada, where the United States imported 5.7 million head of live hogs last year. Canada has never had a confirmed case of the virus, though it does not test for it, government officials said. “Canada has very effective import measures in place to address this risk,” said Dr. Rajiv Arora, senior staff veterinarian for the Canadian Food Inspection Agency's foreign animal disease section. Canada can import live breeding pigs, under permits, from either the United States or the European Union, Arora said. The animals are quarantined by CFIA for a period of time, then inspected and tested - although not for PEDV - before released. Canada imported C$1.7 million ($1.6 million) worth of live swine in 2012, including both slaughter-ready and breeder pigs, according to Canada's Agriculture Department. CHINA HARD HIT Veterinarians and agricultural epidemiologists in the United States are drawing grim lessons from the devastating effect PEDV has had in other countries where it has hit. The first reports of suspected PEDV came in 1971 in the United Kingdom. As years passed, PEDV spread across parts of Europe and Asia. Veterinary researchers later concluded that lax bio-security measures contributed to PEDV's spread in Asia. One of the worst known outbreaks of the virus hit China's pig herds in late 2010, according to the Centers for Disease Control and Prevention's Emerging Infectious Diseases Journal. Vaccines had limited effectiveness and PEDV over ran southern China killing more than 1 million piglets. The death rate for virus-infected piglets ranged from 80 percent to 100 percent. Biosecurity measures in the U.S. food supply have been beefed up over the years, and especially after the outbreaks of mad cow disease and swine flu. Both outbreaks posed risks to human health. Today, trucks carrying live animals are supposed to be cleaned before entering and leaving farms. At commercial hog operations, visitors routinely shower and change clothing before stepping into a barn. Overseas visitors typically wait several days before being in the presence of a commercially raised hog. But the food shield is not impermeable. “If it becomes clear that this is not a novel way for to be transmitted, and that there had to be physical contact, that's going to be a major concern,” said William Marler, a leading food-safety attorney. “It means that there was a failure in the system.”source : http://www.foxnews.com/health/2013/05/29/pork-industry-hunts-for-deadly-pig-virus/

France reports first death from new SARS-like coronavirus

The first person to fall ill in France with the new SARS-like coronavirus, a 65-year-old man who had been travelling in Dubai, has died in hospital from the illness, the health ministry said on Tuesday. Health Minister Marisol Touraine sent her condolences to the family of the man, whose death in the northern French city of Lille brings to 23 the number of people killed worldwide by the new virus. The man was diagnosed with the new virus strain, known as nCoV, on May 8, after being admitted to hospital on April 23, shortly after his return from Dubai, with what seemed at first to be a severe stomach bug and breathing problems. A second man, aged 50, is critically ill with the virus in the same hospital. The two men had shared a ward in April at a different hospital. While there is little evidence of sustained human-to-human transmission of the novel virus, which can cause coughing, fever and pneumonia, health experts are concerned about clustering as it has spread from the Gulf to France, Britain and Germany. The nCoV is from the same viral family that triggered the outbreak of Severe Acute Respiratory Syndrome (SARS) that swept the world in late 2003 and killed 775 people. French health officials have screened dozens of people who had come into contact with the two carriers in Lille.source : http://www.foxnews.com/health/2013/05/28/france-reports-first-death-from-new-sars-like-coronavirus/

H7N9 flu study hints at limited human-to-human spread

It's likely that the new H7N9 bird flu virus can spread through the air on a limited basis, according to a new study that looked at how the virus spreads in animals. The study also provides more evidence that the virus can spread between people in close contact. However, it's unlikely the virus could cause a pandemic, unless it undergoes genetic changes that allow it to spread more efficiently between people, experts say. According to the World Health Organization, as of May 17, health officials knew of 131 people in China who had fallen ill with the H7N9 virus , including 36 who died. Most of these cases about 75 percent were people who had direct contact with poultry. In a few cases, people in the same family caught the disease, suggesting that the virus spreads between people in close contact. However, there is no evidence of sustained human-to-human transmission, WHO says. Because many factors can influence whether a person falls ill with flu, including their overall health, researchers like to study flu viruses in animals, under controlled conditions, to better understand how they spread, said study researcher Dr. Richard Webby, a bird-flu expert at St. Jude Children's Research Hospital in Memphis, Tenn. In the new study, researchers infected six ferrets with the H7N9 virus, all of whom developed flu symptoms. Ferrets are considered a good model to study human flu transmission because efficient spread of the flu in ferrets tends to predict efficient spread in people. Several of the infected ferrets were placed in the same cage as uninfected ferrets. In addition, several uninfected ferrets were placed in cages a short distance away from uninfected ferrets to see if the virus could spread through the air. All of the uninfected ferrets who were in the same cage as the infected ferrets caught the virus, suggesting the virus can spread through direct contact. The flu virus also spread through the air, but less efficiently. Just one of three ferrets caged a short distance from infected ferrets caught the virus. The findings mostly mirror what health officials have seen in people, Webby said. For sustained person-to-person transmission to occur, the virus would likely have to transmit efficiently by both the airborne and direct contact routes, Webby said. Because H7N9 doesn't transmit very well through the air, it “doesn't look like it has the capacity to [cause] a pandemic,” unless the virus changes, Webby said. H7N9 appears to be more infectious than the H5N1 bird flu virus, Webby said. When researchers infect ferrets with H5N1, they usually do not see transmission through airborne or direct contact, Webby said. One bit of good news is that H7N9 does not appear to spread between pigs. In the study, pigs did not catch H7N9 from each other, either through the air or direct contact. Transmission between pigs would be concerning because it would provide more opportunities for the H7N9 virus to evolve and transmit to people that way too, Webby said. Based on the new results, pigs are unlikely to be major players in maintaining of the virus,Webby said. However, Webby noted the study tested just one strain of H7N9, and there are other strains out there that may act differently. The study, conducted by researchers at the University of Hong Kong and others, is published May 23 in the journal Science. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/05/24/h7n-flu-study-hints-at-how-it-may-spread-in-people/

Boosting body’s natural flu killers as way to offset virus mutation problem

Emergence of new influenza strains, such as the recent avian influenza (H5N1) and swine influenza (H1N1 2009), can lead to the emergence of severe pandemics that pose a major threat to the entire world population. Recently, the concern regarding the emergence of such a pandemic arose when a new and deadly avian influenza strain (H7N9) was discovered in China, causing the death of six people in only one month. The body’s immune system can fight influenza infection. Natural killer (NK) cells, which are an essential component of this system, can recognize and eliminate influenza-virus-infected cells and inhibit the spread of the virus in the respiratory system…

Poliovirus vaccine trial shows early promise for recurrent glioblastoma

The treatment, developed at Duke and tested in an ongoing phase 1 study, capitalizes on the discovery that cancer cells have an abundance of receptors that work like magnets drawing the poliovirus, which then infects and kills the cells. The investigational therapy, known as PVSRIPO, uses an engineered form of the virus that is lethal to cancer cells, while harmless to normal cells. …

Swine virus confirmed in Iowa, Indiana hog herds

Farms in two of the nation's leading pork producing states have tested positive for the potentially fatal porcine epidemic diarrhea virus (PEDV), U.S. pork industry veterinarian official said Monday. Three farms in Iowa and one Indiana operation have confirmed cases of the virus, said Dr Lisa Becton, director of swine health information and research for the National Pork Board. The cases in Iowa were located on farms “all across the state, not in one specific area,” Becton said. PEDV does not pose a food safety or health risk to humans and the pork is safe eat. Other animals cannot contract the swine-only virus. Still, this marks the first time PEDV had been found in the United States, and poises yet another challenge for hog farms still recovering from record-high feed costs from last summer's historic drought. “The severity of the outbreak is not yet known, but we're hoping to have a better assessment soon,” Becton told Reuters. Iowa is the nation's leading hog producer with more than 20 million hogs and Indiana is No. 5 with 3.65 million, according to USDA. Agriculture Department officials are pulling together an agricultural epidemiologic survey, and plan to send the questionnaire out to swine veterinarians in the coming days, to try to determine how the virus was introduced into the nation's pork production chain and see how it spread, Becton said. Swine veterinarians across the U.S. are collecting samples from pork farms that have reported possible cases and sending them in for testing at National Veterinary Service Laboratories and other sites. Some veterinarians are also sending in samples of animal feed for testing, to see whether the virus was spread that way, said Dr. Keith Roehr, Colorado's state veterinarian. “There's a lot of biosecurity and prevention measures in place that prevent the spread of disease. That's what's so puzzling in this case. To be in different states, and to have crossed between different swine operations and between different owners, all of which are painstakingly kept separate to prevent the spread of disease - that's unusual,” said Roehr. There is no cure or vaccine for PEDV, which causes diarrhea, vomiting and dehydration in hogs and could result in deaths - particularly in baby pigs whose immune system can be weak. The virus is similar in some ways to transmissible gastroenteritis (TGE) where mortality can range from 50 percent to 100 percent among pigs that are a week old or younger, Becton said. Older pigs can be affected but will recover in a matter of a few weeks after contracting the disease. There is no effective treatment for PEDV other than good care, warm housing and adequate water to combat dehydration. Strict bio-security and quarantine measures can help to slow the spread of the virus. PEDV also is sensitive to heat and sunlight, which may help curtail the spread of the outbreak as the weather turns warmer in the Midwest, veterinarians say. While this marks the first appearance of PEDV in the U.S., the virus dates back to the 1970s. Over the years, it has cropped up on pork operations in England, Canada, China and South Korea and Japan, said Becton. The U.S. Department of Agriculture's National Veterinary Services Laboratories confirmed it had detected the virus in hog populations in Iowa on Friday, and noted that the disease may have spread to other hog producing states. The virus is also not expected to threaten U.S. pork exports, said Becton, who explained USDA does not consider PEDV a reportable disease to the World Organization for Animal Health, so no trade restrictions are expected. Roughly 23 percent of U.S. domestic pork production, which last year totaled 5.383 billion pounds worth $6.322 billion (U.S.) is earmarked for export.source : http://www.foxnews.com/health/2013/05/21/swine-virus-confirmed-in-iowa-indiana-hog-herds/

Tunisia announces 3 cases of coronavirus, 1 death

Tunisia's Health Ministry says a 66-year-old man has died after being infected by the new coronavirus following a visit to Saudi Arabia. The ministry's statement reported that his son and daughter were also diagnosed with the virus but have been treated and since recovered. The cases are the first for Tunisia and indicate that the virus is slowly trickling out of the Middle East, where more than 30 cases have been reported. There have been at least 20 deaths from the virus worldwide. The Tunisian, a diabetic, had been complaining since his return from a trip to Saudi Arabia and Qatar and died from acute respiratory distress at a hospital in Monastir. The new coronavirus is related to SARS, which killed about 800 people in 2003, mostly in Asia.source : http://www.foxnews.com/health/2013/05/21/tunisia-announces-3-cases-coronavirus-1-death/

New SARS-like virus: WHO reports patient-to-nurse spread of deadly infection

Two health workers in Saudi Arabia have become infected with a potentially fatal new SARS-like virus after catching it from patients in their care - the first evidence of such transmission within a hospital, the World Health Organization said. The new virus, known as novel coronavirus, or nCoV, is from the same family of viruses as those that cause common colds and the one that caused the deadly outbreak of Severe Acute Respiratory Syndrome (SARS) that emerged in Asia in 2003. “This is the first time health care workers have been diagnosed with (novel coronavirus) infection after exposure to patients,” the Geneva-based U.N. health agency said in a disease outbreak update late on Wednesday. The health workers are a 45-year-old man, who became ill on May 2 and is currently in a critical condition, and a 43-year-old woman with a coexisting health condition, who fell ill on May 8 and is in a stable condition, the WHO said. France has also reported a likely case of transmission within a hospital, but this was from one patient to another patient who shared the same room for two days. NCoV, like SARS and other similar viruses, can cause coughing, fever and pneumonia. Scientists are on the alert for any sign that nCoV is mutating to become easily transmissible to multiple recipients, like SARS - a scenario that could trigger a pandemic. WHO experts visiting Saudi Arabia to consult with the authorities on the outbreak said on Sunday it seemed likely the new virus could be passed between humans, but only after prolonged, close contact. Initial analysis by scientists at Britain's Health Protection Agency last year found that nCoV's closest relatives were most probably bat viruses. Yet further work by a research team in Germany suggests nCoV may have come through an intermediary - possibly goats. The WHO's Wednesday update said that, while some health care workers in Jordan had previously contracted nCoV, these Saudi cases were the first clear evidence of the virus passing from infected patients. “Health care facilities that provide care for patients with suspected nCoV infection should take appropriate measures to decrease the risk of transmission of the virus to other patients and health care workers,” it said. It also advised health care providers to be “vigilant among recent travelers returning from areas affected by the virus” who develop severe acute respiratory infections. Since nCoV first emerged and was identified in September 2012, the WHO says it has been informed of a total of 40 laboratory-confirmed cases worldwide, including 20 deaths. Saudi Arabia has had most of the cases - with 30 patients infected, 15 of them fatally - but nCoV cases have also been reported in Jordan, Qatar, Britain, Germany and France.source : http://www.foxnews.com/health/2013/05/16/new-sars-like-virus-who-reports-first-patient-to-nurse-infection/

Deaths from West Nile virus hit record last year

U.S. health officials say last year was the worst ever for West Nile virus deaths. The final tally reported Monday was 286 deaths - or two more than the record set in 2002. But there were far fewer illnesses overall, and fewer serious cases than in previous years. The Centers for Disease Control and Prevention had predicted it would be a bad year because of weather conditions that promote breeding of the mosquitoes that spread the virus to people. The CDC report Monday showed Texas had nearly a third of the serious cases, and about a third of the deaths. West Nile virus was first diagnosed in Uganda in 1937, but no cases were reported in the U.S. until 1999 in New York. It gradually spread to the West Coast.source : http://www.foxnews.com/health/2013/05/14/deaths-from-west-nile-virus-hit-record-last-year/

Saudi Arabia confirms 4 new cases of deadly SARS-linked virus

RIYADH, Saudi Arabia – & Saudi Arabia has confirmed four new cases of a deadly new respiratory virus related to SARS that appears centered in the Arabian Peninsula but that has also been reported in Europe. The official Saudi Press Agency said Tuesday that one patient was treated and released from a hospital, while three others remain under medical care. Saudi authorities have reported nearly 30 cases since the virus was identified last year. Other cases have appeared in France, Germany and Britain, possibly linked to travel in the Gulf region. The novel coronavirus has killed at least 18 people since September 2012. The new virus is related to SARS, which killed some 800 people in a global epidemic in 2003, and belongs to a family of viruses that most often causes the common cold.source : http://www.foxnews.com/health/2013/05/14/saudi-arabia-confirms-4-new-cases-deadly-sars-linked-virus/