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New therapeutic target may improve treatment for brain cancer

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The research will be presented at the American Society for Pharmacology and Experimental Therapeutics (ASPET) Annual Meeting during Experimental Biology 2015. Monteagudo’s research indicates a new possible chemotherapeutic target for treating GBM: transglutaminase 2 (TG2), a multifunctional protein that can regulate cell adhesion and motility. Given these documented functions of TG2, Monteagudo and her colleagues in the laboratory of Gail Johnson, Ph.D., at the University of Rochester, were interested in determining if TG2 played an important role in GBM cell growth. …

Stem cells lurking in tumors can resist treatment

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New research proves that the threat posed by cancer stem cells is more prevalent than previously thought. Until now, stem cells had been identified only in aggressive, fast-growing tumors. …

Urine test could lead to better treatment of bladder cancer

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Being able to reliably identify those patients with the most aggressive cancers early via urine tests, and expediting aggressive therapeutic strategies, may significantly improve outcomes. The scientists believe that the validation of two urinary biomarkers could spell a new way of tailoring treatment…

Olaparib shows success in tumor response rate for patients with BRCA-related cancers — ScienceDaily

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For the majority of patients in the study, olaparib was at least their third different cancer therapy. Based on the new data, the authors say olaparib warrants further investigation in phase III trials…

New evidence that exercise therapy, acupuncture benefit breast cancer survivors — ScienceDaily

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In the first study, A Hybrid Effectiveness-Implementation Trial of an Evidence-Based Exercise Intervention for Breast Cancer Survivors, Penn researchers assessed patients participating in “Strength after Breast Cancer,” a Penn Medicine-developed, evidence-based exercise and education program for breast cancer survivors. The study was intended to investigate the ease and effectiveness of transporting a research-based treatment into a practice setting. The primary goal of the study was to demonstrate program effectiveness for patients after transition from research to a practice setting. …

Blood test may help diagnose pancreatic cancer

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In research published today in the American Journal of Gastroenterology, Murray Korc, M.D., the Myles Brand Professor of Cancer Research at the Indiana University School of Medicine and a researcher at the Indiana University Melvin and Bren Simon Cancer Center, and colleagues found that several microRNAs — small RNA molecules — circulate at high levels in the blood of pancreatic cancer patients. “This is a new finding that extends previous knowledge in this field,” Dr. Korc said. …

New analysis methodology may revolutionize breast cancer therapy

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The potential contribution of stroma cells to tumour growth has been widely recognised. …

Decision Analysis Can Help Women Make Choices about Breast Reconstruction — ScienceDaily

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The special topic article by Mia K. Markey, PhD, and colleagues of The University of Texas at Austin and The University of Texas MD Anderson Cancer Center, Houston, introduces plastic surgeons to the use of decision analysis to help women navigate decisions about breast reconstruction after mastectomy for breast cancer. “Decision analysis provides structure for methodic, thoughtful decision-making through the use of reason, logic, and mathematics,” the authors write. Decision Analysis Helps Sort Through Breast Reconstruction Options Decision analysis is defined as ” an exhaustive, iterative process that involves identifying alternatives, obtaining information about the uncertainty of outcomes, and clarifying preferences and values.” Routinely used in business, decision analysis is increasingly applied to complex medical decisions as well. …

Decision Analysis Can Help Women Make Choices about Breast Reconstruction

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The special topic article by Mia K. …

Modified vitamin D shows promise as treatment for pancreatic cancer

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The discovery has led to human trials for pancreatic cancer, even in advance of its publication today in the journal Cell. By attacking a wound repair mechanism called fibrosis, the findings may also have implications for other tough-to-treat tumors, such as lung, kidney and liver cancer…