Tag Archive death

Chemotherapy after bladder cancer surgery may improve survival

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Clinical trials have established the benefit of giving chemotherapy prior to surgery (neoadjuvant chemotherapy) for patients with bladder cancer. However, clinical trials exploring giving chemotherapy after surgery (adjuvant chemotherapy) have been difficult to interpret and many of the trials closed early due to poor accrual without providing an answer. Lead researcher Matthew Galsky, MD and colleagues used a large database of patients diagnosed with cancer in the United States. Specifically, the study found that patients receiving adjuvant chemotherapy after surgical treatment had improved overall survival when compared to patients that received surgical treatment alone with only post-surgical observation. …

Test predicts response to treatment for complication of leukemia stem cell treatment

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Patients with fatal blood cancers like leukemia often require allogenic stem cell SCT to survive. Donor stem cells are transplanted to a recipient, but not without the risk of developing GVHD, a life-threatening complication and major cause of death after SCT. The disease, which can be mild to severe, occurs when the transplanted donor cells (known as the graft) attack the patient (referred to as the host). …

Life expectancy increases globally as death toll falls from major diseases

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Causes of death vary widely by country, but, at the global level, drug use disorders and chronic kidney disease account for some of the largest percent increases in premature deaths since 1990. Death rates from some cancers, including pancreatic cancer and kidney cancer, also increased. …

Study offers future hope for tackling signs of aging

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The research, which has shown promise in clinical samples, has been published in the scientific journal, Cell Death and Disease. The group of scientists coordinated by Dr Salvador Macip from the Mechanisms of Cancer and aging Lab and the Department of Biochemistry of the University of Leicester carried out the study to find new ways of identifying old cells in the body…

Saving ovaries does not help prevent prolapse for women after menopause

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Whether to remove ovaries at hysterectomy for reasons other than cancer is a subject of hot debate. Removing them reduces the risk of breast cancer and dramatically reduces the risk of ovarian cancer. On the other hand, studies have associated removing ovaries with increased risk of death, cardiovascular disease, lung cancer, and osteoporosis and with declines in cognitive ability and sexual function. And many assumed that removing ovaries would also increase the risk of pelvic organ prolapse. …

Cheap malaria drug could treat colorectal cancer effectively too, say experts

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A pilot study by researchers at St George’s, University of London, has found the drug artesunate, which is a widely used anti-malaria medicine, had a promising effect on reducing the multiplication of tumour cells in colorectal cancer patients who were already going to have their cancer surgically removed. Colorectal cancer (CRC) makes up about 10 percent of the annual 746,000 global cancer cases in men and 614,000 cases in women. …

Potential target for treating triple-negative breast cancer identified

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So-called “triple-negative” breast cancer represents between 12 and 17 percent of all breast cancers. It derives its name from the lack of receptors for estrogen, progesterone and Her2. The absence of these receptors rules out proven hormone therapies such as tamoxifen. …

Good diet before diagnosis is linked with lower mortality among ovarian cancer survivors

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The influence of diet, a modifiable lifestyle factor and potential prognostic factor, on survival after an ovarian cancer diagnosis is unclear. To evaluate diet quality and the overall influence of diet on ovarian cancer survival, Cynthia A. Thomson, Ph.D., R.D., a professor from the Mel & Enid Zuckerman College of Public Health and University of Arizona Cancer Center researcher, at the University of Arizona in Tucson, AZ, and colleagues analyzed data from 636 cases of ovarian cancer among postmenopausal women within the Women’s Health Initiative Observational Study or Clinical Trials from 1993 to 1998. Dietary intake was assessed using food frequency questionnaires and estimates of overall diet quality were measured using the Healthy Eating Index-2005. …

Targeted combination therapy halts disease, extends life in advanced melanoma patients

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The multi-centre, double-blind, randomised, phase 3 trial compared oral dabrafenib (150 mg twice daily) and oral trametinib (2 mg once daily) combination therapy with oral dabrafenib (150 mg twice daily) and placebo. …

Research discovers means to free immune system to destroy cancer

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The research is described in a paper published online September 18, 2014, in Immunity, a Cell Press journal. Myeloid-derived suppressor cells (MDSCs) are involved in cancer, inflammation and infection. …