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Osteoporosis drug stops growth of breast cancer cells, even in resistant tumors, study suggests

The findings, presented June 15, 2013, at the annual Endocrine Society meeting in San Francisco, indicate that the drug bazedoxifene packs a powerful one-two punch that not only prevents estrogen from fueling breast cancer cell growth, but also flags the estrogen receptor for destruction. "We found bazedoxifene binds to the estrogen receptor and interferes with its activity, but the surprising thing we then found was that it also degrades the receptor; it gets rid of it," said senior author Donald McDonnell, PhD, chair of Duke’s Department of Pharmacology and Cancer Biology. In animal and cell culture studies, the drug inhibited growth both in estrogen-dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and/or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen-dependent breast cancer…

Red clover: A powerful herb with strong healing properties

Every year, a beautiful crop of red clover spontaneously matures on my lawn. For a few weeks, the dark pink tops adorn the yard. I always look forward to the blooming of red clover, and I take advantage of the bumper crop in my yard by picking some and drying it for herbal tea. Originating from Europe, northern Asia and Africa, red clover is broadly distributed throughout the United Sates. As a fodder crop red clover is cultivated for animals, and the plant benefits soil by fixing nitrogen, thereby making it an ideal cover crop for enriching soil fertility for other crops. In the U.S., red clover is the state flower of pastoral Vermont. The use of red clover as an herbal remedy goes back centuries, and the plant enjoys a history of both topical and internal applications. As a topical aid, red clover is often an ingredient in liniments and balms, for relieving the pain of both eczema and psoriasis, for sores, burns, and as an aid against skin cancer. The pain-relieving properties of red clover are likely due to the presence of the anti-inflammatory compounds eugenol, myricetin and salicylic acid in the flowers. Salicylic acid also demonstrates activity against eczema. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. The flower is a mainstay ingredient in traditional herbal formulas, including Essiac Tea, Jason Winters Tea, and the Hoxsey Therapy. In the best selling herbal classic Back to Eden, author Jethro Kloss declares red clover as a life-saving anti-cancer remedy. Proponents of these therapies claim a multitude of successes, while various health agencies including the FDA and the American Cancer Society declare these same formulas to be of no value. In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer properties, according to various published studies. So the truth of red clover’s possible value for treating cancer likely lies between the positions of advocates and critics. One thing is certain: Red clover is a blood thinner. This is due to the concentration of coumarin found in the blossoms. For cases of thrombosis and other conditions in which thick blood obstructs vessels, red clover tea may be of benefit. However, for those who are taking blood-thinning medications, adding red clover to the mix can be a bad idea. Prior to surgery, drinking red clover is not recommended, as doing so may exacerbate surgical bleeding. Because of its concentration of the phytoestrogens daidzein and genistein, which mimic the activity of estrogen, red clover has been studied for its use in alleviating the discomfort of menopause. In one study reported in the Journal of the American Medical Association, the red clover-based product Promensil showed slightly better activity than a placebo for the relief of hot flashes – but overall the results were underwhelming. In general, red clover has not proven especially effective for menopausal discomfort. The same presence of phytoestrogens – plant compounds that mimic estrogen – has led many doctors to warn against using red clover preparations if women have had reproductive health disorders including endometriosis, uterine fibroids, or breast and uterine cancers. The concern is that the phytoestrogens may increase rather than alleviate these conditions. As a gentle cleansing tea drunk on occasion for overall salutary purposes, red clover appears to offer many benefits to health. High in natural protective antioxidants and anti-inflammatory compounds – and pleasant in flavor – red clover is good for general health, and is a tasty beverage. Rather than buying red clover tea in a store, just harvest a little from your lawn. Dry it on some newspaper for a few days, and you have red clover herbal tea, ready to go.Chris Kilham is a medicine hunter who researches natural remedies all over the world, from the Amazon to Siberia. He teaches ethnobotany at the University of Massachusetts Amherst, where he is Explorer In Residence. Chris advises herbal, cosmetic and pharmaceutical companies and is a regular guest on radio and TV programs worldwide. His field research is largely sponsored by Naturex of Avignon, France. Read more at& MedicineHunter.com.source : http://www.foxnews.com/health/2013/06/12/healing-properties-red-clover/

Vegetable fats tied to less prostate cancer spread

After being diagnosed with prostate cancer, men who eat a diet high in vegetable fats, such as those in nuts and olive oil, may be less likely to have their disease spread, a new study suggests. Researchers found that replacing some carbohydrates with those healthy fats was also tied to a lower risk of dying from any cause during the study. But the opposite was true for saturated and trans fats often found in meat and processed foods. “A lot of doctors will simply say, ‘Cut out fat,'” after a prostate cancer diagnosis, said Dr. Stephen Freedland, a urologist at Duke University Medical Center in Durham, North Carolina. But this study challenges that advice, said Freedland, who wrote a commentary on the findings. “It actually says, if you eat more fat, albeit the right kind of fat,… you're less likely to die of not only prostate cancer, but really of any cause, which really flies in the face of this ‘low-fat, low-fat, low-fat' mantra that we've been told for decades now,” he said. Researchers tracked 4,577 men who were diagnosed with localized prostate cancer during a large study of health workers beginning in 1986. Those men filled out questionnaires every four years on how often they ate or drank about 130 different types of foods and beverages. Over the next eight to nine years, 315 men developed lethal prostate cancer - cancer that spread to other parts of the body or killed them - and 1,064 died from any cause. Men who reported getting the highest proportion of their daily calories from vegetable fat - more than 21 percent - after their diagnosis were about one-third less likely to die during the study than those who ate the least vegetable fat. And they had a borderline lower risk of developing lethal cancer. On the other hand, men who ate a similar amount of animal fat tended to be more likely to die during follow up, from prostate cancer or anything else, than those who skimped on animal meat. Erin Richman of the University of California, San Francisco, and her colleagues found that switching 10 percent of daily calories from carbohydrates to vegetable fat was linked to a 29 percent lower risk of lethal prostate cancer and a 26 percent lower chance of dying from any cause. But replacing 5 percent of those calories with saturated fat, or just 1 percent with trans fat, was tied to a 25 to 30 percent higher risk of death during the study period, according to findings published Monday in JAMA Internal Medicine. “The benefit was really when you were replacing refined carbohydrates with (things like) olive oil and nuts,” Richman said. She said vegetable fats contain antioxidants and may reduce inflammation in the body, thereby making it harder for cancer to spread. The American Cancer Society estimates about one in six U.S. men will be diagnosed with prostate cancer during his lifetime, and one in 36 will die of the disease. Because how animals are fed and how meats are cooked may both affect cancer risks associated with eating animal fats, Freedland said, “It becomes difficult to say, ‘Animals are bad; vegetables are good.' It's not that simple.” He recommends that men with prostate cancer cut out simple sugars and processed foods, as that is one of the easiest ways to get to a healthy weight. But not all fat should go. Richman agreed. “I think there's enough established benefit that you're not going to do any harm by adding nuts or olive oil,” she said.source : http://www.foxnews.com/health/2013/06/11/vegetable-fats-tied-to-less-prostate-cancer-spread/

15 ways to cancer-proof your life

We're all grown-ups here—nightmares aren't a big problem anymore. We're calm, we're cool, we're mostly collected...until it comes to the C-word. For adults, cancer is the thing that goes bump in the night; that bump gets louder when family or friends are diagnosed. Whether your risk is monumental or blessedly average, we know you want to protect yourself. So we've combed through research, interrogated experts, and found cutting-edge strategies to help keep you safe. Worship a wee bit of sun People who get the most vitamin D, which lies dormant in skin until ultraviolet rays activate it, may protect themselves from a variety of cancers, including non-Hodgkin's lymphoma, breast, and colon. Ironically, it even improves survival rates of melanoma, the most serious skin cancer. But 10 to 15 minutes a few days a week is all it takes to benefit. If you're out any longer than that, slather on the sunscreen (Are you applying enough? We’ve got the recommended amount for every body part, here.) If you go the supplement route, aim for 400 IU of vitamin D a day. Eat an orange every day It just may zap a strain of the H. pylori bacteria that causes peptic ulcers and can lead to stomach cancer. Researchers in San Francisco found that infected people with high levels of vitamin C in their blood were less likely to test positive for the cancer-causing strain. (Bonus: research shows a scent of citrus can reduce stress.) Listen to Katie Couric Though colonoscopies are about as popular as root canals, if you're 50 or older, get one. Colorectal cancer is the second leading cause of cancer death in the United States. Don't think you're off the hook because you got a digital fecal occult blood test at your last checkup: Research by the Veterans Affairs Cooperative Study found that the test missed 95 percent of the cases. Schedule your first colonoscopy before your 50th if you have a family history of colon cancer. Steam a little green Piles of studies have shown that piles of broccoli help stave off ovarian, stomach, lung, bladder, and colorectal cancers. And steaming it for three to four minutes enhances the power of the cancer-fighting compound sulforaphane, which has been shown to halt the growth of breast cancer cells. (Sorry, microwaving doesn't do the trick; it strips out most antioxidants.) Get more protection by sprinkling a handful of selenium-rich sunflower seeds, nuts, or mushrooms on your greens. Researchers are discovering that sulforaphane is about 13 times more potent when combined with the mineral selenium. Pick a doc with a past Experience—lots of it—is critical when it comes to accurately reading mammograms. A study from the University of California, San Francisco, found that doctors with at least 25 years' experience were more accurate at interpreting images and less likely to give false positives. Ask about your radiologist's track record. If she is freshly minted or doesn't check a high volume of mammograms, get a second read from someone with more mileage. Drink jolt-less java Drink jolt-less java. Downing two or more cups of decaf a day may lower the incidence of rectal cancer by 52 percent, finds a study from two large and long-term research projects—the Nurses' Health Study and the Health Professionals Follow-Up Study from Harvard University. One theory is that coffee increases bowel movements, which helps to reduce the risk. Why decaf reigns supreme, however, remains a mystery. Drop 10 pounds Being overweight or obese accounts for 20 percent of all cancer deaths among women and 14 percent among men, notes the American Cancer Society. (You're overweight if your body mass index is between 25 and 29.9; you're obese if it's 30 or more.) Plus, losing excess pounds reduces the body's production of female hormones, which may protect against breast, endometrial, and ovarian cancers. Even if you're not technically overweight, gaining just 10 pounds after the age of 30 increases your risk of developing breast, pancreatic, and cervical, among other cancers. Make like a monkey Or a bunny. Women who ate four to six antioxidant-laden bananas a week cut their risk of kidney cancer by 54 percent, compared with those who didn't eat them at all, found an analysis of 61,000 women at the Karolinska Institutet in Sweden. Gnawing on root vegetables such as carrots had the same benefit. Get naked with a friend You'll need help examining every inch of your body—including your back, scalp, and other hard-to-see places—for possible changes in the size or color of moles, blemishes, and freckles. These marks could spell skin cancer. Women, take special note of your legs: Melanoma mainly occurs there. For the guys, the trunk, head, and neck are the most diagnosed spots. While you're at it, check your fingernails and toenails, too. Gray-black discoloration or a distorted or elevated nail may indicate the disease. And whether you see changes or not, after age 40, everyone should see a dermatologist yearly. (Find out 7 more things your nails can say about your health.) See into the future Go to Your Disease Risk to assess your chance of developing 12 types of cancer, including ovarian, breast, and colon. After the interactive tool estimates your risk, you'll get personalized tips for prevention. Pay attention to pain If you're experiencing a bloated belly, pelvic pain, and an urgent need to urinate, see your doc. These symptoms may signal ovarian cancer, particularly if they're severe and frequent. Women and physicians often ignore these symptoms, and that's the very reason that this disease can be deadly. When caught early, before cancer has spread outside the ovary, the relative five-year survival rate for ovarian cancer is a jaw-dropping 90 to 95 percent. Get calcium daily Milk's main claim to fame may also help protect your colon. Those who took calcium faithfully for four years had a 36 percent reduction in the development of new pre-cancerous colon polyps five years after the study had ended, revealed Dartmouth Medical School researchers. (They tracked 822 people who took either 1,200 mg of calcium every day or a placebo.) Though the study was not on milk itself, you can get the same amount of calcium in three 8-ounce glasses of fat-free milk, along with an 8-ounce serving of yogurt or a 2- to 3-ounce serving of low-fat cheese daily. Sweat 30 minutes a day One of the best anticancer potions is a half hour of motion at least five days a week. Any kind of physical activity modulates levels of androgens and estrogen, two things that can protect women against estrogen-driven cancers such as ovarian and endometrial, as well as some types of breast cancer. The latest proof comes by way of a Canadian study that found that women who get regular, moderate exercise may lower their risk of ovarian cancer by as much as 30 percent. Bonus: All that moving might speed everything through your colon, which may help stave off colon cancer. (Trouble carving out 30 minutes a day? Be ready for a fitness opportunity at a moment’s notice by keeping a perfectly packed gym bag in your car at all times.) Stamp out smoking—all around you Lung cancer is well known as one of the main hazards of smoking. But everything the smoke passes on its way to the lungs can also turn cancerous: mouth, larynx, and esophagus. The fun doesn't stop there. Smokers are encouraging stomach, liver, prostate, colorectal, cervical, and breast cancers as well. The good news: If you give up the cigs today, within 15 years, your lung cancer risk will drop to almost pre-smoking lows. Share that news with the people who puff around you, because exposure to someone else's smoke can cause lung cancer, and it may boost your chances of cervical cancer by 40 percent. Step away from the white bread If you eat a lot of things with a high glycemic load—a measurement of how quickly food raises your blood sugar—you may run a higher risk of colorectal cancer than women who eat low-glycemic-load foods, finds a Harvard Medical School study involving 38,000 women. The problem eats are mostly white: white bread, pasta, potatoes, and sugary pastries. The low-glycemic-load stuff comes with fiber. Blew through our list already

Math technique de-clutters cancer-cell data, revealing tumor evolution, treatment leads

Using increasingly cheap and rapid methods to read the billions of "letters" that comprise human genomes — including the genomes of individual cells sampled from cancerous tumors — scientists are generating far more data than they can easily interpret. Today, two scientists from Cold Spring Harbor Laboratory (CSHL) publish a mathematical method of simplifying and interpreting genome data bearing evidence of mutations, such as those that characterize specific cancers. Not only is the technique highly accurate; it has immediate utility in efforts to parse tumor cells, in order to determine a patient’s prognosis and the best approach to treatment. …

Normal molecular pathway affected in poor-prognosis childhood leukemia identified

Leukemia often occurs due to chromosomal translocations, which are broken chromosomes that cause blood cells to grow uncontrollably. One gene that is involved in chromosomal translocations found at high frequency in childhood leukemia is the MLL1 (Mixed Lineage Leukemia 1) gene. Conventional chemotherapy is very ineffective at curing patients with this translocation, in contrast to other types of childhood leukemia, which are relatively curable. …

First dual-action compound kills cancer cells, stops them from spreading

Nathan Luedtke and colleagues explain that the spread of melanoma and other forms of cancer beyond the original location — a process called metastasis — makes cancer such a serious disease. Photodynamic therapy (PDT), which involves administering a drug that kills cancer cells when exposed to light, already is available. But PDT works only on the main tumor and has other drawbacks. …

Metastatic breast cancer study shows success in finding new treatment

The Side-Out Foundation’s pilot study is part of a cutting-edge approach to personalized medicine that looks beyond genomic analysis alone to combine it with what some say is the next frontier in targeted therapy: proteomics. The pilot study is the first of its kind to utilize novel protein activation mapping technology along with the genomic fingerprint of cancer as a way to find the most effective treatment. The trial was announced at the annual meeting of the American Society of Clinical Oncology and is expected to expand into phase two this month. Standard chemotherapy had failed the 25 women who participated in the 2.5-year pilot study, says study co-author Emanuel "Chip" Petricoin, co-director of George Mason’s Center for Applied Proteomics and Molecular Medicine (CAPMM)…

Genomics and particle physics top the scientific charts

Genomics and particle physics - offering different perspectives on the fundamental nature of life and the cosmos - are the two hottest areas of scientific research. Eight of the 21 most closely followed scientists in 2012 studied genes and their functions, while the single most-cited paper last year covered the hunt for the long-sought Higgs boson particle, according to a Thomson Reuters survey on Wednesday. It was the third year in a row in which genomics researchers topped the rankings, in terms of authoring the most highly cited scientific papers, underscoring the central importance of genetics in biological science and medicine. “Genomics is a perennially hot topic as we learn more about how (DNA) sequences play out in the manifestation of disease,” said Christopher King, editor of Thomson Reuters ScienceWatch, which tracks trends in research. The relevance of the work in genomics was evident this week at the American Society of Clinical Oncology (ASCO) congress in Chicago, where key advances in cancer medicine on display hinged on understanding the genetic basis of tumors. The world's “hottest” researcher, as measured by the number of citations during 2012 for papers published between 2010 and 2012, was Richard Wilson at the Washington University School of Medicine, the survey showed. Wilson's laboratory was the first to sequence the genome of a cancer patient and discover genetic signatures related the development of disease. Formation of the universe Other hot genomics researchers on the list included Eric Lander of the Broad Institute of MIT at Harvard and Kari Stefansson, the founder of Icelandic biotech company Decode Genetics, which was acquired last December by Amgen. Papers related to the search for the Higgs boson accounted for nearly one fifth of the 51 papers published in the 2012 hottest research list. The boson and its linked energy field are viewed by physicists as vital in the formation of the universe and in giving mass to matter. No single scientists working on the Higgs particle, however, were identified in the rankings because of the highly collaborative nature of the particle physics research, with some papers involving upwards of 3,000 authors. Scientists working on the ATLAS experiment at the Large Hadron Collider at CERN, the European Organisation for Nuclear Research, outside Geneva received an honorable mention as a group. The survey also highlighted the growing importance of Chinese research in a number of fields, with institutions in the country producing four of the 21 hottest researchers, including Jun Wang from the Beijing Genomics Institute. “When you look at the quantity of papers published by various nations, China has sky-rocketed in the last few years,” said King. “That hasn't necessarily been commensurate with impact in the literature, as measured by citations, but this seems to be starting to change.”source : http://www.foxnews.com/health/2013/06/05/genomics-and-particle-physics-top-scientific-charts/