In 2012, medical school researchers discovered the suppressive effects of the gene HEXIM1 on breast cancer in mouse models. Now they have demonstrated that it also enhances the number and density of blood vessels in the heart — a sure sign of cardiac fitness. …
The work represents a major step toward truly individualized breast cancer prevention in women at high risk for the disease based on their age, family history of breast cancer, and personal medical history. "Our study reveals the first known genetic factors that can help predict which high-risk women should be offered breast cancer prevention treatment and which women should be spared any unnecessary expense and risk from taking these medications," said the study’s lead scientist, James N. Ingle, M.D., professor of oncology at the Mayo Clinic in Rochester, Minn. "We also discovered new information about how the drugs tamoxifen and raloxifene work to prevent breast cancer." Ingle and Mayo-based colleagues in the NIH Pharmacogenomics Research Network (PGRN) conducted the study in collaboration with PGRN-affiliated researchers at the RIKEN Center for Genomic Medicine in Tokyo. …
Forget abandoning carbohydrates or detoxing. The new dieting craze sweeping Britain and taking off in the United States lets people eat whatever they like - but only five days a week. “The Fast Diet”, also known as the 5:2 diet, is the brainchild of TV medical journalist Michael Mosley and journalist Mimi Spencer and allows people to eat what they want for five days but only eat 600 calories a day on the other two. Their book, “The Fast Diet”, has topped bestselling book lists in Britain and the United States this year and been reprinted more than a dozen times. Mosley said the diet is based on work by British and U.S. scientists who found intermittent fasting helped people lose more fat, increase insulin sensitivity and cut cholesterol which should mean reduced risk of heart disease and diabetes. He tried this eating regime for a BBC television science programme called “Eat, Fast, Live Longer” last August after finding out his cholesterol level was too high and his blood sugar in the diabetic range. He was stunned by the results. “I started doing intermittent fasting a year ago, lost 8 kgs (18 pounds) of fat over 3 months and my blood results went back to normal,” Mosley told Reuters. Mosley said he had been amazed at the way the diet had taken off with a list of websites set up by followers of the 5:2 diet or variations of the eating regime to share their experiences. Following the success of “The Fast Diet”, Spencer joined forces with dietitian Sarah Schenker to bring out “The Fast Diet Recipe Book” in April which has topped amazon.co.uk's food and drink list with 150 recipes containing under 300 calories. Eating a 600 calorie daily diet - about a quarter of a normal healthy adult's intake - could consist of two eggs for breakfast, grilled chicken and lettuce for lunch, and fish with rice noodles for dinner with nothing to drink but water, black coffee or tea. One day at a time Mosley put the diet's success down to the fact it is psychologically attractive and leads to steady drop in weight with an average weekly loss of 1 pound (0.46kg) for women and slightly more for men. “The problem with standard diets is that you feel like you are constantly having to exercise restraint and that means you are thinking about food all the time, which becomes self-defeating,” said Mosley. “On this regime you are only really on a diet two days a week. It is also extremely flexible and simple.” Britain's National Health Service (NHS) initially expressed doubts about the diet and its long-term effects, saying side effects could include sleeping difficulties, bad breath, irritability, anxiety, and daytime sleepiness. But as the popularity of the 5:2 diet has grown and become one of the most searched diets on the Internet, the NHS has started to look again at the diet and its effects. On its website last month the NHS said the British Dietetic Association (BDA) reviewed a 2011 study by researchers at the UK's University Hospital of South Manchester that suggested intermittent fasting could help lower the risk of certain obesity-related cancers such as breast cancer. “The increasing popularity of the 5:2 diet should lead to further research of this kind,” the BDA said in a statement. Schenker, a sports and media dietitian who works with football clubs and food companies, said it was a shame that the NHS had criticized the eating regime that had proved such a success with so many people. “We are in the midst of an obesity crisis and you need to balance up which is worse - intermittent fasting of staying obese?” Schenker told Reuters. Despite concerns raised by the NHS, the 5:2 diet has been widely praised by those who follow it. Deb Thomas, 50, a management coach from London, said she has followed the diet for six months and dropped a couple of dress sizes. This has also inspired her husband to join her in fasting two days a week. “It is such an easy diet to follow that fits into my way of life,” Thomas said. “You have a tough day of not eating but you know the next day you can eat normally again, and that keeps you going.”source : http://www.foxnews.com/health/2013/06/13/new-diet-craze-offers-five-days-feasting-for-two-days-famine/
You likely haven't given much thought to your cells since high-school biology, but focusing on them might be the key to unlocking your best body ever. While most diets prioritize cutting calories and fat, the anti-inflammatory diet—Hollywood's new favorite healthy-eating plan—operates on a biochemical level.  Designed to neutralize the inflammation that occurs inside your body, the regimen offers big benefits, including a slimmer waist, a clearer mind, fewer cravings, and better skin. No surprise, then, that image-minded celebrities have taken notice: Matthew Fox followed an anti-inflammatory eating plan to get in shape for his upcoming movie World War Z. So how does it work? Eating high levels of saturated fats, trans fats, and refined sugars (read: the modern American diet) sets off a series of reactions: The “bad fat” triggers the liver to release chemicals to fight the toxins, which causes inflammation. Meanwhile, the glucose in food can't be transported to your cells while the body is inflamed, which means that your brain isn't registering the intake. The result: You're left feeling foggy, hungry, and more prone to cravings, which then restarts the cycle. “The more inflammation you have, the less efficiently you're using your calories, so you eat more and feel worse,” says Jackie Keller, the Los Angeles–based founder of the NutriFit meal-delivery service, who crafts anti-inflammatory diet plans for Channing Tatum, Penelope Cruz, and Charlize Theron. Cellular inflammation also stiffens up your arteries, causes skin breakouts, and makes you more prone to heart disease and cancer. “Because we're eating so many processed foods, inflammation is a bigger problem than ever before,” said Kristin Kirkpatrick, a registered dietitian and wellness manager at the Cleveland Clinic. “This diet is partly about what you don't eat—saturated fats, trans fats, and sugar—and a lot about what you do eat.” The focus is on unsaturated fats in fish and olive oil, plus plenty of produce, especially deeply colored fruits and vegetables, which are packed with phytonutrients that help neutralize inflammation.  Another major hallmark is a reliance on herbs and spices: Powerful compounds including quercetin in garlic, gingerol in ginger, cinnamaldehyde in cinnamon, and curcumin in turmeric may all help fight inflammation, said Kirkpatrick. “Not all of my clients understand the science,” Keller said. “But they feel better and they find it easier to lose weight, and that's what matters. ___________________________________________________ More From Details: Elimination Diets: A Primer Why You Should Be a Meat and Potatoes Guy 8 (Surprising) Things That Make You Fat ___________________________________________________ The Anti-Inflammatory Menu Breakfast: 1 cup cooked steel-cut oats with cinnamon and 1 oz almonds. Morning Snack: 1½ cups seasonal berries with 1 cup nonfat Greek yogurt. Lunch: 4 oz baked chicken, cut into strips, mixed with 2 cups steamed or stir-fried Asian vegetables, such as bok choy and shiitake mushrooms, with garlic and ginger. Afternoon Snack: 1 cup fresh cherries or 1 cup cherry juice. Dinner: 6 oz grilled fresh trout seasoned with curry powder (which includes turmeric), 2 cups dark-green vegetables (preferably broccoli, Brussels sprouts, or kale) cooked in 2 tsp extra-virgin olive oil. Dessert: 1 oz dark chocolate.source : http://www.foxnews.com/health/2013/06/13/new-science-weight-loss-introducing-anti-inflammatory-diet/
Men who suffer from restless legs syndrome may not live as long as those without the condition, according to a new study. The study found that men with restless legs syndrome (RLS) were nearly 40 percent more likely to die over the eight-year study, compared to men without RLS. When the researchers excluded from their analysis men with major chronic conditions such as cancer, heart disease and high blood pressure, those with RLS were 92 percent more likely to die over the study period. “The results of this study indicate that men with RLS had a higher overall mortality,” the researchers wrote in their study. However, the study shows an association, not a cause-and-effect link between having RLSand an increased risk of dying, and the researchers said that it is not known how RLS might increase the mortality risk. In the study, deaths among men with RLS were frequently due to respiratory disease, endocrine disease, metabolic disease and immunologic disorders. Further research is needed to understand the relationship between these diseases and RLS, the researchers said. RLS is a bothersome chronic condition that affects 5 to 10 percent of adults. Patients have an irresistible urge to move the legs, and often experience burning and creeping sensations that are described as “an itch you can't scratch,” or “like insects crawling inside the legs.” In the study, researchers looked at 18,425 men, whose average age was 67, including 700 who were diagnosed with RLS. During an eight-year follow-up, 2,765 of the men died. Among the men with RLS, 25 percent died during the study, compared with 15 percent of those who did not have RLS. The researchers also found that men with RLS were more likely to use antidepressant drugs, had more insomnia complaints, and were more likely to have high blood pressure, cardiovascular disease and Parkinson's disease. However, controlling for these factors didn't change the results, they said. The link between RLS and higher risk of death was not related to other common risk factors such as smoking, older age, low physical activity and lack of sleep. Moreover, men who had conditions such as high blood pressure, cancer or insomnia, had a further increased risk of death if they had RLS too, according to the study. The study was published online June 12 in the journal Neurology. Some of the researchers who worked on the study have received money from pharmaceutical companies that make drugs used to treat restless legs syndrome. “Increasing awareness of RLS, especially training for health professions, should be encouraged if our findings are confirmed by future studies,” the researchers said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/restless-legs-syndrome-linked-to-higher-risk-early-death/
The specific patient populations who appeared to benefit from eribulin, in comparison to capecitabine, are as follows: Patients with more than two organs involved with metastatic breast cancer Patients who had not received chemotherapy for six months or longer Patients who had received anthracycline and/or a taxane therapies in the metastatic setting Previous pre-specified exploratory analysis of overall survival and progression-free survival showed women with triple-negative, ER-negative, HER2-negative also had a greater relative benefit in overall survival with eribulin over capecitabine. …
Mammals can regenerate the very tips of their fingers and toes after amputation, and now new research shows how stem cells in the nail play a role in that process. A study in mice, detailed online June 12 in the journal Nature, reveals the chemical signal that triggers stem cells to develop into new nail tissue, and also attracts nerves that promote nail and bone regeneration. The findings suggest nail stem cells could be used to develop new treatments for amputees, the researchers said. [Inside Life Science: Once Upon a Stem Cell] More from LiveScience In mice and people, regenerating an amputated finger or toe involves regrowing the nail. But whether the amputated portion of the digit can regrow depends on exactly where the amputation occurs: If the stem cells beneath the nail are amputated along with the digit, no regrowth occurs, but if the stem cells remain, regrowth is possible. To understand why these stem cells are crucial to regeneration, researchers turned to mice. The scientists conducted toe amputations in two groups of mice: one group of normal mice, and one group that was treated with a drug that made them unable to make the signals for new nail cells to develop. They found that the signals that guided the stem cells' development into nail cells were vital to regenerating amputated digits. By five weeks after amputation, the normal mice had regenerated their toe and toenail. But the mice that lacked the nail signal failed to regrow either their nails or the toe bone itself, because the stem cells lacked the signals that promote nail-cell development. When the researchers replenished these signals, the toes regenerated successfully. In another experiment, the researchers surgically removed nerves from the mice toes before amputating them. This significantly impaired nail-cell regeneration, similar to what happened to the mice that lacked the signals to produce new nails. Moreover, the nerve removal decreased the levels of certain proteins that promote tissue growth. Together, the results show that nail stem cells are critical for regrowing a lost digit in mice. If the same turns out to be true in humans, the findings could lead to better treatments for amputees. Other animals, including amphibians, can also regenerate lost limbs. For example, aquatic salamanders can regrow complete limbs or even parts of their heart — a process that involves cells in their immune system. By studying these phenomena in other animals, it may be possible to enhance regenerative potential in people, the researchers said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/stem-cells-may-be-secret-to-regenerating-fingers-and-toes/
The artificial sweetener sucralose (sold under the brand name Splenda) could potentially pose health risks, so it needs to be better understood before the sweetener should be assumed to be safe, one advocacy organization says. The Center for Science in the Public Interest, a nonprofit watchdog group, said today that it was downgrading its safety rating of sucralose from “safe” to “caution,” meaning that the additive “may pose a risk and needs to be better tested.” The change was spurred by a recent study from researchers in Italy that found that sucralose caused leukemia in mice, according to the CSPI. This study has not been published, and needs to be reviewed by other scientists to determine whether the findings are credible. While sucralose may turn out to be safer than other artificial sweeteners, “the forthcoming Italian study warrants careful scrutiny before we can be confident that the sweetener is safe for use in food, said CSPI executive director Michael F. Jacobson. The CSPI recommends people avoid the artificial sweeteners saccharin (Sweet N Low), aspartame (NutraSweet and Equal), and acesulfame potassium (Sunett and Sweet One). The issue of whether artificial sweeteners pose health risks is controversial. Many of the studies showing risks, including the new Italian study, have been done in animals, and it's not known whether the same effects would be seen in humans. In addition, rodents, like humans, may develop cancer as a result of old age, and not exposure to chemical additives. This issue has caused some to question the results of studies showing that aspartame-fed rats are at increased risk for cancer over their lifetimes. Even the CSPI says that it considers drinking diet soda, which often contains artificial sweeteners, to be safer than drinking regular soda. Regular soda “poses the greater and demonstrable risks of obesity, diabetes, heart disease, gout, tooth decay, and other health problems,” the CSPI said in a statement. To avoid both the risks of sugar and artificial sweeteners, the CSPI recommends drinking water, seltzer water, flavored unsweetened waters, seltzer mixed with some fruit juice or unsweetened iced tea. It's worth noting that the CSPI also gives caffeine a safety rating of “caution.” Caffeine “keeps many people from sleeping, causes jitteriness, and affects calcium metabolism,” the CSPI says. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/how-safe-is-splenda-group-urges-caution-for-artificial-sweetener/
Doctors have long recommended exercise to reduce the risk of type 2 diabetes, especially in those at high risk for the condition. But a new study found that doing a short walk right after you eat may be the simplest and most effective strategy, especially for older adults. The study,  published in Diabetes Care, found that a 15-minute walk about a half an hour after each meal was as effective at reducing blood sugar as a single 45-minute morning or late afternoon walk.  But researchers found that the quick walk after dinner was even more effective than the longer afternoon walk in lowering blood sugars (glucose) over night into the next day. “The post-meal exercise was especially efficient at lowering the 3-hour post-dinner blood sugar glucose,” said the study’s lead author Dr. Loretta DiPietro, chair of the department of exercise science at George Washington University School of Public Health and Health Services. The study also found that the most effective time to go for a post-meal walk was after the evening meal. Dinner is usually the largest meal of the day, causing the greatest rise in blood sugar, which lasts into the night and the next morning. These affects were significantly reduced by the after dinner walk.    This is an important finding for older people. As you age, your insulin response to help shuttle sugar out of the bloodstream becomes sluggish. Insulin levels also start to fall in the afternoon and into the evening, adding to the weaker response to sugars you consume. Many people end up sitting around after dinner and going to bed with very high blood sugar levels – which according to DiPietro – is the worst thing you can do. When you exercise, contracting muscles help to clear sugar from the blood and get it stored in the muscles or liver. In this study, older adults walked at a moderate pace, not a brisk walk and not a leisurely stroll. This study, though small, was one of the first to look at the timing of exercise. The general recommendations are to get 150 minutes of exercise a week or at least 30 minutes five days a week. But the study looked at what happened a half an hour after a meal, during the time when sugar begins to flood the blood stream. “When you look at the data, you can see the blood sugar started to go up after a meal, and the exercise abruptly halted that upward rise in blood sugar,” said DiPietro. Though the findings need to be confirmed in larger trials, they are important for those with prediabetes and older individuals. An estimated 79 million Americans have prediabetes but most have no idea they are even at risk. “It may be easy for older adults to take a short walk or combine walking after a meal with running errands or walking the dog,” said DiPietro. The findings may be important for others including pregnant women who are at risk of gestational diabetes.  And if you overindulged in a meal, going for a brisk walk may help your body get rid of that excess sugar more efficiently.Laurie Tarkan is an award-winning health journalist whose work appears in the New York Times, among other national magazines and websites. She has authored several health books, including “Perfect Hormone Balance for Fertility.” Follow her on Twitter and Facebook.source : http://www.foxnews.com/health/2013/06/12/walking-after-meals-may-reduce-diabetes-risk/
Sarah Murgnahan, the 10-year-old Pennsylvania girl dying of cystic fibrosis, is getting a brand new pair of lungs. According to a Facebook post from Sarah’s mother, Janet, the family received word this morning of new lungs that had been made available, and Sarah will be taken to the operating room within the next 30 minutes.  The operation will take many hours. Sarah has been in desperate need of a lung transplant for the past 18 months.  However, under the current guidelines for organ donation, children under the age of 12 must wait for pediatric lungs to become available.  Adult lungs cannot be offered to children under 12, until they are offered to adults and adolescents first. The Murnaghans retained a lawyer last week and filed a lawsuit to have the guidelines changed, arguing the rule keeping Sarah off the list is “discriminatory.” A federal court judge granted a temporary order on June 5 that allowed Sarah to join an adult organ transplant list. It is not clear whether Sarah’s donor is an adult or a child. This story is developing.  source : http://www.foxnews.com/health/2013/06/12/girl-dying-cystic-fibrosis-to-receive-lung-transplant-today/