Tag Archives: tokyo

Ebola whole virus vaccine shown effective, safe in primates

The vaccine, described today (March 26, 2015) in the journal Science, was developed by a group led by Yoshihiro Kawaoka, a University of Wisconsin-Madison expert on avian influenza, Ebola and other viruses of medical importance. It differs from other Ebola vaccines because as an inactivated whole virus vaccine, it primes the host immune system with the full complement of Ebola viral proteins and genes, potentially conferring greater protection. “In terms of efficacy, this affords excellent protection,” explains Kawaoka, a professor of pathobiological sciences in the UW-Madison School of Veterinary Medicine and who also holds a faculty appointment at the University of Tokyo…

New mouse model points to therapy for liver disease

Development of effective new therapies for preventing or treating NASH has been stymied by limited small animal models for the disease. In a paper published online in Cancer Cell, scientists at the University of California, San Diego School of Medicine describe a novel mouse model that closely resembles human NASH and use it to demonstrate that interference with a key inflammatory protein inhibits both the development of NASH and its progression to liver cancer. “These findings strongly call for clinical testing of relevant drugs in human NASH and its complications,” said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology in UC San Diego’s Laboratory of Gene Regulation and Signal Transduction. “Our research has shown that, at least in this mouse model, chemical compounds that include already clinically approved drugs that inhibit protein aggregation can also be used to prevent NASH caused by a high fat diet.” The increasing prevalence of NAFLD is linked to the nation’s on-going obesity epidemic. …

Telomere length influences cancer cell differentiation

"Cancer cells may maintain short telomeres to maintain their undifferentiated state," says Hiroyuki Seimiya, a researcher on the study. Telomeres are protective extensions on the ends of chromosomes, which shorten as cells age, like an hourglass running down. They protect the end of the chromosome from deterioration or from fusion with neighboring chromosomes.Without telomeres chromosomes would progressively lose genetic information as cells divide and replicate. Cancer cells have shorter telomeres compared to healthy cells, but they guard their immortality by maintaining these telomeres’ length. …

Gene variants may predict who will benefit from breast cancer prevention drugs

The work represents a major step toward truly individualized breast cancer prevention in women at high risk for the disease based on their age, family history of breast cancer, and personal medical history. "Our study reveals the first known genetic factors that can help predict which high-risk women should be offered breast cancer prevention treatment and which women should be spared any unnecessary expense and risk from taking these medications," said the study’s lead scientist, James N. Ingle, M.D., professor of oncology at the Mayo Clinic in Rochester, Minn. "We also discovered new information about how the drugs tamoxifen and raloxifene work to prevent breast cancer." Ingle and Mayo-based colleagues in the NIH Pharmacogenomics Research Network (PGRN) conducted the study in collaboration with PGRN-affiliated researchers at the RIKEN Center for Genomic Medicine in Tokyo. …

7 warning signs you should not ignore

A few days after Melissa Daly broke her ankle, the calf above it became tender. Within a week, her foot was dark purple. She saw her doctor, who dismissed it as normal bruising and offered a prescription for painkillers. The drugs didn't help, and a week later she woke up in the middle of the night gasping for air.  “I felt like I was suffocating,” she said. Her husband called 911, and within an hour she was on a respirator in the ER. A blood clot had broken off from her calf and lodged in her lungs. The agony she felt is one of seven pains you should never brush off. Read on to make sure that your nagging aches are as innocent as they seem. MORE: 7 Lies We Tell Our Doctors Severe Head Pain This mother of all headaches makes your bachelorette party hangover seem laughable. If you could laugh. The culprit: Odds are, any jackhammering in your brain is just a migraine. But if it's not accompanied by other migraine symptoms (such as a visual aura), sudden and severe pain -- we're talking the absolute worst headache of your life -- can signal a brain aneurysm.  These arterial bulges occur in up to 5 percent of people, but most of the time they don't cause any trouble -- you won't even know you have one unless the weak spot leaks or tears. If that happens, escaping blood can flood the surrounding tissue (causing a violent headache) and cut off the oxygen supply there. Smoking and having a family history of aneurysms increase your odds. The fix: “A burst aneurysm can cause brain damage within minutes, so you need to call 911 immediately,” Dr. Elsa-Grace Giardina, director of the Center for Women's Health at NewYork-Presbyterian Hospital/Columbia University Medical Center, said.  Your doctor will take a CT scan to look for bleeding in the space around the brain. If he finds hemorrhaging, you'll head into the (operating room) pronto for surgery to repair the blood vessel. Throbbing Tooth Spooning your way through a pint of Chubby Hubby has become an exercise in torture. When your teeth touch anything frosty, you feel a dull throb or sharp twinge. The culprit: It's likely that the tooth's nerve has become damaged, usually because the surrounding pearly white is cracked or rotting away. Unless you get it patched up quickly, bacteria in your mouth can infect the nerve. And you definitely don't want that breeding colony to spread throughout your body, said Kimberly Harms, a dentist outside St. Paul, Minnesota. The fix: Time for a cavity check! You may just need a filling to cover the exposed nerve. But if it's infected, you're in for a root canal, in which the tooth's bacteria-laden pulp is removed and replaced with plastic caulking material. Antibiotics can clear up any infection that has spread beyond the mouth. MORE: The 10 Self-Checks Every Woman Should Do Sharp Pain In Your Side A typical runner's side stitch pales in comparison to this piercing stab, which intensifies over a few hours or days. The culprits: You may just need some Beano. But if you feel as if you're being skewered in your right side and you're also nauseated and running a fever, you could have appendicitis. It occurs when something (like a stray piece of feces) migrates into the space where the appendix empties into the colon, blocking it. Soon the organ becomes dangerously inflamed.  Another possibility is an ovarian cyst. Typically these fluid-filled sacs are harmless and disappear on their own. But if one twists or ruptures, it can cause terrible pain. The fix: In both cases, you're looking at emergency surgery.  “If you don't remove an inflamed ap­pendix, it can burst,” Dr. Lin Chang, a gastroenterologist and co-director of UCLA's Center for Neurovisceral Sciences and Women's Health, said.  This can cause dangerous swelling of the tissue surrounding your organs. A twisted cyst also needs to be removed right away, as it can block blood flow to your ovary within hours. If that happens, the doctor will need to cut out the entire ovary (and the eggs inside) along with the cyst. Passing Chest Pain Periodically, you get what feels like a bad case of heartburn, or a tight squeezing sensation, as if you're being laced into a corset. The culprit: You probably just peppered your pizza with too many chilis. But if you know you're at risk for heart problems, don't blow it off -- it could be a heart attack. Every year, about 10,000 women under 45 have one. Symptoms tend to be less severe in women than in men, so “you may just feel pressure, along with fatigue, throat pain, or shortness of breath,” Giardina said. The fix: Feel the burn after feasting on chalupas? Normal. Feel as if you're being squeezed to death by a boa constrictor after a hard workout?

New blood test predicts gestational diabetes risk early in pregnancy

For pregnant women, gestational diabetes can be a troubling complication.  A form of diabetes that develops during pregnancy, gestational diabetes mellitus (GDM) causes glucose levels in the bloodstream to be higher than normal, which can pose significant risks to the unborn baby’s health. While GDM can often be controlled through proper diet, exercise and medication, early diagnosis and treatment are crucial for women hoping to manage their high blood sugar and prevent complications during their pregnancy. In order to better identify the condition in pregnant women earlier, researchers from Tokyo Women’s Medical University have identified a biomarker in pregnant women’s blood that can help determine her risk of developing gestational diabetes. “Currently, at mid-pregnancy – 24 to 28 weeks – a glucose challenge test is performed to find GDM,” study author Dr. Atsuhiro Ichihara, of Tokyo Women’s Medical University, told FoxNews.com.  “However, earlier detection of GDM has been needed for early intervention or prevention,” Ichihara noted that usually only women who have risk factors such as obesity or a family history of GDM are screened earlier on in pregnancy.  Therefore, women who develop GDM and do not have these common risk factors often remain undiagnosed until the second trimester – and a delay in diagnosis often means therapies for GDM are less effective. If left untreated, GDM can increase the risk of jaundice, breathing issues and hypoglycemia in the newborn child.  More extreme side effects of uncontrolled GDM include the risk of premature delivery, preeclampsia, and even the death of the child before or shortly after birth.   Through previous research, Ichihara and his team had determined that the protein renin receptor (P)RR plays a significant role in the assembly and function of the enzyme known as vacuolar H+-ATPase (v-ATPase).  According to Ichihara, the disruption of this enzyme’s functions leads to the development of GDM.  The researchers believed that measuring levels of s(P)RR – the soluble form of (P)RR found in the bloodstream – could help predict whether or not pregnant women eventually develop diabetes. Using the popular diagnostic enzyme-linked immunosorbent assay (ELISA) test, the team analyzed the blood of 716 pregnant women during their first trimesters, measuring for their levels of s(P)RR.  Of the study’s participants, 44 women ultimately developed GDM. Confirming the researchers’ hypothesis, tests results showed that women with elevated levels of s(P)RR in their blood were 2.9 times more likely to develop gestational diabetes than the women with the lowest levels. According to Ichihara, the increased levels of s(P)RR suggest that the mothers are experiencing slowed metabolisms, putting them at risk for GDM. “The increased s(P)RR levels are thought to reflect the enhanced expression of (P)RR,” Ichihara said. “The GDM or pre-GDM patients have impaired metabolism, so the increase in the activity of v-ATPase is required to compensate the impaired metabolism. (P)RR is one of the factors stimulating the v-ATPase activity.” Overall, the research team hopes that this test will be utilized in pregnant women in addition to traditional markers for GDM – such as obesity and high blood pressure.  Ichihara said the test could also come in handy for detecting other conditions, as recent studies have found a connection between elevated s(P)RR levels and the birth of larger babies and high blood pressure in late pregnancy. “The evidence suggests the biomarker is important in the interaction between mother and fetus during pregnancy,” Ichihara said. The research was published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).source : http://www.foxnews.com/health/2013/05/29/new-blood-test-determines-gestational-diabetes-risk-early-in-pregnancy/