Tag Archives: american

Nearly half of sarcoma surgeries done by nonsurgical oncology specialists

The remaining 48 percent of these sarcoma surgeries were conducted by general surgeons, plastic surgeons and orthopedic surgeons, whose post-medical degree fellowship training did not emphasize the multi-disciplinary evaluation and surgical management of sarcomas and other cancers located deep in the soft tissue of the arms and legs, said Robert J. Canter, associate professor of surgery at UC Davis and first author of the journal article. …

Targeting errant immune system enzyme kills myelodysplastic cells

Reporting their results July 8 in Cancer Cell, researchers say their successful laboratory tests in human MDS cells and mouse models of MDS provide a molecular target for designing new drugs to battle a syndrome with few effective treatments. "There is an urgent need to develop new targeted therapies that can eliminate MDS-initiating clone cells and provide a durable therapeutic response," said Daniel Starczynowski, PhD, lead researcher and a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children’s Hospital Medical Center…

Cancer-linked FAM190A gene found to regulate cell division

In laboratory studies of cells, investigators found that knocking down expression of FAM190A disrupts mitosis. In three pancreatic cancer-cell lines and a standard human-cell line engineered to be deficient in FAM190A, researchers observed that cells often had difficulty separating at the end of mitosis, creating cells with two or more nuclei. The American Journal of Pathology published a description of the work online May 17, which comes nearly a century after German scientist Theodor Boveri linked abnormal mitosis to cancer…

Eating right, exercise may help prostate cancer patients reduce risk of aggressive tumors

Led by Lenore Arab, PhD, JCCC member and professor in the departments of medicine and biological chemistry, the researchers examined associations between adherence to WCRF recommendations and risk of highly aggressive prostate cancer among subjects enrolled in the North Carolina-Louisiana Prostate Cancer Project. …

Surgeons report melanoma recurs after 10 years in more than 6 percent of patients

"For patients with melanoma, survival beyond 10 years without a recurrence has been considered nearly synonymous with a cure," said principal investigator Mark Faries, MD, FACS, a professor of surgery at the John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, CA. "However, most studies do not follow up patients longer than 10 years. Our study found that late melanoma recurrence is not rare and that it occurs more frequently in certain patient groups." Patients with a higher chance of melanoma — the deadliest form of skin cancer — recurring more than a decade later, compared with early recurrence of melanoma within the first three years, were typically a younger age at initial diagnosis and generally exhibited less serious characteristics of the original tumor, Dr. Faries and colleagues reported…