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Global health experts call into question sub-Saharan cancer data

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Cancer data compiled by the World Health Organisation’s (WHO) GLOBOCAN project has huge global influence and is used by Governments and international NGOs to determine health and funding priorities in sub-Saharan Africa. However, no independent evaluation of the data has ever been undertaken. For the first time, experts from Queen Mary University of London have critically evaluated all publically available information on the quality of cancer registration systems in sub-Saharan Africa. …

Tamoxifen reduces breast cancer rates by nearly a third for 20 years — ScienceDaily

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The IBIS-I trial (International Breast Cancer Intervention Study), led by Queen Mary University of London and funded by Cancer Research UK, examined the long-term risks and benefits of taking tamoxifen to prevent breast cancer in women at high risk of the disease (aged 35-70 years old, primarily with a family history of breast cancer). During the study 7,154 pre and post-menopausal women were randomized to receive either tamoxifen (20mg daily) or a matching placebo for five years. After completing treatment, the health of all participants was monitored with an average follow-up time of 16 years and maximum of 22 years. The new and extended analysis, presented at the San Antonio Breast Cancer Symposium, revealed 251 women from the tamoxifen group versus 350 from the placebo group developed breast cancer — a reduction of 29 per cent. …

Leukemia: Scientists make major breakthrough in understanding disease

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The study was conducted amongst children with Down’s syndrome — who are 20-50 times more prone to childhood leukemias than other children — and involved analysing the DNA sequence of patients at different stages of leukemia. The researchers uncovered that two key genes (called RAS and JAK) can mutate to turn normal blood cells into cancer cells. However, these two genes never mutate together, as one seems to exclude the other. This discovery means we can begin to identify which of the two genes are mutated in patients, and therefore more effectively target their cancer in lower doses (reducing toxicity for the patient) with less side-effects…

Why we should vaccinate boys against HPV as well as girls

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Gillian Prue, from the School of Nursing and Midwifery at Queen’s University of Belfast, says that the human papillomavirus (HPV) infection is common in men and can lead to genital warts and the development of some head and neck, anal or penile cancers. She says incidence of this has increased in the past two decades with HPV causing 5% of all human cancers. …

Leukemia drug found to stimulate immunity against many cancer types — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/06/140611132034.htm

Kidney, liver transplantation from those with cancer history: Studies provide insight on quality of donations — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/04/140428121301.htm

First genetic link discovered to difficult-to-diagnose breast cancer sub-type — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/04/140417191622.htm

New treatment for those at high risk of breast, ovarian cancer — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/03/140327222454.htm

One-third of UK women might benefit from more frequent mammograms — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/03/140321095234.htm

Drug cuts breast cancer cases by more than 50% in high risk women

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The results of the IBIS II trial, funded by Cancer Research UK and led by Queen Mary University of London, could offer a new option for preventing breast cancer in high risk post-menopausal women which is more effective than tamoxifen and has fewer side-effects. The study looked at almost 4,000 postmenopausal women at high risk of breast cancer with half being given 1mg of anastrozole daily and half given a placebo. In the five years of follow up 40 women in the anastrozole group developed breast cancer compared to 85 women placebo group. …