Tag Archives: school

A path to lower-risk painkillers: Newly-discovered drug target paves way for alternatives to morphine

Now, new research from the University of Michigan Health System and a major pharmaceutical company has identified a novel approach to moderate and severe pain therapy that paves the way for lower dosage painkillers. The findings appear in Proceedings of the National Academy of Sciences. Drugs such as hydrocodone (the main ingredient of Vicodin) and oxycodone (Oxycontin) are often the best options for the treatment of moderate to severe pain for patients facing medical conditions ranging from a wisdom tooth extraction to cancer. The drugs bind to specific molecules (opioid receptors) on nerve cells in the brain and spinal cord to prevent the feeling of pain…

Men with prostate cancer should eat healthy vegetable fats, study suggests

By substituting healthy vegetable fats — such as olive and canola oils, nuts, seeds and avocados — for animal fats and carbohydrates, men with the disease had a markedly lower risk of developing lethal prostate cancer and dying from other causes, according to the study. The research, involving nearly 4,600 men with non-metastatic prostate cancer, could help with the development of dietary guidelines for men with the disease. While prostate cancer affects millions of men around the world, little is known about the relationship between patients’ diets following their diagnosis and progression of the disease…

Men with prostate cancer should eat healthy vegetable fats

By substituting healthy vegetable fats — such as olive and canola oils, nuts, seeds and avocados — for animal fats and carbohydrates, men with the disease had a markedly lower risk of developing lethal prostate cancer and dying from other causes, according to the study. The research, involving nearly 4,600 men with non-metastatic prostate cancer, could help with the development of dietary guidelines for men with the disease. While prostate cancer affects millions of men around the world, little is known about the relationship between patients’ diets following their diagnosis and progression of the disease. …

Birth control pills tied to lower ovarian cancer risk

Women who use birth control pills are less likely to develop ovarian cancer later in life, a new analysis of past studies suggests. Researchers pooled data from 24 studies and found birth control pill users had a 27 percent lower risk of being diagnosed with ovarian cancer. And longer use seemed to be tied to more protection. “It reinforces that there is a positive relationship between the use of oral contraceptives and ovarian cancer prevention in the general public,” said Dr. Laura Havrilesky, who led the study at the Duke University School of Medicine in Durham, North Carolina. “I think it adds some scientific weight to that relationship.” However, the review paper can't prove that using oral contraception lowers a woman's risk of disease - because there could have been other, unmeasured differences between women who took birth control pills and those who didn't, researchers noted. About one in 72 women will be diagnosed with ovarian cancer during her lifetime, according to the American Cancer Society. The disease is often caught at an advanced stage, and the majority of women who are diagnosed will die from ovarian cancer. So researchers are eager to find ways to lower a woman's chance of developing it in the first place. Eating a healthy diet and maintaining a normal weight may be one way to do that. Some studies have suggested that using birth control pills - which contain the hormones estrogen and progestin or progestin only - may also lower a woman's risk over the long run. To clear up that picture, Havrilesky and her colleagues combined data from 24 studies that compared thousands of women who took birth control pills for various lengths of time, at a range of ages, with those who didn't use oral contraception. Any use of birth controls pill was linked to a lower risk of ovarian cancer, they found. Women who were on birth control pills for 10 years or longer were half as likely to develop the disease as those who didn't use them at all, the study team reported Wednesday in Obstetrics & Gynecology. If birth control pills themselves were responsible for that reduced risk, the researchers calculated that 185 women would have to use it for five years to prevent one case of ovarian cancer. But, because none of the studies randomly assigned women to take birth control pills or not - each woman made the decision with her own doctor - it's not clear that the contraceptives, themselves, explain the whole cancer difference. Use caution The researchers said there hasn't been enough time to study how the specific hormone formulations in contemporary birth control pills affect ovarian cancer risk decades down the line. Because of that and other limitations, women should use “considerable caution” when figuring the new findings into their own personal decisions about birth control, they wrote. What's more, other research suggests women who take birth control pills are at a higher risk of developing cervical cancer, said Eduardo Franco, head of cancer epidemiology at McGill University in Montreal, Canada. “It is the sort of thing that requires a frank conversation between a woman and healthcare provider,” Franco, who wasn't involved in the new research, told Reuters Health. He said the findings are not surprising and that many doctors are convinced birth control pills do lower ovarian cancer risk. “I don't think there's a question of the link,” Franco said. What's important, he added, is “understanding the caveats that come with the reduced risk of ovarian cancer.” “What we've got right now may be the best evidence that we ever are able to have. I don't necessarily think that it is enough to tell a physician to have their patients use oral contraceptives solely for the purpose of preventing ovarian cancer,” Havrilesky told Reuters Health. “But I think it's enough to say this is a possible advantage in women who are considering use of oral contraceptives” for birth control or other medical reasons, she said.source : http://www.foxnews.com/health/2013/06/07/birth-control-pills-tied-to-lower-ovarian-cancer-risk/

15 ways to cancer-proof your life

We're all grown-ups here—nightmares aren't a big problem anymore. We're calm, we're cool, we're mostly collected...until it comes to the C-word. For adults, cancer is the thing that goes bump in the night; that bump gets louder when family or friends are diagnosed. Whether your risk is monumental or blessedly average, we know you want to protect yourself. So we've combed through research, interrogated experts, and found cutting-edge strategies to help keep you safe. Worship a wee bit of sun People who get the most vitamin D, which lies dormant in skin until ultraviolet rays activate it, may protect themselves from a variety of cancers, including non-Hodgkin's lymphoma, breast, and colon. Ironically, it even improves survival rates of melanoma, the most serious skin cancer. But 10 to 15 minutes a few days a week is all it takes to benefit. If you're out any longer than that, slather on the sunscreen (Are you applying enough? We’ve got the recommended amount for every body part, here.) If you go the supplement route, aim for 400 IU of vitamin D a day. Eat an orange every day It just may zap a strain of the H. pylori bacteria that causes peptic ulcers and can lead to stomach cancer. Researchers in San Francisco found that infected people with high levels of vitamin C in their blood were less likely to test positive for the cancer-causing strain. (Bonus: research shows a scent of citrus can reduce stress.) Listen to Katie Couric Though colonoscopies are about as popular as root canals, if you're 50 or older, get one. Colorectal cancer is the second leading cause of cancer death in the United States. Don't think you're off the hook because you got a digital fecal occult blood test at your last checkup: Research by the Veterans Affairs Cooperative Study found that the test missed 95 percent of the cases. Schedule your first colonoscopy before your 50th if you have a family history of colon cancer. Steam a little green Piles of studies have shown that piles of broccoli help stave off ovarian, stomach, lung, bladder, and colorectal cancers. And steaming it for three to four minutes enhances the power of the cancer-fighting compound sulforaphane, which has been shown to halt the growth of breast cancer cells. (Sorry, microwaving doesn't do the trick; it strips out most antioxidants.) Get more protection by sprinkling a handful of selenium-rich sunflower seeds, nuts, or mushrooms on your greens. Researchers are discovering that sulforaphane is about 13 times more potent when combined with the mineral selenium. Pick a doc with a past Experience—lots of it—is critical when it comes to accurately reading mammograms. A study from the University of California, San Francisco, found that doctors with at least 25 years' experience were more accurate at interpreting images and less likely to give false positives. Ask about your radiologist's track record. If she is freshly minted or doesn't check a high volume of mammograms, get a second read from someone with more mileage. Drink jolt-less java Drink jolt-less java. Downing two or more cups of decaf a day may lower the incidence of rectal cancer by 52 percent, finds a study from two large and long-term research projects—the Nurses' Health Study and the Health Professionals Follow-Up Study from Harvard University. One theory is that coffee increases bowel movements, which helps to reduce the risk. Why decaf reigns supreme, however, remains a mystery. Drop 10 pounds Being overweight or obese accounts for 20 percent of all cancer deaths among women and 14 percent among men, notes the American Cancer Society. (You're overweight if your body mass index is between 25 and 29.9; you're obese if it's 30 or more.) Plus, losing excess pounds reduces the body's production of female hormones, which may protect against breast, endometrial, and ovarian cancers. Even if you're not technically overweight, gaining just 10 pounds after the age of 30 increases your risk of developing breast, pancreatic, and cervical, among other cancers. Make like a monkey Or a bunny. Women who ate four to six antioxidant-laden bananas a week cut their risk of kidney cancer by 54 percent, compared with those who didn't eat them at all, found an analysis of 61,000 women at the Karolinska Institutet in Sweden. Gnawing on root vegetables such as carrots had the same benefit. Get naked with a friend You'll need help examining every inch of your body—including your back, scalp, and other hard-to-see places—for possible changes in the size or color of moles, blemishes, and freckles. These marks could spell skin cancer. Women, take special note of your legs: Melanoma mainly occurs there. For the guys, the trunk, head, and neck are the most diagnosed spots. While you're at it, check your fingernails and toenails, too. Gray-black discoloration or a distorted or elevated nail may indicate the disease. And whether you see changes or not, after age 40, everyone should see a dermatologist yearly. (Find out 7 more things your nails can say about your health.) See into the future Go to Your Disease Risk to assess your chance of developing 12 types of cancer, including ovarian, breast, and colon. After the interactive tool estimates your risk, you'll get personalized tips for prevention. Pay attention to pain If you're experiencing a bloated belly, pelvic pain, and an urgent need to urinate, see your doc. These symptoms may signal ovarian cancer, particularly if they're severe and frequent. Women and physicians often ignore these symptoms, and that's the very reason that this disease can be deadly. When caught early, before cancer has spread outside the ovary, the relative five-year survival rate for ovarian cancer is a jaw-dropping 90 to 95 percent. Get calcium daily Milk's main claim to fame may also help protect your colon. Those who took calcium faithfully for four years had a 36 percent reduction in the development of new pre-cancerous colon polyps five years after the study had ended, revealed Dartmouth Medical School researchers. (They tracked 822 people who took either 1,200 mg of calcium every day or a placebo.) Though the study was not on milk itself, you can get the same amount of calcium in three 8-ounce glasses of fat-free milk, along with an 8-ounce serving of yogurt or a 2- to 3-ounce serving of low-fat cheese daily. Sweat 30 minutes a day One of the best anticancer potions is a half hour of motion at least five days a week. Any kind of physical activity modulates levels of androgens and estrogen, two things that can protect women against estrogen-driven cancers such as ovarian and endometrial, as well as some types of breast cancer. The latest proof comes by way of a Canadian study that found that women who get regular, moderate exercise may lower their risk of ovarian cancer by as much as 30 percent. Bonus: All that moving might speed everything through your colon, which may help stave off colon cancer. (Trouble carving out 30 minutes a day? Be ready for a fitness opportunity at a moment’s notice by keeping a perfectly packed gym bag in your car at all times.) Stamp out smoking—all around you Lung cancer is well known as one of the main hazards of smoking. But everything the smoke passes on its way to the lungs can also turn cancerous: mouth, larynx, and esophagus. The fun doesn't stop there. Smokers are encouraging stomach, liver, prostate, colorectal, cervical, and breast cancers as well. The good news: If you give up the cigs today, within 15 years, your lung cancer risk will drop to almost pre-smoking lows. Share that news with the people who puff around you, because exposure to someone else's smoke can cause lung cancer, and it may boost your chances of cervical cancer by 40 percent. Step away from the white bread If you eat a lot of things with a high glycemic load—a measurement of how quickly food raises your blood sugar—you may run a higher risk of colorectal cancer than women who eat low-glycemic-load foods, finds a Harvard Medical School study involving 38,000 women. The problem eats are mostly white: white bread, pasta, potatoes, and sugary pastries. The low-glycemic-load stuff comes with fiber. Blew through our list already

Tumors disable immune cells by using up sugar

The scientists found that when they kept sugar away from critical immune cells called T cells, the cells no longer produced interferon gamma, an inflammatory compound important for fighting tumors and some kinds of infection. "T cells can get into tumors, but unfortunately they are often ineffective at killing the cancer cells," said Erika Pearce, PhD, assistant professor of pathology and immunology. …

Medical breakthrough for multiple sclerosis sufferers

In a breakthrough discovery, researchers have discovered a treatment capable of reducing the debilitating autoimmune response that occurs in people suffering from multiple sclerosis (MS). When patients are diagnosed with multiple sclerosis, their bodies begin to attack the protein myelin, which insulates the body’s spinal cord, brain and optic nerves. As a result, MS patients experience symptoms such as numbness in their limbs, paralysis and sometimes blindness. However, during a phase one clinical trial of a new treatment for MS patients, researchers were able to curtail the body’s attacks on myelin by 50 to 75 percent, while sustaining the functionality of the rest of the immune system. Current treatments for MS seek to lessen the body’s autoimmune response to myelin, but this often results in decreased effectiveness of the entire immune system. “Most therapies for autoimmune diseases employ approaches broadly called immunosuppressors – they knock down immune response without specificity,” study co-author Stephen Miller, professor of microbiology-immunology at Northwestern University Feinberg School of Medicine, told FoxNews.com.  “People can become highly susceptible to everyday infections and develop higher rates of cancer.” Miller and his colleagues sought a more targeted ‘tolerance’ treatment that would leave the greater immune system intact while knocking out only the autoimmune response to myelin. “In MS, the idea is to target autoreactive T-cells directed against myelin…which would (reduce) disease progression, but wouldn’t make patient susceptible to higher rates of infection,” Miller said. In a study published in the journal Science Translational Medicine, a small group of MS patients were treated intravenously with an infusion of their own white blood cells, which had been engineered to carry billions of myelin antigens. Researchers hoped the cells would teach the body to stop attacking myelin. Miller and his team needed to determine if the treatment, which was based on 30 years of previous research, could be safely applied in humans – and they were pleased to discover it could be. “It was safe to infuse as many as 3 billion autologous cells that we collected and manipulated back into the same patient and didn’t trigger exacerbations,” Miller said. “Most patients didn’t show any increased signs of disease during the six-month follow up.” Furthermore, the treatment did not seem to impede the larger immune system. Researchers tested this by analyzing whether or not each patient continued to retain their immunity to tetanus, for which all of the patients had previously been vaccinated. “Among four patients receiving the highest doses (of autologous cells),  immune response to myelin antigens had diminished or gone away - but tetanus had not gone away,” Miller said. This indicated that the immune system’s ability to fight other diseases after the procedure remained intact. Though researchers caution that the study was too small to draw any significant conclusions, they are optimistic about the outcomes of larger studies and the ability of this treatment to help halt the progress of MS – particularly among recently-diagnosed patients. “The idea is that if we’re able to intervene early enough in disease process, we can stop the autoimmune destruction and (the patient) will have little or no clinical deficit as result of earlier attacks before being diagnosed,” Miller said. Researchers hope to receive funding to begin a phase two trial soon.source : http://www.foxnews.com/health/2013/06/06/medical-breakthrough-for-multiple-sclerosis-sufferers/

5 low-fat foods that are making you fat

You may know that so-called low-fat and fat-free diet foods are often packed with sugar, salt, and chemical-laden additives. But did you realize that your body digests these “healthy” alternatives in record time, leaving you hungry for more?  That's only part of the problem, according to New York City dietitian Keri Glassman, the author of The New You and Improved Diet. Packaging, no matter how well-intentioned and honest, is another culprit: When people see low-fat on a label, they think they can eat more than they really should and end up chowing down on 28 percent more calories, according to research from the Cornell University Food and Brand Lab. Below, we've rounded up five common low-fat foods that aren't scoring you a six-pack anytime soon. Chips Low-fat chips taste a whole lot better than they used to, thanks to the addition of more salt, carbs, and other additives. When fat is removed from chips, manufacturers make up for lost taste and texture with the salty stuff. Many bags of low-fat chips contain about 20 percent more sodium and 15 percent more carbohydrates than their full-fat versions—not to mention about twice the number of ingredients. Peanut Butter You already know peanuts are little fat repositories, but this is mostly good fat: Polyunsaturated fatty acids increase protein concentration and the size of muscular cells, adding to your lean muscle mass without a single workout, according to research published in Clinical Science. What's more, old fat stored in the body's peripheral tissues can't get worked off efficiently without new fat to activate fat-burning pathways in the liver, according to research from the Washington University School of Medicine in St. Louis.  What many food companies don't tell you is that they've replaced that healthy fat with maltodextrin, a carbohydrate used as a filler in many processed foods. This means you're trading the healthy fat from peanuts for empty carbs and double the sugar for a savings of a meager 10 calories. So next time you're making a peanut butter and jelly sandwich, ditch the empty calories in the low-fat alternative and opt for the full-fat original—just be sure to spread it on in moderation. ___________________________________________________ More From Details: 7 Trends You'll Be Wearing Next Fall Foods That Will Make You Look Younger 14 Healthiest Snack Foods You Can Buy 12 Must-See Sneakers ___________________________________________________ Cheese You'll be hard-pressed to find low-fat or fat-free cheese at the deli counter. Why?

In-flight emergencies: Not as common as you think

Medical emergencies can occur at any time and that means, even while you’re on vacation or flying to your destination. But don’t be alarmed; you may be surprised as to how rare they are. A recent study published in the New England Journal of Medicine investigated the outcomes of medical emergencies on commercial flights between 2008 and 2010.   They found that for every 1 million passengers, 16 emergencies occurred – in other words, one emergency for every 600 flights.   The most common emergencies included fainting at 37.4 percent, respiratory symptoms at 12.1 percent and nausea or vomiting at 9.5 percent.  Interestingly, cardiovascular events like cardiac arrest, and obstetric or gynecological issues each accounted for less than or equal to 0.5 percent.   The Federal Aviation Administration (FAA) mandates that all aircraft carry an emergency medical kit.  These kits are required to have, among other things, aspirin tablets, nitroglycerine tablets, saline solution and epinephrine. These kits are designed to provide flight crew or on-board medical professionals with resources to treat ill passengers, after consulting a ground-based physician in a medical communication center.   According to the report, flights had to be diverted and land at a different destination in only 7.3 percent of the cases.  Often, the reason flights were able to continue to the original destination is because of the training of the flight crew, the supplies in mandatory medical kits and the presence of medical professionals on board.   Oxygen was the most commonly used treatment almost 50 percent of the time, followed by saline solution at 5.2 percent and aspirin at 5 percent. This study does a nice job quantifying the incidence of in-flight medical emergencies and the resulting treatments and providers.   Keep in mind that such medical emergencies are rare, but do occur daily given the vast amount of airline travel across the world.   Rest assured that traveling physicians and other medical professionals are often on board and able to help ill passengers; at minimum, the flight crew will have contact with a physician at an academic medical communication center to remotely aid in treatment.  Dr. David B. Samadi is the Vice Chairman of the Department of Urology and Chief of Robotics and Minimally Invasive Surgery at the Mount Sinai School of Medicine in New York City. He is a board-certified urologist, specializing in the diagnosis and treatment of urological disease, with a focus on robotic prostate cancer treatments. To learn more please visit his websites RoboticOncology.com and SMART-surgery.com. Find Dr. Samadi on Facebook.source : http://www.foxnews.com/health/2013/06/05/in-flight-emergencies-not-as-common-as-may-think/

New app provides health info straight from doctors

Being in the dark about your health can be very unsettling, so people often turn to the Internet for answers. But sometimes, it can be difficult to separate fact from fiction on web sites. To help people get better answers to their biggest health questions, two physicians developed a free new app called iTriage. The app’s content is written by a team of doctors and health professionals, and the information available on the app has been reviewed by Harvard Medical School, according to iTriage’s web site. The app includes tools to check symptoms, explore possible causes, research medications and even find a doctor. Additionally, a section on the app called My iTriage allows users to store their personal health records and insurance information. The iTriage app is a useful tool, but if you’re sick, be sure to seek professional help. For more information go to iTriageHealth.comsource : http://www.foxnews.com/health/2013/06/05/new-app-provides-health-info-straight-from-doctors/