Tag Archives: program

‘Undruggable’ cancer may be druggable after all: New target identified

The gene, SALL4, gives stem cells their ability to continue dividing as stem cells rather than becoming mature cells. Typically, cells only express SALL4 during embryonic development, but the gene is re-expressed in nearly all cases of acute myeloid leukemia and 10 to 30 percent of liver, lung, gastric, ovarian, endometrial, and breast cancers, strongly suggesting it plays a role in tumor formation. In work published in the New England Journal of Medicine, two HSCI-affiliated labs — one in Singapore and the other in Boston — show that knocking out the SALL4 gene in mouse liver tumors, or interfering with the activity of its protein product with a small inhibitor, treats the cancer. "Our paper is about liver cancer, but it is likely true about lung cancer, breast cancer, ovarian cancer, many, many cancers," said HSCI Blood Diseases Program leader Daniel Tenen, who also heads a laboratory at the Cancer Science Institute of Singapore (CSI Singapore)…

The best city to have a heart attack?

A trip to Sin City isn't always fun and games, with MGM Resorts properties in Las Vegas averaging roughly 45 to 50 sudden cardiac arrests a year on the casino floor. With heart attacks becoming commonplace in casinos, properties on The Strip are training employees to use defibrillators, also known as AEDs – turning casinos into what some consider the safest place to, well, have a heart attack. “We're able to get anywhere on a property a lot quicker than calling 911,” said Dr. David Slattery, the medical director for MGM Resorts defibrillator training program. A defibrillator applies electrical energy to the affected heart area, giving the individual a better chance of surviving by regaining their natural rhythm. Both MGM and Caesars properties, which make up a majority of the casinos on the Las Vegas Strip, train employees on the casino floor to use these defibrillators at a moment’s notice. Whether the heart attack is noticed by a security officer near a slot machine or by a surveillance camera, the odds are high you'll get some immediate help. “If you look just at the casino floor, where the response time is less than three minutes, about 60 to 70 percent of those come back after sudden cardiac arrest,” said Slattery. The AED training at MGM is certified by the American Heart Association, incorporating regular “mock drills” where employees reenact the situation, attaching the defibrillator to a mannequin while administering CPR. The drill incorporates three individuals, with each person taking a turn at resuscitating the individual. The training is becoming a model for other industries. “There are companies out there, and I'm associated with one called Cardio Ready, and these companies actually model what they do after the Vegas model,” said cardiologist Dr. Kevin Campbell. “They manage AEDs for hotels, businesses and banks, and that sort of thing.” Slattery calls the security officers the “special forces” since the officers arrive within the first minutes of cardiac arrest. It looks to be a special force that's definitely worth betting on.Pete Griffin is part of the Junior Reporter program at Fox News. Get more information on the program here.source : http://www.foxnews.com/health/2013/06/16/best-city-to-have-heart-attack/

Airport therapy dogs take the stress out of travel

There’s a new breed of airport dog. They aren’t looking for drugs or bombs — they are looking for people who need a buddy, a belly to rub or a paw to shake. “His job is to be touched,” volunteer Kyra Hubis said about Henry James, her 5-year-old golden retriever that works a few hours a week at the San Jose airport. “I am just standing there with him. They are talking to him. If I need to answer for him, I do. But I am at the end of his leash, he’s not at the end of mine.” Mineta San Jose International Airport is widely credited with introducing the first airport therapy dog in the days after Sept. 11, 2001, when flights were grounded, passengers were stranded and reaching friends and relatives in the East was nearly impossible. Passengers were anxious and afraid. Enter Orion, owned by a volunteer airport chaplain who got permission to bring the dog to work. He made such a difference that San Jose formalized the program and now has nine dogs. Miami International Airport got onboard the program with one and Los Angeles International Airport has 30 and is hoping to expand its program. The dogs are intended to take the stress out of travel — the crowds, long lines and terrorism concerns. You never know why people are flying, said Heidi Huebner, director of volunteers at LAX, which launched Pets Unstressing Passengers (PUPs) in April. Travelers might be in town for a vacation, a funeral, to visit a sick family member or to attend a business meeting. “You can literally feel the stress levels drop, people start smiling, strangers start talking to each other and everybody walks away feeling really, really good,” Huebner said. Dogs have to be healthy, skilled, stable, well-mannered and able to work on a slack 4-foot leash, said Billie Smith, executive director of Wyoming-based Therapy Dogs, Inc., which certifies the LAX animals. They have to be comfortable with crowds, sounds, smells — and they need to pass through security like all airport workers. Handlers are taught to watch for people who fear or dislike dogs or those who might have allergies. In most cases, people approach the dogs, identifiable by the vests or bandannas they wear. Los Angeles’ dogs, which are featured on trading cards, are as varied as its airport passengers. There’s a long-haired Dalmatian, a Lab-pointer mix, a field spaniel, a poodle, three Australian Labradoodles, a Doberman and a 150-pound Irish wolfhound named Finn who has two tricks. “He looks you in the eye and lays down on the job,” said owner Brian Valente. “When I’m around Finn, it makes me feel like things are OK. When Finn’s around other people, they are OK. It’s almost instant, even if just for a moment,” Valente said. Miami’s sole dog, Casey, a 4-year-old golden retriever, is a star. She has her own website, fan mail, business cards and a role on “Airport 24/7: Miami,” a weekly reality show on the Travel Channel. “Casey is so pure and genuine,” explained Dickie Davis, director of terminal operations and customer service. “She’s not asking for anything or selling anything. She is just a love magnet.” When Claudia McCaskill’s family recently flew home from vacation in Brazil she requested Casey meet the plane to greet her 5-year-old daughter, Carina, who is autistic. She knew Carina would be low on energy and patience and they still had a 2.5-hour drive home to St. Lucie. Casey and handler Liz Miller were there with a gift basket and Carina fell in love with the dog. “Thank you for visiting us at the airport so I would be happy,” Carina said in a video the family made for Casey. Now Carina wants to go back and see Casey again. “I can’t say how much we appreciate what they did for us. It not only helped our daughter, but us too,” McCaskill said. Despite all the smiles, there are also hard moments. Before departing from San Jose, a soldier kneeled down and told Henry James: “OK, buddy, you take care of the house while I am gone,” Hubis said. A woman who said her husband of 40 years told her he wanted a divorce that morning wept on Henry’s shoulder. “He just sat there,” Hubis said. “He knew. He can feel.”source : http://www.foxnews.com/health/2013/06/10/airport-therapy-dogs-take-stress-out-travel/

Skipping shots at sick visits tied to vaccine delays

Kids who don't get vaccines when they see their pediatrician for a sick visit - despite being due for the shots - are more likely to fall behind on immunizations and routine check-ups, according to a new study. “It's pretty common that kids will come in (for a sick visit) at a time when they should be getting their shots,” said Steve Robison, the study's author and a researcher at the Oregon Immunization Program, part of the state's health department. Sometimes babies end up skipping those shots, perhaps because parents are concerned they could make a sick baby feel worse or doctors are worried that parents won't come back for a well-baby check-up if infants are already caught up on vaccines. “The challenge is, if they come in sick, are they going to come back and get shots and well-baby visits in a timely way?” Robison said. His findings suggest those babies end up worse off if doctors forgo shots until they're better. “It's very clear that vaccinating at sick visits improves the vaccination rate,” said Dr. Alexander Fiks, a pediatrician at The Children's Hospital of Philadelphia, who was not part of this study. “For parents, what I would say is, don't be afraid to get vaccines at sick visits because, for most kids with minor illnesses, it's really no problem. Medically, it's fine,” he added. The Centers for Disease Control and Prevention recommends that babies receive at least 16 vaccine doses during their first six months. Those are spread across well-child visits. In an earlier study, Robison and his colleagues found a growing number of parents in Oregon are not sticking to the recommended vaccine schedule - so kids end up getting their shots late or not at all. This time, Robison looked at the immunization records of 1,060 children who went to the doctor for an ear infection around the time when a well-baby check-up should occur. All of the children had state-funded health insurance. About 8 percent of the sick babies received a diphtheria, tetanus and pertussis (DTaP) vaccine at the sick visit itself, and another 57 percent had one within a few weeks. The others were late on their shots. Fiks said the findings support the results of other studies showing that when doctors skip shots at sick visits, kids are more likely to end up not following the immunization schedule. What's more, giving shots at sick visits did not seem to stop parents from bringing their baby back for well-child visits. Compared to babies who received their immunizations at routine check-ups, those who had their shots at sick visits had just as many well-baby visits by age two - about five, on average. And kids who skipped the shot at their sick visit, but had another visit within a few weeks, ended up receiving more routine check-ups compared to similar normally-vaccinated children, Robison reported in the medical journal Pediatrics. On the other hand, kids who didn't get a shot at the sick visit or within four weeks had slightly fewer routine visits over their first two years. Increasingly, children are becoming “under-vaccinated,” researchers said. A study earlier this year found that half of some 300,000 kids born between 2004 and 2008 had fallen behind on their immunizations at some point before age 2. The concern is that those children are vulnerable to the diseases that vaccines are designed to prevent. “The more kids within a given classroom who are unprotected, the more likely it is for there to be an outbreak,” said Fiks. The researchers agreed that a minor illness is not a reason to fall behind on routine shots. “If you want to keep the kids on schedule so that they're protected from disease, it's best to give the shot,” Robison said.source : http://www.foxnews.com/health/2013/06/06/skipping-shots-at-sick-visits-tied-to-vaccine-delays/

Research for Her: Bridging the gender gap in health studies

Before Kelli Sargent’s mother, Nanci, was diagnosed with stage 3C ovarian cancer in 2000, she and her family knew little about the disease’s warning signs. Frustrated by the lack of research and awareness surrounding ovarian cancer, Sargent and her mother started a nonprofit called “Run for Her” in conjunction with Cedars-Sinai Medical Center in 2005. The event, a 5,000-meter run held in Los Angeles, raises funds and spreads awareness about ovarian cancer. Though Nanci lost her battle with ovarian cancer five years ago, Run for Her is still dedicated to its mission. Now, a new program at Cedars-Sinai called Research for Her is collaborating with Run for Her to overcome another obstacle standing in the way of improved outcomes for ovarian cancer patients: the lack of women participating in clinical trials. Women are historically underrepresented in clinical trials and erasing this gender gap could help scientist’s develop better screening methods for diseases like ovarian cancer – something that Sargent believes could have saved her mother’s life. “If you catch ovarian cancer early…it’s basically curable. You have such an optimistic future,” Sargent told FoxNews.com. “But only less than 20 percent of cases are caught early.” Sign up, save lives While doctors are uncertain why fewer women choose to enroll in clinical trials, they know unequal gender representation in studies can have serious health implications. “If we don’t find out how drugs work in the real population, then they may simply not work as well as we hope that we do,” Dr. BJ Rimel, co-founder of Research for Her and a gynecologic oncologist in the department of obstetrics and gynecology at Cedars-Sinai, told FoxNews.com. Furthermore, the lack of female research participants has slowed studies seeking to explore the basic causes and markers of diseases like ovarian cancer.  Understanding the basic mechanisms behind these disorders could help lead to earlier detection methods – and ultimately save lives. It wasn’t until Rimel began her career at Cedars-Sinai in 2011, with a dream of conducting clinical trials, that she understood the severity of the problem. “I realized the enrollment for clinical trials at Cedars was abysmal,” Rimel said. “We weren’t making a dent. We were offering all these great things, but nothing was happening.” Rimel eventually met Dr. Catherine Deng, associate director of the Wasserman Breast Cancer Risk Reduction Program and surgeon at the Saul and Joyce Brandman Breast Center at Cedars-Sinai, who was having difficulty getting women to sign up for her breast cancer registry. With help from the already established Run for Her, the two women joined forces and launched the Research for Her clinical trial online registry. Doctors suspect that women haven't signed up for clinical trails in the past because of a lack of information, or because of the difficult sign-up process. Previously, the registration process for clinical trials was cumbersome, done primarily in the doctor’s office and using pen and paper.   “Women aren’t going to seek out a clinical trial when they have 19 other things to do, just to figure out if they qualify,” Sargent said. But with Research for Her, the sign-up process is easy. It takes only about 10 minutes, can be done online and all medical information is confidential, according to Rimel. If a woman qualifies for a trial, a research coordinator will contact her personally with more information – though there is no obligation to participate. “We want to make this simple,” Rimel said. And they seem to be on to something. Since the program’s launch on March 18, Research for Her has succeeded in registering 160 women for clinical trials – a huge increase for the program. Promising research One exciting trial currently benefitting from the Research for Her registry seeks to pinpoint chemical markers in the blood that may act as early identifiers for ovarian cancer. “We are trying to enroll women in the study (that are) already at risk for ovary cancer. The general population has a low risk, but for women with a high risk, we don’t know how best to screen them,” Rimel said. Thanks to the registry, researchers have been able to connect with a larger pool of women eligible to participate in the trial. “This registry has allowed us to find these women and contact them and get people in the study…that we haven’t been able to fill before now,” Rimel said.   Ultimately, Rimel and Deng hope to register 2,000 women through Research for Her by the end of the year. But in the long term, Rimel hopes that the program will be used nationwide to boost participation in clinical trials and further the progress of medical research. “Right now, it’s a single institution, but we hope if this takes off that we can network with others to make it a real way to help people (get) in clinical trials,” Rimel said. “That is my dream for this.” Sargent hopes that getting the word out about registry will help improve detection and treatment methods for women’s cancers – and save other women battling the disease that their mothers fought. “There is so much to learn, especially as research is advancing,” Sargent said. “They need this information from women.” Click for more on Research for Her. source : http://www.foxnews.com/health/2013/06/04/research-for-her-bridging-gender-gap-in-health-studies/

Money talks when it comes to weight loss

The secret to weight loss may be much simpler than anyone ever imagined – so simple, in fact, you may wonder why it hasn’t been thought of before? A study completed by Mayo Clinic researchers has discovered that money is the most effective motivator when it comes to weight loss. When conducting a comparison between study groups, one group was incentivized, the other was not. The results were overwhelming, with 62 percent of study participants from the incentivized group completing the study, compared to only 26 of the non-incentivized group. And, the incentivized group lost an average of 9.08 pounds versus 2.34 pounds in the other group. Financial incentives for weight loss began to gain popularity in January, as New Year’s resolutions to finally drop excess pounds began to dominate water cooler chatter in offices across the nation. A number of websites and wellness firms now offer individuals, as well as teams, the ability to place bets on their weight loss efforts, and some even offer additional tools to help you succeed. According to a report by the National Business Group on Health, teaming up with co-workers to whittle your middle is an effective way to lose weight.  The media lit up in the wake of New Year’s resolutions to discuss the increases in employer-incentivized weight loss competitions. Wellness consultant groups and websites, like DietBet.com and Healthywage.com, have helped tens of thousands of employees shed as much as 5 percent of their body weight in just three months – enough to make a significant  difference in certain health risk factors. The effectiveness of the program is in line with the Mayo Clinic study: money talks when it comes to weight loss. And inside the office, the team mentality only enhances success. Independent wellness firms work with employers to establish teams within the office and offer a grand prize (as much as $10,000 cash) for the winning team and smaller prizes for milestones along the way, as well as runner-up rewards. In an interview, an employee of a participating company told The Wall Street Journal that staying on track was easier because he feared letting down his team in the pursuit of $10,000. A fellow teammate responded, agreeing, “The last thing you want to do is catch the wrath of your team.” Independent firms offer complete programs, including private weigh-ins. Employees may participate on a voluntary basis and a small fee is often required, but the rewards – even if you don’t win the grand prize – often outweigh the fee. There is speculation, as with most diets, about maintaining your weight loss after the allure of the money has long passed. However, studies have shown that in team weight loss “competitions” like these, many times teammates continue to help each other stay on track. Physician-supervised weight loss is also a healthy way to not only achieve weight loss results for contests like these, but to ensure you maintain it. Your doctor can be a vital part of your weight management team and help you uncover strategies that will lead to long term weight loss success – long after you have pocketed your weight loss earnings. Click to learn more about the Mayo Clinic study. Dr. Jennifer Landa is Chief Medical Officer of BodyLogicMD, the nation's largest franchise of physicians specializing in bioidentical hormone therapy. Dr. Jen spent 10 years as a traditional OB-GYN, and then became board-certified in regenerative medicine, with an emphasis on bio-identical hormones, preventative medicine and nutrition. She is the author of “The Sex Drive Solution for Women.” & Learn more about her programs at www.jenlandamd.com.& source : http://www.foxnews.com/health/2013/05/27/money-talks-when-it-comes-to-weight-loss/

Technique to detect breast cancer in urine developed

Dr. Yinfa Ma, Curators’ Teaching Professor of chemistry at Missouri S&T, uses a device called a P-scan, to detect the concentration of certain metabolites called pteredines in urine samples. These biomarkers are present in the urine of all human beings, but abnormally high concentrations can signal the presence of cancer. Ma believes the levels continue to rise as the cancer advances…