Tag Archives: pennsylvania

Protein is involved with colon cancer cell’s ability to invade other cells

Previous research shows that km23-1 is involved in the movement of cancer cells and in the control of specific proteins at the leading edge of moving cells. Kathleen Mulder, professor of biochemistry and molecular biology, who discovered the protein, now says km23-1 is used in the cancer cell’s ability to move out of a tumor in the early stages ofinvasion. "km23-1 may be able to help in this process due to its role in the assembly of large groups of proteins favorable to cancer invasion," Mulder said. Colorectal cancer is the third most common cancer in the United States. …

Aspirin may fight cancer by slowing DNA damage

"Aspirin and other non-steroidal anti-inflammatory drugs, which are commonly available and cost-effective medications, may exert cancer-preventing effects by lowering mutation rates," said Carlo Maley, PhD, a member of the UCSF Helen Diller Family Comprehensive Cancer Center, and an expert on how cancers evolve in the body over time. In the study, published June 13 in the online journal PLOS Genetics, Maley, working with gastroenterologist and geneticist Brian Reid, MD, PhD, of the Fred Hutchinson Cancer Research Center, analyzed biopsy samples from 13 patients with a pre-cancerous condition called Barrett’s esophagus who were tracked for six to 19 years. In an "observational crossover" study design, some patients started out taking daily aspirin for several years, and then stopped, while others started taking aspirin for the first time during observation…

Baby Matters recalls recliner linked to infant deaths

Baby Matters LLC is recalling baby recliners linked to five infant deaths as part of a settlement with the Consumer Product Safety Commission, the U.S. agency said on Friday. The settlement calls for the company, based in Berwyn, Pennsylvania, to recall its foam rubber Nap Nanny and Nap Nanny Chill infant recliners and their covers, in exchange for the CPSC dropping an administrative complaint that it filed in December 2012, the agency said in a statement. Four infants have died in the Nap Nanny Generation Two recliners, and a fifth death involved the Chill model, the agency said. The CPSC also received 92 reports of infants hanging or falling over the side of the recliners, including some children who were restrained in the product's harness. The agency urged consumers to stop using Nap Nanny and Nap Nanny Chill recliners. It said Baby Matters was no longer in business and was not accepting returns. About 165,000 of the Nap Nanny and Chill products were sold between 2009 and 2012 for about $130 each. In December 2012, Amazon.com Inc, Buy Buy Baby Inc, Diapers.com, and Toys R Us/Babies R Us {TOY.UL] announced a voluntary recall of Nap Nanny and Chill models sold in their stores. Consumers who bought a Nap Nanny from one of those retailers should contact them for information on receiving a refund, the CPSC said. “CPSC urges other consumers to immediately dispose of the products to ensure that they are not used again,” the statement said.source : http://www.foxnews.com/health/2013/06/14/baby-matters-recalls-recliner-linked-to-infant-deaths/

Protein protects against breast cancer recurrence in animal model

Precisely what causes breast cancer recurrence has been poorly understood. But now a piece of the puzzle has fallen into place: Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer — a finding that suggests potential new therapeutic strategies. The study, performed in the laboratory of Lewis A. …

Girl dying of cystic fibrosis receives lung transplant

Sarah Murnaghan, the 10-year-old Pennsylvania girl dying of cystic fibrosis, is receiving her long-awaited lung transplant. According to a Facebook post from Sarah’s mother, Janet, the family received word this morning of new lungs that had been made available, and Sarah is currently in surgery.  The operation will take many hours. A spokeswoman from the Children’s Hospital of Philadelphia (CHOP), where Sarah has been hospitalized, said they do not have any information to release. In the Facebook post, Janet said the family is overwhelmed with emotions, and she thanked everyone for their unending support.  She also asked her followers to pray for Sarah's donor. “Please pray for Sarah's donor, her HERO, who has given her the gift of life,” Janet Murnaghan wrote. “Today their family has experienced a tremendous loss, may God grant them a peace that surpasses understanding.” United States Senator Pat Toomey (R-Pa.) released the following statement after being informed by the family of Sarah’s good news: “I am deeply grateful to the organ donor and his or her family for the potentially life-saving gift to Sarah. Now that a suitable donor has been found, a prayer would help, too - a prayer Sarah's body accepts the new organ the way doctors believe it can. The judge gave Sarah a chance to receive a new lung.  Now the surgical team at CHOP is giving her a chance at life.”   Sarah has been in desperate need of a lung transplant for the past 18 months.  She has been hospitalized at Children’s Hospital of Philadelphia for the past three months, where she has been on a ventilator. Under the current guidelines for organ donation, children under the age of 12 must wait for pediatric lungs to become available.  Adult lungs cannot be offered to children under 12, until they are offered to adults and adolescents first.   The Murnaghans have been in the midst of a legal battle over the established rules for organ donation after they filed a lawsuit last week to have the guidelines changed, arguing the rule keeping Sarah off the list was “discriminatory.” A federal court judge granted a temporary order on June 5 that allowed Sarah to join an adult organ transplant list. It is not yet clear whether Sarah’s donor is an adult or a child. Judge Michael Baylson made his ruling after hearing oral arguments on the case and had scheduled a preliminary injunction hearing for June 14. Baylson's order told Department of Health and Human Services (HHS) Secretary Kathleen Sebelius to direct the group that manages the organ transplant list to cease application of it in Sarah's case. Secretary Sebelius declined to intervene in the case early last week, despite urgent pleas from several members of Congress from Pennsylvania. Sebelius said that such decisions should be made by medical experts and noted that there were three other children at Children's Hospital alone in the same condition. Over the weekend, Sarah's condition worsened, and she was intubated on Saturday after she experienced additional trouble breathing. The Associated Press contributed to this report.source : http://www.foxnews.com/health/2013/06/12/girl-dying-cystic-fibrosis-to-receive-lung-transplant-today/