A new finding by University of Pennsylvania scientists has identified key steps that trigger this disintegration of cellular regulation. Their discovery — that a protein called Exo70 has a split personality, with one form keeping cells under tight control and another contributing to the ability of tumors to invade distant parts of the body — points to new possibilities for diagnosing cancer metastasis. The research, published in the journal Developmental Cell, was conducted by a team of researchers from the School of Arts and Sciences’ Department of Biology; the Perelman School of Medicine’s pathobiology and laboratory medicine, medicine and genetics departments, and China’s Hangzhou Normal University School of Medicine. …
source : http://www.foxnews.com/health/2013/06/28/family-reveals-10-year-old-girl-who-fought-organ-donation-guidelines-had-second/
source : http://www.foxnews.com/health/2013/06/20/stop-judging-angelina-jolie/
Sarah Murnaghan, the 10-year-old Pennsylvania girl at the middle of an organ transplant battle, finally underwent her long-awaited lung transplant on Wednesday. I am so happy that this little girl got a new chance at life. &#160;All of us who have been following this case so closely realize just how critical this child has been for the future of organ transplantation. On Tuesday night, Sarah’s mother, Janet, said they had found a match for her daughter. &#160;And with the great skill of her surgeons and nurses, along with the support of everyone involved in her care, the technical part of her surgery has been successful. &#160; Throughout this whole ordeal, I never lost hope that Sarah would become a candidate for transplant surgery. And I think it speaks volumes about the spirit of the American people who stood behind her and demanded she get a fair shot at life. But the doctor in me tells me we have to be cautiously optimistic because there are still major hurdles that Sarah has to overcome. From a medical standpoint, in cases like this one, there is always the worry about infection. &#160;Organ transplants require large complex surgeries with organs that are very prone to infection – especially the lungs. &#160;And moving forward, Sarah has to undergo immunosuppressive therapy, which predisposes her to the development of infection. There are also significant issues of metabolism. &#160;The function of the lungs is to oxygenate the blood, but this oxygenation contributes to the overall metabolic stability of the body. &#160;Right now, it’s too soon to tell whether her metabolic condition can be stabilized through these new lungs. Finally, with any organ transplant surgery, you also have the possibility of organ rejection, which could theoretically develop over the course of the next few days. &#160;The good news is that she is young, and she is receiving the best health care possible. &#160; I spoke to Dr. Donald McCain, chief of surgical oncology and the vice chairman of the John Theurer Cancer Center at Hackensack University Medical Center in N.J., about other potential obstacles Sarah faces. &#160;He noted that because the donor was an adult, resizing the lungs may also create medical issues. “The size of the lungs are much too great, which is why they don’t use adult lungs in general (for pediatric patients),” McCain said. &#160;“They must remove part of lung tissue, andâ€¦you have to do that surgically, creating a surgical line that didn’t exist before. &#160;That surgical line normally will not have the same strength as obviously a non-surgical line. &#160;That creates a potential weak point that is risky for an air leak.” McCain also added that even if Sarah overcomes these hurdles, there is a long road of recovery ahead. “Lung transplants are some of the sickest patients you wind up having, unlike liver and kidney transplant patients, who usually do quite well,” McCain said. &#160;“With lung transplants, these patients are in the hospital a very long time and are usually very sick.” To me, the aggravating part of this story is that this sweet girl only got her chance at life at the last minute. &#160;Had she been placed on the adult organ transplant list earlier, perhaps her condition would have been a little bit stronger when she received her new lungs. But I’m still very optimistic that Sarah will have a good recovery. It saddens me that it finally took a judge to see the common sense and force HHS Secretary Kathleen Sebelius into doing the right thing. &#160;I just hope that other children under similar circumstances get the justice they deserve in enough time.source : http://www.foxnews.com/health/2013/06/13/after-successful-lung-transplant-challenging-recovery-awaits-girl-with-cystic/
Sarah Murnaghan, the 10-year-old Pennsylvania girl dying of cystic fibrosis, is receiving her long-awaited lung transplant. According to a Facebook post from Sarah’s mother, Janet, the family received word this morning of new lungs that had been made available, and Sarah is currently in surgery. &#160;The operation will take many hours. A spokeswoman from the Children’s Hospital of Philadelphia (CHOP), where Sarah has been hospitalized, said they do not have any information to release. In the Facebook post, Janet said the family is overwhelmed with emotions, and she thanked everyone for their unending support. &#160;She also asked her followers to pray for Sarah's donor. “Please pray for Sarah's donor, her HERO, who has given her the gift of life,” Janet Murnaghan wrote. “Today their family has experienced a tremendous loss, may God grant them a peace that surpasses understanding.” United States Senator Pat Toomey (R-Pa.) released the following statement after being informed by the family of Sarah’s good news: “I am deeply grateful to the organ donor and his or her family for the potentially life-saving gift to Sarah. Now that a suitable donor has been found, a prayer would help, too - a prayer Sarah's body accepts the new organ the way doctors believe it can. The judge gave Sarah a chance to receive a new lung. &#160;Now the surgical team at CHOP is giving her a chance at life.” &#160; Sarah has been in desperate need of a lung transplant for the past 18 months. &#160;She has been hospitalized at Children’s Hospital of Philadelphia for the past three months, where she has been on a ventilator. Under the current guidelines for organ donation, children under the age of 12 must wait for pediatric lungs to become available. &#160;Adult lungs cannot be offered to children under 12, until they are offered to adults and adolescents first. &#160; The Murnaghans have been in the midst of a legal battle over the established rules for organ donation after they filed a lawsuit last week to have the guidelines changed, arguing the rule keeping Sarah off the list was “discriminatory.” A federal court judge granted a temporary order on June 5 that allowed Sarah to join an adult organ transplant list. It is not yet clear whether Sarah’s donor is an adult or a child. Judge Michael Baylson made his ruling after hearing oral arguments on the case and had scheduled a preliminary injunction hearing for June 14. Baylson's order told Department of Health and Human Services (HHS) Secretary Kathleen Sebelius to direct the group that manages the organ transplant list to cease application of it in Sarah's case. Secretary Sebelius declined to intervene in the case early last week, despite urgent pleas from several members of Congress from Pennsylvania. Sebelius said that such decisions should be made by medical experts and noted that there were three other children at Children's Hospital alone in the same condition. Over the weekend, Sarah's condition worsened, and she was intubated on Saturday after she experienced additional trouble breathing. The Associated Press contributed to this report.source : http://www.foxnews.com/health/2013/06/12/girl-dying-cystic-fibrosis-to-receive-lung-transplant-today/
I told you so - the government is bamboozling us about Plan B. The Obama administration announced on Monday that it will now allow girls and women of all ages to purchase the Plan B pill without a prescription. This is exactly what I have been warning the American public about. I am now totally convinced that our current federal government loves confusion. When you have a single agenda, and many ways to spin it, the American public never gets a clear answer and that is exactly what has happened with the Plan B emergency contraception controversy. Just last week, a U.S. appeals court ruled that the U.S. Food and Drug Administration (FDA) must make only certain forms of the emergency contraception pill available to children of all ages, without a prescription.&#160; In a confusing ruling, the court stated that while the two-pill version of emergency contraception could be sold over-the-counter to women of all ages, the one-pill version would still only be sold to women age 17 or older. The court did not explain its reasoning. One has to remember that the FDA first approved this form of over-the-counter contraception for women of all ages back in 2011. When that initial FDA ruling came out, there was a loud public outcry and restrictions were quickly put in place barring women under the age of 17 from purchasing these pills. But of course, that was just one spin on the story. In April, a New York judge ruled that restricting access to Plan B was inappropriate, forcing the FDA to reconsider their initial finding that emergency contraception should be available to children of all ages. And then, we got another spin on the story, as the FDA tried to lower the age limit for access to emergency contraception to 15 last month. There was another outcry and more criticism, because we know perfectly well that a 15-year-old may not have a clear understanding of how to utilize emergency contraception. Now, we see that the FDA will get to do what they wanted to do in the first place. How convenient. So, what’s the message here?
I am now totally convinced that our current federal government loves confusion. When you have a single agenda, and many ways to spin it, the American public never gets a clear answer and that is exactly what has happened with the Plan B emergency contraception controversy. A U.S. appeals court ruled on Wednesday that the U.S. Food and Drug Administration (FDA) must make certain forms of the emergency contraception pill available to children of all ages, without a prescription. This is exactly what I have been warning the American public about. One has to remember that the FDA first approved this form of over-the-counter contraception for women of all ages back in 2011. When that initial FDA ruling came out, there was a loud public outcry and restrictions were quickly put in place barring women under the age of 17 from purchasing these pills. But of course, that was just one spin on the story. In April, a New York judge ruled that restricting access to Plan B was inappropriate, forcing the FDA to reconsider their initial finding that emergency contraception should be available to children of all ages. And then, we got a third spin on the story, as the FDA tried to lower the age limit for access to emergency contraception to15 in May. There was another outcry and more criticism, because we know perfectly well that a 15-year-old may not have a clear understanding of how to utilize emergency contraception. Now, we see that an appeals court is forcing the FDA to do what they wanted to do in the first place. How convenient. And the final ruling is still unclear, after the court decided on Wednesday that while the two-pill version of emergency contraception can now be sold over-the-counter to women of all ages, the one-pill version will still only be sold to women age 17 or older. The court did not explain its reasoning. While there is still a lot of confusion about the ruling, it seems as though the FDA will ultimately get its way. So, what’s the message here?
The next time you want a drink of water, instead of going to the faucet or the refrigerator dispenser, try looking in your crisper drawer. Unless you’re a bachelor with nothing in the drawer but a dried out apple and a wilted lettuce leaf, I’m betting you’ve got the secret to delicious tasting water right there in your refrigerator. I’m sure you’ve heard a thousand times that you need to drink more water. &#160;So I’m not going to tell you again. I’m just going to ask one question. &#160; Why aren’t you doing it? Your body needs water to be healthy. Your skin will feel softer, and you will look younger if you drink more water. Soda, coffee and tea and all those other chemical-filled drinks just aren’t giving your body the water it craves. &#160; As a health advocate, I have to tell you that you need to try harder to find water that you like to drink – and that’s where your crisper drawer comes in. You can make a huge variety of delicious flavored waters just by adding some of your favorite fruits, vegetables or herbs. &#160;I got my inspiration from the website 52 Kitchen Adventures. The author lists 50 of her favorite flavor combinations, including things like lemon and lavender, watermelon and mint, cucumber and lime or papaya and mango. &#160;It’s easy to do. &#160;Just wash your produce carefully, cut it up and add it to your water. &#160;If you use herbs, rub the fresh leaves between your hands to bruise them before adding them to the water. Depending on what you include, you may want to pour it through a filter to remove the small particles before you drink it. A fine mesh strainer for loose tea or a paper coffee filter will work great for this. Try out different flavors by making one glass at a time or mix up a whole pitcher and you’ll be set for the day. If you just can’t wait to try it, you can drink it as soon as you put it all together. But to get the most flavor, you’ll want to let it sit in the refrigerator for a couple of hours. Just remember, this is fresh produce, so if you leave the fruit in the water for more than a day or two, the water may change color and start to taste bitter. &#160;That’s a good sign it’s time to dump that batch and start over. My best suggestion is to mix up as much as you think you can drink in 24 hours. &#160;If you get to the end of the day and have some left over, strain out the fruit and freeze it into ice cubes for tomorrow. If you want to jump-start a cold pitcher of water, try using frozen mixed fruit or berries. &#160;That way the fruit will flavor and chill the water at the same time. &#160; This can also be a great way to get your kids started on a healthier path. &#160;Let them choose their favorite fruit for their own special blend, or hold a family contest to see who can come up with the best flavor. &#160;If you have the space, let everyone create their own mix then judge which flavor was the family favorite by seeing which flavor is gone first. Even if the kids guzzle their own creations to win, you’ll know they are drinking the healthy water they need to stay hydrated. And hopefully you’ll all be forming a water-drinking habit that will last for the rest of your lives. So what’s your favorite way to flavor your water? &#160;Visit EmpowHER to share your ideas under the “wellness” category.Michelle King Robson (pronounced robe-son) is one of the nation's leading women's health and wellness advocates. She is the Founder, Chairperson and CEO of EmpowHER, one of the fastest-growing and largest social health companies dedicated exclusively to women's health and wellness. & In 2011 EmpowHER reached more than 60 million women onsite and through syndication expects to reach more than 250 million in 2012.source : http://www.foxnews.com/health/2013/06/03/tired-water-mix-your-own-fresh-flavors/
Two paralyzed British men who want to die but cannot kill themselves went to court on Monday seeking protection from prosecution for those who could help them end their lives. The case is one of the most high-profile attempts to change the law on the right to die in Britain, where assisted suicide is illegal. “I'm constantly thinking, 'how on Earth can I do it without getting someone into trouble?'” said Paul Lamb, who was left paralyzed by a car accident in 1990. “I just want my wishes to be respected, that's all I want,” Lamb, 57, told reporters outside the courtroom. He is immobile except for limited movement in his right hand, requires 24-hour care and is constantly on morphine to relieve pain. Judge Igor Judge, speaking at the start of the hearing in the Court of Appeal, said he was aware of the men's “desperate situation” and he was sympathetic. “But they must surely know that we cannot decide this case as a matter of personal sympathy. We have to decide it as a point of law.” Lamb was in court in his wheelchair as the judge spoke. The other man, named only as Martin, is a 48-year-old who was left unable to speak or move after a stroke four years ago. He can communicate only through movements of the head and eyes. “It is their experience that their life has become unbearable,” said Paul Bowen, a lawyer representing Lamb. Law “inadequate” The details of the two men's cases are different, but in essence both are seeking help from the courts in ensuring that anyone who helps them to die will not be prosecuted. Bowen cited a report to parliament last year that concluded that British law in the area of assisted dying was “inadequate, incoherent and should not continue”. The issue of whether or not to decriminalize assisted suicide for people whose lives are unbearable to them is a matter of debate in many countries. Right-to-die advocates say people capable of making that decision should be allowed to die with dignity. Opponents say liberalizing the law could leave vulnerable people at risk. Switzerland and the U.S. states of Oregon, Washington and Montana are among places where some forms of euthanasia or assisted suicide are legal under certain circumstances. By coincidence, Monday's court hearing started two days before a bill is due to be presented to the British parliament that would legalize assisted suicide in certain circumstances. But Bowen said that even if that bill were to become law at some point, it would not be enough for Lamb. Lamb's case was originally brought by a man with locked-in syndrome, Tony Nicklinson. A court dismissed both Nicklinson's and Martin's cases last August on the grounds that it was for parliament and not for a court to change the law in this area. After being told the court's decision on August 14, Nicklinson refused food and medication and died on August 22. Lamb, who was not involved at that stage, has since been allowed to take up the legal battle where Nicklinson left off.source : http://www.foxnews.com/health/2013/05/13/paralyzed-british-men-fight-right-to-die-case-in-court/