Tag Archives: medicine

Scotland researchers look to develop synthetic blood

Researchers in Scotland have been given a license by the Medicines and Healthcare Products Regulatory Agency (MHRA) to manufacture blood out of stem cells – essentially creating synthetic blood, BBC News reported. If their endeavor proves successful, they hope to move on to clinical trials, testing the blood in people.  According to BBC News, the regular use of synthetic blood could put an end to blood supply shortages and help people avoid infections contracted through donated blood. “Attaining these licenses has been a key goal for the Scottish Center for Regenerative Medicine, and we are delighted to have reached this important milestone,” said Janet Downie, chief operating officer at Roslin Cells, where the research is being conducted. Conducting clinical trials in humans would require another license from MHRA, along with other regulatory agencies. Click for more from BBC News.source : http://www.foxnews.com/health/2013/05/31/scotland-researchers-look-to-develop-synthetic-blood/

Medical marijuana for your pet?

More people are using medical marijuana to treat pets for a variety of conditions, ranging from separation anxiety and noise phobia to cancer, according to the Journal of the American Veterinary Medical Association (JAVMA) News. Now, as more states begin to legalize the drug for humans, veterinarians and pet owners are calling for more research into the use and safety of the drug in pets. After using medical marijuana to treat his own chronic back pain, Enest Misko, a 77-year-old from Chatsworth, Calif., decided to use a form of the drug to treat his pet cat, Borzo, who was having difficulty walking. Misko gave the cat a glycerin tincture of marijuana made for pets, and within a few days of taking the drug, Misko said the cat appeared to be pain-free. The drug can be found in licensed medical marijuana dispensaries in Los Angeles. “I don’t get high from (marijuana), but the pain goes away. So I tried it on my cat, my 24-year-old cat, who’s feeling better,” Misko told the JAVMA News. Within the past few years, veterinarians have noticed an uptick in people claiming to use medical marijuana treatments for their pets and some have even begun to experiment with it on their own pets.  Dr. Douglas Kramer, a veterinarian in Los Angeles, Calif., who runs a mobile office focused on pain management and palliative care for pets, noted that approximately 300 people have told him they’ve treated their pets with medical marijuana since 2011. Kramer became intrigued by the drug’s potential when his Siberian husky, Nikita, was diagnosed with terminal cancer. “Nikita was wasting away, and she’d stopped eating,” he told JAVMA News. “I’d exhausted every available pharmaceutical pain option, even steroids. At that point, it was a quality of life issue, and I felt like I’d try anything to ease her suffering.” After Kramer began feeding Nikita small amounts of marijuana, the dog’s appetite returned, and she rested more comfortably during her final months. Based on his own reviews of medical marijuana research, Kramer believes the drug may be suitable for use in veterinary patients and that it deserves more attention from the veterinary research community. “I don’t want to come across as being overly in favor of giving marijuana to pets,” Kramer told JAVMA News. “My position is the same as the (American Medical Association’s position). We need to investigate marijuana further to determine whether the case reports I’m hearing are true or whether there’s a placebo effect at work. We also need to know what the risks are.” Other veterinarians note that medical marijuana has the potential to be used in pet treatments but agree that more research needs to be done. Dr. Dawn Boothe, director of the Clinical Pharmacology Laboratory at Auburn University’s College of Veterinary Medicine, said it wouldn’t surprise her to see FDA-approved drugs made from cannabinoid derivatives being used in pets one day. “My gut reaction is they do probably provide some therapeutic effect benefit,” said Boothe. “But, I’m never going to say there’s enough benefit that marijuana should be given to pets. I’m saying there’s enough justification that we need to study it.” Click for more from the JAVMA News.source : http://www.foxnews.com/health/2013/05/31/medical-marijuana-for-your-pet/

Quit-smoking treatments safe, effective, review says

Popular smoking cessation treatments - such as nicotine replacements and antidepressants - improve people's chances of kicking the habit without much risk, according to a review of past research. “It seems very clear that medications can help. They're not the magic bullet but you do improve your chances of quitting - generally - if you try them. And as far as we can tell, they're safe to use,” said Kate Cahill, who led the study. Several reviews have looked at the effectiveness of smoking cessation treatments, but the researchers wanted to put those results into a single large review to help people who want to use medical treatments to stop smoking, Cahill, a senior researcher for the Cochrane Tobacco Addiction Group at the University of Oxford, UK, said. About one fifth of the U.S. and UK populations are current smokers, according to the researchers. Previous studies have found between 70 percent and 75 percent want to quit, but only about 3 percent accomplish that every year. For the new study, the researchers pulled data from 12 reviews published by the Cochrane Collaboration, an international research organization that evaluates medical evidence. Those analyses, which were conducted between 2008 and 2012, included data from 267 studies of more than 101,000 smokers. The studies typically compared smokers trying to quit without the help of a smoking cessation treatment to smokers using nicotine replacement therapies, such as nicotine gum and patches, or prescription drugs. The medications include varenicline (marketed by Pfizer as Chantix or Champix) and bupropion (marketed by GlaxoSmithKline as Zyban or Wellbutrin, but available as a generic). The researchers found that the nicotine replacement therapies and the antidepressant bupropion led about eighteen people to successfully give up smoking for every 10 people who quit without treatments. Varenicline performed even better and led to about 28 people quitting for every 10 who did so without medication. What's more, Cahill and her colleagues found that lesser-known smoking cessation treatments were also effective. Those include the antidepressant nortriptyline and cytisine, a plant-derived supplement available in Eastern Europe. All of the treatments also appeared to be reasonably safe, according to the researchers who published their results on Thursday in The Cochrane Library. Previous reports have found that about 1 in every 1,000 people taking bupropion has a seizure, but the researchers found a lower rate of 1 in 1,500. Also, despite conflicting reports over the safety of varenicline, the researchers didn't find evidence that the drug increased the risk of neuropsychiatric or heart problems. Judith Prochaska, who researches tobacco treatment but was not involved in the new study, said not all smokers will use smoking cessation tools but it's important for them to know they're available. Nicotine replacement therapy is available over the counter in the U.S. and varenicline and bupropion are available with a prescription for about $4 per day - less than a pack of cigarettes, said Prochaska, associate professor of medicine at the Stanford Prevention Research Center in California. “They have been shown to pretty much double the likelihood that somebody will quit,” she added. Cahill cautioned, however, that smoking cessation tools won't work for everyone, but “they certainly help some people.”source : http://www.foxnews.com/health/2013/05/31/quit-smoking-treatments-safe-effective-review-says/

Could shedding extra pounds improve psoriasis?

Losing weight may ease psoriasis and improve quality of life for some overweight people with the chronic skin disease, new research from Denmark suggests. But the trial may have been too small to fully flesh out that link, and researchers said future studies will have to follow larger groups of patients for more time to make definitive conclusions. “The results, I would say, are promising,” said Dr. Joel Gelfand, a dermatologist from the University of Pennsylvania Perelman School of Medicine in Philadelphia. “It's still excellent advice to patients who are overweight with psoriasis to lose weight.” According to the National Institutes of Health, more than three percent of U.S. adults have psoriasis, which is characterized by itchy, painful plaques on the skin. Over the years, researchers have learned that obese people are more likely to develop psoriasis than their thinner peers and tend to have more severe disease. That could be due to more body-wide inflammation among people carrying around extra fat. “It's more than one thing that causes it, but obesity is probably one of the factors that can bring on psoriasis,” Gelfand, who wasn't involved in the new study, told Reuters Health. Genetics also plays a role. Conversely, Gelfand said there's been some suggestion that losing weight may ease psoriasis symptoms, based on reports of people who had bariatric surgery and saw their skin condition improve. For the new study, researchers led by Dr. Peter Jensen from Copenhagen University Hospital Gentofte wanted to shed more light on how weight loss influences psoriasis. They randomly assigned 30 overweight and obese people with psoriasis to go on a 4-month weight-loss diet of 800 to 1,200 calories per day and another 30 to stick to typical nutrition guidelines. By the end of the study, participants in the diet group had lost an average of 35 pounds, on average, compared to just one pound in the non-diet group. Dieters had a borderline larger improvement in their psoriasis severity and the amount of their body covered by psoriasis plaques. They started the study with an average severity score of 4.8, on a scale of 0 to 72. By 4 months, that had fallen to 2.5. Non-dieters saw only a slight drop in their psoriasis cover and severity, from 5.5 to 5.2. People in the weight-loss group also reported greater improvements in their quality of life during the study period, Jensen and his colleagues wrote Wednesday in JAMA Dermatology. The diet was tied to some mild side effects, including headaches and dizziness. One patient complained of being hungry throughout the study, the researchers reported, and another “consumed large amounts of sugar-free licorice, resulting in hypokalemia (low potassium) that normalized after he was instructed to stop eating licorice.” Gelfand said that because patients started out with mild to moderate psoriasis, they didn't have much room to improve when they lost weight. That, combined with the small group size, limits some of the conclusions that can be taken from the study. “The next step would be to do a much larger study in patients who have more severe psoriasis,” Gelfand said. In the meantime, he said weight loss can have other benefits for heavy people with psoriasis, such as improving how they respond to some medications and lowering their risk of heart disease.source : http://www.foxnews.com/health/2013/05/31/could-shedding-extra-pounds-improve-psoriasis/

Biologists take snapshot of fleeting protein process

The biological "freeze-frame" shows the initial step in the formation of actin, a sturdy strand-like filament that is vital for humans. Actin filaments help cells maintain their shape. The filaments, which are called F-actin, also play key roles in muscle contraction, cell division and other critical processes. "One of the major distinctions between cancerous cells and healthy cells is their shape," said study co-author Jianpeng Ma, professor of bioengineering at Rice and the Lodwick T. …

Decontaminating patients cuts hospital infections dramatically

Infections in U.S. hospitals kill tens of thousands of people each year, and many institutions fight back by screening new patients to see if they carry a dangerous germ, and isolating those who do. But a big study suggests a far more effective approach: Decontaminating every patient in intensive care. Washing everyone with antiseptic wipes and giving them antibiotic nose ointment reduced bloodstream infections dramatically in the study at more than 40 U.S. hospitals. The practice could prove controversial, because it would involve even uninfected patients and because experts say it could lead to germs becoming more resistant to antibiotics. But it worked better than screening methods, now required in nine states. The study found that 54 patients would need to be decontaminated to prevent one bloodstream infection. Nevertheless, the findings are “very dramatic” and will lead to changes in practice and probably new laws, said Dr. William Schaffner, a Vanderbilt University infectious-disease specialist who was not involved in the research. Some hospitals are already on board. The study targeted ICU patients, who tend to be older, sicker, weaker and most likely to be infected with dangerous bacteria, including drug-resistant staph germs. The decontamination method worked like this: For up to five days, 26,000 ICU patients got a nose swab twice a day with bacteria-fighting ointment, plus once-daily bathing with antiseptic wipes. Afterward, they were more than 40 percent less likely to get a bloodstream infection of any type than patients who had been screened and isolated for a dangerous germ called MRSA, or methicillin-resistant Staphylococcus aureus. In the year before the experiment began, there were 950 bloodstream infections in intensive care patients at the hospitals studied. The results suggest that more than 400 of those could have been prevented if all hospitals had used the decontamination method. “We've definitively shown that it is better to target high-risk people,” not high-risk germs, said lead author Dr. Susan Huang, a researcher and infectious-disease specialist at the University of California, Irvine. The hospitals in the study are all part of the Hospital Corporation of America system, the nation's largest hospital chain. HCA spokesman Ed Fishbough said the 162-hospital company is adopting universal ICU decontamination. The study was published online Wednesday in the New England Journal of Medicine. The study focused on the MRSA germ. It can live on the skin or in the nose without causing symptoms but can be life-threatening when it reaches the bloodstream or vital organs. It is especially dangerous because it is resistant to many antibiotics. More than 70,000 ICU patients were randomly selected to get one of three treatments: MRSA screening and isolation; screening, isolation and decontamination of MRSA carriers only; and universal decontamination without screening. Partial decontamination worked better than just screening, and universal decontamination was best. About a decade ago, hospital-linked invasive MRSA infections sickened more than 90,000 people nationwide each year, leading to roughly 20,000 deaths. As hospitals improved cleanliness through such measures as better hand-washing and isolating carriers of deadly germs, those numbers dropped by about a third, with fewer than 10,000 deaths in 2011, according to the Centers for Disease Control and Prevention. The CDC has been recommending screening and isolation in certain cases. Now it's having experts review the results and help determine whether the agency should revise its recommendations, said the CDC's Dr. John Jernigan. “It is a very important finding. It advances our understanding of how best to control infections caused by MRSA” and other germs, Jernigan said. The CDC and the federal Agency for Healthcare Research and Quality helped pay for the study. Dr. Carolyn Clancy, who heads the research agency, said the findings have “the potential to influence clinical practice significantly and create a safer environment where patients can heal without harm.” Jernigan said the decontamination approach is much simpler than screening and isolation. But he said its costs need to be studied. Huang said the five-day nose treatment costs about $35 for brand-name ointment but only $4 for a generic version. The antiseptic wipes cost only about $3 to $5 more per day than usual washing methods, she said. But those costs might be offset by other savings from avoiding widespread screening and isolation, she said. Intensive care patients are already routinely bathed. The study just swapped soap with wipes containing a common antiseptic. Some study authors have received fees from makers of antiseptic wipes or have done research or unpaid consulting for those companies. The nose ointment treatment is more controversial because it could cause more germs to become resistant to the antibiotic, Jernigan said. “That's something we're going to have to very closely monitor if this practice is implemented widely,” he said. An editorial accompanying the study voices similar concerns and notes that research published earlier this year found that using just antiseptic wipes on ICU patients reduced bloodstream infections. Two infection control specialists at Virginia Commonwealth University wrote the editorial. Editorial co-author Dr. Michael Edmond said his university's hospital is among those that already use antiseptic wipes on ICU patients. While MRSA screening and isolation is widely accepted, Edmond said that approach “takes a toll on patients.” Isolating patients who test positive for MRSA but don't have symptoms makes patients angry and depressed, and studies have shown that isolated patients are visited less often by nurses and tend to have more bedsores and falls, he said.source : http://www.foxnews.com/health/2013/05/30/decontaminating-patients-cuts-hospital-infections/

New possibilities for prostate cancer treatment revealed

Published today in Science Translational Medicine, a study led by Monash University researchers has found prostate cancer cells that survive androgen withdrawal treatment. Previously unidentified, these cells are potential targets for future treatments. As they are present early in disease development, there is the possibility of therapy before the cancer reaches the aggressive, incurable stage. Prostate cancer is the most common form of cancer in men, with around 20,000 new cases diagnosed each year in Australia…

Kidney stones: Symptoms and treatment

Chances are you or someone you know has had a kidney stone at some point in their life; they are very common, affecting approximately one in ten people throughout their lifetime.  The risk of kidney stones is higher in the United States than the rest of the world and this number has only been increasing over the past two to three decades.  Despite the high incidence in the U.S., however, this is a condition that affects people worldwide and has done so for millennia; bladder and kidney stones have even been found in Egyptian mummies. Kidney stones are small, hard deposits, typically composed of mineral and acid salts, that form inside your kidneys.  As one might expect, because urine is a vehicle for waste excretion, it is comprised of numerous chemicals and wastes (including calcium, oxalate, urate, cysteine, xanthine and phosphate).  When the urine is too concentrated, that is too little liquid and too much waste, crystals will begin to form.  Over time, these crystals can join together and form a larger stone-like solid.   There is no single cause for kidney stones and often, the cause is unknown.  There are, however, different types of kidney stones, which can help pinpoint the origin.  Calcium stones (in the form of calcium oxalate or calcium phosphate), for example, are the most common form of kidney stone.  Oxalate is a naturally occurring substance in food, so anything that increases levels of this compound, can increase the risk of a kidney stone.  Uric acid stones often form in people who do not consume enough fluids, eat high protein diets or have gout.  Struvite stones often form as the result of a kidney infection.   Treatment for kidney stones primarily depends on the size of the stone.  If it is smaller than four millimeters in diameter, you have a good chance of passing it spontaneously. Consuming two to three quarts of water a day and using a pain reliever can help pass these small stones.  Larger stones may require invasive treatment including: surgery, using a scope passed through the urethra or shock-wave lithotripsy, where high-energy sound waves break up the stone in to more easily passable stones. Risk factors for developing kidney stones include: being over age 40, being male, ingesting too little water, too much/little exercise, obesity, weight loss surgery, digestive diseases, and consuming a diet high in salt, protein or sugar, especially fructose.  Having a family history of kidney stones can also increase your risk of developing them; furthermore, if you have already experienced kidney stones, you are at an increased risk of developing more.   Prevention of kidney stones can be as simple as a few dietary changes.  Consuming more water during the day is one of the easiest measures you can take.  Doctors recommend excreting about 2.6 quarts of urine every day.  Depending on the severity of your kidney stones, you may want to measure and monitor your urine excretion.  Consume fewer oxalate-rich foods, especially if you tend to form calcium oxalate stones.  Such foods include chocolate, soy products, okra, beets, sweet potatoes, tea and nuts.  Consume foods low in salt and animal protein.  Speak with your doctor about your calcium intake via food and supplements before making any changes here.  Furthermore, speak with your doctor about the possibility of prescription drugs to help with your kidney stones.  Dr. David B. Samadi is the Vice Chairman of the Department of Urology and Chief of Robotics and Minimally Invasive Surgery at the Mount Sinai School of Medicine in New York City. He is a board-certified urologist, specializing in the diagnosis and treatment of urological disease, with a focus on robotic prostate cancer treatments. To learn more please visit his websites RoboticOncology.com and SMART-surgery.com. Find Dr. Samadi on Facebook.source : http://www.foxnews.com/health/2013/05/29/kidney-stones-symptoms-and-treatment/

Cholesterol sets off chaotic blood vessel growth

The work, led by Yury Miller, MD, PhD, associate professor of medicine at UC San Diego, will be published in the advance online edition of the journal Nature on May 29. Cholesterol is a structural component of the cell and is indispensable for normal cellular function, although its excess often leads to abnormal proliferation, migration, inflammatory responses or cell death. The researchers studied how the removal of cholesterol from endothelial cells (cells that line the blood vessels) impacts the development of new blood vessels, the process called angiogenesis. According to Miller, removal of excess cholesterol from endothelial cells is essential for restraining excessive growth of blood vessels. …

‘Junk DNA’ plays active role in cancer progression, researchers find

The researchers, led by Dr Cristina Tufarelli, in the School of Graduate Entry Medicine and Health Sciences, discovered that the presence of this faulty genetic element — known as chimeric transcript LCT13 — is associated with the switching off of a known tumour suppressor gene (known as TFPI-2) whose expression is required to prevent cancer invasion and metastasis. …