Tag Archives: major

Aspirin may fight cancer by slowing DNA damage

"Aspirin and other non-steroidal anti-inflammatory drugs, which are commonly available and cost-effective medications, may exert cancer-preventing effects by lowering mutation rates," said Carlo Maley, PhD, a member of the UCSF Helen Diller Family Comprehensive Cancer Center, and an expert on how cancers evolve in the body over time. In the study, published June 13 in the online journal PLOS Genetics, Maley, working with gastroenterologist and geneticist Brian Reid, MD, PhD, of the Fred Hutchinson Cancer Research Center, analyzed biopsy samples from 13 patients with a pre-cancerous condition called Barrett’s esophagus who were tracked for six to 19 years. In an "observational crossover" study design, some patients started out taking daily aspirin for several years, and then stopped, while others started taking aspirin for the first time during observation…

After successful lung transplant, challenging recovery awaits girl with cystic fibrosis

Sarah Murnaghan, the 10-year-old Pennsylvania girl at the middle of an organ transplant battle, finally underwent her long-awaited lung transplant on Wednesday. I am so happy that this little girl got a new chance at life.  All of us who have been following this case so closely realize just how critical this child has been for the future of organ transplantation. On Tuesday night, Sarah’s mother, Janet, said they had found a match for her daughter.  And with the great skill of her surgeons and nurses, along with the support of everyone involved in her care, the technical part of her surgery has been successful.   Throughout this whole ordeal, I never lost hope that Sarah would become a candidate for transplant surgery. And I think it speaks volumes about the spirit of the American people who stood behind her and demanded she get a fair shot at life. But the doctor in me tells me we have to be cautiously optimistic because there are still major hurdles that Sarah has to overcome. From a medical standpoint, in cases like this one, there is always the worry about infection.  Organ transplants require large complex surgeries with organs that are very prone to infection – especially the lungs.  And moving forward, Sarah has to undergo immunosuppressive therapy, which predisposes her to the development of infection. There are also significant issues of metabolism.  The function of the lungs is to oxygenate the blood, but this oxygenation contributes to the overall metabolic stability of the body.  Right now, it’s too soon to tell whether her metabolic condition can be stabilized through these new lungs. Finally, with any organ transplant surgery, you also have the possibility of organ rejection, which could theoretically develop over the course of the next few days.  The good news is that she is young, and she is receiving the best health care possible.   I spoke to Dr. Donald McCain, chief of surgical oncology and the vice chairman of the John Theurer Cancer Center at Hackensack University Medical Center in N.J., about other potential obstacles Sarah faces.  He noted that because the donor was an adult, resizing the lungs may also create medical issues. “The size of the lungs are much too great, which is why they don’t use adult lungs in general (for pediatric patients),” McCain said.  “They must remove part of lung tissue, and…you have to do that surgically, creating a surgical line that didn’t exist before.  That surgical line normally will not have the same strength as obviously a non-surgical line.  That creates a potential weak point that is risky for an air leak.” McCain also added that even if Sarah overcomes these hurdles, there is a long road of recovery ahead. “Lung transplants are some of the sickest patients you wind up having, unlike liver and kidney transplant patients, who usually do quite well,” McCain said.  “With lung transplants, these patients are in the hospital a very long time and are usually very sick.” To me, the aggravating part of this story is that this sweet girl only got her chance at life at the last minute.  Had she been placed on the adult organ transplant list earlier, perhaps her condition would have been a little bit stronger when she received her new lungs. But I’m still very optimistic that Sarah will have a good recovery. It saddens me that it finally took a judge to see the common sense and force HHS Secretary Kathleen Sebelius into doing the right thing.  I just hope that other children under similar circumstances get the justice they deserve in enough time.source : http://www.foxnews.com/health/2013/06/13/after-successful-lung-transplant-challenging-recovery-awaits-girl-with-cystic/

Restless legs syndrome linked to higher risk of early death

Men who suffer from restless legs syndrome may not live as long as those without the condition, according to a new study. The study found that men with restless legs syndrome (RLS) were nearly 40 percent more likely to die over the eight-year study, compared to men without RLS. When the researchers excluded from their analysis men with major chronic conditions such as cancer, heart disease and high blood pressure, those with RLS were 92 percent more likely to die over the study period. “The results of this study indicate that men with RLS had a higher overall mortality,” the researchers wrote in their study. However, the study shows an association, not a cause-and-effect link between having RLSand an increased risk of dying, and the researchers said that it is not known how RLS might increase the mortality risk. In the study, deaths among men with RLS were frequently due to respiratory disease, endocrine disease, metabolic disease and immunologic disorders. Further research is needed to understand the relationship between these diseases and RLS, the researchers said. RLS is a bothersome chronic condition that affects 5 to 10 percent of adults. Patients have an irresistible urge to move the legs, and often experience burning and creeping sensations that are described as “an itch you can't scratch,” or “like insects crawling inside the legs.” In the study, researchers looked at 18,425 men, whose average age was 67, including 700 who were diagnosed with RLS. During an eight-year follow-up, 2,765 of the men died. Among the men with RLS, 25 percent died during the study, compared with 15 percent of those who did not have RLS. The researchers also found that men with RLS were more likely to use antidepressant drugs, had more insomnia complaints, and were more likely to have high blood pressure, cardiovascular disease and Parkinson's disease. However, controlling for these factors didn't change the results, they said. The link between RLS and higher risk of death was not related to other common risk factors such as smoking, older age, low physical activity and lack of sleep. Moreover, men who had conditions such as high blood pressure, cancer or insomnia, had a further increased risk of death if they had RLS too, according to the study. The study was published online June 12 in the journal Neurology. Some of the researchers who worked on the study have received money from pharmaceutical companies that make drugs used to treat restless legs syndrome. “Increasing awareness of RLS, especially training for health professions, should be encouraged if our findings are confirmed by future studies,” the researchers said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/restless-legs-syndrome-linked-to-higher-risk-early-death/

Significant under-use of genetic testing for inherited cancers puts health of entire families at risk

"Given that such testing can provide many options to enable individuals to manage their cancer risk, it is vital to encourage awareness and acceptance among both the public and medical professionals," he will say. "For example, removal of the ovaries in women over 40 years old who carry a BRCA mutation decreases their overall cancer mortality by 20% and prophylactic mastectomy can reduce the chances of breast cancer in women carrying such a mutation by around 90%…

FDA panel votes to relax Avandia restrictions

U.S. health advisers voted on Thursday to recommend relaxing market restrictions on GlaxoSmithKline's diabetes drug Avandia, the former blockbuster at the center of one of the biggest drug controversies in recent years. The vote, by a divided Food and Drug Administration advisory committee of outside health experts, could modestly enlarge the market for Avandia in the United States and lay the groundwork for further research into the drug's health risks. FDA will now take the vote into consideration for a final decision on how the pill also known by the generic name rosiglitazone can be used. The committee did not consider a specific change in protocol. But 13 experts on the 26-member panel who backed modification said current restrictions that require prescribing physicians and pharmacists to be certified should be relaxed or eliminated after a reexamination of Glaxo safety data settled longstanding concerns about the danger of death from cardiovascular disease. “In general, this drug doesn't look any different than any other diabetes drug,” said Dr. William Hiatt, a cardiologist from the University of Colorado, who was among seven experts who backed lifting restrictions altogether. Five committee members favored keeping the current sales restrictions, while one voted to withdraw Avandia from the market altogether. Glaxo, which no longer plans to promote Avandia, issued a statement saying the company would work with FDA as it considers its decision. “We continue to believe that Avandia is a safe and effective treatment option for type 2 diabetes when used for the appropriate patient and in accordance with labeling,” Dr. James Shannon, Glaxo's chief medical officer, said in a statement. The British drugmaker's stock closed nearly 1.5 percent lower in London trading before the committee voted. Avandia was once the world's best-selling treatment for type 2 diabetes, with annual sales of $3.2 billion. In 2010 its use in the United States was heavily restricted and it was withdrawn from the market in Europe because of the possibility of increased risk of heart attack and stroke. Only 3,000 people in the United States take it today, down from about 120,000 just before the restrictions were put in place. Much of the advisory committee's two-day meeting focused on a Duke University reexamination of a Glaxo safety study known as Record that confirmed initial findings of no significant increased heart risk from the drug. That reassured some experts that earlier concerns with the quality of the research had been unwarranted and encouraged support for the restrictive protocols, while retaining continued guidance on potential dangers for patients and care providers. A departing train But others said the original data was incomplete and compiled through a flawed study design, while other research pointed to the possibility of significant increased risk of cardiovascular death. “When you look at the overall totality of evidence, it is not sufficient enough to either implicate or exonerate rosiglitazone versus cardiovascular risk,” said advisory panel member Dr. Sanjay Kaul of the Cedars-Sinai Heart Institute. Several committee members endorsed suggestions for a major new clinical trial to determine precisely the drug's risks in the face of a growing worldwide diabetes threat. But other experts concluded that years of negative publicity made funding major research unfeasible except for new diabetes treatments now in the pharmaceutical pipeline. “The train has left the station,” said Gerald van Belle, director of the Clinical Trials Center at the University of Washington. Experts including the advisory committee's chairman, Dr. Kenneth Burman of the Washington Hospital Center, favored the creation of a registry to monitor the health of patients who currently take the drug if major studies into safety and efficacy were not an option. Some experts view Avandia as a potential alternative to other diabetes treatments, including insulin, that could become more important as the incidence of obesity and diabetes grows, bringing with it a host of costly chronic ailments ranging from heart and kidney disease to blindness and dementia. “When treating diabetes we really do need drugs that lower blood sugar without causing hypoglycemia, and there's not a lot that's available,” Dr. Ellen Seely of Harvard Medical School. “When you're dealing with individual patients, you come up often against dead ends on what you can do. And it's important to have options,” she said. But panel members agreed the market potential for Avandia may never again be large. Glaxo has settled lawsuits filed by tens of thousands of U.S. patients who had taken Avandia and claimed Glaxo failed to inform them about safety risks. Several thousand other cases remain pending. The drugmaker last July agreed to pay $3 billion to settle what U.S. officials called the largest case of healthcare fraud in U.S. history. The agreement resolved allegations that Glaxo failed through 2007 to provide the FDA safety data on Avandia and that the company improperly marketed other drugs.source : http://www.foxnews.com/health/2013/06/07/fda-panel-votes-to-relax-avandia-restrictions/

Obesity surgery-diabetes study shows pros and cons

Obesity surgery worked much better at reducing and even reversing diabetes than medication and lifestyle changes in one of the most rigorous studies of its kind. But the researchers and others warn that possible serious complications need to be considered. The yearlong study indicates that the most common weight-loss surgery, gastric bypass, can effectively treat diabetes in patients with mild to moderate obesity - about 50 to 70 pounds overweight, the researchers reported Tuesday in the Journal of the American Medical Association. Other studies have shown the operation can reverse diabetes in severely obese patients, although sometimes the disease comes back. About a third of the 60 adults who got bypass surgery in the new study developed serious problems within a year of the operation, though some cases were not clearly linked with the surgery. That rate is similar to what's been seen in previous studies. But for the most serious complications - infections, intestinal blockages and bleeding - the rate was 6 percent, slightly higher than in earlier research. The most dangerous complication occurred in one patient when stomach contents leaked from the surgery site, leading to an overwhelming infection, leg amputation and brain injury. Lead author Dr. Sayeed Ikramuddin, an obesity surgeon at the University of Minnesota, called that case “a fluke.” A journal editorial says such devastating complications are rare, but that “the frequency and severity of complications ... is problematic” in the study and that the best way to treat patients with both obesity and diabetes “remains unknown.” A research review in the journal said more long-term evidence on risks and benefits is needed to determine if obesity surgery is an appropriate way to treat diabetes in patients who aren't severely obese - at least 100 pounds overweight. More than 20 million Americans have Type 2 diabetes; most are overweight or obese. Diabetics face increased risks for heart disease and strokes, and poorly controlled diabetes can damage the kidneys, eyes and blood vessels. About 160,000 people nationwide undergo various types of obesity surgery each year. Bypass surgery, the type studied, involves stapling the stomach to create a small pouch and attaching it to a lower part of the intestines. The American Society for Metabolic & Bariatric Surgery says obesity surgery is safe and that the death rate is less than 1 percent, lower than for gallbladder and hip replacement surgery. The study involved 120 patients at five hospitals in New York, Minnesota and Taiwan. All patients got medicines for diabetes, obesity, cholesterol and/or high blood pressure. They all were advised to cut calories and increase physical activity. Sixty patients also had surgery, and the two groups were compared after one year. The surgery group lost on average nearly 60 pounds and 75 percent lowered blood sugar levels to normal or near normal levels. The non-surgery group lost an average 17 pounds and just 30 percent reached the blood-sugar goal. The surgery group also needed less medication after the operation. The researchers say the diabetes changes were likely due to the weight loss but that hormonal changes affecting blood sugar may have contributed. The surgery group showed a trend toward having less high blood pressure and elevated cholesterol - both major risk factors for heart disease, although those between-group differences could have been due to chance. Ikramuddin, the lead author, said the study results don't mean that all mildly obese diabetics should have obesity surgery, but that “in the correct patient, surgery might be an important thing to consider.”source : http://www.foxnews.com/health/2013/06/05/obesity-surgery-diabetes-study-shows-pros-and-cons/

7 ways to avoid the worst summer calorie bombs

It's officially the season of flip flops, swimsuits, and lots of summer traditions that revolve around…food! From going out for ice cream to munching on popcorn while taking in a blockbuster film, the weeks between now and Labor Day can present some major nutritional hurdles. Here's how to sidestep seven classic calorie bombs, and seriously upgrade your health. Trade ice cream for frozen treats Many of my clients crack open a pint of ice cream, with every intention of stopping at one serving, only to wind up polishing off the whole thing. Switching to frozen yogurt shaves off some calories, but a pint can still cost you 800, twice as much as a slice of cheesecake. The swap: Nix store bought pints, and make your own novelty treats. Whip up a smoothie in the blender, pour it into popsicle molds and freeze. One cup of unsweetened almond milk, combined with one cup of frozen pitted cherries and one tablespoon each almond butter and dark chocolate chips will make four to six pops for just 280 total calories. Or whip up a batch of frozen bananas—dip mini naners into organic nonfat Greek yogurt seasoned with cinnamon or vanilla (or a plant-based alternative like coconut milk yogurt), sprinkle with oats and nuts, wrap in wax paper, and freeze. Health.com: Supercool Low-Cal Frozen Treats Lighten up your umbrella drinks A piña colada is the quintessential summer cocktail, but a 12-ounce portion packs 600 calories, the amount in an entire six pack of light beer. The swap: Rather than giving up those fun frou frou drinks, whip up your own tropical concoction. Combine a shot of rum with 4 ounces of 100 percent pineapple juice, a quarter cup of frozen banana slices, a quarter cup of unsweetened coconut milk, and a handful of ice. A refreshing, and much slimmer substitute, at just 175 calories. Reassess your sushi Old school sushi rolls, made with steamed rice, lean seafood, and veggies provide about 200 calories each, but many “new wave” sushis are loaded with creamy sauces, fatty meats, fried ingredients, and cream cheese, which can tack on at least a few hundred more. A dragon roll, for example, can pack 500 calories, more than a quarter pound burger. The swap: Ditch the white rice, which is soaked in water with sugar to make it sticky, and order appetizers and side dishes. All together, seared tuna, edamame and seaweed salad add up to less than 350 calories. Health.com: How to Order Healthy Asian Takeout Rethink your thirst quenchers There's nothing like a tall glass of ice cold lemonade on a hot summer day, but most are made from water, sweetener, and lemon flavoring (not fresh fruit), and a lot more sugar than you might think. Sixteen ounces of standard lemonade contains the equivalent of fourteen cubes of sugar, about same amount as soda, with absolutely zero vitamin C. The swap: Make your own. Just a quarter cup of fresh squeezed lemon juice provides over 50 percent of your daily vitamin C needs, a nutrient linked in research to less body fat and smaller waist measurements. For extra flavor, aroma, color, and an antioxidant boost, add sprigs of fresh mint. And if you need a little sweetener, add a splash of a pure fruit juice, rather than sugar. At just 40 calories per quarter cup, 100 percent white grape juice is a good option, but mashing a little fresh fruit in the bottom of the pitcher, like juicy strawberries (6 calories each), will also do the trick. Order your movie popcorn naked I absolutely cannot go to the movies and not get popcorn; it's one of my totally worth it splurges. Fortunately popcorn itself is actually a member of the whole grain family, an important food group most Americans fall short on, that's linked to a lower risk of heart disease, type 2 diabetes, cancer, and obesity. And because “popped corn” is fluffy, it's far lower in carbs than dense pretzels, chips, nachos, or candy. The secret to keeping it light is passing on the buttery topping. The swap: In this case, it's more of a strategy than a swap. A small order can contain 225-400 calories, but going bare (sans butter), saves 130 calories per tablespoon (about the size of your thumb, from where it bends to the tip). Health.com: Best and Worst Movie Foods Remodel your munchies Chips and dip are staples at summer get-togethers, but they're a real recipe for waistline disaster. A handful of potato chips and a golf ball sized portion of French onion dip add up to 375 calories, about as much as a medium order of fast food fries. The swap: Upgrade to hummus and veggies, and instead of pre-packaged, blend your own batch. A serving made from a half cup chickpeas, a half teaspoon of minced garlic, and tablespoon each of water, fresh squeezed lemon and extra virgin olive oil, provides less than 250 calories, but is packed with 6 grams of satisfying protein, 7 grams of filling fiber, good-for-you fat, and a spectrum of antioxidants. Scoop it up with low cal, nutrient-rich veggies, like fresh broccoli florets, grape tomatoes, and sliced cucumber. Deflate your buns Whether you grill up turkey, salmon, or black bean burgers, one of the savviest ways to slash excess calories is to get rid of the bun, especially if you'll be indulging in any other starchy sides, like potato salad. You probably won't miss it (I've never had a client who included hamburger buns on his or her can't-live-without food list), and replacing it can instantly save you 150-300 calories. The swap: Seventy five percent of Americans fail to fit in the recommended minimum three daily veggie servings, and one of the best ways to fill the gap is to wrap your protein of choice in either crisp lettuce leaves, or two grilled Portobello mushroom caps. The latter provide just 30 calories each, along with fiber, plenty of antioxidants, vitamin D, and a little bonus protein. Outer leaves of romaine, or bibb lettuce are virtually calorie free, and great sources of immune-supporting vitamin A. And while veggies may be a little messier than a bun, the nutritional trade offs are well worth the extra effort! Cynthia Sass is a registered dietitian with master's degrees in both nutrition science and public health. Frequently seen on national TV, she's Health's contributing nutrition editor, and privately counsels clients in New York, Los Angeles, and long distance. Cynthia is currently the sports nutrition consultant to the New York Rangers NHL team and the Tampa Bay Rays MLB team, and is board certified as a specialist in sports dietetics. Her latest New York Times best seller is S.A.S.S! Yourself Slim: Conquer Cravings, Drop Pounds and Lose Inches. This article originally appeared on Health.com.source : http://www.foxnews.com/health/2013/06/04/7-ways-to-avoid-worst-summer-calorie-bombs/