Tag Archives: institute

Naturally conceived quintuplets born in Czech Republic for first time

A 23-year-old Czech woman has given birth to quintuplets for the first time in the Czech Republic. Officials at Prague's Institute for the Care of Mother and Child say four boys - Deniel, Michael, Alex and Martin - and a girl - Terezka - were born by cesarean section on Sunday. Zbynek Stranak, chief doctor at the neonatal section of the institute says the birth took place “without any complications.” Stranak says that Alexandra Kinova and her five babies have been placed at an intensive care unit. He says the babies who were naturally conceived have a 95-percent chance to grow up healthy. The father was present at the birth. Kinova who is from Milovice, a town located northeast of Prague, already had a son.source : http://www.foxnews.com/health/2013/06/03/naturally-conceived-quintuplets-born-in-czech-republic-for-first-time/

Longer tamoxifen use reduces breast cancer recurrence

Breast cancer is less likely to recur if women previously treated for the disease take the drug tamoxifen for 10 years, instead of the recommended five years, according to a British study. The study was a component of a larger international trial, for which similar results were announced last year. “I think it's huge because it's the second trial to show a benefit for 10 years versus five years,” said Dr. Sandra Swain, medical director of the Cancer Institute at Washington Hospital Center and president of the American Society of Clinical Oncology, or ASCO. “It is important not only in the U.S., but for the world. It is a very inexpensive drug.” Tamoxifen, available as a low-cost generic, has long been used for younger, premenopausal, women with early-stage breast cancer that responds to estrogen. Most start taking the estrogen-blocking drug immediately after completing their initial surgery or chemotherapy. Around 70 percent of breast cancers are estrogen-receptor positive, meaning they are fueled by the hormone. ASCO guidelines now call for women at increased risk of breast cancer to take tamoxifen for five years. For postmenopausal women, the guidelines say raloxifene, an estrogen receptor modulator sold by Eli Lilly under the brand name Evista, may also be considered. The latest findings, presented at the annual ASCO meeting in Chicago this weekend, found that side effects increased with longer tamoxifen use, but concluded that overall benefits outweigh those risks. Researchers estimated that, compared with taking no tamoxifen, 10 years of the drug reduces breast cancer death rates by a third in the first 10 years and by half after that. “Until now, there have been doubts whether continuing tamoxifen beyond five years is worthwhile,” said lead study author Richard Gray, professor of medical statistics at the University of Oxford. Between 1991 and 2005, 6,953 women in the United Kingdom who had been taking tamoxifen for five years were randomly assigned to continue treatment or to stop immediately. Breast cancer recurred in 16.7 percent of the 10-year group, compared with 19.3 percent in the five-year group. Longer treatment also reduced the risk of dying from breast cancer. The women who continued tamoxifen treatment had a 25 percent lower recurrence rate and a 23 percent lower breast cancer mortality rate than the women who had been allocated to stop after only five years. The results were called “practice changing for premenopausal women with hormone receptor-positive breast cancer,” by Dr. Sylvia Adams, associate professor New York University School of Medicine. In the United States, postmenopausal women at high risk of breast cancer are usually offered drugs in a newer class known as aromatase inhibitors, such as Arimidex, sold by AstraZeneca. “For premenopausal women the standard of care will likely include 10 years of tamoxifen,” Dr. Adams said. “For women who enter menopause during that period, AIs are still an option. Tamoxifen will also be an option.” Rare but serious side effects of tamoxifen include increased risk of endometrial cancer (cancer of the lining of the uterus), blood clots and stroke. The British researchers said they observed no excess incidence of stroke with 10 years of tamoxifen therapy, although the endometrial cancer risk was higher. They estimated that for every endometrial cancer death that occurs as a side effect of long-term tamoxifen, 30 deaths from breast cancer would be prevented.source : http://www.foxnews.com/health/2013/06/03/longer-tamoxifen-use-reduces-breast-cancer-recurrence/

Targeted therapy boosts lung cancer outcomes

In a trial involving patients with non-small cell lung cancer (NSCLC) whose tumor cells harbored an abnormal ALK gene, those who received the oral drug crizotinib, which acts directly on ALK, went a median time of 7.7 months before their disease began to worsen, compared to 3 months for patients who received traditional chemotherapy. Patients treated with crizotinib also had a better quality of life than those treated with standard chemotherapy. The findings will be released as an advanced online publication by the New England Journal of Medicine on June 1. …

7 warning signs you should not ignore

A few days after Melissa Daly broke her ankle, the calf above it became tender. Within a week, her foot was dark purple. She saw her doctor, who dismissed it as normal bruising and offered a prescription for painkillers. The drugs didn't help, and a week later she woke up in the middle of the night gasping for air.  “I felt like I was suffocating,” she said. Her husband called 911, and within an hour she was on a respirator in the ER. A blood clot had broken off from her calf and lodged in her lungs. The agony she felt is one of seven pains you should never brush off. Read on to make sure that your nagging aches are as innocent as they seem. MORE: 7 Lies We Tell Our Doctors Severe Head Pain This mother of all headaches makes your bachelorette party hangover seem laughable. If you could laugh. The culprit: Odds are, any jackhammering in your brain is just a migraine. But if it's not accompanied by other migraine symptoms (such as a visual aura), sudden and severe pain -- we're talking the absolute worst headache of your life -- can signal a brain aneurysm.  These arterial bulges occur in up to 5 percent of people, but most of the time they don't cause any trouble -- you won't even know you have one unless the weak spot leaks or tears. If that happens, escaping blood can flood the surrounding tissue (causing a violent headache) and cut off the oxygen supply there. Smoking and having a family history of aneurysms increase your odds. The fix: “A burst aneurysm can cause brain damage within minutes, so you need to call 911 immediately,” Dr. Elsa-Grace Giardina, director of the Center for Women's Health at NewYork-Presbyterian Hospital/Columbia University Medical Center, said.  Your doctor will take a CT scan to look for bleeding in the space around the brain. If he finds hemorrhaging, you'll head into the (operating room) pronto for surgery to repair the blood vessel. Throbbing Tooth Spooning your way through a pint of Chubby Hubby has become an exercise in torture. When your teeth touch anything frosty, you feel a dull throb or sharp twinge. The culprit: It's likely that the tooth's nerve has become damaged, usually because the surrounding pearly white is cracked or rotting away. Unless you get it patched up quickly, bacteria in your mouth can infect the nerve. And you definitely don't want that breeding colony to spread throughout your body, said Kimberly Harms, a dentist outside St. Paul, Minnesota. The fix: Time for a cavity check! You may just need a filling to cover the exposed nerve. But if it's infected, you're in for a root canal, in which the tooth's bacteria-laden pulp is removed and replaced with plastic caulking material. Antibiotics can clear up any infection that has spread beyond the mouth. MORE: The 10 Self-Checks Every Woman Should Do Sharp Pain In Your Side A typical runner's side stitch pales in comparison to this piercing stab, which intensifies over a few hours or days. The culprits: You may just need some Beano. But if you feel as if you're being skewered in your right side and you're also nauseated and running a fever, you could have appendicitis. It occurs when something (like a stray piece of feces) migrates into the space where the appendix empties into the colon, blocking it. Soon the organ becomes dangerously inflamed.  Another possibility is an ovarian cyst. Typically these fluid-filled sacs are harmless and disappear on their own. But if one twists or ruptures, it can cause terrible pain. The fix: In both cases, you're looking at emergency surgery.  “If you don't remove an inflamed ap­pendix, it can burst,” Dr. Lin Chang, a gastroenterologist and co-director of UCLA's Center for Neurovisceral Sciences and Women's Health, said.  This can cause dangerous swelling of the tissue surrounding your organs. A twisted cyst also needs to be removed right away, as it can block blood flow to your ovary within hours. If that happens, the doctor will need to cut out the entire ovary (and the eggs inside) along with the cyst. Passing Chest Pain Periodically, you get what feels like a bad case of heartburn, or a tight squeezing sensation, as if you're being laced into a corset. The culprit: You probably just peppered your pizza with too many chilis. But if you know you're at risk for heart problems, don't blow it off -- it could be a heart attack. Every year, about 10,000 women under 45 have one. Symptoms tend to be less severe in women than in men, so “you may just feel pressure, along with fatigue, throat pain, or shortness of breath,” Giardina said. The fix: Feel the burn after feasting on chalupas? Normal. Feel as if you're being squeezed to death by a boa constrictor after a hard workout?

Small molecule could have big impact on cancer

In a study published online May 28 in the journal Nature Communications, Ahn and his colleagues at UT Southwestern Medical Center describe the rational design of the molecule, as well as laboratory tests that show its effectiveness at blocking the cancer-promoting function of proteins called androgen receptors. Androgen receptors are found inside cells and have complex surfaces with multiple "docking points" where various proteins can bind to the receptor. …

Biophysicists measure mechanism that determines fate of living cells

Cells in the human body do not function in isolation. Living cells rely on communication with their environment — neighboring cells and the surrounding matrix — to activate a wide range of cellular functions, including reproduction of new cells, differentiation of stem cells into distinct cell types, cell adhesion, and migration of white blood cells to fight bodily infections. This cellular communication occurs on the molecular level and it is reciprocal: a cell receives cues from and also transmits function-activating cues to its neighbors…

Polish man gets face transplant just 3 weeks after injury

WARSAW, Poland – & A 33-year-old Polish man received a face transplant just three weeks after being disfigured in a workplace accident, in what his doctors said Wednesday is the fastest time frame to date for such an operation. It was Poland's first face transplant. Face transplants are extraordinarily complicated and relatively rare procedures that usually require extensive preparation of the recipient over a period of months or years. But medical officials said the Polish patient's condition was deteriorating so rapidly that a transplant was seen as the only way to save his life. The patient is now being watched for any potential infections. In a photo taken Tuesday, just six days after the surgery, the patient, identified only by his first name, Grzegorz, was shown giving a thumbs-up sign from his hospital bed. Another picture, based on computer tomography, showed the extensive damage to his skull. He was injured in an April 23 accident at his job at a stone mason's workshop near the southwestern city of Wroclaw when a machine used to cut stone tore off most of his face and crushed his upper jaw. He received intensive treatment at a hospital in Wroclaw that saved his life and eyesight. But an attempt to reattach his own face failed, leaving an area close to the brain exposed to infections, doctors said. The damage was too extensive for doctors to temporarily seal the exposed areas. So he was taken to the Cancer Center and Institute of Oncology in Gliwice, the only place in Poland licensed to perform face transplants. The center has experience in facial reconstruction for patients disfigured by cancer and its experts have practiced face transplants on cadavers. Doctors at the center said the 27-hour face and bone transplant was performed May 15 soon after a matching donor was found. The surgery reconstructed the area around the eyes, the nose, jaws and palate and other parts of the man's face. Pictures show stitches running from above the patient's right eye, under the left eye and around the face to the neck. The donor, a 34-year-old man, was chosen from a national registry of potential donors after his age, gender, blood group and body features were determined to be a good match for the injured man. The head of the team of surgeons and other specialists, Dr. Adam Maciejewski, said it was the first time a face transplant was carried out so soon after the damage. Face transplants are usually a last resort after conventional reconstructive and plastic surgeries have been tried. “In such an extensive injury, where the structures close to the skull base and in contact with the brain area are exposed, any infection would be dangerous, not to mention the impossibility to function normally, including problems with breathing, with eating,” Maciejewski said. “All that led us in one direction.” “We assume the surgery will allow the patient to return to normal life. He will be able to breathe, to eat, to see.” Maciejewski said that over time, the face will mold to the man's facial bone structure and he will not look like the donor. The patient is now breathing on his own and responds to questions by nodding his head or squeezing the hands of doctors. But his condition is serious and it will be months before the procedure can be declared a full success, said Dr. Krzysztof Olejnik, head of the team of anesthesiologists. Another member of the transplant team, surgeon Dr. Maciej Grajek, told The Associated Press that the patient was receiving drugs to ward off any potential viral, bacterial or skin infections, but the face is alive and is healing. Though he is in sterile isolation, the patient has started the rehabilitation process. He will stay on special drugs for the rest of his life to prevent rejection of his new face. More than two dozen transplants of the face or parts of the face have been performed around the world. The first one was a partial face transplant in a woman maimed by her dog in France in 2005. Dr. Bohdan Pomahac, who in 2011 led a team in the United States that performed a full face and double-hand transplant on a woman mauled by a chimpanzee, said in an email he believes that in the future surgeons will decide more swiftly on a transplant, just as the Polish team did. “This is the way we likely will practice in the future,” said Pomahac, a reconstructive surgeon at Harvard-affiliated Brigham and Women's Hospital in Boston. However, he cautioned that patients should be given more time to be fully involved in a decision that will have a life-long impact on them. “I still think that a traumatized patient, even with all the psychological support, probably has a hard time making the right decision within hours/days after life-changing trauma,” Pomahac said. Dr. Zbigniew Wlodarczyk, who has performed limb transplants in Poland but was not involved in the face transplant, told the AP the surgery was groundbreaking because it was carried out on a fresh injury and on tissues that have not healed, but that leaving such an extensive wound open would have led to infection and the patient's death. “Such rare but spectacular procedures show the possibilities of medicine today and advance it,” he said.  ”This places Poland in the elite group of countries performing such transplants.  source : http://www.foxnews.com/health/2013/05/23/polish-man-gets-face-transplant-just-3-weeks-after-injury/

Could eating less save your brain? Study shows reducing calories delays nerve cell loss

Calorie restriction may not always be fun, but cutting back has benefits beyond even weight loss. Studies have shown that eating less can help slow aging, prolong life and even decrease the effects of diseases like Alzheimer’s in a variety of organisms. Based on this knowledge, a group of researchers from the Massachusetts Institute of Technology (MIT) decided to dig further and ask: Could calorie restriction also delay nerve cell loss in the brain – and the changes in learning and memory that go along with it? “We reasoned – and other folks reasoned – that because cognitive decline and neurodegeneration are characteristics of the aging process, that calorie restriction might also work in the brain to slow neurodegeneration,” lead study author, Dr. Johannes Gräff from the Picower Institute for Learning and Memory at MIT, and Howard Hughes Medical Institute, told FoxNews.com. Gräff and his colleagues tested their theory using a group of mice engineered to experience rapid neurodegeneration. Researchers decreased half of the mice’s calorie intake by 30 percent and kept the remaining mice on a normal diet. After three months, researchers tested the learning and memory skills in each group of mice, expecting to see a decline in both cognitive areas. However, while the mice eating normally showed evidence of significant learning and memory deficits related to nerve cell loss, the calorie-restricted mice showed no defecits in their learning or memory skills. “That was one of the first experiments we did, and that was quite promising and cool that it worked,” Gräff said. In the next phase of the study, researchers took a more in-depth look at the brains of both groups of mice. “What we further did was to look through the brains to check the extent or amount of neurodegeneration, and what we found was that neurodegeneration had been slowed down by calorie restriction,” Gräff said. Researchers were curious if reduced neurodegeneration could still be achieved by utilizing proteins activated during calorie restriction – without actually restricting calories. Eventually, they targeted an enzyme called Sirtuin 1 (SIRT1). “This protein is one candidate that has been known to be more abundantly expressed as a result of calorie restriction in our tissues,” Gräff said. The scientists then gave a separate group of mice, also engineered to experience rapid neurodegeneration, a pharmacological dose of SIRT1, without restricting their calorie intake. These mice experienced the same effects as the calorie-restricted mice, showing slower rates of nerve cell loss and no learning or memory deficits after a three-month period. Graff noted that more research needed to be done in this area, and he hopes to further explore the relationship between calorie restriction, SIRT1 and neurodegeneration. “We have the choice – (to look into how) to reduce calorie intake in order to slow onset of neurodegeneration, or we look to this pharmacological activator (to do the same thing),” Gräff said. “Do you want to engage more into reducing caloric intake or revert to pharmacological means for the same effect?” This study is published in the May 22nd issue of The Journal of Neuroscience.source : http://www.foxnews.com/health/2013/05/22/could-eating-less-save-your-brain-study-shows-reducing-calorie-intake-delays/

Could eating less save your brain? Study shows reducing calorie intake delays nerve cell loss

Calorie restriction may not always be fun, but cutting back has benefits beyond even weight loss. Studies have shown that eating less can help slow aging, prolong life and even decrease the effects of diseases like Alzheimer’s in a variety of organisms. Based on this knowledge, a group of researchers from the Massachusetts Institute of Technology (MIT) decided to dig further and ask: Could calorie restriction also delay nerve cell loss in the brain – and the changes in learning and memory that go along with it? “We reasoned – and other folks reasoned – that because cognitive decline and neurodegeneration are characteristics of the aging process, that calorie restriction might also work in the brain to slow neurodegeneration,” lead study author, Dr. Johannes Gräff from the Picower Institute for Learning and Memory at MIT, and Howard Hughes Medical Institute, told FoxNews.com. Gräff and his colleagues tested their theory using a group of mice engineered to experience rapid neurodegeneration. Researchers decreased half of the mice’s calorie intake by 30 percent and kept the remaining mice on a normal diet. After three months, researchers tested the learning and memory skills in each group of mice, expecting to see a decline in both cognitive areas. However, while the mice eating normally showed evidence of significant learning and memory deficits related to nerve cell loss, the calorie-restricted mice showed no defecits in their learning or memory skills. “That was one of the first experiments we did, and that was quite promising and cool that it worked,” Gräff said. In the next phase of the study, researchers took a more in-depth look at the brains of both groups of mice. “What we further did was to look through the brains to check the extent or amount of neurodegeneration, and what we found was that neurodegeneration had been slowed down by calorie restriction,” Gräff said. Researchers were curious if reduced neurodegeneration could still be achieved by utilizing proteins activated during calorie restriction – without actually restricting calories. Eventually, they targeted an enzyme called Sirtuin 1 (SIRT1). “This protein is one candidate that has been known to be more abundantly expressed as a result of calorie restriction in our tissues,” Gräff said. The scientists then gave a separate group of mice, also engineered to experience rapid neurodegeneration, a pharmacological dose of SIRT1, without restricting their calorie intake. These mice experienced the same effects as the calorie-restricted mice, showing slower rates of nerve cell loss and no learning or memory deficits after a three-month period. Graff noted that more research needed to be done in this area, and he hopes to further explore the relationship between calorie restriction, SIRT1 and neurodegeneration. “We have the choice – (to look into how) to reduce calorie intake in order to slow onset of neurodegeneration, or we look to this pharmacological activator (to do the same thing),” Gräff said. “Do you want to engage more into reducing caloric intake or revert to pharmacological means for the same effect?” This study is published in the May 22nd issue of The Journal of Neuroscience.source : http://www.foxnews.com/health/2013/05/22/could-eating-less-save-your-brain-study-shows-reducing-calorie-intake-delays/

American Cancer Society turns 100 as cancer rates fall

The American Cancer Society - one of the nation's best known and influential health advocacy groups - is 100 years old this week. Back in 1913 when it was formed, cancer was a lesser threat for most Americans. The biggest killers then were flu, pneumonia, tuberculosis, and stomach bugs. At a time when average life expectancy was 47, few lived long enough to get cancer. But 15 doctors and businessmen in New York City thought cancer deserved serious attention, so they founded the American Society for the Control of Cancer. The modern name would come 31 years later. The cancer society's rise coincided with the taming of infectious diseases and lengthening life spans. “Cancer is a disease of aging, so as people live longer there will be more cancer,” explained Dr. Michael Kastan, executive director of Duke University's Cancer Institute. Cancer became the nation's No. 2 killer in 1938, a ranking it has held ever since. It also became perhaps the most feared disease - the patient's own cells growing out of control, responding only to brutal treatments: surgery, radiation and poisonous chemicals. The cancer society is credited with being the largest and most visible proponent of research funding, prevention and programs to help house and educate cancer patients. Last year, the organization had revenues of about $925 million. It employs 6,000 and has 3 million volunteers, calling itself the largest voluntary health organization in the nation. “The American Cancer Society really is in a league of its own,” Kastan said. The rate of new cancer cases has been trending downward ever so slightly. Some historical highlights: 1913 - The American Society for the Control of Cancer is founded in New York City. 1944 - The organization is renamed the American Cancer Society. The change is spurred by Mary Lasker, the wife of advertising mogul Albert Lasker. 1946 - A research program is launched, built on $1 million raised by Mary Lasker. A year later, Dr. Sidney Farber of Boston announces the first successful chemotherapy treatment. 1948 - The cancer society pushes the Pap test, which has been credited with driving a 70 percent decline in uterine and cervical cancer. 1964 - Prodded by the cancer society and other groups, U.S. Surgeon General Luther Terry issues a report irrefutably linking smoking to cancer. 1971 - The cancer society helps lead passage of the National Cancer Act to ramp up research money. President Nixon declares a national “war on cancer,” which becomes an extended effort derided by some as a “medical Vietnam.” 1976 - The cancer society suggests women 40 and older consider a mammogram if their mother or sisters had breast cancer. 1976 - The cancer society hosts a California event to encourage smokers to quit for the day. A year later, the annual Great American Smokeout is launched nationally. 1988 - Atlanta becomes headquarters for the society. 1997 - The cancer society recommends yearly mammograms for women over 40. 2000 - Dr. Brian Druker of Oregon reports the first success with “targeted” cancer therapy. 2003 - The cancer society stops recommending monthly breast self-exams. But it continues to urge annual mammograms for most women over 40, even after a government task force says most don't need screening until 50. 2012 - The cancer society reports the rate of new cancer cases has been inching down by about half a percent each year since 1999.source : http://www.foxnews.com/health/2013/05/22/american-cancer-society-turns-100-as-us-cancer-rates-fall/