"Understanding this previously ignored part of the human genome, its role in human development, and how it may be taken over by disease, opens a new frontier in science with important implications for medical advances," said Philipp Kapranov, Ph.D., lead researcher at the St. …
HPV has been linked to anal, penile and certain types of throat cancers in men. Since the virus is also responsible for various cancers in women, vaccinating boys will play a crucial role in reducing cancer rates across the sexes. "HPV is the single most common sexually transmitted infection," says Newman, Canada Research Chair in Health and Social Justice. …
The study is described in the journal Cancer Investigation. Researchers at the UT Health Science Center injected immune-deficient mice with human prostate cancer cells. Within three to four weeks, tumors typically start to grow in a large number of these mice…
Now it seems each week yields important new discoveries about the deadly skin cancer. "I’ve been doing this for 30 years, and now is by any measure the most exciting time for melanoma research," said Brian Nickoloff, director of the Nicholas V. Perricone, M.D., Division of Dermatology and Cutaneous Sciences at Michigan State University’s College of Human Medicine. …
The proteins are part of a group called apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) cytidine deaminases. The investigators found that APOBEC mutations can outnumber all other mutations in some cancers, accounting for over two-thirds in some bladder, cervical, breast, head and neck, and lung tumors. The scientists published their findings online July 14 in the journal Nature Genetics. Dmitry Gordenin, Ph.D., is corresponding author of the paper and a senior associate scientist at the National Institute of Environmental Health Sciences (NIEHS), part of NIH. …
The discovery, reported in the July 14 issue of Nature Genetics, follows the team’s earlier finding that the enzyme, called APOBEC3B, is responsible for more than half of breast cancer cases. The previous study was published in Nature in February. APOBEC3B is part of a family of antiviral proteins that Harris has studied for more than a decade. …
The findings were published July 11 in Molecular Cell. Telomeres have been compared to the plastic tips at the end of shoelaces because they prevent the ends of chromosomes from fraying and sticking to each other, which scrambles the genetic information and may promote cancer…
Results of the study were presented today at the annual meeting of ESHRE by Dr Carrie Williams from the Institute of Child Health, University College London, UK. This was a large population-based linkage study between the Human Fertilisation & Embryology Authority (HFEA, the UK’s regulatory authority for ART clinics) and the UK’s National Registry of Childhood Tumours (NRCT).(1) The HFEA records of all 106,381 children born after assisted conception in the UK from 1992 to 2008 were linked to NRCT records to calculate the number of children who subsequently developed cancer. Once the databases were linked, cancer rates in the ART cohort were compared with population rates, whilst stratifying for potential mediating factors including birth weight, multiple births, treatment type and infertility cause. …
Reporting their results July 8 in Cancer Cell, researchers say their successful laboratory tests in human MDS cells and mouse models of MDS provide a molecular target for designing new drugs to battle a syndrome with few effective treatments. "There is an urgent need to develop new targeted therapies that can eliminate MDS-initiating clone cells and provide a durable therapeutic response," said Daniel Starczynowski, PhD, lead researcher and a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children’s Hospital Medical Center…
CHD7 encodes a so-called chromatin remodeler, an important class of epigenetic regulators. DNA is wound around bead-like nucleosomes consisting of histone proteins. The string of beads is then twisted into a structure called chromatin…