Tag Archives: drugs

New plan of attack in cancer fight: Two-drug combination, under certain circumstances, can eliminate disease

As described in a paper recently published in eLife, Martin Nowak, a professor of mathematics and of biology and director of the Program for Evolutionary Dynamics, and co-author Ivana Bozic, a postdoctoral fellow in mathematics, show that, under certain conditions, using two drugs in a "targeted therapy" — a treatment approach designed to interrupt cancer’s ability to grow and spread — could effectively cure nearly all cancers. Though the research is not a cure for cancer, Nowak said it does offer hope to researchers and patients alike. "In some sense this is like the mathematics that allows us to calculate how to send a rocket to the moon, but it doesn’t tell you how to build a rocket that goes to the moon," Nowak said…

Injectable ‘smart sponge’ holds promise for controlled drug delivery

"We wanted to mimic the function of health beta-cells, which produce insulin and control its release in a healthy body," says Dr. Zhen Gu, lead author of a paper describing the work and an assistant professor in the joint biomedical engineering program at North Carolina State University and the University of North Carolina at Chapel Hill. …

Adding chemotherapy to surgery improves survival in advanced gastric cancer, study confirms

At the meeting Prof Sung Hoon Noh, a gastric surgeon from Yonsei University College of Medicine, Korea, presented 5-year follow-up from the phase III CLASSIC trial, which added combination chemotherapy to a standard surgical procedure called D2 gastrectomy. The chemotherapy regimen studied in the trial is called XELOX, which is a combination of the drugs capecitabine and oxaliplatin. …

Research IDs potential treatment for deadly, HIV-related blood cancer

The USC team shows that a class of drugs called BET bromodomain inhibitors effectively targets primary effusion lymphoma (PEL), a type of cancer for which those drugs were not expected to be effective. "It’s a reversal of the paradigm," said Preet Chaudhary, chief of the Nohl Division of Hematology and Blood Diseases at the Keck School of Medicine of USC and principal investigator of the study. "Our results suggest that this new class of drug may be an effective treatment for a wider range of cancers than previously thought." PEL is caused by infection with Kaposi’s sarcoma-associated herpes virus, the most common cause of cancer among patients with AIDS. The prognosis for PEL is poor, with a median survival of three to six months. …

Restless legs syndrome linked to higher risk of early death

Men who suffer from restless legs syndrome may not live as long as those without the condition, according to a new study. The study found that men with restless legs syndrome (RLS) were nearly 40 percent more likely to die over the eight-year study, compared to men without RLS. When the researchers excluded from their analysis men with major chronic conditions such as cancer, heart disease and high blood pressure, those with RLS were 92 percent more likely to die over the study period. “The results of this study indicate that men with RLS had a higher overall mortality,” the researchers wrote in their study. However, the study shows an association, not a cause-and-effect link between having RLSand an increased risk of dying, and the researchers said that it is not known how RLS might increase the mortality risk. In the study, deaths among men with RLS were frequently due to respiratory disease, endocrine disease, metabolic disease and immunologic disorders. Further research is needed to understand the relationship between these diseases and RLS, the researchers said. RLS is a bothersome chronic condition that affects 5 to 10 percent of adults. Patients have an irresistible urge to move the legs, and often experience burning and creeping sensations that are described as “an itch you can't scratch,” or “like insects crawling inside the legs.” In the study, researchers looked at 18,425 men, whose average age was 67, including 700 who were diagnosed with RLS. During an eight-year follow-up, 2,765 of the men died. Among the men with RLS, 25 percent died during the study, compared with 15 percent of those who did not have RLS. The researchers also found that men with RLS were more likely to use antidepressant drugs, had more insomnia complaints, and were more likely to have high blood pressure, cardiovascular disease and Parkinson's disease. However, controlling for these factors didn't change the results, they said. The link between RLS and higher risk of death was not related to other common risk factors such as smoking, older age, low physical activity and lack of sleep. Moreover, men who had conditions such as high blood pressure, cancer or insomnia, had a further increased risk of death if they had RLS too, according to the study. The study was published online June 12 in the journal Neurology. Some of the researchers who worked on the study have received money from pharmaceutical companies that make drugs used to treat restless legs syndrome. “Increasing awareness of RLS, especially training for health professions, should be encouraged if our findings are confirmed by future studies,” the researchers said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/12/restless-legs-syndrome-linked-to-higher-risk-early-death/

Shape of nanoparticles points the way toward more targeted drugs

A new study involving Sanford-Burnham Medical Research Institute’s Erkki Ruoslahti, M.D., Ph.D., contributing to work by Samir Mitragotri, Ph.D., at the University of California, Santa Barbara, found that the shape of nanoparticles can enhance drug targeting. The study, published in Proceedings of the National Academy of Sciences, found that rod-shaped nanoparticles — or nanorods — as opposed to spherical nanoparticles, appear to adhere more effectively to the surface of endothelial cells that line the inside of blood vessels. …

Nearly 40 percent of designated drivers drink before driving, study suggests

Partygoers, beware.  Your designated sober driver may not always be alcohol-free. A new study, conducted in a Florida college town, found that two out of five designated drivers drink alcohol before getting behind the wheel, Medical Daily reported.  Of these inebriated drivers, half had a blood alcohol content (BAC) of .05 percent – enough to affect driving ability while still being under the legal limit. Researchers from the University of Florida spent three months observing more than 1,000 bar patrons as they left drinking establishments throughout the college town of Gainesville, Fla.  The team asked people if they had been deemed the designated driver and whether they would volunteer to take a breathalyzer test before leaving. Throughout the course of the study, 165 individuals identified themselves as designated drivers.  Of this group, 35 percent had at least one drink before leaving the bar, and around half of the drinkers had a BAC between .02 and .05 percent.  The other half had a BAC above .05 percent. According to the study’s researchers, social pressure to drink in combination with a legal BAC limit of .08 percent often leads to designated drivers having one or two drinks before hitting the road.  However, the scientists maintained that numerous studies have documented significant alcohol-related impairment at a BAC level of .05 percent. “Considering the low BAC levels at which driving-related abilities are negatively affected, these ï¬�ndings identify the need for consensus across researcher, layperson, and communication campaigns that a (designated driver) must be someone who abstains from drinking entirely,” the researchers wrote. Nearly one-third of all traffic-related deaths in the United Sates involve alcohol-impaired drivers, resulting in nearly 11,000 deaths each year, according to the Centers for Disease Control and Prevention (CDC).  In an attempt to curb these deaths, the National Highway Transportation Safety Board has recommended that the legal BAC limit for driving be reduced from .08 percent to .05 percent. The University of Florida study will be published in the July issue of The Journal of Studies on Alcohol and Drugs.  However, the average age of study participants was 28 and the individuals tested were not ethnically or racially diverse, meaning the results cannot be applied to the general American population. Click for more from Medical Daily.source : http://www.foxnews.com/health/2013/06/10/nearly-40-percent-designated-drivers-drink-before-driving-study-suggests/

Metastatic breast cancer study shows success in finding new treatment

The Side-Out Foundation’s pilot study is part of a cutting-edge approach to personalized medicine that looks beyond genomic analysis alone to combine it with what some say is the next frontier in targeted therapy: proteomics. The pilot study is the first of its kind to utilize novel protein activation mapping technology along with the genomic fingerprint of cancer as a way to find the most effective treatment. The trial was announced at the annual meeting of the American Society of Clinical Oncology and is expected to expand into phase two this month. Standard chemotherapy had failed the 25 women who participated in the 2.5-year pilot study, says study co-author Emanuel "Chip" Petricoin, co-director of George Mason’s Center for Applied Proteomics and Molecular Medicine (CAPMM)…

Statins linked to muscle pain, sprains

Cholesterol-lowering drugs could be tied to more muscle problems than researchers previously believed, a new study hints. Researchers compared two groups of similar people enrolled in military health insurance and found those taking a statin were about 10 percent more likely to have muscle pain, sprains or strains. Past studies have tied the popular cholesterol drugs to muscle weakness as well as the rare muscle-wasting disease rhabdomyolysis. The new study expands on those findings and suggests the muscle-related side effects of statins might be broader, researchers said. However, they don't prove statins caused the pain and injuries seen among some patients. “I would strongly recommend that no one should stop taking statins based on this study… simply because statins have been life-saving for many patients,” said the study's lead researcher, Dr. Ishak Mansi. However, he said side effects including muscle injuries are something to think about for people who are discussing with their doctor whether they really need to be on a statin. And they're another reason to try to maintain a healthy lifestyle - including exercising and not smoking - to avoid needing drugs in the first place, he added. Mansi, from the VA North Texas Health Care System in Dallas, and his colleagues compared the health records of two groups of patients who were the same age and had the same types of medical conditions. People in one group had been prescribed a statin in late 2004 and 2005; those in the other group never took statins during the study period. The researchers tracked the medical records of each of those patients - about 14,000 in total - through early 2010 for signs of muscle problems. They found 87 percent of statin users had some type of muscle or joint problem - including arthritis and muscle injuries - compared to 85 percent of people who didn't take a statin. Strains, sprains and dislocations, in particular, were reported for 35 percent of people on a statin, compared to 32.5 percent of those not taking a cholesterol-lowering drug. And medical records showed muscle pain among 73.5 percent of statin users, versus 71.5 percent of non-users, Mansi's team reported in JAMA Internal Medicine. Mansi said those proportions are a bit higher than usual both in the statin and non-statin groups - possibly because his study included military members and veterans, who are more likely to get injured. The researchers calculated that 37 people would have to be treated with statins for one more to have a muscle strain or sprain, and 58 people for one more case of muscle or joint pain. About one-quarter of U.S. adults aged 45 and older take statins to protect against heart attacks and strokes. The drugs are especially recommended for people with diabetes or a history of cardiovascular problems. Dr. Paul Thompson, chief of cardiology at Hartford Hospital in Connecticut, said his own research suggests about 5 percent of people will have muscle problems related to statin use. “We think it's a much bigger problem than it's given credit for,” Thompson, who wasn't involved in the new study, said. However, he said, those muscle problems don't seem to be permanent. “I encourage people to not worry about the possibilities of muscle troubles,” he said. “If they get muscle troubles, we'll stop the drug, and it will go away.” Mansi agreed that people “don't need to be excessively worried” about muscle pain or injuries tied to statins, but that they're something to consider. “Patients need to discuss with their doctors the benefit-risk ratio of statins for them specifically,” he said.source : http://www.foxnews.com/health/2013/06/05/statins-linked-to-muscle-pain-sprains/