Tag Archives: north-carolina

Elevated cholesterol, triglycerides may increase risk for prostate cancer recurrence

“While laboratory studies support an important role for cholesterol in prostate cancer, population-based evidence linking cholesterol and prostate cancer is mixed,” said Emma Allott, PhD, postdoctoral associate at Duke University School of Medicine in Durham, North Carolina. “Understanding associations between obesity, cholesterol, and prostate cancer is important given that cholesterol levels are readily modifiable with diet and/or statin use, and could therefore have important, practical implications for prostate cancer prevention and treatment. “Our findings suggest that normalization, or even partial normalization, of serum lipid levels among men with dyslipidemia [abnormal lipid profile] may reduce the risk of prostate cancer recurrence,” said Allott. …

Racial disparity in colon cancer: New study sheds light

The population-based study of 503 people with colon cancer found that 14 percent of Caucasians and 7 percent of African-Americans had a genetic marker called microsatellite instability, or MSI. These types of tumors are known to be resistant to the chemotherapy drug 5FU. Yet, even without chemotherapy, these patients tend to have better outcomes. …

New technique targets specific areas of cancer cells with different drugs

"In testing on laboratory mice, our technique resulted in significant improvement in breast cancer tumor reduction as compared to conventional treatment techniques," says Dr. Zhen Gu, senior author of a paper on the research and an assistant professor in the joint biomedical engineering program at NC State and UNC-Chapel Hill. …

Injectable ‘smart sponge’ holds promise for controlled drug delivery

"We wanted to mimic the function of health beta-cells, which produce insulin and control its release in a healthy body," says Dr. Zhen Gu, lead author of a paper describing the work and an assistant professor in the joint biomedical engineering program at North Carolina State University and the University of North Carolina at Chapel Hill. …

Human and canine lymphomas share molecular similarities, first large-scale comparison shows

A team of scientists from the University of North Carolina School of Medicine, North Carolina State University’s College of Veterinary Medicine and Duke University have conducted one of the first studies to directly compare canine and human B-cell lymphoma by examining molecular similarities and differences between the two species. The study was published June 19, 2013 online in the journal Cancer Research. Kristy Richards, MD, PhD, corresponding author, said, "Comparing the molecular similarities of lymphomas across species has allowed us to see what parts of lymphoma development and growth are evolutionarily conserved. This teaches us more about what components of human lymphoma biology are most fundamental and critical. …

African-Americans experience longer delays between diagnosis and treatment of prostate cancer

To see if there is a difference in the time from cancer diagnosis to initiation of treatment for African American men compared with Caucasian men with prostate cancer, Ronald Chen, MD, MPH, of the University of North Carolina at Chapel Hill, and his colleagues analyzed data from the Surveillance, Epidemiology and End Results (SEER)-Medicare registry, which links cancer diagnosis data to a master file of Medicare records. Their analysis included 2,506 African American and 21,454 Caucasian patients diagnosed with early (non-metastatic) prostate cancer from 2004 to 2007 and treated within 12 months of diagnosis…