Tag Archives: humans

An ‘ambulance’ for the brain

“It is estimated that 20% of humans at some time will need a treatment that targets the brain,” explains Meritxell Teixid�, associate researcher at IRB Barcelona and leader of this line of investigation, “and for many diseases there are some good candidate drugs but none have the capacity to reach their target and thus there is a subsequent loss of potential. Our shuttle offers a solution to an urgent clinical need.” The work has been carried out in IRB Barcelona’s Peptides and Proteins Lab. Directed by Ernest Giralt, also senior professor of the UB, this lab is one of the few leading labs worldwide devoted to these kinds of developments…

Mouse study finds gut microorganisms may determine cancer treatment outcome

NCI scientists found that tumors of germ-free mice (mice completely lacking these microorganisms), or mice treated with antibiotics to deplete the gut of bacteria, were largely impaired in their ability to respond to immunotherapy that slows cancer growth and prolongs survival. The mice were also impaired in their ability to respond to mainstay chemotherapy drugs such as oxaliplatin and cisplatin. These findings in mice may underscore the importance of microorganisms in optimal cancer treatment outcomes in humans. …

Human and canine lymphomas share molecular similarities, first large-scale comparison shows

A team of scientists from the University of North Carolina School of Medicine, North Carolina State University’s College of Veterinary Medicine and Duke University have conducted one of the first studies to directly compare canine and human B-cell lymphoma by examining molecular similarities and differences between the two species. The study was published June 19, 2013 online in the journal Cancer Research. Kristy Richards, MD, PhD, corresponding author, said, "Comparing the molecular similarities of lymphomas across species has allowed us to see what parts of lymphoma development and growth are evolutionarily conserved. This teaches us more about what components of human lymphoma biology are most fundamental and critical. …

Dogs bring swarm of bacteria into your home

Your loyal pooch may be bringing a whole world of bacteria into your home but don't panic. Research suggests that exposure to a wide variety of microbes may be good for us. A new study reveals that homes with dogs have greater bacterial diversity than canine-free dwellings. Dog-related diversity is particularly high on television screens and pillowcases, the researchers found. “When you bring a dog into your house, you are not just bringing a dog, you are also introducing a suite of dog-associated [microbe] taxa directly into your home environment, some of which may have direct or indirect effects on human health,” the researchers wrote today (May 22) in the journal PLOS ONE. [5 Wacky Things That Are Good For You] Microbes around us The microbes in our environment are the subject of increased interest by scientists, thanks to studies revealing how intertwined human lives are with those of the single-celled. Skin microbes, for example, may be key for warding off disease. And the load of microbes living in the human gut may influence everything from immunity to obesity. North Carolina State University biologist Rob Dunn and his colleagues wanted to step back from the body to better understand the microbes in our environment at large. They gave 40 families a home-sampling kit and asked them to swab down nine locations in their houses: a kitchen cutting board, a kitchen counter, a refrigerator shelf, a toilet seat, a pillowcase, a television screen, the main door's exterior handle and the upper trim on both an interior door and on an exterior door. The researchers then examined the microbial DNA from the swabs to detect different families of microscopic tenants living on these surfaces. All told, the 40 homes harbored 7,726 different types of bacteria. The most common were Proteobacteria, Firmicutes and Actinobacteria, all families containing a wide range of species. Types of bacteria tended to differ by location: Kitchen environments (cutting boards, counters and shelves) had similar colonies from home to home, as did frequently touched surfaces (toilet seats, pillowcases, door handles) and rarely cleaned surfaces (door trims and television screens). “This makes sense,” Dunn said in a statement. “Humans have been living in houses for thousands of years, which is sufficient time for organisms to adapt to living in particular parts of houses. We know, for example, that there is a species that only lives in hot-water heaters. We deposit these bacterial hitchhikers in different ways in different places, and they thrive or fail depending on their adaptations.” Bacteria related to human skin were found most frequently on pillowcases and toilet seats as were bacteria commonly found in human feces. Bacteria from leaves and produce were found most often on door trims and also on kitchen surfaces. Bacteria from the soil were found across the home, but were most common on the exterior door trim, the researchers found. Doggie diversity Dunn and his colleagues next looked for variables that would alter bacterial communities from home to home, such as the presence of cats, children, carpet and other factors. The only one they found that made any difference was whether or not the family had a pet dog. Pillowcases and TV screens of dog-owning families had 42 percent and 52 percent more microbial groups, respectively, than pillowcases and TV screens of non-dog-owning families. This extra diversity, unsurprisingly, was made up largely of bacteria known to live on dog fur. (Other factors, such as the level of humidity in a home, could also influence microbe diversity, the researchers wrote, but they were unable to measure those factors in this study.) Dog owners shouldn't ship Fido off to the countryside for fear of nasty bacteria, though. In fact, the family pet may be a boon to health. Previous studies have found that pregnant women who live in homes with dogs are less likely to have children with allergies. Scientists speculate that the reason might be an exposure to greater numbers of microbes that keeps the immune system from turning on the body. “Our study provides evidence to robustly support this assumption,” Dunn and his colleagues wrote. The researchers are planning to process samples from a total of 1,300 homes across the United States to look for geographic differences in microbial roommates. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/05/23/dogs-bring-swarm-bacteria-into-your-home/