A University of Utah-led study reports that cancers select against a protein complex called the mitochondrial pyruvate carrier (MPC), and re-introduction of MPC in colon cancer cells impairs several properties of cancer, including growth. The research, which appears online on Oct…
Drugs already in use, called tyrosine kinase inhibitors (TKIs), target BCR-ABL and are effective at controlling the disease. They do not cure CML but control it in a way that allows patients to get back to normal life and a normal expected lifespan…
source : http://www.sciencedaily.com/releases/2014/05/140529182747.htm
source : http://www.sciencedaily.com/releases/2014/05/140519104743.htm
"Better understanding of the processes that regulate the growth of blood vessels puts us in a position ultimately to develop new treatments for diseases related to blood vessel growth," and to better understand cancer metastasis, says bioengineering professor Jeff Weiss of the university’s Scientific Computing and Imaging Institute. Weiss and Lowell Edgar, a postdoctoral fellow in bioengineering, published their study Wednesday, Jan. 22, in the Public Library of Science’s online journal PLOS ONE. …
“Almost two-thirds (64.5%) of women who have had hysterectomies reported having recent Pap tests,” said Deanna Kepka, PhD, MPH, co-author of the study, a Huntsman Cancer Institute (HCI) investigator, and assistant professor in the College of Nursing at the University of Utah. “And half (50.4%) of women over 65 who have no cervical cancer history also reported a recent Pap test. This represents 14 million women in the United States receiving an unnecessary procedure.” Because the risk of developing this slow-growing cancer is very small at such a late stage in life, Pap tests do not benefit women over age 65 who have no history of cervical cancer or pre-cancerous conditions…
The study identified multiple, distinct Y chromosomes associated with a significant excess risk of prostate cancer, said Lisa Cannon-Albright, Ph.D., Professor and Chief of the Division of Genetic Epidemiology at the University of Utah School of Medicine. Dr. Cannon-Albright, who headed the study and presented the results today, said that her lab plans to search these Y chromosomes for the genetic mutations that can predispose a man to develop prostate cancer, the second most frequently diagnosed cancer in the U.S. …
In the largest population-based study to date, researchers from Huntsman Cancer Institute (HCI) at the University of Utah made this finding based on nearly 127,000 individuals who underwent colonoscopy in Utah between 1995 and 2009. The results appear online in “Early View” of the journal Cancer. Family history of colon cancer is widely accepted as a factor that increases risk for the disease. …
Wnt proteins are a large family of proteins that active signaling pathways (a set of biological reactions in a cell) to control several vital steps in embryonic development. In adults, Wnt-mediated functions are frequently altered in many types of cancers and, specifically, within cell subpopulations that possess stem cell-like properties…
New research has revealed that soldiers who experienced multiple concussions during active service are much more likely to have suicidal thoughts than those who sustained just one injury or never had a concussion, the Los Angeles Times reported. The study relates to two disturbing trends U.S. military has experienced over the last decade: an increase in suicides and an increase in concussions.  In 2012, the Army experienced a record 324 suicides, exceeding the number of combat deaths in Afghanistan for that year. And numerous roadside bombs have caused thousands of military personnel to suffer from damaging concussions, also known as mild traumatic brain injury (TBI).   Many studies have speculated that these growing number of concussions may lead to an increase in military suicides, and this new paper, published in the journal JAMA Psychiatry, further highlights that relationship.   Craig Bryan, the study’s lead author and an Air Force psychologist who served in Iraq in 2009, analyzed 161 military subjects, most of whom were men serving in the Army.  The subjects had been referred to Bryan for suspected concussions and were subsequently questioned about their history of head trauma, depression, PTSD and suicidal tendencies. Among the 85 subjects who had suffered two or more concussions, 12 percent reported they had considered suicide.  However, of the 58 subjects who had experienced only one concussion, just 3 percent had thought about suicide. None of the remaining 18 subjects, who had never experience a concussion, reported any suicidal thoughts. “All of a sudden the likelihood of being suicidal increased dramatically once you had the second head injury,” Bryan, now head of research at the University of Utah’s National Center for Veterans Studies, told the Los Angeles Times. Both depression and post-traumatic stress disorder (PTSD) were controlled for in the study, meaning TBI is potentially a significant component of suicides. While researchers do not fully understand why TBI contributes to suicide, it is possible that mild TBI can impair problem-solving skills and the ability to fit in socially, leading doctors to speculate that these impairments may lead to suicidal ideation. Bryan also noted that it’s possible another factor is causing the two trends – impulsiveness.  The trait is a well-known risk factor for suicide, and impulsiveness can also increase the likelihood of suffering from a concussion, Bryan said. Overall, Bryan said the topic needs further research, as various studies involving football, ice hockey and other contact sports have also shown a similar relationship between TBI and suicidal behavior. Click for more from the Los Angeles Times.source : http://www.foxnews.com/health/2013/05/16/multiple-concussions-may-be-causing-increase-in-military-suicides-study/