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BPA linked to higher risk for obesity among young girls

A chemical commonly found in plastic food containers, water bottles and canned foods called bisphenol-A (BPA) has long been linked to serious health issues, including infertility and birth defects.Now, researchers say exposure to BPA may also be associated with a higher risk for obesity among puberty-age girls. In a study published in the journal PLOS ONE, researchers measured the levels of BPA present in urine samples from 1,326 children between the ages of 9 and 12. Researchers discovered that girls who had higher levels of BPA in their urine had a greater risk for being overweight. The effect was not seen in the boys involved in the study. Girls who had more than 2 micrograms per liter of BPA in their urine were twice as likely to be overweight, compared to girls with below normal levels of BPA in their urine. And girls that had more than 10 micrograms of BPA per liter in their urine had a ten times greater risk for obesity. Dr. Di-Kun Le, the study’s principal investigator and a reproductive and perinatal epidemiologist at the Kaiser Permanente Division of Research in Oakland, Calif., has been studying the effects of BPA for years. “Animal (studies) started to show that BPA can impact metabolic processes, which often leads to obesity and diabetes,” Le told FoxNews.com. “So we decided to look at it (in humans).” Le noted that though he expected to find a link between obesity and BPA levels, he didn’t expect it to be such a strong correlation.   While the research does not necessarily prove BPA is the reason for the girls’ obesity, Le said that the effect is likely caused by the fact that BPA is an endocrine disrupter and acts similarly to the hormone estrogen, which impacts metabolic function. Because of the damage that BPA incurs on the endocrine system, Le believes exposure to BPA is contributing to the global obesity epidemic.   “Overeating a little won’t cause obesity, but (by) having this kind of endocrine damage without knowing it, and adding more food, the consequences are magnified,” Le said. Though Le said there are currently no Food and Drug Administration (FDA) regulations forcing manufacturers to label how much BPA is used in packaging, he hopes this research will add to the body of evidence mounting against the chemical. He warns that people should try to avoid products containing BPA as much as possible. “Buy BPA-free containers, particularly containers used for kids. Kids and fetuses are the most affected populations,” Le said. “Also try to reduce using plastics. It’s not feasible to use none, but reduce exposure to plastic containers…and reduce the use of canned foods.” Le hopes to study the effects of BPA further, by testing its impact on unborn babies. “I want to look when pregnant women, and their fetuses, are exposed to even small amounts of BPA, how it’s going to damage (them),” Le said. “When you damage the fetus, you damage the rest of their life.”source : http://www.foxnews.com/health/2013/06/13/bpa-linked-to-higher-risk-for-obesity-among-young-girls/

Allergic and autoimmune diseases linked, mouse study suggests

The results of previous research had shown that people with minor variations in the BACH2 gene often develop allergic or autoimmune diseases, and that a common factor in these diseases is a compromised immune system. In this study in mice, the Bach2 gene was found to be a critical regulator of the immune system’s reactivity. The study, headed by researchers at the National Cancer Institute (NCI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), both part of NIH, and their colleagues appeared online in Nature, June 2, 2013. …

Mystery behind dormant breast tumor cells that become metastatic unlocked

In a small but significant number of breast cancer patients, cancerous cells can move through the bloodstream from breast tissue to secondary sites in other parts of the body where they may remain in a dormant state, clinically undetected, for an extended period of time, before suddenly becoming metastatic. …

Sugary drinks tied to kidney stone risk

Adults who drink at least one sugar-sweetened drink a day are slightly more likely to develop kidney stones than people who rarely imbibe them, according to a new study. While the recommendation for kidney stone prevention has been to drink a lot of fluids, the study suggests that it's not just the amount of fluid but the type of drink that also matters. Dr. Gary Curhan, the senior author of the study, said patients often ask for dietary advice to help prevent kidney stones. While the recommendation has been to drink plenty of fluids, Curhan said, patients often ask, “what should I drink? There's a lot of lore out there.” To see whether the type of beverage might matter, Curhan, of the Channing Division of Network Medicine at Brigham and Women's Hospital, and his colleagues collected data from three massive surveys of nearly 200,000 people. The questionnaires surveyed participants every two to four years and asked about diet, lifestyle and health, including how much they drank certain beverages and whether they developed kidney stones. None of the people in the study had kidney stones at the start. They found that 159 out of every 100,000 people who drank a sugar-sweetened non-cola beverage, such as clear soda, less than once a week developed kidney stones, compared to 306 out of every 100,000 who drank soda daily. After accounting for other factors, that translated to a 33 percent greater chance of developing kidney stones. Frequent punch drinkers also had an 18 percent higher chance of developing kidney stones. For every 100,000 people who drank punch at least every day, 226 developed kidney stones, compared to 158 out of every 100,000 participants who had punch less than once a week. Curhan said that while the numbers of people developing kidney stones in each group are not enormously different, the increased risk spread across an entire population is quite big. “Sodas are so commonly used that even though the absolute rate doesn't look that different, if there's a huge number of people consuming it, then the magnitude on the public health can be quite substantial,” Curhan told Reuters Health. Other drinks, such as coffee, tea, wine, beer and orange juice were tied to a lower risk of developing kidney stones. For instance, 205 out of every 100,000 people who rarely drank coffee developed kidney stones, compared to 137 out of every 100,000 people who drank it daily. Just 96 out of every 100,000 people who drank red wine daily developed kidney stones, while 174 out of every 100,000 people who drank red wine less than once a week developed kidney stones. Curhan's study, published in the Clinical Journal of the American Society of Nephrology, follows others showing a link between stones and fructose, non-dairy calcium, vitamin C supplements and other factors. The new study doesn't prove cause-and-effect between certain drinks and kidney stones, but it's possible that sugar could be involved, Curhan said, because it might play a role in how the body handles calcium. Another possibility is that sugary drinks might be contributing to obesity, and obesity is also tied to a higher kidney stone risk, said Dr. Elaine Worcester, a professor at the University of Chicago, who was not part of the study. Despite the lack of proof of a cause-effect relationship, Worcester said “these kinds of studies are the best we have to give advice to our patients.”source : http://www.foxnews.com/health/2013/05/23/sugary-drinks-tied-to-kidney-stone-risk/

Genetic testing guidelines under fire

If you underwent a genetic test for a heart condition, but the test also revealed that you have a high risk of colon cancer, would you want to know? A respected scientific society says your doctor should tell you, but the group is receiving criticism for its recommendation that “incidental findings” of genetic tests be shared with patients. Incidental findings are unexpected results, unrelated to the reason for testing. What to do with these findings has been a controversial issue for adults undergoing genetic testing, as well as children. In March, the American College of Medical Genetics and Genomics (ACMG) released guidelines saying that when patients receive genetic testing for any medical reason, they should be screened for mutations in an additional 57 genes, including mutations that strongly increase the risk of breast, ovarian and colon cancer. The ACMG argues that doctors have an obligation to look for and report these mutations because there are ways that people can act to reduce their of developing a medical disorder. However, some researchers and bioethicists say the new recommendations go too far, and take away patients' rights to refuse medical information they do not wish to know. Informed consent A crucial part of genetic testing ethics is ensuring that patients understand what a test might find, and what those findings could mean for future treatment. Under the new recommendations, a patient who consents to any genetic test is consenting to be screened for mutations in an additional 57 genes. Some bioethicists take issue with this approach, because patients may not wish to know their results for all of these genes. A positive result for any one of these mutations may increase patients' anxiety, or cause them to live their life differently, said Susan Wolf, a professor of law, medicine and public policy at the University of Minnesota. Under the new guidelines, “unless they are willing to have this extra analysis done, the only option is to walk away from the sequencings altogether,” Wolf said. “It's all or nothing.” Arthur Caplan, a bioethicist at New York University School of Medicine's Division of Medical Ethics, agreed that patients should have an opportunity to refuse. “People do not have any obligations to accept any findings that they hadnt been expecting,” Caplan said. And even calling such findings “incidental” is a misnomer, Wolf said, because under the new guidelines, researchers have to actively test for these gene mutations. What about kids? Earlier this year, both the American Academy of Pediatrics and the AMCG advised that children not be screened for genetic conditions that occur in adulthood (such as breast cancer), unless some action in childhood can lower the risk of disease or death. Children should wait until they are at least 18 years old to decide if they want to know their risk, the guidelines say. But under the new recommendations, children should be informed about any findings from the extra screening, including those that relate to adult disorders. Supporters of the new recommendations say that they are not at odds with earlier guidelines. Dr. Robert Green, of Harvard Medical School, and colleagues, wrote in the May 16 issue of the journal Science that if doctors are screening a child for a genetic disease that occurs in adulthood, the child would presumably have a family history of the disease. With incidental findings, no other family members, including the child, would be known to be at risk. So reporting an incidental finding could alert the child, as well as other family members including adults, to their risk of a certain condition, Green said. But others disagree, saying the new recommendations contradict earlier guidelines, and are not in children's best interest. “You've deprived the child of their own choice later as an adult,” Wolf said. Practical issues The guidelines also say that patients should be counseled about the implications of genetic testing before the test is ordered. But some argue that discussing all 57 genes would be demanding. “That is going to be a rather time consuming process,” said Dr. Harry Ostrer, a medical geneticist at the Albert Einstein College of Medicine in New York City. Wolf and others are calling on the AMCG to reconsider the new guidelines. The AMCG says that the guidelines will be reviewed yearly and updated in light of new evidence. But in the meantime, doctors are in a bind about what to do when screening patients. “It really creates a big dilemma because, when an organization like the AMCG makes a recommendation, it's seen as establishing a standard of care,” Ostrer said. If doctors don't follow the guidelines, patients could sue for malpractice if it turns out they are a carrier of a mutation that the additional screening would have caught, Ostrer said. Ostrer said he would like to see more evidence about how patients respond to being told about incidental findings. Studies looking at this question are being carried out now, he said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/05/20/genetic-testing-guidelines-under-fire/

Teen who text and drive also likelier to take other risks in car

Teenagers who text while driving are also more likely to engage in other risky activities, such as riding with an intoxicated driver or not wearing a seatbelt, a new study suggests. Researchers from the U.S. Centers for Disease Control and Prevention (CDC) found four in every nine high school students had sent or received texts while driving in the past month. “Considering it's against the law for teens to be texting while driving in 45 states, it's a little concerning,” said Emily Olsen, a health statistician in the CDC's Division of Adolescent and School Health and the report's lead author. Past studies conducted in single states have found anywhere from one quarter to almost three quarters of teenagers text while driving, the study team wrote Monday in Pediatrics. To get a more nationally representative picture, Olsen and her colleagues analyzed responses to the CDC's annual youth risk survey. On the 2011 survey, conducted in public and private schools across the country, 8,505 high school students ages 16 and older were asked about potentially dangerous driving behaviors they had engaged in over the past month. Just under 45 percent had texted while driving at least once during that span, and close to 12 percent of teens said they texted behind the wheel every day. Although the study team didn't measure how cell phone use may have affected safety in the car, past research shows that texting while driving can slow reaction times and impair a driver's ability to stay in one lane. The more frequently students reported texting and driving, the more likely they were to also answer “yes” to other risky behaviors, the researchers found. For example, 3 percent of teens who didn't text at the wheel had recently driven after drinking alcohol. That compared to 19 percent who reported texting and driving at least once in the past month and 34 percent who said they texted in the car daily. Likewise, 19 percent of non-texters had ridden in a car with another driver who had been drinking, versus 33 percent of high school students who reported texting and driving themselves. “It's concerning that kids are participating in these multiple behaviors, either while they're driving or while they're a passenger,” Olsen said. “Each one of these things is quite dangerous (on its own).” Jessica Mirman, who has studied teen motor vehicle cell phone use at Children's Hospital of Philadelphia's Center for Injury Research and Prevention, agreed. “That just really highlighted that as far as prevention goes, we really need something comprehensive,” Mirman, who wasn't involved in the new research, said. “It's not just about texting. It's not just about drinking.” Olsen said parents have the best chance of being able to curb unsafe activities in the car by continuing to talk with their children about safe driving even after they have their license. Teens, she pointed out, are already more likely to get into - and have trouble getting out of - dangerous situations on the road, due to their inexperience. “Anything that takes their attention away from the task of driving, it can wait,” she said. Parents who are worried about their teens' driving behavior should reach out to their pediatrician or a school counselor, Mirman advised, as that risk-taking might reflect other underlying problems.source : http://www.foxnews.com/health/2013/05/13/teen-texting-at-wheel-tied-to-more-driving-risks/

Immune cells that suppress genital herpes infections identified

The discovery of this subtype of immune cells, called CD8+ T cells, opens a new avenue of research to develop a vaccine to prevent and treat herpes simplex virus type 2, or HSV-2. Identifying these T cells’ specific molecular targets, called epitopes, is the next step in developing a vaccine. The findings are described in the May 8 advance online edition of Nature…