Tag Archives: data

Discovery goes from the lab to the patient

"This approval marks more than a decade of work with my fellow researchers and highlights the growing importance of genomic and genetic tests in the oncology clinic," said Perou. "This test is the result of data coming from modern, cutting-edge genomic technologies, and thus it is exciting to see the bench to bedside story fulfilled." A team of UNC researchers and collaborating researchers from three other institutions — Washington University in St. Louis, the University of Utah and the BC Cancer Agency — designed this test that categorizes breast tumors into one of four main subtypes by looking at the expression of 50 genes. The four types are luminal A, luminal B, HER2-enriched and basal-like. …

Unstable chromosomes linked to less favorable response to RT and surgery in prostate cancer patients

In this study, researchers assessed the outcomes of 280 prostate cancer (Cap) patients, and reviewed the DNA "fingerprints" of each patient’s tumor (using the patient’s initial diagnostic core biopsy) to determine if gene copy number alterations (CNAs), or breaks in CFSs, were related to a less positive response to treatment. Two groups were analyzed: 126 localized intermediate risk CaP patients who had received image-guided radiation therapy (IGRT) treatments, with a mean dose of 74.6 Gy; and 154 localized intermediate and high risk CaP patients who had undergone radical prostatectomy (RP), which is the surgical removal of the entire prostate gland. Utilizing an array comparative genomic hybridization (aCGH), DNA from frozen needle biopsies of the RT patients was analyzed for 13 previously characterized CFSs: FRA2G, FRA3B, FRA4F, FRA6E, FRA6F, FRA7E, FRA7G, FRA7H, FRA7I, FRA7K, FRA8C, FRA9E, FRA16D. …

Cancer cells propagated from early prostate cancer

The scientists’ findings, suggesting that potentially lethal castration-resistant prostate carcinoma cells already exist in some cancer patients at the very early stages of their disease, will be published by PLOS ONE on September 25, 2013. The work describes the isolation and propagation of the earliest prostate cancer cells yet identified in human prostate cancer biopsy samples, allowing the detailed molecular characterization of these very early-stage cancer cells, including analysis of gene expression and mutations. …

Walking after meals may reduce diabetes risk

Doctors have long recommended exercise to reduce the risk of type 2 diabetes, especially in those at high risk for the condition. But a new study found that doing a short walk right after you eat may be the simplest and most effective strategy, especially for older adults. The study,  published in Diabetes Care, found that a 15-minute walk about a half an hour after each meal was as effective at reducing blood sugar as a single 45-minute morning or late afternoon walk.  But researchers found that the quick walk after dinner was even more effective than the longer afternoon walk in lowering blood sugars (glucose) over night into the next day. “The post-meal exercise was especially efficient at lowering the 3-hour post-dinner blood sugar glucose,” said the study’s lead author Dr. Loretta DiPietro, chair of the department of exercise science at George Washington University School of Public Health and Health Services. The study also found that the most effective time to go for a post-meal walk was after the evening meal. Dinner is usually the largest meal of the day, causing the greatest rise in blood sugar, which lasts into the night and the next morning. These affects were significantly reduced by the after dinner walk.    This is an important finding for older people. As you age, your insulin response to help shuttle sugar out of the bloodstream becomes sluggish. Insulin levels also start to fall in the afternoon and into the evening, adding to the weaker response to sugars you consume. Many people end up sitting around after dinner and going to bed with very high blood sugar levels – which according to DiPietro – is the worst thing you can do. When you exercise, contracting muscles help to clear sugar from the blood and get it stored in the muscles or liver. In this study, older adults walked at a moderate pace, not a brisk walk and not a leisurely stroll. This study, though small, was one of the first to look at the timing of exercise. The general recommendations are to get 150 minutes of exercise a week or at least 30 minutes five days a week. But the study looked at what happened a half an hour after a meal, during the time when sugar begins to flood the blood stream. “When you look at the data, you can see the blood sugar started to go up after a meal, and the exercise abruptly halted that upward rise in blood sugar,” said DiPietro. Though the findings need to be confirmed in larger trials, they are important for those with prediabetes and older individuals. An estimated 79 million Americans have prediabetes but most have no idea they are even at risk. “It may be easy for older adults to take a short walk or combine walking after a meal with running errands or walking the dog,” said DiPietro. The findings may be important for others including pregnant women who are at risk of gestational diabetes.  And if you overindulged in a meal, going for a brisk walk may help your body get rid of that excess sugar more efficiently.Laurie Tarkan is an award-winning health journalist whose work appears in the New York Times, among other national magazines and websites. She has authored several health books, including “Perfect Hormone Balance for Fertility.” Follow her on Twitter and Facebook.source : http://www.foxnews.com/health/2013/06/12/walking-after-meals-may-reduce-diabetes-risk/

Researchers move closer to development of universal flu vaccine

Researchers say they have made a major step towards the development of a universal flu vaccine, after a new immunotherapy approach has shown promise in animal studies, Medical News Today reported. The method involves creating a stronger immune reaction against the flu virus in the body, protecting against more viral strains than the current vaccines do. A new flu vaccine is developed each year in order to offer the most protection against the circulating viruses.  But for the developers, it is usually a race against the clock, as the data they use quickly becomes out of date once it reaches them. Also, there is always the possibility that new flu virus strains will emerge after the vaccine has been created. The development of a universal flu vaccine would eliminate the need for the development of annual flu shots. To test their new approach, researchers from the National Institute of Allergy and Infectious Diseases (NIAID) created a vaccine that utilized a fusion of the protein ferritin, which can assemble itself into tiny nanoparticles, and the protein hemagglutinin (HA), which is found on the surface of the influenza virus.   The protein combination ultimately produced nanoparticles with eight protruding viral spikes, which served as the basis for the vaccine’s antigen – what the immune system responds to when creating antibodies. Through a series of tests on mice and ferrets, the researchers found the vaccine was more effective at boosting immunity against a much wider range of virus strains than the current flu vaccine, including strains they were not testing for. According to the researchers, the vaccine is effective because it prompts the immune system to develop antibodies to the parts of the flu virus that stay the same from strain to strain.  They say the study’s findings, published in the journal Nature, could lead to a universal flu vaccine that protects against numerous strains of the influenza virus. Click for more from Medical News Today.source : http://www.foxnews.com/health/2013/05/23/researchers-move-closer-to-development-universal-flu-vaccine/

Bionimbus protected data cloud to enable researchers to analyze cancer data

The Bionimbus Protected Data Cloud, as it is called, enables researchers who are authorized by the National Institutes of Health (NIH) to access and analyze data in The Cancer Genome Atlas (TCGA) without having to set up secure, compliant computing environments capable of managing and analyzing terabytes of data, download the data — which can take weeks — and then install the appropriate tools needed to perform the desired analyses. Using technology that was developed in part by the Open Science Data Cloud, a National Science Foundation-supported project that is developing cloud infrastructure for large scientific datasets, the Bionimbus Protected Data Cloud provides researchers with a more cost- and time-effective mechanism to extract knowledge from massive amounts of data. Drawing insights from big data is imperative for addressing some of today’s most vexing environmental, health and safety challenges. …

Skin cancer strikes men differently

Malignant skin cancers develop in different areas of the head and neck in men and women. The reason may simply be because men are often the drivers of a car, while women are more often the passengers, according to a study in the Journal of Investigative Dermatology. Up to 20 percent of aggressive skin cancers called melanomas occur on the head and neck, which are exposed to greater amounts of ultraviolet radiation than other parts of the body. But few studies have compared gender differences in the distribution of these cancers, the researchers said. The study analyzed 279 head-and-neck melanomas diagnosed in 121 men and 158 women in their early 70s from the Champagne-Ardenne region of France, between 2004 and 2009. About half of the cancers were invasive, or had spread beyond the initial site. The data revealed two distinct patterns. In men, 57 percent of melanomas were located in the peripheral area of the head and neck, which included the scalp, forehead, temple, ears and neck, while 43 percent developed on the eyelids, nose, cheeks, chin and mouth, or the central area. In women, 79 percent of melanomas developed in the central area and 21 percent in the peripheral area. Peripheral cancers were more common on the left side in men and on the right side in women, and tended to be invasive, researchers said. Men spend more time driving than women and are often the principal driver, researchers said, which may explain the asymmetrical distribution of melanomas. The peripheral area is particularly exposed to UV radiation while traveling in a car, although longer hair on women appears to provide some protection, they said. Click for more from The Wall Street Journal.source : http://www.foxnews.com/health/2013/05/15/skin-cancer-strikes-men-differently/