Tag Archives: clinical

In nonsmoking women, breastfeeding for more than six months may protect against breast cancer

To look at the relationship between breast cancer and certain aspects of pregnancy and breastfeeding, Emilio González-Jiménez, PhD, of the University of Granada in Spain, and his colleagues analyzed the medical records of 504 female patients who were 19 to 91 years of age and who had been diagnosed and treated for breast cancer from 2004 to 2009 at the San Cecilio University Hospital in Granada. …

Metastatic breast cancer study shows success in finding new treatment

The Side-Out Foundation’s pilot study is part of a cutting-edge approach to personalized medicine that looks beyond genomic analysis alone to combine it with what some say is the next frontier in targeted therapy: proteomics. The pilot study is the first of its kind to utilize novel protein activation mapping technology along with the genomic fingerprint of cancer as a way to find the most effective treatment. The trial was announced at the annual meeting of the American Society of Clinical Oncology and is expected to expand into phase two this month. Standard chemotherapy had failed the 25 women who participated in the 2.5-year pilot study, says study co-author Emanuel "Chip" Petricoin, co-director of George Mason’s Center for Applied Proteomics and Molecular Medicine (CAPMM)…

Therapy that heats and destroys bone tumors eases patients’ pain

Mark Hurwitz, MD, Director of Thermal Oncology for the Department of Radiation Oncology at Thomas Jefferson University and Hospital reported that the treatment, magnetic resonance image-guided focused ultrasound (MRIgFU) ablation therapy, significantly reduced pain in 67 percent of patients who received the treatment. …

Stretching, meditation eases PTSD in nurses, study shows

Nurses deal with traumatic experiences on a daily basis – a factor which puts them at higher risk for post-traumatic stress disorder (PTSD), an anxiety disorder diagnosed in over 7 million U.S. adults every year. Now, researchers have discovered a simple solution to help nurses, and others with PTSD, cope with their disease: just one hour of stretching and meditation every week. In a study published in the Journal of Clinical Endocrinology & Metabolism, lead study author Sang H. Kim, of the National Institutes of Health, studied a group of 22 nurses experiencing PTSD symptoms. He chose to focus his research on nurses, in part, because his mother was a nurse. “(My mother) always used to tell me nurses need to not only take care of others – they need to take care of themselves, too,” Kim said. At the beginning of the study, Kim assessed the nurses’ PTSD symptoms using the PCL-C: PTSD checklist – civilian version, a questionnaire commonly used to diagnose PTSD. He also took blood samples from each nurse in order to analyze their levels of the stress hormone cortisol.   When people experience PTSD, their cortisol levels dip below normal – the opposite of what usually happens when people get stressed. Kim wanted to see if a meditation and stretching regimen would be able to help normalize cortisol levels. “My question was if we can reverse this, can we reverse PTSD symptoms?” Kim said. Half of the group of nurses participated in a 60-minute mind-body class once a week. The class was taught by Kim, who holds a doctorate in exercise science, and has 40 years of experience as a martial artist. During each session, the women performed meditation, stretching, balancing and deep-breathing exercising. “(It was) similar to yoga or tai chi or chi gong types of movement, but I simplified it in a way that they could do it anywhere, anytime and in any amount of time,” Kim said. “Nurses are always in demand so they sometimes only have one minute or 30 seconds.” After eight weeks of participating in the once-weekly class, the nurses experienced a 41 percent decrease in PTSD symptoms and a 67 percent increase in cortisol levels in the blood. Kim said that researchers only expected to see up to a 20 percent decrease in PTSD symptoms and were surprised – and impressed – by their results. “What we found is simple, but profound – only eight weeks of meditation relieved PTSD symptoms and normalized stress hormone levels,” Kim said.   The nurses who participated in the mind-body classes also experienced a reduction in PTSD symptoms such as flashbacks or emotional detachment – and they were able to  resume hobbies and improve their overall quality of life, according to Kim. “About four weeks in, many told me… ‘I sleep better these days and get less angry in my work and I now know if something comes up I can breathe, go to the bathroom, close the door and do this movement for one minute and come out and feel better,’” Kim said. The other half of the women in Kim’s study did not participate in the mind-body class. Comparatively, they experienced only a 4 percent decrease in PTSD symptoms and a 17 percent improvement in blood-cortisol levels during the same period of time. “The conclusion here is that mind-body practices like yoga or tai chi or chi gong - people think these things are hokey but…they are working,” Kim said. “(They are a) very effective and low-cost (way) for reducing stress even in people who suffer chronically high levels of stress, like PTSD patients.”source : http://www.foxnews.com/health/2013/05/30/stretching-meditation-eases-ptsd-in-nurses-study-shows/

Poliovirus vaccine trial shows early promise for recurrent glioblastoma

The treatment, developed at Duke and tested in an ongoing phase 1 study, capitalizes on the discovery that cancer cells have an abundance of receptors that work like magnets drawing the poliovirus, which then infects and kills the cells. The investigational therapy, known as PVSRIPO, uses an engineered form of the virus that is lethal to cancer cells, while harmless to normal cells. …