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Image Guided Radiation Therapy Is Commonly Used to Ensure Accuracy in Treating Pediatric Tumors

IGRT is the process of using frequent imaging, typically performed in the treatment room prior to radiation delivery, throughout a patient’s course of radiation therapy treatment to improve localization of the target and normal structures, which allows for more precise and accurate radiation delivery. IGRT is a common practice in both photon (traditional radiation therapy) and proton therapy to treat tumors close to sensitive structures and organs or in areas of the body prone to movement or change in shape. This study, “Practice patterns of photon and proton pediatric image guided radiation treatment: Results from an International Pediatric Research Consortium,” evaluates the use of IGRT in treatment planning for pediatric cancers in an international consortium comprised of seven institutions using either photon or proton therapy with dedicated pediatric expertise. Choosing optimal IGRT regimens that spare healthy tissue and organs is a particular concern for pediatric patients to help prevent potential late effects associated with the distribution of the radiation dose and the total radiation dose the patient receives. …

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Multicenter study underscores need for uniform approach to bladder cancer

According to the lead author, Dr. Francesco Atzori, progress in developing new effective drugs in bladder cancer has been stagnant in the last decades. "In patients who recur or who are refractory to first-line therapy, response rates and outcomes are grim, and to date, no second-line therapy has been clearly established," he explained…

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Keeping centrioles in check to ensure proper cell division

Their results are published in the journal Current Biology today. Centrioles — orchestrators of cell division When our cells divide, their genetic material — in the form of X-shaped chromosomes — is aligned in the middle of the cell and segregated to opposite poles of the cell by a spindle of long tubular fibers, so-called microtubules. The structures that organize the two poles of the spindle in animal cells are called centrosomes…

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