Tag Archives: vessel

Viewing cancer on the move: New device yields close-up look at metastasis

The inventors, from the university’s Whiting School of Engineering and its Institute for NanoBioTechnology (INBT), published details and images from their new system recently in the journal Cancer Research. Their article reported on successful tests that captured video of human breast cancer cells as they burrowed through reconstituted body tissue material and made their way into an artificial blood vessel. “There’s still so much we don’t know about exactly how tumor cells migrate through the body, partly because, even using our best imaging technology, we haven’t been able to see precisely how these individual cells move into blood vessels,” said Andrew D. …

Most prostate cancer patients surveyed five years after vessel-sparing radiation therapy report preserved sexual function — ScienceDaily

The study examined the patient-reported outcomes of 91 men with prostate cancer who received MRI-guided, vessel-sparing radiation at University of Michigan Providence Cancer Institute. The vessel-sparing radiation technique limits the amount of radiation to critical erectile tissues using MRI scans to identify the blood vessels responsible for erections. When radiation dose is limited to these critical structures, the risk of erectile dysfunction is lowered. …

Computer simulation of blood vessel growth

"Better understanding of the processes that regulate the growth of blood vessels puts us in a position ultimately to develop new treatments for diseases related to blood vessel growth," and to better understand cancer metastasis, says bioengineering professor Jeff Weiss of the university’s Scientific Computing and Imaging Institute. Weiss and Lowell Edgar, a postdoctoral fellow in bioengineering, published their study Wednesday, Jan. 22, in the Public Library of Science’s online journal PLOS ONE. …

Microfluidic platform gives clear look at a crucial step in cancer metastasis

While the initial process by which cancer cells enter the bloodstream — called intravasation — is well characterized, how cells escape blood vessels to permeate other tissues and organs is less clear. This process, called extravasation, is a crucial step in cancer metastasis. Now researchers at MIT have developed a microfluidic device that mimics the flow of cancer cells through a system of blood vessels…

Protein in blood exerts natural anti-cancer protection

The study, published June 24 online in the Proceedings of the National Academy of Sciences, suggests it may be possible to harness the power of this naturally occurring anticancer agent as a way to treat cancer, including metastases. In several different publications it has been described the ability of decorin to affect a number of biological processes including inflammatory responses, wound healing, and angiogenesis. In this new article, the study’s senior investigator, Renato Iozzo, M.D., Ph.D., has labeled decorin a "soluble tumor repressor" — the first to be found that specifically targets new blood vessels, which are pushed to grow by the cancer, and forces the vessel cells to "eat" their internal components. …