Tag Archives: study

Low-fat fish oil changes cancer tissue in prostate cancer, study shows

The findings are important because lowering the cell cycle progression (CCP) score may help prevent prostate cancers from becoming more aggressive, said study lead author William Aronson, a clinical professor of urology at UCLA and chief of urologic oncology at the West Los Angeles Veterans Affairs Medical Center. "We found that CCP scores were significantly lower in the prostate cancer in men who consumed the low-fat fish oil diet as compare to men who followed a higher fat Western diet," Aronson said…

Tipping the balance between senescence, proliferation

In this issue of the Journal of Clinical Investigation, Abdul Mondal and colleagues at the National Cancer Institute evaluated the expression of these two p53 isoforms in T lymphocytes from healthy donors and donors with lung cancer. In healthy patients, the authors observed an age dependent accumulation of senescent cells and that these cells had an increase in p53β compared to Δ133p53. In lung tumor-associated cells, there was a higher level of the Δ133p53 isoform. …

Exercise training as ‘prehabilitation’ before surgery

CPET is a non-invasive measurement of the cardiovascular and respiratory system during exercise to assess exercise capacity and cardiopulmonary fitness. According to the researchers, the role of exercise training or ‘prehabilitation’ for optimising preoperative physiological function to counter catabolic effects of surgery has received little attention in cancer patients…

Sofrito contains substances that reduce risk of cardiovascular disease

The study, PREvention with a MEDiterranean Diet (PREDIMED) has recently shown the link between the Mediterranean diet and low levels of cardiovascular disease. The questionnaire used as a reference asked consumers how often they ate vegetables, pasta, rice and other dishes made with sofrito, but the beneficial compounds of this product had never been analysed. Now researchers from the University of Barcelona (UB) and the Biomedical Research Centres Network — Physiopathology of Obesity and Nutrition (CIBERobn) of the Carlos III Health Institute, have for the first time identified polyphenols and carotenoids -healthy antioxidant substances- in sofrito, by using a high resolution mass spectrometry technique. The results have been published in the ‘Food Chemistry’ magazine and they show the presence of at least 40 types of polyphenols. …

New function of two molecules involved in metastasis

Transcription factors are proteins that regulate gene expression. They activate or deactivate a gene’s function. Researchers at IMIM have studied the function of one of these transcription factors, Snail1, in mouse cells during the Epithelial-Mesenchymal Transition (EMT). Sandra Peiró, a researcher from the IMIM Research Group on Epithelial-Mesenchymal Transition and Tumor Progression explains: "EMT is a process consisting of converting epithelial cells, the ones covering the internal and external surfaces of the body, into what are known as mesenchymal cells. …

Low-intensity therapy for Burkitt lymphoma highly effective

Burkitt lymphoma is the most aggressive type of lymphoma, which is a cancer that begins in cells of the immune system. It is more common in equatorial Africa than in Western countries. In Uganda, for example, the estimated prevalence of Burkitt lymphoma is between 5 and 20 cases per 100,000 inhabitants, whereas in the United States, according to NCI’s statistical database for 2001-2009, prevalence was 0.4 cases per 100,000 inhabitants…

Biologists ID new cancer weakness

A new study from MIT biologists has found that tumor cells with mutated p53 can be made much more vulnerable to chemotherapy by blocking another gene called MK2. In a study of mice, tumors lacking both p53 and MK2 shrank dramatically when treated with the drug cisplatin, while tumors with functional MK2 kept growing after treatment. The findings suggest that giving cancer patients a combination of a DNA-damaging drug and an MK2 inhibitor could be very effective, says Michael Yaffe, the David H. Koch Professor in Science and senior author of a paper describing the research in the Nov…

Researchers test bandaging for swollen arm

But there’s no difference if simple compression bandages or a complicated daily lymphatic massage are used as treatment, McMaster University researchers have found. "In the future, patients who receive or can only afford elastic sleeves and gloves should be comforted knowing that their care has not been compromised," said Dr. Ian Dayes, associate professor of oncology for the Michael G…

New discovery on early immune system development

The immune system is complex and a number of genetic diseases are attributed to defects in the cells that form its origins. The study from Lund and Oxford University presents unique findings on the formation of these cells. We know that the first blood stem cells are formed in the aorta region and then travel to the liver, which is the body’s major blood-forming organ during the fetal stage…