Tag Archive myc

Long-sought drug candidate can halt tumor growth, scientists demonstrate

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Scientists at The Scripps Research Institute (TSRI) tried a similar strategy when they attempted to disrupt the function of MYC, a cancer regulator thought to be “undruggable.” The researchers found that a credit card-like molecule they developed somehow moves in and disrupts the critical interactions between MYC and its binding partner. The research, published the week of August 11 in the journal Proceedings of the National Academy of Sciences, also shows the drug candidate can stop tumor growth in animal models. …

Genetic mutations linked to salivary gland tumors

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The research, recently published online ahead of print by the Proceedings of the National Academy of Sciences, shows that a pair of proteins joined together by a genetic mutation — known as CRTC1/MAML2 (C1/M2) — work with MYC, a protein commonly associated with other cancers, to promote the oral cancer’s growth and spread. “This research provides new insights into the molecular mechanisms of these malignances and points to a new direction for potential therapies,” says TSRI biologist Michael Conkright, PhD, who led the study…

Function of cancer-causing gene explored by researchers — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/03/140326182240.htm

Adult cancer drugs show promise against an aggressive childhood brain tumor — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/03/140327135742.htm

Survival protein a potential new target for many cancers

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The discovery offers hope for treating many types of cancer that are driven to grow and spread through the actions of a cancer-causing protein called MYC. Up to 70 per cent of human cancers, including many leukemias and lymphomas, have unusually high levels of MYC, which causes cancerous changes in cells by forcing them into abnormally rapid growth…

Why tumor cells go on dangerous tours

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The protein c-MYC is referred to as a master regulator because it controls the activity of hundreds of genes, including many that drive cell growth and cell proliferation. …

New strategy for defeating neuroblastoma

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Neuroblastoma is the third most common form of cancer in children. …