“This drug delivery system is DNA-based, which means it is biocompatible and less toxic to patients than systems that use synthetic materials,” says Dr. Zhen Gu, senior author of a paper on the work and an assistant professor in the joint biomedical engineering program at NC State and UNC Chapel Hill. …
In a paper published today in the journal Cancer Cell, the researchers report how the drug, known as DTP3, kills myeloma cells in laboratory tests in human cells and mice, without causing any toxic side effects, which is the main problem with most other cancer drugs. The new drug works by stopping a key process that allows cancer cells to multiply…
“Colorectal cancer is still one of the most frequent and deadliest cancers worldwide. But diagnosed in time it can be cured in 9 out of 10 cases,” said Professor Serge Haan from the Life Science Research Unit at the University of Luxembourg…
Scientists at Brigham Young University discovered the two proteins that pair up and switch on this process — known as autophagy. …
It’s known that stem cells come out of the bone marrow and travel to the tiny thymus gland behind the breastbone to learn to become one of two CD4T cell types: one leads an attack, the other keeps the peace. One widely held concept of why they become one or the other is that, despite coming from the same neighborhood and going to the same school, they are exposed to different things in the thymus, said Dr. Leszek Ignatowicz, immunologist at the Medical College of Georgia at Georgia Regents University. In this case, the “things” are ligands and developing T cells are potentially exposed to thousands of these tiny pieces of us inside the thymus…
In an effort to solve this mystery, neuroscientists at The University of Texas Health Science Center at Houston (UTHealth) conducted an experiment in an animal memory model and their results point to a possible explanation. Findings appeared in The Journal of Neuroscience. In the study involving a sea snail that shares many of the same memory mechanisms as humans and a drug used to treat a variety of cancers, the scientists identified memory mechanisms blocked by the drug. …
And habitual drinking is known to increase susceptibility to bacterial pneumonia, septicaemia, tuberculosis and viral hepatitis. The researchers therefore wanted to find out if there was any association between drinking patterns and susceptibility to HPV infection. They included 1313 men who were already taking part in the US arm of the HPV in Men (HIM) study, an international study that is tracking the natural history of HPV infection in men. …
In an effort to solve this mystery, neuroscientists at The University of Texas Health Science Center at Houston (UTHealth) conducted an experiment in an animal memory model and their results point to a possible explanation. Findings appeared in The Journal of Neuroscience. In the study involving a sea snail that shares many of the same memory mechanisms as humans and a drug used to treat a variety of cancers, the scientists identified memory mechanisms blocked by the drug. Then, they were able to counteract or unblock the mechanisms by administering another agent. …
The team of investigators from Memorial Sloan Kettering Cancer Center, New York City, analyzed data from the National Cancer Data Base (NCDB) of the American College of Surgeons and the American Cancer Society, and looked at more than 1 million women who underwent mastectomy due to breast cancer between 1998 and 2011. …
The scientists, from the Division of Gynaecologic Oncology at Yale School of Medicine funded by the National Institutes of Health, showed that the drug afatinib not only killed off uterine serous cancer cells after stopping their growth but also caused tumors to shrink. The drug, a type of personalized medicine, attacks faults in the HER2 gene which lie at the heart of the cancer cells. This stops the disease in its tracks. Drugs which target HER2 are already used to treat breast cancer…