Tag Archives: journal

New prostate cancer screening guideline recommends not using PSA test — ScienceDaily

“Some people believe men should be screened for prostate cancer with the PSA test but the evidence indicates otherwise,” states Dr. Neil Bell, member of the Canadian Task Force on Preventive Health Care and chair of the prostate cancer guideline working group. “These recommendations balance the possible benefits of PSA screening with the potential harms of false positives, overdiagnosis and treatment of prostate cancer.” For men with prostate cancer diagnosed through PSA screening, between 11.3% and 19.8% will receive a false-positive diagnosis, and 40% to 56% will be affected by overdiagnosis leading to invasive treatment…

Prostate cancer risk reduced by sleeping with many women, but increased with many men, study finds — ScienceDaily

Marie-Elise Parent and Marie-Claude Rousseau, professors at university’s School of Public Health, and their colleague Andrea Spence, published their findings in the journal Cancer Epidemiology. The results were obtained as part of the Montreal study PROtEuS (Prostate Cancer & Environment Study), in which 3,208 men responded to a questionnaire on, amongst other things, their sex lives. Of these men, 1,590 were diagnosed with prostate cancer between September 2005 and August 2009, while 1,618 men were part of the control group. Risk associated with number of partners Overall, men with prostate cancer were twice as likely as others to have a relative with cancer…

Improving breast cancer chemo by testing patient’s tumors in a dish — ScienceDaily

A team of biomedical engineers at Vanderbilt University headed by Assistant Professor Melissa Skala has developed the technique, which uses fluorescence imaging to monitor the response of three-dimensional chunks of tumors removed from patients and exposed to different anti-cancer drugs. In an article published last month by the journal Cancer Research the engineers describe applying the technique to the three major forms of breast cancer. They report that the test can detect significant drops in the metabolic activity levels of all three types of tumors within 72 hours when exposed to an effective drug whereas tumors that were resistant to a drug show no change…

Radiation exposure linked to aggressive thyroid cancers, researchers confirm for the first time

Researchers examined thyroid cancers diagnosed up to two decades after the Chernobyl accident and found that higher thyroid radiation doses estimated from measurements taken shortly after the accident were associated with more aggressive tumor features. “Our group has previously shown that exposures to radioactive iodine significantly increase the risk of thyroid cancer in a dose-dependent manner. The new study shows that radiation exposures are also associated with distinct clinical features that are more aggressive,” said the paper’s first author, Lydia Zablotska, MD, PhD, associate professor in the Department of Epidemiology and Biostatistics at UC San Francisco (UCSF). The paper will be published online in the journal Cancer…

Blood test may help diagnose pancreatic cancer

In research published today in the American Journal of Gastroenterology, Murray Korc, M.D., the Myles Brand Professor of Cancer Research at the Indiana University School of Medicine and a researcher at the Indiana University Melvin and Bren Simon Cancer Center, and colleagues found that several microRNAs — small RNA molecules — circulate at high levels in the blood of pancreatic cancer patients. “This is a new finding that extends previous knowledge in this field,” Dr. Korc said. …

Improving breast cancer chemo by testing patient’s tumors in a dish

A team of biomedical engineers at Vanderbilt University headed by Assistant Professor Melissa Skala has developed the technique, which uses fluorescence imaging to monitor the response of three-dimensional chunks of tumors removed from patients and exposed to different anti-cancer drugs. In an article published last month by the journal Cancer Research the engineers describe applying the technique to the three major forms of breast cancer. …

Prostate cancer, kidney disease detected in urine samples on the spot — ScienceDaily

But a cunningly simple new device can stop that vital information from “going to waste.” Brigham Young University chemist Adam Woolley and his students made a device that can detect markers of kidney disease and prostate cancer in a few minutes. All you have to do is drop a sample into a tiny tube and see how far it goes…

Why targeted drug doesn’t benefit patients with early-stage lung cancer

Oncologists use erlotinib to treat lung cancers that have a mutation in a gene called epidermal growth factor receptor (EGFR). The gene mutation causes EGFR to run like it has a stuck accelerator, and erlotinib blocks the overactive molecule. The study shows that while erlotinib effectively causes tumors to shrink — suggesting that the drug is helping — this drug also increases the aggressiveness of the tumor so that growth is accelerated when therapy ends. This study finds that this is due to a secondary and previously unknown effect of inhibiting EGFR…