Tag Archives: group

New therapeutic target that prevents cell division

The Cell Division & Cancer Group, led by Spanish National Cancer Research Centre (CNIO) researcher Marcos Malumbres, has managed to decode a new mechanism that regulates cell division, in which the key molecule involved, Greatwall − also known as Mastl− could be a new therapeutic target for oncology treatments. The study is published today in the scientific journal Proceedings of the National Academy of Sciences (PNAS). GREATWALL: A KEY PLAYER OF THE CELL DIVISION PUZZLE The control of cell division or mitosis depends on many proteins, amongst them, Aurora and Polo. Currently, many pharmaceutical companies have shown interest in these molecules, for which inhibitors have already been developed, some of which are currently undergoing clinical trials in oncology…

Anti-cancer drug benefits women with breast cancer who have failed previous treatments

In a late-breaking presentation to the 2013 European Cancer Congress (ECC2013) [1] today, Professor Hans Wildiers will say: "This study shows that even in heavily pre-treated women, 75% of whom had cancer that has spread to the internal organs, T-DM1 nearly doubles progression-free survival — the length of time before disease progression or death, whichever occurs first — compared to standard therapy, and with a more favourable safety profile. …

Less blood clot risk linked to estradiol than to Premarin pills

"Although oral estrogens are effective for managing menopause symptoms, not enough is known about the cardiovascular safety of different oral hormone therapy products relative to each other," said first author Nicholas L. Smith, PhD. He is a professor of epidemiology at the UW School of Public Health, the director of the Veterans Affairs (VA) Seattle Epidemiologic Research and Information Center (ERIC) at the VA Puget Sound Health Care System, and an affiliate investigator at Group Health Research Institute. To further understand the differences in risk, the researchers also measured clotting (coagulation) factors in the blood of women who did not develop a clot. …

Critical gaps discovered in breast cancer research

It is estimated that around 570,000 people are living with, or after, a diagnosis of breast cancer in the UK, and this number is expected to double by 2030. Breast cancer, therefore, remains a significant challenge. Over 100 specialist breast cancer scientists, clinicians and heath care professionals reviewed a wide range of issues and challenges involved in breast cancer research, prevention and treatment. Through facilitated discussions and consultation, including appraisal from experts and patients, they produced an account outlining ten major gaps and five strategic solutions. …

Potent mechanism helps viruses shut down body’s defense system against infection

Published in the August issue of the journal Cell Host and Microbe, the findings describe a novel mechanism that this group of so-called "enveloped viruses" uses to disarm the host’s innate immune response. The mechanism the scientists uncovered is based on these viruses activating a class of molecules, known as TAM receptors, which are located on the outside of certain immune cells…