“Our ability to combine a novel microfluidic CTC isolation device, developed here at MGH, with single-cell RNA sequencing has given us new biological insights into these cells and revealed novel avenues to try and block the spread of cancer,” says lead author David T. Ting, MD, MGH Cancer Center. Pancreatic cancer is among the most deadly of tumors because it spreads rapidly via CTCs carried in the bloodstream. …
While they exist in small populations in humans, the large amounts of antibodies secreted by plasma cells make them key to the body’s immune system and its ability to defend itself against pathogens, such as bacteria and viruses. Proper maintenance of a pool of plasma cells is also critical for the establishment of lifelong immunity elicited by vaccination. …
It is estimated that around 570,000 people are living with, or after, a diagnosis of breast cancer in the UK, and this number is expected to double by 2030. Breast cancer, therefore, remains a significant challenge. Over 100 specialist breast cancer scientists, clinicians and heath care professionals reviewed a wide range of issues and challenges involved in breast cancer research, prevention and treatment. Through facilitated discussions and consultation, including appraisal from experts and patients, they produced an account outlining ten major gaps and five strategic solutions. …