Heavy cell phone use linked to oxidative stress
To further explore the relationship between cancer rates and cell phone use, Dr. …
Tag Archives: dna
Molecular robots can help researchers build more targeted therapeutics
"This is a proof of concept study using human cells," said Sergei Rudchenko, Ph.D., director of flow cytometry at Hospital for Special Surgery (HSS) in New York City and a senior author of the study. …
Scientists unable to find evidence of ’embryonic-like’ cells in marrow of adult mice
The cells long have been believed to be the only naturally occurring pluripotent cells. (Under the right conditions, pluripotent cells can become any other cell in the body.) But some people object to the fact that the embryo is destroyed during their isolation…
Missing piece of pediatric cancer puzzle found
In a study published in the July issue of the Proceedings of the National Academy of Sciences, researchers found a missing piece of the pediatric cancer puzzle. Changxian Shen, PhD, senior research associate at the Center for Childhood Cancer and Blood Diseases at The Research Institute at Nationwide Children’s Hospital, and Peter Houghton, PhD, director of the center, may have identified one mechanism behind the early development of some pediatric solid tumors — as well as a target for future pediatric cancer therapies…
Chromosomal abnormalities may explain increased cancer risk in type 2 diabetes
Their work was published on July 14, 2013 on the Nature Genetics website. There are more than 200 million diabetics worldwide, and one in three suffer from vascular or nerve complications. In 2012, two studies published in Nature Genetics showed that large chromosomal clonal mosaic events (CMEs)(2) affecting large portions of chromosomes (or even their totality), could be observed in the DNA of blood or saliva cells from some ageing individuals. These studies also suggested that CMEs could predict the risk of cancer, and notably leukemia, in these individuals. …
Cancer researchers discover how BRCA mutation starts breast, ovarian cancers
The answer, says Dr. Mak in research published today in the Journal of Experimental Medicine, is found in the way estrogen rushes in to "rescue" cells whose healthy functioning has been altered by oxidative stress, a well-established factor in cancer development…
CSI-style DNA fingerprinting tracks down cause of cancer spread
Metastasis is responsible for the overwhelming majority of cancer deaths and there are many theories as to how it occurs, but the problem remains yet unsolved. …
Proteins involved in immunity potentially cause cancer
The proteins are part of a group called apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) cytidine deaminases. The investigators found that APOBEC mutations can outnumber all other mutations in some cancers, accounting for over two-thirds in some bladder, cervical, breast, head and neck, and lung tumors. The scientists published their findings online July 14 in the journal Nature Genetics. Dmitry Gordenin, Ph.D., is corresponding author of the paper and a senior associate scientist at the National Institute of Environmental Health Sciences (NIEHS), part of NIH. …
Surprising detail about skin cancer uncovered
The Journal of the American Medical Association Dermatology recently published their study on its online site. "First, we wanted to know if people with a single primary tumor were more likely to die from melanoma than people with multiple primary tumors," says Dr. Berwick…
Gene therapy using lentivirus to treat Wiskott-Aldrich Syndrome promising
The new research, led by researchers at the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy was published in Science Express. The disorder that weakens the body’s immune system is caused by a mutation in a gene that encodes the protein WASP. The most often used therapy is a bone marrow or stem cell transplant from a matching donor — often a sibling or relative…