The team has developed an innovative process allowing them to generate a particular type of synthetic amino acid — and a particular type of designer protein — that has not been done before. The advance is announced by the Jamieson Research Group in the Department of Chemistry at the University of Leicester…
The results are good news for children and adolescents with Philadelphia chromosome-like ALL (Ph-like ALL), a subtype that until now was associated with a poor prognosis. …
Histoplasmosis and other fungal diseases are linked to fungi that are often concentrated in bird droppings and are found in soils. The study by investigators at Vanderbilt University and the Tennessee Valley Healthcare System-Veterans Affairs was led by Vanderbilt first author Stephen Deppen, Ph.D., and principal investigator Eric Grogan, M.D., MPH, and appeared in the Sept. 24 issue of JAMA. Positron emission tomography (PET) combined with fludeoxyglucose F18 (FDG) is currently recommended for the noninvasive diagnosis of lung nodules suspicious for lung cancer…
In a paper published September 17 in the online journal Magnetic Resonance in Medicine, researchers at the University of California, San Diego School of Medicine, University of Pittsburgh and elsewhere describe the first human tests of using a perfluorocarbon (PFC) tracer in combination with non-invasive magnetic resonance imaging (MRI) to track therapeutic immune cells injected into patients with colorectal cancer. “Initially, we see this technique used for clinical trials that involve tests of new cell therapies,” said first author Eric T. Ahrens, PhD, professor in the Department of Radiology at UC San Diego…
By clarifying which patients are at highest risk for reduced sperm production as adults, researchers expect the findings to eventually increase use of pre-treatment fertility preservation methods such as sperm banking. The study involved drugs called alkylating agents that are widely used to treat a variety of pediatric cancers. …
Looking over data gathered from more than 17,000 surveys completed by men diagnosed with prostate cancer, Fox Chase researchers tracked when patients’ urinary and sexual symptoms changed following each type of treatment, and by how much. “The ultimate goal,” says study author Matthew Johnson, MD, Resident Physician in the Department of Radiation Oncology at Fox Chase, “is to develop a predictive tool that lets patients decide which treatment is right for them based on the symptoms they have beforehand, and their tolerance for any change — even temporary — in those symptoms.” After a diagnosis of prostate cancer, men have multiple treatment options, including surgery to remove the prostate and several types of radiation therapy…
RTOG 0236 was a Phase II North American multicenter trial from May 2004 until October 2006 of patients age 18 and older with biopsy-proven peripheral T1-T2 N0M0 non-small cell lung cancer (early stage with no lymph node involvement or metastases). Patients in the study all had medical conditions that precluded them from surgery, so they received SBRT, a specialized type of external beam therapy that uses focused radiation beams at a tumor using detailed imaging…
Looking over data gathered from more than 17,000 surveys completed by men diagnosed with prostate cancer, Fox Chase researchers tracked when patients’ urinary and sexual symptoms changed following each type of treatment, and by how much. “The ultimate goal,” says study author Matthew Johnson, MD, Resident Physician in the Department of Radiation Oncology at Fox Chase, “is to develop a predictive tool that lets patients decide which treatment is right for them based on the symptoms they have beforehand, and their tolerance for any change — even temporary — in those symptoms.” After a diagnosis of prostate cancer, men have multiple treatment options, including surgery to remove the prostate and several types of radiation therapy. They can receive external beam radiation directed towards their prostate, known as intensity modulated radiation therapy (IMRT), or undergo a procedure that implants radioactive seeds in their prostate called low dose rate brachytherapy (LDR). …
Harvard Stem Cell Institute scientists at the Massachusetts General Hospital Center for Regenerative Medicine and the Harvard University Department of Stem Cell and Regenerative Biology led the work, published in the journal Cell, in collaboration with researchers at the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology. “It’s been known for decades that cancer cells use energy differently than most cell types,” said senior author David Scadden, MD. “So we thought, maybe there are metabolism differences between blood stem cells and their immediate descendants; and are they so different from cancer that you might able to manipulate energy sources with something that could have an effect on cancer and not harm normal cells?” Scadden’s team began by examining blood stem cells and their direct offspring — blood progenitor cells that have a more limited ability to differentiate. The researchers modified the way the cells take up nutrients in two ways: via a glucose (sugar) on-off switch, and through subtle adjustments that raise or lower glucose, like a volume dial. …
Dr. McNeill’s team has an international reputation for their work in understanding how cells become organized into tissues and how growth is regulated during development. The group focuses on mutations in the fat (ft) gene…