A team of researchers, led by Candice A.M. Sauder, M.D., while a resident at the Indiana University Department of Surgery, reported online in BMC Cell Biology that healthy breast cells separated from their normal environment were able to transform into types of cells similar to those seen in metaplastic carcinoma, a form of triple negative breast cancer. …
The researchers found that retinoblastoma protein (RB), a protein known to reduce cancer risk, is significantly less active in male brain cells than in female brain cells. The study appears Aug. …
“It is well-established that individual tumors are genetically heterogeneous — comprised of multiple subgroups of cancer cells, each with its own genomic signature, or pattern of gene mutations,” said the study’s senior author, Kornelia Polyak, MD, PhD, of Dana-Farber. …
GRP78, a protein that protects cells from dying, is more abundant in cancer cells and tissue than in normal organs and is thought to play a role in helping pancreatic cancer cells survive and thrive. Researchers at the University of Minnesota have found triptolide, an extract of the Chinese herb thunder god vine (Tirpterygium wilforii), suppresses GRP78, eventually leading to pancreatic cancer cell death. For mammals to use the proteins in our bodies, a process called protein folding must occur in the endoplasmic reticulum (ER) of cells. If proteins are not folded fast enough, unfolded proteins begin to build up and the cell becomes stressed…
source : http://www.sciencedaily.com/releases/2014/07/140716151106.htm
source : http://www.sciencedaily.com/releases/2014/07/140702122242.htm
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source : http://www.sciencedaily.com/releases/2014/06/140627113054.htm
source : http://www.sciencedaily.com/releases/2014/06/140627145932.htm