Tag Archives: adult

Research in fruit flies provides new insight into Barrett’s esophagus

A new study, published June 27, 2013 online in Cell Reports, suggests a different cause, namely a change in stem cell function, for this transformation. Researchers at the Buck Institute manipulated a signaling pathway (BMP-like Dpp) implicated in the development of Barrett’s esophagus. After manipulation, the adult stem cells that normally generate the lining of the esophagus of fruit flies morphed into the type of stem cells that generate stomach cells. "Up until this point, it’s not been clear what this signaling pathway does in stem cells of the gastrointestinal tract, or how it influences the regeneration of various types of epithelial cells in the gut of the fly," said Heinrich Jasper, PhD, a professor at the Buck Institute for Research on Aging and senior author of the study…

After successful lung transplant, challenging recovery awaits girl with cystic fibrosis

Sarah Murnaghan, the 10-year-old Pennsylvania girl at the middle of an organ transplant battle, finally underwent her long-awaited lung transplant on Wednesday. I am so happy that this little girl got a new chance at life.  All of us who have been following this case so closely realize just how critical this child has been for the future of organ transplantation. On Tuesday night, Sarah’s mother, Janet, said they had found a match for her daughter.  And with the great skill of her surgeons and nurses, along with the support of everyone involved in her care, the technical part of her surgery has been successful.   Throughout this whole ordeal, I never lost hope that Sarah would become a candidate for transplant surgery. And I think it speaks volumes about the spirit of the American people who stood behind her and demanded she get a fair shot at life. But the doctor in me tells me we have to be cautiously optimistic because there are still major hurdles that Sarah has to overcome. From a medical standpoint, in cases like this one, there is always the worry about infection.  Organ transplants require large complex surgeries with organs that are very prone to infection – especially the lungs.  And moving forward, Sarah has to undergo immunosuppressive therapy, which predisposes her to the development of infection. There are also significant issues of metabolism.  The function of the lungs is to oxygenate the blood, but this oxygenation contributes to the overall metabolic stability of the body.  Right now, it’s too soon to tell whether her metabolic condition can be stabilized through these new lungs. Finally, with any organ transplant surgery, you also have the possibility of organ rejection, which could theoretically develop over the course of the next few days.  The good news is that she is young, and she is receiving the best health care possible.   I spoke to Dr. Donald McCain, chief of surgical oncology and the vice chairman of the John Theurer Cancer Center at Hackensack University Medical Center in N.J., about other potential obstacles Sarah faces.  He noted that because the donor was an adult, resizing the lungs may also create medical issues. “The size of the lungs are much too great, which is why they don’t use adult lungs in general (for pediatric patients),” McCain said.  “They must remove part of lung tissue, and…you have to do that surgically, creating a surgical line that didn’t exist before.  That surgical line normally will not have the same strength as obviously a non-surgical line.  That creates a potential weak point that is risky for an air leak.” McCain also added that even if Sarah overcomes these hurdles, there is a long road of recovery ahead. “Lung transplants are some of the sickest patients you wind up having, unlike liver and kidney transplant patients, who usually do quite well,” McCain said.  “With lung transplants, these patients are in the hospital a very long time and are usually very sick.” To me, the aggravating part of this story is that this sweet girl only got her chance at life at the last minute.  Had she been placed on the adult organ transplant list earlier, perhaps her condition would have been a little bit stronger when she received her new lungs. But I’m still very optimistic that Sarah will have a good recovery. It saddens me that it finally took a judge to see the common sense and force HHS Secretary Kathleen Sebelius into doing the right thing.  I just hope that other children under similar circumstances get the justice they deserve in enough time.source : http://www.foxnews.com/health/2013/06/13/after-successful-lung-transplant-challenging-recovery-awaits-girl-with-cystic/

Secretary Sebelius, stop hiding behind bureaucratic rules and save a child’s life

Many are calling on Health and Human Services Secretary Kathleen Sebelius to allow Sarah Murnaghan, a 10-year-old girl dying of cystic fibrosis, to be allowed on the adult organ transplant list.  According to current federal policy, the minimum age for her to be included on the list is 12. Currently, Sarah cannot receive an adult lung transplant until the available organs are offered to adult patients first. Of course, Secretary Sebelius could always make an exception by allowing this girl to be put on the transplant list.  Exceptions to federal regulations are made every day by the Department of Health and Human Services, whether you’re talking about the use of non-FDA approved drugs to treat cancer or the use of new technical equipment for surgical therapies. In this specific case, however, we’re talking about saving a child whose only hope is to compete among other patients for a transplant.  It is a perfect example of how rules are sometimes meant to be changed – or broken completely – especially when you’re talking about saving a person’s life. Secretary Sebelius has only ordered a revision of the policy, which could take a lengthy amount of time – something Sarah does not have.  To me, this shows lack of leadership and, certainly, lack of compassion.  Doctors and nurses make instant decisions when it comes to helping others in need, and I believe that someone who is in charge of the largest health care agency on the planet should have a more proactive approach when dealing with these kinds of emergency situations. The field of medicine has changed dramatically when it comes to the surgical techniques that transplant surgeons use.  From minimally invasive therapy to partial organ transplants, new technical miracles continue to develop. Therefore, the argument that an adult organ may not be usable in a 10-year-old is no longer valid, and certainly open for discussion in our clinical community.  As reports have told us, Sarah’s surgeons do agree that in her case, an adult transplant just might work. The rule not allowing a child to be eligible for a transplant from an adult organ until the age of 12 is archaic, and it should not have taken a case like this for Secretary Sebelius – whose tenure has lasted for the past four years – to ask for a revision today. I agree with many who have said that this child is a victim of age discrimination.  But I also agree that Sarah has been ignored by our federal health leaders and has been placed in a bureaucratic Neverland.source : http://www.foxnews.com/health/2013/06/04/secretary-sebelius-stop-hiding-behind-bureaucratic-rules-and-save-childs-life/

Michael Douglas’ interview: Can you get throat cancer from oral sex?

The Guardian newspaper published an interview with Michael Douglas on Sunday, in which the 68-year-old actor said his throat cancer hadn’t been caused by drinking or smoking – but by having oral sex. “Without wanting to get too specific, this particular cancer is caused by HPV, which actually comes about from cunnilingus,” Douglas told the British newspaper.  Douglas also went on to speculate that the stress of his son Cameron’s incarceration might have helped trigger the cancer as well. While a representative for Douglas maintains the actor did not specifically say oral sex was the cause of his cancer, the conversation still begs the question: Does having oral sex play a role in the development of oral cancer? While a connection between the two may seem bizarre, it is very possible that some oral cancers are the end result of intimate sexual contact. Rates of oral cancer – sometimes referred to as head and neck cancers – have been on the rise over the past decade.  While the main risk factors for oral cancers typically include drinking alcohol and smoking, around 25 percent of mouth and 35 percent of throat cancers are related to human papilloma virus (HPV) infection. “(HPV) is present within the fluids that are part of oral sexual behavior,” Dr. Marshall Posner, director of the head and neck oncology program at Mount Sinai Hospital in New York City, told FoxNews.com. “The vaginal fluids and semen will contain epithelial cells that have the virus on them and also free viral particles that can cause infection.” HPV cannot be transmitted through blood contact, but Posner said it may be possible to contract the virus from the direct contact of fluids through kissing. This can occur if an individual kisses someone who previously performed oral sex on someone else who had the virus. “If the virus is present in the oral pharynx and if it gets secreted in the saliva, then the saliva will contain potentially dangerous viral particles,” Posner said. There are more than 100 different types of HPV, and nearly everyone contracts some form of the virus in their youth.  Fortunately, the majority of HPV strains do not cause any symptoms, and in 90 percent of cases, the infection is naturally eradicated from the body within two years. However, some HPV types can cause genital warts, while others may lead to certain cancers in rare cases. HPV 16 and HPV 18 – which are sexually transmitted – are most closely associated with HPV-positive oropharyngeal cancer. According to Posner, 3 percent of adult males and 1 percent of adult females will have detectable HPV 16 in their saliva at any given moment in time.  However, just because HPV is detected in a sample of someone with oral cancer does not necessarily mean HPV caused the cancer.  According to the National Health Service in Britain, the virus becomes part of the pre-existing cancer cells’ genetic material, fostering the cells to grow. Oropharyngeal cancer symptoms include a lump in the back of the throat or mouth, pain in the ear or back of tongue, and difficulty swallowing. While the prognosis for HPV-negative oropharyngeal cancer is around 40 to 50 percent, the survival outcomes are generally better for HPV-positive cancers, ranging from 80 to 95 percent.  However, that prognosis is affected by drinking and smoking, which may have been a problem for Douglas. In the United States, HPV-related oropharyngeal cancer represents 60 percent of the total number of orapharyngeal cancer cases, which equal to about 15,000 per year.  Posner estimated that those cases will increase to 20,000 a year by the year 2015. While researchers cannot fully explain the rising rates of these cancers, one of the biggest risk factor for contracting HPV-positive oroharyngeal cancer includes having a high number of sexual partners, Posner said. “In smoking cigarettes and cancer, it doesn’t matter what brands you smoked, it matters how many you smoked,” Posner said.  “With HPV, it’s about the number of ‘brands’ you’ve been involved with. If you have numerous partners, you have a much higher risk of developing cancer. So (monogamous) people should go ahead and have the same intimate and personal relationship that they have with their partners and not be worried about it.” For those looking to protect themselves from contracting dangerous forms of HPV, practicing safe sex by using protection such as condoms and dental dams may help to diminish the spread of sexually transmitted diseases.  Posner also called for parents to get their children – including young boys –vaccinated against HPV. “I think people should make every effort to have children vaccinated, so I don’t have to treat this in the future,” Posner said.  I think it’s very important and to cure cancer we have to support research – it’s the best way we have to figure out how to cure this. Click to learn more about HPV from Mount Sinai Hospital.source : http://www.foxnews.com/health/2013/06/03/michael-douglass-reveal-can-get-throat-cancer-from-oral-sex/

Michael Douglas’ reveal: Can you get throat cancer from oral sex?

Michael Douglas made a shocking announcement on Sunday, maintaining that his throat cancer hadn’t been caused by drinking or smoking – but by having oral sex. “Without wanting to get too specific, this particular cancer is caused by HPV, which actually comes about from cunnilingus,” Douglas told The Guardian newspaper.  The 68-year-old actor also went on to speculate that the stress of his son Cameron’s incarceration might have helped trigger the cancer as well. While a connection between oral sex and cancer may seem bizarre, it is very possible that some oral cancers are the end result of intimate sexual contact. Rates of oral cancer – sometimes referred to as head and neck cancers – have been on the rise over the past decade.  While the main risk factors for oral cancers typically include drinking alcohol and smoking, around 25 percent of mouth and 35 percent of throat cancers are related to human papilloma virus (HPV) infection. “(HPV) is present within the fluids that are part of oral sexual behavior,” Dr. Marshall Posner, director of the head and neck oncology program at Mount Sinai Hospital in New York City, told FoxNews.com. “The vaginal fluids and semen will contain epithelial cells that have the virus on them and also free viral particles that can cause infection.” HPV cannot be transmitted through blood contact, but Posner said it may be possible to contract the virus from the direct contact of fluids through kissing. This can occur if an individual kisses someone who previously performed oral sex on someone else who had the virus. “If the virus is present in the oral pharynx and if it gets secreted in the saliva, then the saliva will contain potentially dangerous viral particles,” Posner said. There are more than 100 different types of HPV, and nearly everyone contracts some form of the virus in their youth.  Fortunately, the majority of HPV strains do not cause any symptoms, and in 90 percent of cases, the infection is naturally eradicated from the body within two years. However, some HPV types can cause genital warts, while others may lead to certain cancers in rare cases. HPV 16 and HPV 18 – which are sexually transmitted – are most closely associated with HPV-positive oropharyngeal cancer. According to Posner, 3 percent of adult males and 1 percent of adult females will have detectable HPV 16 in their saliva at any given moment in time.  However, just because HPV is detected in a sample of someone with oral cancer does not necessarily mean HPV caused the cancer.  According to the National Health Service in Britain, the virus becomes part of the pre-existing cancer cells’ genetic material, fostering the cells to grow. Oropharyngeal cancer symptoms include a lump in the back of the throat or mouth, pain in the ear or back of tongue, and difficulty swallowing. While the prognosis for HPV-negative oropharyngeal cancer is around 40 to 50 percent, the survival outcomes are generally better for HPV-positive cancers, ranging from 80 to 95 percent.  However, that prognosis is affected by drinking and smoking, which may have been a problem for Douglas. In the United States, HPV-related oropharyngeal cancer represents 60 percent of the total number of orapharyngeal cancer cases, which equal to about 15,000 per year.  Posner estimated that those cases will increase to 20,000 a year by the year 2015. While researchers cannot fully explain the rising rates of these cancers, one of the biggest risk factor for contracting HPV-positive oroharyngeal cancer includes having a high number of sexual partners, Posner said. “In smoking cigarettes and cancer, it doesn’t matter what brands you smoked, it matters how many you smoked,” Posner said.  “With HPV, it’s about the number of ‘brands’ you’ve been involved with. If you have numerous partners, you have a much higher risk of developing cancer. So (monogamous) people should go ahead and have the same intimate and personal relationship that they have with their partners and not be worried about it.” For those looking to protect themselves from contracting dangerous forms of HPV, practicing safe sex by using protection such as condoms and dental dams may help to diminish the spread of sexually transmitted diseases.  Posner also called for parents to get their children – including young boys –vaccinated against HPV. “I think people should make every effort to have children vaccinated, so I don’t have to treat this in the future,” Posner said.  I think it’s very important and to cure cancer we have to support research – it’s the best way we have to figure out how to cure this. Click to learn more about HPV from Mount Sinai Hospital.source : http://www.foxnews.com/health/2013/06/03/michael-douglass-reveal-can-get-throat-cancer-from-oral-sex/