Tag Archives: reports

Key mechanism, potential target to prevent leukemia found

The studies, in animal models, could lead to new effective treatments for leukemias that are resistant to chemotherapy, said Reuben Kapur, Ph.D., Freida and Albrecht Kipp Professor of Pediatrics at the Indiana University School of Medicine. The research was reported today in the journal Cell Reports. “The issue in the field for a long time has been that many patients relapse even though chemotherapy and other currently available drugs get rid of mature blast cells quite readily,” Dr. Kapur said, referring to the cancerous cells that overrun the blood system in leukemia. …

Role of hormone in response to ovarian cancer treatment

The work comes out of the molecular therapeutic laboratory directed by Richard G. Moore, MD, of Women & Infants’ Program in Women’s Oncology. Entitled “HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation,” the research was recently published in the international science journal Scientific Reports, a Nature publishing group. The goal of the study was to investigate the role of the hormone HE4 in modulating an ovarian cancer’s response to hormones and hormonal therapies. …

Mechanism promoting multiple DNA mutations described by scientists

However, recent studies have shown that cancer development frequently involves the formation of multiple mutations that arise simultaneously and in close proximity to each other. These groups of clustered mutations are frequently found in regions where chromosomal rearrangements take place. The discovery, published in the journal Cell Reports, may one day lead to new cancer therapies, according to a University of Iowa biologist and her colleagues, and a group of researchers from the National Institute of Environmental Health Sciences led by Senior Associate Scientist Dmitry Gordenin. The formation of clustered mutations may result from the process of DNA repair. …

New study shows promise for preventing therapy resistance in tumor cells

Loss of the tumor suppressor p53 often contributes to therapy resistance in tumors. In the study, published in Cell Reports, the University of Kentucky’s Vivek Rangnekar and his colleagues activated wild type p53 in normal cells to trigger cell death in the p53-deficient cancer cells. Because p53 is intact and functional in normal cells, the researchers harnessed its potential to inhibit the growth of p53-deficient cancer cells…

Researchers identify switch that controls growth of most aggressive brain tumor cells

Findings of their investigation show that the protein RIP1 acts as a mediator of brain tumor cell survival, either protecting or destroying cells. Researchers believe that the protein, found in most glioblastomas, can be targeted to develop a drug treatment for these highly malignant brain tumors. The study was published online Aug. 22 in Cell Reports…

Discovered the role of noncoding 5S rRNA in protecting the p53 tumor suppressor gene

The results have been published in the online edition of Cell Reports. Cell growth The ability of cells to grow is directly related to the amount of protein synthesized by ribosomes, the intracellular machinery responsible for translating messenger RNA transcribed from DNA into amino acids containing proteins. …

Research in fruit flies provides new insight into Barrett’s esophagus

A new study, published June 27, 2013 online in Cell Reports, suggests a different cause, namely a change in stem cell function, for this transformation. Researchers at the Buck Institute manipulated a signaling pathway (BMP-like Dpp) implicated in the development of Barrett’s esophagus. After manipulation, the adult stem cells that normally generate the lining of the esophagus of fruit flies morphed into the type of stem cells that generate stomach cells. "Up until this point, it’s not been clear what this signaling pathway does in stem cells of the gastrointestinal tract, or how it influences the regeneration of various types of epithelial cells in the gut of the fly," said Heinrich Jasper, PhD, a professor at the Buck Institute for Research on Aging and senior author of the study…