Mayo researchers studied three patients — two women and a man — who were treated for inflammatory disease and developed melanoma tumors in one eye within a year to two of taking TNF inhibitors. While this type of condition is probably rare, according to the researchers, there might be an increased risk if the patient has a pre-existing nevus (freckle of the eye). …
The envelope (or Env) protein of HIV is a key target for vaccine makers: it is a key component in RV144, an experimental vaccine that is so far the only candidate to show promise in clinical trials. Also called gp120, the Env protein associates with another protein called gp41 and three gp120/gp41 units associate to form the final trimeric structure. The gp120 trimer is the machine that allows HIV to enter and attack host cells. …
“Triclosan’s increasing detection in environmental samples and its increasingly broad use in consumer products may overcome its moderate benefit and present a very real risk of liver toxicity for people, as it does in mice, particularly when combined with other compounds with similar action,” said Robert H. Tukey, PhD, professor in the departments of Chemistry and Biochemistry and Pharmacology. Tukey led the study, together with Bruce D…
Their findings are published today in the journal, Nature Scientific Reports. …
Their research appears in The FASEB Journal. “We hope that this study will lead to novel treatment approaches for women diagnosed with late-stage ovarian cancer,” said Jim Petrik, a Guelph biomedical sciences professor. He worked on the study with Guelph graduate student Samantha Russell and cancer researchers from Harvard Medical School…
The research, published recently in two articles, one in of the Journal of Neuroscience, the other in Cell Cycle, highlights the close links between spinal cord injury and loss of brain function, and suggests potential treatment to prevent such changes. “Animal studies have shown that traumatic brain injury, even mild repeated injuries, can result in progressive brain tissue damage and cognitive decline, as well as widespread brain inflammation. But little research has examined whether these problems occur after spinal cord injuries,” said UM SOM anesthesiology professor and noted neurobiologist Alan Faden, MD, who led the study. “Our studies the first to show that isolated SCI can cause progressive loss of brain cells in key brain regions,” said Faden. …
Clinicians term an individual’s initial diagnosis a first primary cancer. A second primary cancer is one diagnosed at some point after the first diagnosis. …
The studies, in animal models, could lead to new effective treatments for leukemias that are resistant to chemotherapy, said Reuben Kapur, Ph.D., Freida and Albrecht Kipp Professor of Pediatrics at the Indiana University School of Medicine. The research was reported today in the journal Cell Reports. “The issue in the field for a long time has been that many patients relapse even though chemotherapy and other currently available drugs get rid of mature blast cells quite readily,” Dr. Kapur said, referring to the cancerous cells that overrun the blood system in leukemia. …
John Roeske, PhD, and colleagues presented how they developed and evaluated the technology at the recent annual meeting of the American Society for Therapeutic Radiology and Oncology. Their approach uses dual-energy imaging combined with fluoroscopy to view tumors during radiation therapy. This technology does not require an X-ray that produces both high-and low-energy images. Existing hardware can be used to eliminate visuals of the ribs and other bones making it easier to see the tumor…
In one of the first studies of its kind to examine British perceptions of obesity, fewer than 10 per cent of those who are clinically obese accept they have a serious weight problem. In a 2012 survey of around 2000 adults, only 11 per cent of obese women accurately acknowledged they were “obese,” with most describing themselves as “very overweight” or “just right.” And among men, only seven per cent correctly described themselves as being “obese” and another 16 per cent as “very overweight.” Approximately 10 per cent of people in the survey knew the BMI threshold for obesity and those who did were more likely to define themselves as “obese.” Researchers suggest that as bigger sizes become the new “normal,” people are less likely to recognise the health problems associated with their weight. Professor Jane Wardle, co-author and director of the Cancer Research UK Health Behaviour Centre at UCL, said: “It’s a real worry that people don’t recognise that their weight places them in the obese category, because it means they aren’t aware they are at increased risk of a number of health problems including cancer. …