Tag Archives: cycle

Do spinal cord injuries cause subsequent brain damage?

The research, published recently in two articles, one in of the Journal of Neuroscience, the other in Cell Cycle, highlights the close links between spinal cord injury and loss of brain function, and suggests potential treatment to prevent such changes. “Animal studies have shown that traumatic brain injury, even mild repeated injuries, can result in progressive brain tissue damage and cognitive decline, as well as widespread brain inflammation. But little research has examined whether these problems occur after spinal cord injuries,” said UM SOM anesthesiology professor and noted neurobiologist Alan Faden, MD, who led the study. “Our studies the first to show that isolated SCI can cause progressive loss of brain cells in key brain regions,” said Faden. …

Searching for magic bullet against cancer caused by asbestos: One step closer?

In December, the research team of Antonio Giordano, a pathologist, Director and Founder of the Sbarro Health Research Organization in Philadelphia, PA, and Professor of Pathology and Oncology at the University of Siena, Italy, published two separate studies aiming to address the urgent need to identify possible new methods for mesothelioma treatment. In the first study, published in the scientific journal Cell Cycle, Giordano’s researchers tested on mesothelioma cells the effect of two drugs designed to reactivate the p53 protein, one of the most important ‘tumor suppressors’, which is turned off in most human cancers. "In mesothelioma, although p53 is rarely mutated, it is inactivated by alterations in its pathway," says Francesca Pentimalli of the National Cancer Institute of Naples, Italy, lead author of the study. …

Key role of protein in segregation of genetic material during cell division

Cell-cycle Cells in all organisms grow and divide into two daughter cells by an ordered sequence of events called "cell cycle." Basically , the cells have to complete four main processes during the cell cycle : growth ( G1 and G2 phases ) , doubling the DNA ( S phase ) , segregate chromosomes ( M phase , mitosis) and divide ( cytokinesis ) . …

Novel study charts aggressive prostate cancer

Investigators in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute have made extensive progress in understanding the molecular mechanisms of disease progression. These results may help scientists better understand the prognosis of patients diagnosed with advanced prostate cancer. The study, published in the journal Cell Cycle and led by Dolores Di Vizio, MD, PhD, may ultimately lead to the development of new biomarkers for not only prognosis, but also a patient’s potential response to therapy. "One of the long-standing difficulties in treating men with advanced prostate cancer has been predicting the response to given therapies or treatments," said Di Vizio, associate professor in the Department of Surgery, Department of Pathology and Laboratory Medicine and Department of Biomedical Sciences. …

Metformin for breast cancer less effective at higher glucose concentrations

Metformin, the most common first-line drug in the treatment of type-2 diabetes, has been shown in previous studies to reduce breast cancer risk, improve survival, and increase the effectiveness of chemotherapy. Numerous Phase III clinical trials are currently evaluating the benefits and best uses of metformin in breast cancer patients. "We show that metformin works differently in high- compared to low-glucose conditions. Not only does it require a higher concentration of metformin to be active in high-glucose conditions, but we report that the drug regulates different genes within cancer cells at high as compared to normal glucose levels," says Ann Thor, MD, CU Cancer Center investigator, Todd Professor of Pathology at the University of Colorado School of Medicine, and the study’s principal investigator. …

7 tips to stop your summer weight obsession

With summer approaching, you might spend time preparing for swimsuit season. Rather than dreading this time of year, here are some tips to begin to practice appreciating your body so you can enjoy the sun. 1.   Accept your weight. You may think the more you fight your weight, the more you’ll succeed in losing weight. This simply isn’t true. Accepting doesn’t mean not taking steps towards changing your weight, it means not letting your weight hold you back from your life. If you’re waiting until you lose weight to apply for jobs or start online dating, your weight is going to weigh you down. Do what you care about now. 2.   Go on a weight-talk diet. It’s tempting to ask your friends if you’ve lost weight, ask them about what they’re doing to lose weight, or discuss together who you think needs to lose weight. There is way more to talk about than weight. When the topic comes up, practice moving the topic to something more fun! 3.   Only visit your scale once a week. Weight fluctuates within six pounds on any given day depending of what you’ve had to eat and drink. Rather than checking your weight compulsively and worrying you gained weight after you ate a big meal, only weigh yourself once a week and make it at a set time, like 8 a.m. Monday mornings. 4.   Go shopping.   If you are in between sizes and your clothes are uncomfortably snug, you will constantly remember you’ve gained weight and eat to cope with this negative feeling. I’ve seen a lot of clients feel better and eat better by wearing clothes that fit. Buying clothes your size is not giving up, it’s being practical. 5. If you compare, be fair. It’s weirdly tempting to compare yourself to the thinnest person you see or a celebrity you admire. Yet, this is so unfair and sets you up to feel inferior and obsess further. Rather than compare yourself to someone remarkably thin or fit, compare yourself to every eighth person you see. Better yet, don’t compare. When you notice you’re judging yourself in comparison to someone else, remind yourself that’s a judgment and let go. 6. Eat regular meals. Many people who struggle with obsessing around food get caught in this cycle: Overeat --> limit what they eat to make up for the indulgence --> feel hungry --> overeat. Rather than get caught in this cycle of feeling too full then feeling too hungry, eat three meals and two snacks. If you ate too much for breakfast, eat a normal lunch; this will prevent you from skimping on lunch and splurging on dinner. 7. Relax your face when you look in the mirror. One of the ways to improve your body image and stop engaging in negative thoughts about your appearance is to relax your face and body when you look in the mirror. There’s a facial feedback loop and the facial expressions we make solidify how we feel. Research on Botox shows people whose facial muscles are paralyzed experience less intense emotions. One way to relax your face is to ever so slightly lift the upper corners of your lips. If you don’t want your daughter to learn to grimace in front of the mirror, become a role model for self-acceptance.Jennifer Taitz & is a licensed clinical psychologist based in New York City. She is the author of End Emotional Eating: Using Dialectical Behavior Therapy Skills to Cope with Difficult Emotions and Develop Healthy Relationship to Food. Visit her website drjennytaitz.com to learn more.source : http://www.foxnews.com/health/2013/05/14/7-tips-to-stop-your-summer-weight-obsession/