Category Archives: Cancer

Allergic and autoimmune diseases linked, mouse study suggests

The results of previous research had shown that people with minor variations in the BACH2 gene often develop allergic or autoimmune diseases, and that a common factor in these diseases is a compromised immune system. In this study in mice, the Bach2 gene was found to be a critical regulator of the immune system’s reactivity. The study, headed by researchers at the National Cancer Institute (NCI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), both part of NIH, and their colleagues appeared online in Nature, June 2, 2013. …

Genetic signature of deadly brain cancer identified

"This study identifies a core set of genes and pathways that are dysregulated during both the early and late stages of tumor progression," said University of Rochester Medical Center (URMC) neurologist Steven Goldman, M.D., Ph.D., the senior author of the study and co-director of the Center for Translational Neuromedicine. "By virtue of their marked difference from normal cells, these genes appear to comprise a promising set of targets for therapeutic intervention." As its name implies, gliomas arise from a cell type found in the central nervous system called the glial cell. Gliomas progress in severity over time and ultimately become highly invasive tumors known as glioblastomas, which are difficult to treat and almost invariably fatal. …

Potential new way to suppress tumor growth discovered

Writing in this week’s online Early Edition of the Proceedings of the National Academy of Sciences (PNAS), Willis X. Li, PhD, a professor in the Department of Medicine at UC San Diego, reports that a particular form of a signaling protein called STAT5A stabilizes the formation of heterochromatin (a form of chromosomal DNA), which in turn suppresses the ability of cancer cells to issue instructions to multiply and grow. Specifically, Li and colleagues found that the unphosphorylated form of STAT promotes and stabilizes heterochromatin, which keeps DNA tightly packaged and inaccessible to transcription factors. …

Mystery behind dormant breast tumor cells that become metastatic unlocked

In a small but significant number of breast cancer patients, cancerous cells can move through the bloodstream from breast tissue to secondary sites in other parts of the body where they may remain in a dormant state, clinically undetected, for an extended period of time, before suddenly becoming metastatic. …

Michael Douglas’ interview: Can you get throat cancer from oral sex?

The Guardian newspaper published an interview with Michael Douglas on Sunday, in which the 68-year-old actor said his throat cancer hadn’t been caused by drinking or smoking – but by having oral sex. “Without wanting to get too specific, this particular cancer is caused by HPV, which actually comes about from cunnilingus,” Douglas told the British newspaper.  Douglas also went on to speculate that the stress of his son Cameron’s incarceration might have helped trigger the cancer as well. While a representative for Douglas maintains the actor did not specifically say oral sex was the cause of his cancer, the conversation still begs the question: Does having oral sex play a role in the development of oral cancer? While a connection between the two may seem bizarre, it is very possible that some oral cancers are the end result of intimate sexual contact. Rates of oral cancer – sometimes referred to as head and neck cancers – have been on the rise over the past decade.  While the main risk factors for oral cancers typically include drinking alcohol and smoking, around 25 percent of mouth and 35 percent of throat cancers are related to human papilloma virus (HPV) infection. “(HPV) is present within the fluids that are part of oral sexual behavior,” Dr. Marshall Posner, director of the head and neck oncology program at Mount Sinai Hospital in New York City, told FoxNews.com. “The vaginal fluids and semen will contain epithelial cells that have the virus on them and also free viral particles that can cause infection.” HPV cannot be transmitted through blood contact, but Posner said it may be possible to contract the virus from the direct contact of fluids through kissing. This can occur if an individual kisses someone who previously performed oral sex on someone else who had the virus. “If the virus is present in the oral pharynx and if it gets secreted in the saliva, then the saliva will contain potentially dangerous viral particles,” Posner said. There are more than 100 different types of HPV, and nearly everyone contracts some form of the virus in their youth.  Fortunately, the majority of HPV strains do not cause any symptoms, and in 90 percent of cases, the infection is naturally eradicated from the body within two years. However, some HPV types can cause genital warts, while others may lead to certain cancers in rare cases. HPV 16 and HPV 18 – which are sexually transmitted – are most closely associated with HPV-positive oropharyngeal cancer. According to Posner, 3 percent of adult males and 1 percent of adult females will have detectable HPV 16 in their saliva at any given moment in time.  However, just because HPV is detected in a sample of someone with oral cancer does not necessarily mean HPV caused the cancer.  According to the National Health Service in Britain, the virus becomes part of the pre-existing cancer cells’ genetic material, fostering the cells to grow. Oropharyngeal cancer symptoms include a lump in the back of the throat or mouth, pain in the ear or back of tongue, and difficulty swallowing. While the prognosis for HPV-negative oropharyngeal cancer is around 40 to 50 percent, the survival outcomes are generally better for HPV-positive cancers, ranging from 80 to 95 percent.  However, that prognosis is affected by drinking and smoking, which may have been a problem for Douglas. In the United States, HPV-related oropharyngeal cancer represents 60 percent of the total number of orapharyngeal cancer cases, which equal to about 15,000 per year.  Posner estimated that those cases will increase to 20,000 a year by the year 2015. While researchers cannot fully explain the rising rates of these cancers, one of the biggest risk factor for contracting HPV-positive oroharyngeal cancer includes having a high number of sexual partners, Posner said. “In smoking cigarettes and cancer, it doesn’t matter what brands you smoked, it matters how many you smoked,” Posner said.  “With HPV, it’s about the number of ‘brands’ you’ve been involved with. If you have numerous partners, you have a much higher risk of developing cancer. So (monogamous) people should go ahead and have the same intimate and personal relationship that they have with their partners and not be worried about it.” For those looking to protect themselves from contracting dangerous forms of HPV, practicing safe sex by using protection such as condoms and dental dams may help to diminish the spread of sexually transmitted diseases.  Posner also called for parents to get their children – including young boys –vaccinated against HPV. “I think people should make every effort to have children vaccinated, so I don’t have to treat this in the future,” Posner said.  I think it’s very important and to cure cancer we have to support research – it’s the best way we have to figure out how to cure this. Click to learn more about HPV from Mount Sinai Hospital.source : http://www.foxnews.com/health/2013/06/03/michael-douglass-reveal-can-get-throat-cancer-from-oral-sex/

Michael Douglas’ reveal: Can you get throat cancer from oral sex?

Michael Douglas made a shocking announcement on Sunday, maintaining that his throat cancer hadn’t been caused by drinking or smoking – but by having oral sex. “Without wanting to get too specific, this particular cancer is caused by HPV, which actually comes about from cunnilingus,” Douglas told The Guardian newspaper.  The 68-year-old actor also went on to speculate that the stress of his son Cameron’s incarceration might have helped trigger the cancer as well. While a connection between oral sex and cancer may seem bizarre, it is very possible that some oral cancers are the end result of intimate sexual contact. Rates of oral cancer – sometimes referred to as head and neck cancers – have been on the rise over the past decade.  While the main risk factors for oral cancers typically include drinking alcohol and smoking, around 25 percent of mouth and 35 percent of throat cancers are related to human papilloma virus (HPV) infection. “(HPV) is present within the fluids that are part of oral sexual behavior,” Dr. Marshall Posner, director of the head and neck oncology program at Mount Sinai Hospital in New York City, told FoxNews.com. “The vaginal fluids and semen will contain epithelial cells that have the virus on them and also free viral particles that can cause infection.” HPV cannot be transmitted through blood contact, but Posner said it may be possible to contract the virus from the direct contact of fluids through kissing. This can occur if an individual kisses someone who previously performed oral sex on someone else who had the virus. “If the virus is present in the oral pharynx and if it gets secreted in the saliva, then the saliva will contain potentially dangerous viral particles,” Posner said. There are more than 100 different types of HPV, and nearly everyone contracts some form of the virus in their youth.  Fortunately, the majority of HPV strains do not cause any symptoms, and in 90 percent of cases, the infection is naturally eradicated from the body within two years. However, some HPV types can cause genital warts, while others may lead to certain cancers in rare cases. HPV 16 and HPV 18 – which are sexually transmitted – are most closely associated with HPV-positive oropharyngeal cancer. According to Posner, 3 percent of adult males and 1 percent of adult females will have detectable HPV 16 in their saliva at any given moment in time.  However, just because HPV is detected in a sample of someone with oral cancer does not necessarily mean HPV caused the cancer.  According to the National Health Service in Britain, the virus becomes part of the pre-existing cancer cells’ genetic material, fostering the cells to grow. Oropharyngeal cancer symptoms include a lump in the back of the throat or mouth, pain in the ear or back of tongue, and difficulty swallowing. While the prognosis for HPV-negative oropharyngeal cancer is around 40 to 50 percent, the survival outcomes are generally better for HPV-positive cancers, ranging from 80 to 95 percent.  However, that prognosis is affected by drinking and smoking, which may have been a problem for Douglas. In the United States, HPV-related oropharyngeal cancer represents 60 percent of the total number of orapharyngeal cancer cases, which equal to about 15,000 per year.  Posner estimated that those cases will increase to 20,000 a year by the year 2015. While researchers cannot fully explain the rising rates of these cancers, one of the biggest risk factor for contracting HPV-positive oroharyngeal cancer includes having a high number of sexual partners, Posner said. “In smoking cigarettes and cancer, it doesn’t matter what brands you smoked, it matters how many you smoked,” Posner said.  “With HPV, it’s about the number of ‘brands’ you’ve been involved with. If you have numerous partners, you have a much higher risk of developing cancer. So (monogamous) people should go ahead and have the same intimate and personal relationship that they have with their partners and not be worried about it.” For those looking to protect themselves from contracting dangerous forms of HPV, practicing safe sex by using protection such as condoms and dental dams may help to diminish the spread of sexually transmitted diseases.  Posner also called for parents to get their children – including young boys –vaccinated against HPV. “I think people should make every effort to have children vaccinated, so I don’t have to treat this in the future,” Posner said.  I think it’s very important and to cure cancer we have to support research – it’s the best way we have to figure out how to cure this. Click to learn more about HPV from Mount Sinai Hospital.source : http://www.foxnews.com/health/2013/06/03/michael-douglass-reveal-can-get-throat-cancer-from-oral-sex/

Elephant at Oregon Zoo diagnosed with tuberculosis

The Oregon Zoo has quarantined an elephant that tested positive for tuberculosis. “Rama,” an Asian elephant that was born at the Portland-based zoo in 1983, tested positive on Friday. He shows no symptoms of the disease, poses no threat to visitors and is expected to make a complete recovery, zoo staff said. “We're confident Rama is going to be fine,” zoo director Kim Smith told The Oregonian newspaper. “It's a very treatable disease. We've caught it early with Rama. We feel very good about this.” Treatment with drugs, however, is expensive, costing more than $50,000, the newspaper reported. None of the other elephants in the zoo's heard of eight Asian elephants are showing signs of tuberculosis, but they will be retested. The zoo tested some staff members Friday and will continue this week. It's unknown how Rama contracted the disease. Tuberculosis spreads among people and between people and animals through airborne bacteria carried in droplets. To become infected, you must be directly exposed to the bacteria while it's airborne. “In order to contact TB, you have to be in really close contact for hours at a stretch,” Smith said. The zoo has tested the herd annually for TB since 1999, based on guidelines developed by the U.S. Department of Agriculture. Those guidelines stemmed from the 1996 deaths of two circus elephants touring in California. An estimated 3 percent of the elephants in the United States have the disease, according to a 2000 study published in the journal Zoo Biology. The zoo gets 1.6 million visitors a year and the elephant herd is a popular attraction. Rama is the smallest of its adult bull elephants, weighing 9,000 pounds.source : http://www.foxnews.com/health/2013/06/03/elephant-at-portland-zoo-has-tuberculosis/

Deadly MERS virus spreads to Italy

Three people were being treated Saturday for a new respiratory virus that is alarming global health officials, in the first cases in Italy, says the country's health ministry. A 45-year-old man who had recently returned from a 40-day visit to Jordan was hospitalized in Tuscany with a high fever, cough and respiratory problems, says the ministry. Tuscan regional officials say that a young child who is related to the man and a work colleague also have the virus, the ministry said. All three patients were reported to be in good condition and were being treated in isolation. The virus is related to SARS, which killed about 800 people in a global epidemic in 2003. The U.N. health agency said earlier Saturday that it had been informed of 51 confirmed cases of the new virus since September. Thirty of those cases were fatal, including that of a Frenchman who died earlier in the week. Cases in Britain and Germany also have been reported. Most of those infected had traveled to Qatar, Saudi Arabia, Jordan or Pakistan.source : http://www.foxnews.com/health/2013/06/03/deadly-mers-virus-spreads-to-italy/